Eg5 targeting agents: From new anti-mitotic based inhibitor discovery to cancer therapy and resistance von Garcia-Saez, Isabel, Skoufias, Dimitrios A.

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Structure of an H1-Bound 6-Nucleosome Array Reveals an Untwisted Two-Start Chromatin Fiber Conformation von Garcia-Saez, Isabel, Menoni, Hervé, Boopathi, Ramachandran, Shukla, Manu S., Soueidan, Lama, Noirclerc-Savoye, Marjolaine, Le Roy, Aline, Skoufias, Dimitrios A., Bednar, Jan, Hamiche, Ali, Angelov, Dimitar, Petosa, Carlo, Dimitrov, Stefan

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Structure and Dynamics of a 197 bp Nucleosome in Complex with Linker Histone H1 von Bednar, Jan, Garcia-Saez, Isabel, Boopathi, Ramachandran, Cutter, Amber R., Papai, Gabor, Reymer, Anna, Syed, Sajad H., Lone, Imtiaz Nisar, Tonchev, Ognyan, Crucifix, Corinne, Menoni, Hervé, Papin, Christophe, Skoufias, Dimitrios A., Kurumizaka, Hitoshi, Lavery, Richard, Hamiche, Ali, Hayes, Jeffrey J., Schultz, Patrick, Angelov, Dimitar, Petosa, Carlo, Dimitrov, Stefan

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Structural basis of cytotoxicity mediated by the type III secretion toxin ExoU from Pseudomonas aeruginosa von Gendrin, Claire, Contreras-Martel, Carlos, Bouillot, Stéphanie, Elsen, Sylvie, Lemaire, David, Skoufias, Dimitrios A, Huber, Philippe, Attree, Ina, Dessen, Andréa

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Is the Fate of Clinical Candidate Arry-520 Already Sealed? Predicting Resistance in Eg5-Inhibitor Complexes von Indorato, Rose-Laure, Talapatra, Sandeep K, Lin, Fangzhu, Haider, Shozeb, Mackay, Simon P, Kozielski, Frank, Skoufias, Dimitrios A

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Phosphorylation of the CENP-A amino-terminus in mitotic centromeric chromatin is required for kinetochore function von Goutte-Gattat, Damien, Shuaib, Muhammad, Ouararhni, Khalid, Gautier, Thierry, Skoufias, Dimitrios A., Hamiche, Ali, Dimitrov, Stefan

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Self protein-protein interactions are involved in TPPP/p25 mediated microtubule bundling von DeBonis, Salvatore, Neumann, Emmanuelle, Skoufias, Dimitrios A.

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New chemical tools for investigating human mitotic kinesin Eg5 von Klein, Emmanuel, DeBonis, Salvatore, Thiede, Bernd, Skoufias, Dimitrios A., Kozielski, Frank, Lebeau, Luc

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Drug resistance dependent on allostery: A P-loop rigor Eg5 mutant exhibits resistance to allosteric inhibition by STLC von Indorato, Rose-Laure, DeBonis, Salvatore, Garcia-Saez, Isabel, Skoufias, Dimitrios A.

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Mutations in the human kinesin Eg5 that confer resistance to monastrol and S-trityl- l-cysteine in tumor derived cell lines von Tcherniuk, Sergey, van Lis, Robert, Kozielski, Frank, Skoufias, Dimitrios A.

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Structure and Dynamics of a 197 bp Nucleosome in Complex with Linker Histone H1 von Bednar, Jan, Garcia-Saez, Isabel, Boopathi, Ramachandran, Cutter, Amber R., Papai, Gabor, Reymer, Anna, Syed, Sajad H., Lone, Imtiaz Nisar, Tonchev, Ognyan, Crucifix, Corinne, Menoni, Hervé, Papin, Christophe, Skoufias, Dimitrios A., Kurumizaka, Hitoshi, Lavery, Richard, Hamiche, Ali, Hayes, Jeffrey J., Schultz, Patrick, Angelov, Dimitar, Petosa, Carlo, Dimitrov, Stefan

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S-Trityl-L-cysteine Is a Reversible, Tight Binding Inhibitor of the Human Kinesin Eg5 That Specifically Blocks Mitotic Progression von Skoufias, Dimitrios A., DeBonis, Salvatore, Saoudi, Yasmina, Lebeau, Luc, Crevel, Isabelle, Cross, Robert, Wade, Richard H., Hackney, David, Kozielski, Frank

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The Flexible Ends of CENP-A Nucleosome Are Required for Mitotic Fidelity von Roulland, Yohan, Ouararhni, Khalid, Naidenov, Mladen, Ramos, Lorrie, Shuaib, Muhammad, Syed, Sajad Hussain, Lone, Imtiaz Nizar, Boopathi, Ramachandran, Fontaine, Emeline, Papai, Gabor, Tachiwana, Hiroaki, Gautier, Thierry, Skoufias, Dimitrios, Padmanabhan, Kiran, Bednar, Jan, Kurumizaka, Hitoshi, Schultz, Patrick, Angelov, Dimitar, Hamiche, Ali, Dimitrov, Stefan

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IPP51, a chalcone acting as a microtubule inhibitor with in vivo antitumor activity against bladder carcinoma von Martel-Frachet, Véronique, Keramidas, Michelle, Nurisso, Alessandra, DeBonis, Salvatore, Rome, Claire, Coll, Jean-Luc, Boumendjel, Ahcène, Skoufias, Dimitrios A, Ronot, Xavier

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Receptor–Ligand Interaction-Based Virtual Screening for Novel Eg5/Kinesin Spindle Protein Inhibitors von Nagarajan, Shanthi, Skoufias, Dimitrios A, Kozielski, Frank, Pae, Ae Nim

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Relocation of Aurora B and Survivin from Centromeres to the Central Spindle Impaired by a Kinesin‐Specific MKLP‐2 Inhibitor von Tcherniuk, Sergey, Skoufias, Dimitrios A, Labriere, Christophe, Rath, Oliver, Gueritte, Françoise, Guillou, Catherine, Kozielski, Frank

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Molecular distinctions between Aurora A and B: a single residue change transforms Aurora A into correctly localized and functional Aurora B von Hans, Fabienne, Skoufias, Dimitrios A, Dimitrov, Stefan, Margolis, Robert L

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Mitosis persists in the absence of Cdk1 activity when proteolysis or protein phosphatase activity is suppressed von Skoufias, Dimitrios A, Indorato, Rose-Laure, Lacroix, Françoise, Panopoulos, Andreas, Margolis, Robert L

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STLC-resistant cell lines as tools to classify chemically divergent Eg5 targeting agents according to their mode of action and target specificity von Indorato, Rose-Laure, DeBonis, Salvatore, Kozielski, Frank, Garcia-Saez, Isabel, Skoufias, Dimitrios A.

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In vitro screening for inhibitors of the human mitotic kinesin Eg5 with antimitotic and antitumor activities von DeBonis, Salvatore, Skoufias, Dimitrios A, Lebeau, Luc, Lopez, Roman, Robin, Gautier, Margolis, Robert L, Wade, Richard H, Kozielski, Frank

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