Brick by brick: metabolism and tumor cell growth von DeBerardinis, Ralph J, Sayed, Nabil, Ditsworth, Dara, Thompson, Craig B

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Translational profiling identifies a cascade of damage initiated in motor neurons and spreading to glia in mutant SOD1-mediated ALS von Sun, Shuying, Sun, Ying, Ling, Shuo-Chien, Ferraiuolo, Laura, McAlonis-Downes, Melissa, Zou, Yiyang, Drenner, Kevin, Wang, Yin, Ditsworth, Dara, Tokunaga, Seiya, Kopelevich, Alex, Kaspar, Brian K., Lagier-Tourenne, Clotilde, Cleveland, Don W.

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Direct conversion of patient fibroblasts demonstrates non-cell autonomous toxicity of astrocytes to motor neurons in familial and sporadic ALS von Meyer, Kathrin, Ferraiuolo, Laura, Miranda, Carlos J., Likhite, Shibi, McElroy, Sohyun, Renusch, Samantha, Ditsworth, Dara, Lagier-Tourenne, Clotilde, Smith, Richard A., Ravits, John, Burghes, Arthur H., Shaw, Pamela J., Cleveland, Don W., Kolb, Stephen J., Kaspar, Brian K.

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Spinal subpial delivery of AAV9 enables widespread gene silencing and blocks motoneuron degeneration in ALS von Bravo-Hernandez, Mariana, Tadokoro, Takahiro, Navarro, Michael R., Platoshyn, Oleksandr, Kobayashi, Yoshiomi, Marsala, Silvia, Miyanohara, Atsushi, Juhas, Stefan, Juhasova, Jana, Skalnikova, Helena, Tomori, Zoltan, Vanicky, Ivo, Studenovska, Hana, Proks, Vladimir, Chen, PeiXi, Govea-Perez, Noe, Ditsworth, Dara, Ciacci, Joseph D., Gao, Shang, Zhu, Wenlian, Ahrens, Eric T., Driscoll, Shawn P., Glenn, Thomas D., McAlonis-Downes, Melissa, Da Cruz, Sandrine, Pfaff, Samuel L., Kaspar, Brian K., Cleveland, Don W., Marsala, Martin

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ALS-linked TDP-43 mutations produce aberrant RNA splicing and adult-onset motor neuron disease without aggregation or loss of nuclear TDP-43 von Arnold, Eveline S, Ling, Shuo-Chien, Huelga, Stephanie C, Lagier-Tourenne, Clotilde, Polymenidou, Magdalini, Ditsworth, Dara, Kordasiewicz, Holly B, McAlonis-Downes, Melissa, Platoshyn, Oleksandr, Parone, Philippe A, Da Cruz, Sandrine, Clutario, Kevin M, Swing, Debbie, Tessarollo, Lino, Marsala, Martin, Shaw, Christopher E, Yeo, Gene W, Cleveland, Don W

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Therapeutic AAV9-mediated Suppression of Mutant SOD1 Slows Disease Progression and Extends Survival in Models of Inherited ALS von Foust, Kevin D, Salazar, Desirée L, Likhite, Shibi, Ferraiuolo, Laura, Ditsworth, Dara, Ilieva, Hristelina, Meyer, Kathrin, Schmelzer, Leah, Braun, Lyndsey, Cleveland, Don W, Kaspar, Brian K

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Activation of Poly(ADP)-ribose Polymerase (PARP-1) Induces Release of the Pro-inflammatory Mediator HMGB1 from the Nucleus von Ditsworth, Dara, Zong, Wei-Xing, Thompson, Craig B.

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Macrophage Migration Inhibitory Factor as a Chaperone Inhibiting Accumulation of Misfolded SOD1 von Israelson, Adrian, Ditsworth, Dara, Sun, Shuying, Song, SungWon, Liang, Jason, Hruska-Plochan, Marian, McAlonis-Downes, Melissa, Abu-Hamad, Salah, Zoltsman, Guy, Shani, Tom, Maldonado, Marcus, Bui, Anh, Navarro, Michael, Zhou, Huilin, Marsala, Martin, Kaspar, Brian K., Da Cruz, Sandrine, Cleveland, Don W.

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Alkylating DNA damage stimulates a regulated form of necrotic cell death von Zong, Wei-Xing, Ditsworth, Dara, Bauer, Daniel E, Wang, Zhao-Qi, Thompson, Craig B

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HIF2α inhibition promotes p53 pathway activity, tumor cell death, and radiation responses von Bertout, Jessica A, Majmundar, Amar J, Gordan, John D, Lam, Jennifer C, Ditsworth, Dara, Keith, Brian, Brown, Eric J, Nathanson, Katherine L, Simon, M. Celeste

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DNA alkylating therapy induces tumor regression through an HMGB1-mediated activation of innate immunity von Guerriero, Jennifer L, Ditsworth, Dara, Catanzaro, Joseph M, Sabino, Gregory, Furie, Martha B, Kew, Richard R, Crawford, Howard C, Zong, Wei-Xing

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A scalable solution for isolating human multipotent clinical-grade neural stem cells from ES precursors von Bohaciakova, Dasa, Hruska-Plochan, Marian, Tsunemoto, Rachel, Gifford, Wesley D, Driscoll, Shawn P, Glenn, Thomas D, Wu, Stephanie, Marsala, Silvia, Navarro, Michael, Tadokoro, Takahiro, Juhas, Stefan, Juhasova, Jana, Platoshyn, Oleksandr, Piper, David, Sheckler, Vickie, Ditsworth, Dara, Pfaff, Samuel L, Marsala, Martin

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Chemotherapy induces tumor clearance independent of apoptosis von Guerriero, Jennifer L, Ditsworth, Dara, Fan, Yongjun, Zhao, Fangping, Crawford, Howard C, Zong, Wei-Xing

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α4 Is an Essential Regulator of PP2A Phosphatase Activity von Kong, Mei, Ditsworth, Dara, Lindsten, Tullia, Thompson, Craig B.

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Oligomerization Is a General Mechanism for the Activation of Apoptosis Initiator and Inflammatory Procaspases von Chang, David W., Ditsworth, Dara, Liu, Hongtu, Srinivasula, Srinivasa M., Alnemri, Emad S., Yang, Xiaolu

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Non-apoptotic routes to defeat cancer von Guerriero, Jennifer L., Ditsworth, Dara, Zong, Wei-Xing

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Mutant TDP-43 within motor neurons drives disease onset but not progression in amyotrophic lateral sclerosis von Ditsworth, Dara, Maldonado, Marcus, McAlonis-Downes, Melissa, Sun, Shuying, Seelman, Amanda, Drenner, Kevin, Arnold, Eveline, Ling, Shuo-Chien, Pizzo, Donald, Ravits, John, Cleveland, Don W., Da Cruz, Sandrine

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NF-kappaB: Key mediator of inflammation-associated cancer von Ditsworth, Dara, Zong, Wei-Xing

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Activation of poly(ADP)-ribose polymerase (PARP-1) induces release of the pro-inflammatory mediator HMGB1 from the nucleus von Ditsworth, Dara, Zong, Wei-Xing, Thompson, Craig B.

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The PP2A-associated Protein α4 Plays a Critical Role in the Regulation of Cell Spreading and Migration von Kong, Mei, Bui, Thi V., Ditsworth, Dara, Gruber, Josh J., Goncharov, Dmitry, Krymskaya, Vera P., Lindsten, Tullia, Thompson, Craig B.

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