Metabotropic glutamate receptors as targets for new antipsychotic drugs: Historical perspective and critical comparative assessment von Wierońska, Joanna M, Zorn, Stevin H, Doller, Dario, Pilc, Andrzej

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Dusting off old blueprints: Is it time to reconsider metabotropic glutamate receptor 2 for therapeutic drug development? von Bespalov, Anton, Lütjens, Robert, Doller, Dario

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The “Century of Biology” and the Evolving Role of Medicinal Chemists in Neuroscience von Doller, Dario

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Chemical Biology at Lundbeck: Enhancing CNS drug discovery research von Doller, Dario

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Discovery of N-(1-Ethylpropyl)-[3-methoxy-5-(2-methoxy-4-trifluoromethoxyphenyl)-6-methyl-pyrazin-2-yl]amine 59 (NGD 98−2): An Orally Active Corticotropin Releasing Factor-1 (CRF-1... von Hodgetts, Kevin J, Ge, Ping, Yoon, Taeyoung, Lombaert, Stéphane De, Brodbeck, Robbin, Gulianello, Michael, Kieltyka, Andrzej, Horvath, Raymond F, Kehne, John H, Krause, James E, Maynard, George D, Hoffman, Diane, Lee, Younglim, Fung, Laurence, Doller, Dario

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Synergy between l-DOPA and a novel positive allosteric modulator of metabotropic glutamate receptor 4: Implications for Parkinson's disease treatment and dyskinesia von Bennouar, Khaled-Ezaheir, Uberti, Michelle A., Melon, Christophe, Bacolod, Maria D., Jimenez, Hermogenes N., Cajina, Manuel, Kerkerian-Le Goff, Lydia, Doller, Darío, Gubellini, Paolo

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The antipsychotic-like effects in rodents of the positive allosteric modulator Lu AF21934 involve 5-HT1A receptor signaling: mechanistic studies von Wierońska, Joanna M., Sławińska, Anna, Łasoń-Tyburkiewicz, Magdalena, Gruca, Piotr, Papp, Mariusz, Zorn, Stevin H., Doller, Darío, Kłeczek, Natalia, Noworyta-Sokołowska, Karolina, Gołembiowska, Krystyna, Pilc, Andrzej

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Quality of Research Tools

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Metabolism-Based Identification of a Potent Thrombin Receptor Antagonist von Clasby, Martin C, Chackalamannil, Samuel, Czarniecki, Michael, Doller, Dario, Eagen, Keith, Greenlee, William, Kao, Grace, Lin, Yan, Tsai, Hsingan, Xia, Yan, Ahn, Ho-Sam, Agans-Fantuzzi, Jacqueline, Boykow, George, Chintala, Madhu, Foster, Carolyn, Smith-Torhan, April, Alton, Kevin, Bryant, Matthew, Hsieh, Yunsheng, Lau, Janice, Palamanda, Jairam

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Tricyclic Thiazolopyrazole Derivatives as Metabotropic Glutamate Receptor 4 Positive Allosteric Modulators von Hong, Sang-Phyo, Liu, Kevin G, Ma, Gil, Sabio, Michael, Uberti, Michelle A, Bacolod, Maria D, Peterson, John, Zou, Zack Z, Robichaud, Albert J, Doller, Darío

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Discovery of Potent Orally Active Thrombin Receptor (Protease Activated Receptor 1) Antagonists as Novel Antithrombotic Agents von Chackalamannil, Samuel, Xia, Yan, Greenlee, William J, Clasby, Martin, Doller, Darìo, Tsai, Hsingan, Asberom, Theodros, Czarniecki, Michael, Ahn, Ho-Sam, Boykow, George, Foster, Carolyn, Agans-Fantuzzi, Jacqueline, Bryant, Matthew, Lau, Janice, Chintala, Madhu

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Allosteric Modalities for Membrane-Bound Receptors: Insights from Drug Hunting for Brain Diseases von Coughlin, Quinn, Hopper, Allen T, Blanco, Maria-Jesus, Tirunagaru, Vijaya, Robichaud, Albert J, Doller, Dario

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Failed trials for central nervous system disorders do not necessarily invalidate preclinical models and drug targets von Bespalov, Anton, Steckler, Thomas, Altevogt, Bruce, Koustova, Elena, Skolnick, Phil, Deaver, Daniel, Millan, Mark J., Bastlund, Jesper F., Doller, Dario, Witkin, Jeffrey, Moser, Paul, O'Donnell, Patricio, Ebert, Ulrich, Geyer, Mark A., Prinssen, Eric, Ballard, Theresa, Macleod, Malcolm

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Discovery and structure–activity relationship of 1,3-cyclohexyl amide derivatives as novel mGluR5 negative allosteric modulators von Zhou, Hao, Topiol, Sidney W., Grenon, Michel, Jimenez, Hermogenes N., Uberti, Michelle A., Smith, Daniel G., Brodbeck, Robbin M., Chandrasena, Gamini, Pedersen, Henrik, Madsen, Jens Christian, Doller, Darío, Li, Guiying

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The selective functionalization of saturated hydrocarbons: Gif chemistry von Barton, Derek H. R, Doller, Dario

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Synthesis and insecticidal activity of fluorinated 2-(2,6-dichloro-4-trifluoromethylphenyl)-2,4,5,6-tetrahydrocyclopentapyrazoles von Meegalla, Sanath K., Doller, Dario, Liu, Ruiping, Sha, DeYou, Lee, YuKai, Soll, Richard M., Wisnewski, Nancy, Silver, Gary M., Dhanoa, Dale

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Distinct effects of mGlu4 receptor positive allosteric modulators at corticostriatal vs. striatopallidal synapses may differentially contribute to their antiparkinsonian action von Gubellini, Paolo, Melon, Christophe, Dale, Elena, Doller, Dario, Kerkerian-Le Goff, Lydia

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4-(1-Phenyl-1H-pyrazol-4-yl)quinolines as novel, selective and brain penetrant metabotropic glutamate receptor 4 positive allosteric modulators von Jimenez, Hermogenes N., Liu, Kevin G., Hong, Sang-Phyo, Reitman, Michael S., Uberti, Michelle A., Bacolod, Maria D., Cajina, Manuel, Nattini, Megan, Sabio, Michael, Doller, Darío

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5-amino-1-(2,6-dichloro-4-trifluoromethyl-phenyl)-3-[3H3]-methylsulfanyl-1H-pyrazole-4-carbonitrile (CTOM): synthesis and characterization of a novel and selective insect GABA rece... von Meegalla, Sanath K, Doller, Dario, Silver, Gary M, Wisnewski, Nancy, Soll, Richard M, Dhanoa, Dale

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Potent, low molecular weight thrombin receptor antagonists von Chackalamannil, Samuel, Doller, Darı́o, Eagen, Keith, Czarniecki, Michael, Ahn, Ho-Sam, Foster, Carolyn J., Boykow, George

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