An Asymmetric Synthesis of the Tricyclic Core and a Formal Total Synthesis of Roseophilin via an Enyne Metathesis von Trost, Barry M, Doherty, George A

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Discovery of Danoprevir (ITMN-191/R7227), a Highly Selective and Potent Inhibitor of Hepatitis C Virus (HCV) NS3/4A Protease von Jiang, Yutong, Andrews, Steven W., Condroski, Kevin R., Buckman, Brad, Serebryany, Vlad, Wenglowsky, Steve, Kennedy, April L., Madduru, Machender R., Wang, Bin, Lyon, Michael, Doherty, George A., Woodard, Benjamin T., Lemieux, Christine, Do, Mary Geck, Zhang, Hailong, Ballard, Joshua, Vigers, Guy, Brandhuber, Barbra J., Stengel, Peter, Josey, John A., Beigelman, Leonid, Blatt, Lawrence, Seiwert, Scott D.

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SAR and characterization of non-substrate isoindoline urea inhibitors of nicotinamide phosphoribosyltransferase (NAMPT) von Curtin, Michael L., Heyman, H. Robin, Clark, Richard F., Sorensen, Bryan K., Doherty, George A., Hansen, T. Matthew, Frey, Robin R., Sarris, Kathy A., Aguirre, Ana L., Shrestha, Anurupa, Tu, Noah, Woller, Kevin, Pliushchev, Marina A., Sweis, Ramzi F., Cheng, Min, Wilsbacher, Julie L., Kovar, Peter J., Guo, Jun, Cheng, Dong, Longenecker, Kenton L., Raich, Diana, Korepanova, Alla V., Soni, Nirupama B., Algire, Mikkel A., Richardson, Paul L., Marin, Violeta L., Badagnani, Ilaria, Vasudevan, Anil, Buchanan, F. Greg, Maag, David, Chiang, Gary G., Tse, Chris, Michaelides, Michael R.

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Discovery of A‑1331852, a First-in-Class, Potent, and Orally-Bioavailable BCL‑XL Inhibitor von Wang, Le, Doherty, George A, Judd, Andrew S, Tao, Zhi-Fu, Hansen, T. Matthew, Frey, Robin R, Song, Xiaohong, Bruncko, Milan, Kunzer, Aaron R, Wang, Xilu, Wendt, Michael D, Flygare, John A, Catron, Nathaniel D, Judge, Russell A, Park, Chang H, Shekhar, Shashank, Phillips, Darren C, Nimmer, Paul, Smith, Morey L, Tahir, Stephen K, Xiao, Yu, Xue, John, Zhang, Haichao, Le, Phuong N, Mitten, Michael J, Boghaert, Erwin R, Gao, Wenqing, Kovar, Peter, Choo, Edna F, Diaz, Dolores, Fairbrother, Wayne J, Elmore, Steven W, Sampath, Deepak, Leverson, Joel D, Souers, Andrew James

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Antibody responses and correlates of protection in the general population after two doses of the ChAdOx1 or BNT162b2 vaccines von Wei, Jia, Pouwels, Koen B., Stoesser, Nicole, Matthews, Philippa C., Diamond, Ian, Studley, Ruth, Rourke, Emma, Cook, Duncan, Bell, John I., Newton, John N., Farrar, Jeremy, Howarth, Alison, Marsden, Brian D., Hoosdally, Sarah, Jones, E. Yvonne, Stuart, David I., Crook, Derrick W., Peto, Tim E. A., Walker, A. Sarah, Eyre, David W.

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Performance characteristics of five immunoassays for SARS-CoV-2: a head-to-head benchmark comparison von Ainsworth, Mark, Andersson, Monique, Auckland, Kathryn, Baillie, J Kenneth, Barnes, Eleanor, Beer, Sally, Blackwell, Luke, Borak, Martyna, Bown, Abbie, Brooks, Tim, Burgess-Brown, Nicola A, Camara, Susana, Catton, Matthew, Chau, Kevin K., Clutterbuck, Elizabeth, Coker, Jesse, Crawford-Jones, David, Crook, Derrick W, D'Arcangelo, Silvia, Dequaire, Julie M M, Dimitriadis, Stavros, Dingle, Kate E, Doherty, George, Dong, Tao, Dunachie, Susanna J, Ebner, Daniel, Emmenegger, Marc, Espinosa, Alexis, Eyre, David W, Fassih, Shayan, Felle, Sally, Fernandez-Cid, Alejandra, Fernandez Mendoza, Maria, Fordwoh, Thomas, Fox McKee, Deborah, Frater, John, Gallardo Sanchez, Veronica, Gent, Nick, Georgiou, Dominique, Groves, Christopher J, Hammond, Peter M, Hatch, Stephanie B., Hill, Jennifer, Howarth, Alison, Jones, Elizabeth, Kavanagh, James, Kirton, Richard, Klenerman, Paul, Knight, Julian C, Koukouflis, Leonidas, Kwok, Andrew, Leuschner, Ullrich, Levin, Robert, Linder, Aline, Lockett, Teresa, Marinou, Spyridoula, Martinez, Jose, Martins Ferreira, Lucas, Mason, Lara, Matthews, Philippa C, Mentzer, Alexander J, Mobbs, Alexander, Mongkolsapaya, Juthathip, Mukhopadhyay, Shubhashish M M, Neville, Matthew J, Oakley, Sarah, Oliveira, Marta, Otter, Ashley, Pascoe, Jordan, Perez, Elena, Perumal, Prem K, Peto, Timothy E A, Pickford, Hayleah, Ploeg, Rutger J, Richardson, Anastasia, Ritter, Thomas G, Roberts, David J, Rodger, Gillian, Rollier, Christine S, Rowe, Cathy, Rudkin, Justine K, Screaton, Gavin, Semple, Malcolm G, Sienkiewicz, Alex, Silva-Reyes, Laura, Skelly, Donal T, Sobrino Diaz, Alberto, Stafford, Lizzie, Stockdale, Lisa, Stoesser, Nicole, Stuart, David I, Thraves, Hannah, Vipond, Richard, Walker, Timothy M, Wareing, Susan, Warren, Yolanda, Wells, Charlie, Wilson, Clare, Withycombe, Kate, Young, Rebecca K

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Discovery of diphenyl lactam derivatives as N-type calcium channel blockers von Doherty, George A., Bhatia, Pramila, Vortherms, Timothy A., Marsh, Kennan C., Wetter, Jill M., Mack, Helmut, Scott, Victoria E., Jarvis, Michael F., Stewart, Andrew O.

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Antibody responses to SARS-CoV-2 vaccines in 45,965 adults from the general population of the United Kingdom von Wei, Jia, Stoesser, Nicole, Matthews, Philippa C., Ayoubkhani, Daniel, Studley, Ruth, Bell, Iain, Bell, John I., Newton, John N., Farrar, Jeremy, Diamond, Ian, Rourke, Emma, Howarth, Alison, Marsden, Brian D., Hoosdally, Sarah, Jones, E. Yvonne, Stuart, David I., Crook, Derrick W., Peto, Tim E. A., Pouwels, Koen B., Eyre, David W., Walker, A. Sarah

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Anti-spike antibody response to natural SARS-CoV-2 infection in the general population von Wei, Jia, Matthews, Philippa C., Stoesser, Nicole, Maddox, Thomas, Lorenzi, Luke, Studley, Ruth, Bell, John I., Newton, John N., Farrar, Jeremy, Diamond, Ian, Rourke, Emma, Howarth, Alison, Marsden, Brian D., Hoosdally, Sarah, Jones, E. Yvonne, Stuart, David I., Crook, Derrick W., Peto, Tim E. A., Pouwels, Koen B., Walker, A. Sarah, Eyre, David W.

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Tracking the Emergence of SARS-CoV-2 Alpha Variant in the United Kingdom von Walker, A. Sarah, Vihta, Karina-Doris, Gethings, Owen, Pritchard, Emma, Jones, Joel, House, Thomas, Bell, Iain, Bell, John I, Newton, John N, Farrar, Jeremy, Diamond, Ian, Studley, Ruth, Rourke, Emma, Hay, Jodie, Hopkins, Susan, Crook, Derrick, Peto, Tim, Matthews, Philippa C, Eyre, David W, Stoesser, Nicole, Pouwels, Koen B

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An Observational Cohort Study on the Incidence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection and B.1.1.7 Variant Infection in Healthcare Workers by Anti... von Lumley, Sheila F, Rodger, Gillian, Constantinides, Bede, Sanderson, Nicholas, Chau, Kevin K, Street, Teresa L, O’Donnell, Denise, Howarth, Alison, Hatch, Stephanie B, Marsden, Brian D, Cox, Stuart, James, Tim, Warren, Fiona, Peck, Liam J, Ritter, Thomas G, de Toledo, Zoe, Warren, Laura, Axten, David, Cornall, Richard J, Jones, E Yvonne, Stuart, David I, Screaton, Gavin, Ebner, Daniel, Hoosdally, Sarah, Chand, Meera, Crook, Derrick W, O’Donnell, Anne-Marie, Conlon, Christopher P, Pouwels, Koen B, Walker, A Sarah, Peto, Tim E A, Hopkins, Susan, Walker, Timothy M, Stoesser, Nicole E, Matthews, Philippa C, Jeffery, Katie, Eyre, David W

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Symptoms and Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Positivity in the General Population in the United Kingdom von Vihta, Karina Doris, Pouwels, Koen B, Peto, Tim E A, Pritchard, Emma, Eyre, David W, House, Thomas, Gethings, Owen, Studley, Ruth, Rourke, Emma, Cook, Duncan, Diamond, Ian, Crook, Derrick, Matthews, Philippa C, Stoesser, Nicole, Walker, Ann Sarah

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Community prevalence of SARS-CoV-2 in England from April to November, 2020: results from the ONS Coronavirus Infection Survey von Pouwels, Koen B, House, Thomas, Pritchard, Emma, Robotham, Julie V, Birrell, Paul J, Gelman, Andrew, Vihta, Karina-Doris, Bowers, Nikola, Boreham, Ian, Thomas, Heledd, Bell, Iain, Bell, John I, Newton, John N, Farrar, Jeremy, Benton, Pete, Walker, Ann Sarah, Pouwels, Koen B., Crook, Derrick, Matthews, Philippa C., Peto, Tim, Pritchard, Emma, Stoesser, Nicole, Vihta, Karina-Doris, Howarth, Alison, Doherty, George, Kavanagh, James, Chau, Kevin K., Martins Ferreira, Lucas, Marsden, Brian D., Mongkolsapaya, Juthathip, Cornall, Richard, Stuart, David I., Screaton, Gavin, Bell, John, Cox, Stuart, Paddon, Kevin, James, Tim, House, Thomas, Newton, John N., Birrell, Paul, Sheppard, Tim, Athey, Graham, Moody, Dan, Curry, Leigh, Brereton, Pamela, Hay, Jodie, Vansteenhouse, Harper, Benton, Pete, Rourke, Emma, Henry, Sarah, Scruton, James, Stokes, Peter, Thomas, Tina, Allen, John, Black, Russell, Bovill, Heather, Braunholtz, David, Brown, Dominic, Collyer, Sarah, Crees, Megan, Daglish, Colin, Davies, Byron, Donnarumma, Hannah, Douglas-Mann, Julia, Felton, Antonio, Finselbach, Hannah, Fordham, Eleanor, Ipser, Alberta, Jenkins, Joe, Kent, Katherine, Kerai, Geeta, Lloyd, Lina, Masding, Victoria, Osborn, Ellie, Patel, Alpi, Pereira, Elizabeth, Pett, Tristan, Reeve, Donna, Shah, Palvi, Snook, Ruth, Studley, Ruth, Sutherland, Esther, Swinn, Eliza, Thomas, Heledd, Tudor, Anna, Weston, Joshua, Leib, Shayla, Tierney, James, Farkas, Gabor, Cobb, Raf, Compton, Lewis, Irving, James, Clarke, John, Mullis, Rachel, Ireland, Lorraine, Airimitoaie, Diana, Fisher, Sarah, Moore, Zoe, McLean, James, Kerby, Matt

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Protection against SARS-CoV-2 Omicron BA.4/5 variant following booster vaccination or breakthrough infection in the UK von Wei, Jia, Matthews, Philippa C., Stoesser, Nicole, Newton, John N., Diamond, Ian, Studley, Ruth, Taylor, Nick, Bell, John I., Farrar, Jeremy, Kolenchery, Jaison, Marsden, Brian D., Hoosdally, Sarah, Jones, E. Yvonne, Stuart, David I., Crook, Derrick W., Peto, Tim E. A., Walker, A. Sarah, Pouwels, Koen B., Eyre, David W.

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Improving the representativeness of UK’s national COVID-19 Infection Survey through spatio-temporal regression and post-stratification von Pouwels, Koen B., Eyre, David W., House, Thomas, Aspey, Ben, Matthews, Philippa C., Stoesser, Nicole, Newton, John N., Diamond, Ian, Studley, Ruth, Taylor, Nick G. H., Bell, John I., Farrar, Jeremy, Kolenchery, Jaison, Marsden, Brian D., Hoosdally, Sarah, Jones, E. Yvonne, Stuart, David I., Crook, Derrick W., Peto, Tim E. A., Walker, A. Sarah

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N-Aryl 2,6-Dimethoxybiphenylalanine Analogues as VLA-4 Antagonists von Doherty, George A, Kamenecka, Theodore, McCauley, Ermenegilda, Van Riper, Gail, Mumford, Richard A, Tong, Sharon, Hagmann, William K

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SARS-CoV-2 antibody trajectories after a single COVID-19 vaccination with and without prior infection von Wei, Jia, Matthews, Philippa C., Stoesser, Nicole, Diamond, Ian, Studley, Ruth, Rourke, Emma, Cook, Duncan, Bell, John I., Newton, John N., Farrar, Jeremy, Howarth, Alison, Marsden, Brian D., Hoosdally, Sarah, Jones, E. Yvonne, Stuart, David I., Crook, Derrick W., Peto, Tim E. A., Walker, A. Sarah, Eyre, David W., Pouwels, Koen B.

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COVID-19 vaccination, risk-compensatory behaviours, and contacts in the UK von Buckell, John, Jones, Joel, Matthews, Philippa C., Diamond, Sir Ian, Rourke, Emma, Studley, Ruth, Cook, Duncan, Walker, Ann Sarah, Pouwels, Koen B.

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Discovery of A-1331852, a First-in-Class, Potent, and Orally-Bioavailable BCL-X L Inhibitor von Wang, Le, Doherty, George A., Judd, Andrew S., Tao, Zhi-Fu, Hansen, T. Matthew, Frey, Robin R., Song, Xiaohong, Bruncko, Milan, Kunzer, Aaron R., Wang, Xilu, Wendt, Michael D., Flygare, John A., Catron, Nathaniel D., Judge, Russell A., Park, Chang H., Shekhar, Shashank, Phillips, Darren C., Nimmer, Paul, Smith, Morey L., Tahir, Stephen K., Xiao, Yu, Xue, John, Zhang, Haichao, Le, Phuong N., Mitten, Michael J., Boghaert, Erwin R., Gao, Wenqing, Kovar, Peter, Choo, Edna F., Diaz, Dolores, Fairbrother, Wayne J., Elmore, Steven W., Sampath, Deepak, Leverson, Joel D., Souers, Andrew James

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N-Tetrahydrofuroyl-( l)-phenylalanine derivatives as potent VLA-4 antagonists von Yang, Ginger X., Chang, Linda L., Truong, Quang, Doherty, George A., Magriotis, Plato A., de Laszlo, Stephen E., Li, Bing, MacCoss, Malcolm, Kidambi, Usha, Egger, Linda A., McCauley, Ermengilda, Van Riper, Gail, Mumford, Richard A., Schmidt, John A., Hagmann, William K.

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