The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901 von Barrett, Stephen D., Bridges, Alexander J., Dudley, David T., Saltiel, Alan R., Fergus, James H., Flamme, Cathlin M., Delaney, Amy M., Kaufman, Michael, LePage, Sophie, Leopold, Wilbur R., Przybranowski, Sally A., Sebolt-Leopold, Judith, Van Becelaere, Keri, Doherty, Annette M., Kennedy, Robert M., Marston, Dan, Howard, W. Allen, Smith, Yvonne, Warmus, Joseph S., Tecle, Haile

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Role of nerve growth factor in the trinitrobenzene sulfonic acid-induced colonic hypersensitivity von Delafoy, Laure, Raymond, Frederic, Doherty, Annette M, Eschalier, Alain, Diop, Laurent

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Structure-activity relationships of a series of 2-amino-4-thiazole-containing renin inhibitors von Patt, William C, Hamilton, Harriet W, Taylor, Michael D, Ryan, Michael J, Taylor, David G, Connolly, Cleo J. C, Doherty, Annette M, Klutchko, Sylvester R, Sircar, Ila

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Discovery of a Novel Series of Orally Active Non-Peptide Endothelin-A (ETA) Receptor-Selective Antagonists von Doherty, Annette M, Patt, William C, Edmunds, Jeremy J, Berryman, Kent A, Reisdorph, Billy R, Plummer, Mark S, Shahripour, Aurash, Lee, Chet, Cheng, Xue-Min

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Characterization of [ 125 I]‐PD164333, an ET A selective non‐peptide radiolabelled antagonist, in normal and diseased human tissues von Davenport, Anthony P, Kuc, Rhoda E, Ashby, Michael J, Patt, William C, Doherty, Annette M

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Phosphodiesterase 4 inhibitors as novel anti-inflammatory agents von Doherty, Annette M

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Endothelin: a new challenge von Doherty, Annette M

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Design of a functional hexapeptide antagonist of endothelin von Cody, Wayne L, Doherty, Annette M, He, John X, DePue, Patricia L, Rapundalo, Stephen T, Hingorani, Gary A, Major, Terry C, Panek, Robert L, Dudley, David T

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Total synthesis of furanocembranolides. 1. Stereocontrolled preparation of key heterocyclic building blocks and assembly of a complete seco-pseudopterane framework von Paquette, Leo A, Doherty, Annette M, Rayner, Christopher M

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Structure−Activity Relationships for a Novel Series of Pyrido[2,3-d]pyrimidine Tyrosine Kinase Inhibitors von Hamby, James M, Connolly, Cleo J. C, Schroeder, Mel C, Winters, R. Thomas, Showalter, H. D. Hollis, Panek, Robert L, Major, Terry C, Olsewski, Bronislawa, Ryan, Michael J, Dahring, Tawny, Lu, Gina H, Keiser, Joan, Amar, Aneesa, Shen, Cindy, Kraker, Alan J, Slintak, Veronika, Nelson, James M, Fry, David W, Bradford, Laura, Hallak, Hussein, Doherty, Annette M

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Relationship between phosphodiesterase type 4 inhibition and anti-inflammatory activity of CI-1044 in rat airways von Pruniaux, Marie-Pierre, Lagente, Vincent, Ouaged, Malika, Bertin, Bernadette, Moreau, François, Julien-Larose, Christine, Rocher, Marie-Noelle, Leportier, Christelle, Martin, Brigitte, Bouget, Anita, Dubuit, Jean-Pierre, Burnouf, Catherine, Doherty, Annette M., Bertrand, Claude P.

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Soluble 2-Substituted Aminopyrido[2,3-d]pyrimidin-7-yl Ureas. Structure−Activity Relationships against Selected Tyrosine Kinases and Exploration of in Vitro and in Vivo Anticancer... von Schroeder, Mel C, Hamby, James M, Connolly, Cleo J. C, Grohar, Patrick J, Winters, R. Thomas, Barvian, Mark R, Moore, Charles W, Boushelle, Stacey L, Crean, Sheila M, Kraker, Alan J, Driscoll, Denise L, Vincent, Patrick W, Elliott, William L, Lu, Gina H, Batley, Brian L, Dahring, Tawny K, Major, Terry C, Panek, Robert L, Doherty, Annette M, Showalter, H. D. Hollis

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Synthesis, Structure−Activity Relationships, and Pharmacological Profile of 9-Amino-4-oxo-1-phenyl-3,4,6,7-tetrahydro[1,4]diazepino[6,7,1-h i]indoles:  Discovery of Potent, Selecti... von Burnouf, Catherine, Auclair, Eric, Avenel, Nadine, Bertin, Bernadette, Bigot, Christèle, Calvet, Alain, Chan, Kam, Durand, Corinne, Fasquelle, Veronique, Féru, Frédéric, Gilbertsen, Richard, Jacobelli, Henry, Kebsi, Adel, Lallier, Emmanuelle, Maignel, Jacquie, Martin, Brigitte, Milano, Stéphane, Ouagued, Malika, Pascal, Yves, Pruniaux, Marie-Pierre, Puaud, Jocelyne, Rocher, Marie-Noëlle, Terrasse, Christophe, Wrigglesworth, Roger, Doherty, Annette M

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Synthesis of (.+-.)-11,0(3)-dihydropseudopterolide von Paquette, Leo A, Rayner, Christopher M, Doherty, Annette M

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Structure−Activity Relationships for 1-Phenylbenzimidazoles as Selective ATP Site Inhibitors of the Platelet-Derived Growth Factor Receptor von Palmer, Brian D, Smaill, Jeff B, Boyd, Maruta, Boschelli, Diane H, Doherty, Annette M, Hamby, James M, Khatana, Sonya S, Kramer, James B, Kraker, Alan J, Panek, Robert L, Lu, Gina H, Dahring, Tawny K, Winters, R. Thomas, Showalter, H. D. Hollis, Denny, William A

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Two new reagents for the guanylation of primary, secondary and aryl amines von Kent, Darin R., Cody, Wayne L., Doherty, Annette M.

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Discovery and structure-activity studies of a novel series of pyrido[2,3- d]pyrimidine tyrosine kinase inhibitors von Connolly, Cleo J.C., Hamby, James M., Schroeder, Mel C., Barvian, Mark, Lu, Gina H., Panek, Robert L., Amar, Aneesa, Shen, Cindy, Kraker, Alan J., Fry, David W., Klohs, Wayne D., Doherty, Annette M.

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Structure−Activity Relationships in a Series of Orally Active γ-Hydroxy Butenolide Endothelin Antagonists von Patt, William C, Edmunds, Jeremy J, Repine, Joseph T, Berryman, Kent A, Reisdorph, Billy R, Lee, Chet, Plummer, Mark S, Shahripour, Aurash, Haleen, Stephen J, Keiser, Joan A, Flynn, Mike A, Welch, Kathleen M, Reynolds, Elwood E, Rubin, Ron, Tobias, Brian, Hallak, Hussein, Doherty, Annette M

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[125I]‐PD 151242: a selective radioligand for human ETA receptors von Davenport, Anthony P., Kuc, Rhoda E., Fitzgerald, Fiona, Maguire, Janet J., Berryman, Kent, Doherty, Annette M.

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Butenolide Endothelin Antagonists with Improved Aqueous Solubility von Patt, William C, Cheng, Xue-Min, Repine, Joseph T, Lee, Chet, Reisdorph, Bill R, Massa, Mark A, Doherty, Annette M, Welch, Kathleen M, Bryant, John W, Flynn, Michael A, Walker, Donnelle M, Schroeder, Richard L, Haleen, Stephen J, Keiser, Joan A

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