Azaxanthene Based Selective Glucocorticoid Receptor Modulators: Design, Synthesis, and Pharmacological Evaluation of (S)-4-(5-(1-((1,3,4-Thiadiazol-2-yl)amino)-2-methyl-1-oxopropan... von Weinstein, David S, Gong, Hua, Doweyko, Arthur M, Cunningham, Mark, Habte, Sium, Wang, Jin Hong, Holloway, Deborah A, Burke, Christine, Gao, Ling, Guarino, Victor, Carman, Julie, Somerville, John E, Shuster, David, Salter-Cid, Luisa, Dodd, John H, Nadler, Steven G, Barrish, Joel C

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Novel Synthesis of the Hexahydroimidazo[1,5b]isoquinoline Scaffold: Application to the Synthesis of Glucocorticoid Receptor Modulators von Xiao, Hai-Yun, Wu, Dauh-Rurng, Malley, Mary F, Gougoutas, Jack Z, Habte, Sium F, Cunningham, Mark D, Somerville, John E, Dodd, John H, Barrish, Joel C, Nadler, Steven G, Dhar, T. G. Murali

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Discovery and SAR of 2-amino-5-[(thiomethyl)aryl]thiazoles as potent and selective Itk inhibitors von Das, Jagabandhu, Liu, Chunjian, Moquin, Robert V., Lin, James, Furch, Joseph A., Spergel, Steven H., McIntyre, Kim W., Shuster, David J., O’Day, Kathleen D., Penhallow, Becky, Hung, Chen-Yi, Kanner, Steven B., Lin, Tai-An, Dodd, John H., Barrish, Joel C., Wityak, John

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Imidazopyrimidines, potent inhibitors of p38 MAP kinase von Rupert, Kenneth C, Henry, James R, Dodd, John H, Wadsworth, Scott A, Cavender, Druie E, Olini, Gilbert C, Fahmy, Bohumila, Siekierka, John J

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Discovery of 4-(5-(Cyclopropylcarbamoyl)-2-methylphenylamino)-5-methyl-N-propylpyrrolo[1,2-f][1,2,4]triazine-6-carboxamide (BMS-582949), a Clinical p38α MAP Kinase Inhibitor for th... von Liu, Chunjian, Lin, James, Wrobleski, Stephen T, Lin, Shuqun, Hynes, John, Wu, Hong, Dyckman, Alaric J, Li, Tianle, Wityak, John, Gillooly, Kathleen M, Pitt, Sidney, Shen, Ding Ren, Zhang, Rosemary F, McIntyre, Kim W, Salter-Cid, Luisa, Shuster, David J, Zhang, Hongjian, Marathe, Punit H, Doweyko, Arthur M, Sack, John S, Kiefer, Susan E, Kish, Kevin F, Newitt, John A, McKinnon, Murray, Dodd, John H, Barrish, Joel C, Schieven, Gary L, Leftheris, Katerina

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Discovery of ((4-(5-(Cyclopropylcarbamoyl)-2-methylphenylamino)-5-methylpyrrolo[1,2-f][1,2,4]triazine-6-carbonyl)(propyl)carbamoyloxy)methyl-2-(4-(phosphonooxy)phenyl)acetate (BMS-... von Liu, Chunjian, Lin, James, Hynes, John, Wu, Hong, Wrobleski, Stephen T, Lin, Shuqun, Dhar, T G Murali, Vrudhula, Vivekananda M, Sun, Jung-Hui, Chao, Sam, Zhao, Rulin, Wang, Bei, Chen, Bang-Chi, Everlof, Gerry, Gesenberg, Christoph, Zhang, Hongjian, Marathe, Punit H, McIntyre, Kim W, Taylor, Tracy L, Gillooly, Kathleen, Shuster, David J, McKinnon, Murray, Dodd, John H, Barrish, Joel C, Schieven, Gary L, Leftheris, Katerina

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Dimethyl-diphenyl-propanamide Derivatives As Nonsteroidal Dissociated Glucocorticoid Receptor Agonists von Yang, Bingwei V, Weinstein, David S, Doweyko, Lidia M, Gong, Hua, Vaccaro, Wayne, Huynh, Tram, Xiao, Hai-yun, Doweyko, Arthur M, Mckay, Lorraine, Holloway, Deborah A, Somerville, John E, Habte, Sium, Cunningham, Mark, McMahon, Michele, Townsend, Robert, Shuster, David, Dodd, John H, Nadler, Steven G, Barrish, Joel C

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Phosphodiesterase 7A-Deficient Mice Have Functional T Cells von Yang, Guchen, McIntyre, Kim W, Townsend, Robert M, Shen, Henry H, Pitts, William J, Dodd, John H, Nadler, Steven G, McKinnon, Murray, Watson, Andrew J

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The identification of novel p38α isoform selective kinase inhibitors having an unprecedented p38α binding mode von Wrobleski, Stephen T., Lin, Shuqun, Murali Dhar, T.G., Dyckman, Alaric J., Li, Tianle, Pitt, Sidney, Zhang, Rosemary, Fan, Yi, Doweyko, Arthur M., Tokarski, John S., Kish, Kevin F., Kiefer, Susan E., Sack, John S., Newitt, John A., Witmer, Mark R., McKinnon, Murray, Barrish, Joel C., Dodd, John H., Schieven, Gary L., Leftheris, Katerina

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Discovery of potent and selective nonsteroidal indazolyl amide glucocorticoid receptor agonists von Sheppeck, James E., Gilmore, John L., Xiao, Hai-Yun, Dhar, T.G. Murali, Nirschl, David, Doweyko, Arthur M., Sack, Jack S., Corbett, Martin J., Malley, Mary F., Gougoutas, Jack Z., Mckay, Lorraine, Cunningham, Mark D., Habte, Sium F., Dodd, John H., Nadler, Steven G., Somerville, John E., Barrish, Joel C.

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Benzothiazole based inhibitors of p38α MAP kinase von Liu, Chunjian, Lin, James, Pitt, Sidney, Zhang, Rosemary F., Sack, John S., Kiefer, Susan E., Kish, Kevin, Doweyko, Arthur M., Zhang, Hongjian, Marathe, Punit H., Trzaskos, James, Mckinnon, Murray, Dodd, John H., Barrish, Joel C., Schieven, Gary L., Leftheris, Katerina

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Synthesis and evaluation of carbamoylmethylene linked prodrugs of BMS-582949, a clinical p38α inhibitor von Liu, Chunjian, Lin, James, Everlof, Gerry, Gesenberg, Christoph, Zhang, Hongjian, Marathe, Punit H., Malley, Mary, Galella, Michael A., Mckinnon, Murray, Dodd, John H., Barrish, Joel C., Schieven, Gary L., Leftheris, Katerina

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Utilization of a nitrogen–sulfur nonbonding interaction in the design of new 2-aminothiazol-5-yl-pyrimidines as p38α MAP kinase inhibitors von Lin, Shuqun, Wrobleski, Stephen T., Hynes, John, Pitt, Sidney, Zhang, Rosemary, Fan, Yi, Doweyko, Arthur M., Kish, Kevin F., Sack, John S., Malley, Mary F., Kiefer, Susan E., Newitt, John A., McKinnon, Murray, Trzaskos, James, Barrish, Joel C., Dodd, John H., Schieven, Gary L., Leftheris, Katerina

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Selective Itk Inhibitors Block T-Cell Activation and Murine Lung Inflammation von Lin, Tai-An, McIntyre, Kim W, Das, Jagabandhu, Liu, Chunjian, O'Day, Kathleen D, Penhallow, Becky, Hung, Chen-Yi, Whitney, Gena S, Shuster, David J, Yang, XiaoXia, Townsend, Robert, Postelnek, Jennifer, Spergel, Steven H, Lin, James, Moquin, Robert V, Furch, Joseph A, Kamath, Amrita V, Zhang, Hongjian, Marathe, Punit H, Perez-Villar, Juan J, Doweyko, Arthur, Killar, Loran, Dodd, John H, Barrish, Joel C, Wityak, John, Kanner, Steven B

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Synthesis and structure–activity relationships of novel indazolyl glucocorticoid receptor partial agonists von Gilmore, John L., Sheppeck, James E., Wang, Jim, Dhar, T.G. Murali, Cavallaro, Cullen, Doweyko, Arthur M., Mckay, Lorraine, Cunningham, Mark D., Habte, Sium F., Nadler, Steven G., Dodd, John H., Somerville, John E., Barrish, Joel C.

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Discovery and SAR of 2-amino-5-(thioaryl)thiazoles as potent and selective Itk inhibitors von Das, Jagabandhu, Furch, Joseph A., Liu, Chunjian, Moquin, Robert V., Lin, James, Spergel, Steven H., McIntyre, Kim W., Shuster, David J., O’Day, Kathleen D., Penhallow, Becky, Hung, Chen-Yi, Doweyko, Arthur M., Kamath, Amrita, Zhang, Hongjian, Marathe, Punit, Kanner, Steven B., Lin, Tai-An, Dodd, John H., Barrish, Joel C., Wityak, John

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Pyrazolo-pyrimidines: A novel heterocyclic scaffold for potent and selective p38α inhibitors von Das, Jagabandhu, Moquin, Robert V., Pitt, Sidney, Zhang, Rosemary, Shen, Ding Ren, McIntyre, Kim W., Gillooly, Kathleen, Doweyko, Arthur M., Sack, John S., Zhang, Hongjian, Kiefer, Susan E., Kish, Kevin, McKinnon, Murray, Barrish, Joel C., Dodd, John H., Schieven, Gary L., Leftheris, Katerina

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5-Amino-pyrazoles as potent and selective p38α inhibitors von Das, Jagabandhu, Moquin, Robert V., Dyckman, Alaric J., Li, Tianle, Pitt, Sidney, Zhang, Rosemary, Shen, Ding Ren, McIntyre, Kim W., Gillooly, Kathleen, Doweyko, Arthur M., Newitt, John A., Sack, John S., Zhang, Hongjian, Kiefer, Susan E., Kish, Kevin, McKinnon, Murray, Barrish, Joel C., Dodd, John H., Schieven, Gary L., Leftheris, Katerina

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5-Cyanopyrimidine Derivatives as a Novel Class of Potent, Selective, and Orally Active Inhibitors of p38α MAP Kinase von Liu, Chunjian, Wrobleski, Stephen T, Lin, James, Ahmed, Gulzar, Metzger, Axel, Wityak, John, Gillooly, Kathleen M, Shuster, David J, McIntyre, Kim W, Pitt, Sidney, Shen, Ding Ren, Zhang, Rosemary F, Zhang, Hongjian, Doweyko, Arthur M, Diller, David, Henderson, Ian, Barrish, Joel C, Dodd, John H, Schieven, Gary L, Leftheris, Katerina

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Discovery of pyrrolo[2,1- f][1,2,4]triazine C6-ketones as potent, orally active p38α MAP kinase inhibitors von Dyckman, Alaric J., Li, Tianle, Pitt, Sidney, Zhang, Rosemary, Shen, Ding Ren, McIntyre, Kim W., Gillooly, Kathleen M., Shuster, David J., Doweyko, Arthur M., Sack, John S., Kish, Kevin, Kiefer, Susan E., Newitt, John A., Zhang, Hongjian, Marathe, Punit H., McKinnon, Murray, Barrish, Joel C., Dodd, John H., Schieven, Gary L., Leftheris, Katerina

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