Design and Validation of Linkers for Site-Specific Preparation of Antibody-Drug Conjugates Carrying Multiple Drug Copies Per Cysteine Conjugation Site von Kumar, Amit, Mao, Shenlan, Dimasi, Nazzareno, Gao, Changshou

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A Biparatopic HER2-Targeting Antibody-Drug Conjugate Induces Tumor Regression in Primary Models Refractory to or Ineligible for HER2-Targeted Therapy von Li, John Y., Perry, Samuel R., Muniz-Medina, Vanessa, Wang, Xinzhong, Wetzel, Leslie K., Rebelatto, Marlon C., Hinrichs, Mary Jane Masson, Bezabeh, Binyam Z., Fleming, Ryan L., Dimasi, Nazzareno, Feng, Hui, Toader, Dorin, Yuan, Andy Q., Xu, Lan, Lin, Jia, Gao, Changshou, Wu, Herren, Dixit, Rakesh, Osbourn, Jane K., Coats, Steven R.

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Antibody-Drug Conjugates Bearing Pyrrolobenzodiazepine or Tubulysin Payloads Are Immunomodulatory and Synergize with Multiple Immunotherapies von Rios-Doria, Jonathan, Harper, Jay, Rothstein, Raymond, Wetzel, Leslie, Chesebrough, Jon, Marrero, Allison, Chen, Cui, Strout, Patrick, Mulgrew, Kathy, McGlinchey, Kelly, Fleming, Ryan, Bezabeh, Binyam, Meekin, John, Stewart, David, Kennedy, Maureen, Martin, Philip, Buchanan, Andrew, Dimasi, Nazzareno, Michelotti, Emil, Hollingsworth, Robert

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SLC46A3 as a Potential Predictive Biomarker for Antibody-Drug Conjugates Bearing Noncleavable Linked Maytansinoid and Pyrrolobenzodiazepine Warheads von Kinneer, Krista, Meekin, John, Tiberghien, Arnaud C, Tai, Yu-Tzu, Phipps, Sandrina, Kiefer, Christine Mione, Rebelatto, Marlon C, Dimasi, Nazzareno, Moriarty, Alyssa, Papadopoulos, Kyriakos P, Sridhar, Sriram, Gregson, Stephen J, Wick, Michael J, Masterson, Luke, Anderson, Kenneth C, Herbst, Ronald, Howard, Philip W, Tice, David A

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Fractionated Dosing Improves Preclinical Therapeutic Index of Pyrrolobenzodiazepine-Containing Antibody Drug Conjugates von Hinrichs, Mary Jane Masson, Ryan, Pauline M, Zheng, Bo, Afif-Rider, Shameen, Yu, Xiang Qing, Gunsior, Michele, Zhong, Haihong, Harper, Jay, Bezabeh, Binyam, Vashisht, Kapil, Rebelatto, Marlon, Reed, Molly, Ryan, Patricia C, Breen, Shannon, Patel, Neki, Chen, Cui, Masterson, Luke, Tiberghien, Arnaud, Howard, Phillip W, Dimasi, Nazzareno, Dixit, Rakesh

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A Nanoparticle Platform To Evaluate Bioconjugation and Receptor-Mediated Cell Uptake Using Cross-Linked Polyion Complex Micelles Bearing Antibody Fragments von Florinas, Stelios, Liu, Marc, Fleming, Ryan, Van Vlerken-Ysla, Lilian, Ayriss, Joanne, Gilbreth, Ryan, Dimasi, Nazzareno, Gao, Changshou, Wu, Herren, Xu, Ze-Qi, Chen, Shaoyi, Dirisala, Anjaneyulu, Kataoka, Kazunori, Cabral, Horacio, Christie, R. James

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Preclinical Evaluation of MEDI0641, a Pyrrolobenzodiazepine-Conjugated Antibody-Drug Conjugate Targeting 5T4 von Harper, Jay, Lloyd, Christopher, Dimasi, Nazzareno, Toader, Dorin, Marwood, Rose, Lewis, Leeanne, Bannister, David, Jovanovic, Jelena, Fleming, Ryan, D'Hooge, Francois, Mao, Shenlan, Marrero, Allison M, Korade, 3rd, Martin, Strout, Patrick, Xu, Linda, Chen, Cui, Wetzel, Leslie, Breen, Shannon, van Vlerken-Ysla, Lilian, Jalla, Sanjoo, Rebelatto, Marlon, Zhong, Haihong, Hurt, Elaine M, Hinrichs, Mary Jane, Huang, Keven, Howard, Philip W, Tice, David A, Hollingsworth, Robert E, Herbst, Ronald, Kamal, Adeela

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A Biparatopic HER2-Targeting Antibody-Drug Conjugate Induces Tumor Regression in Primary Models Refractory to or Ineligible for HER2-Targeted Therapy von Li, John Y., Perry, Samuel R., Muniz-Medina, Vanessa, Wang, Xinzhong, Wetzel, Leslie K., Rebelatto, Marlon C., Masson Hinrichs, Mary Jane, Bezabeh, Binyam Z., Fleming, Ryan L., Dimasi, Nazzareno, Feng, Hui, Toader, Dorin, Yuan, Andy Q., Xu, Lan, Lin, Jia, Gao, Changshou, Wu, Herren, Dixit, Rakesh, Osbourn, Jane K., Coats, Steven R.

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Hydrolytically Stable Site-Specific Conjugation at the N‑Terminus of an Engineered Antibody von Thompson, Pamela, Bezabeh, Binyam, Fleming, Ryan, Pruitt, Monica, Mao, Shenlan, Strout, Patrick, Chen, Cui, Cho, Song, Zhong, Haihong, Wu, Herren, Gao, Changshou, Dimasi, Nazzareno

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The Design and Characterization of Oligospecific Antibodies for Simultaneous Targeting of Multiple Disease Mediators von Dimasi, Nazzareno, Gao, Changshou, Fleming, Ryan, Woods, Robert M., Yao, Xiao-Tao, Shirinian, Lena, Kiener, Peter A., Wu, Herren

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STRUCTURE AND FUNCTION OF NATURAL KILLER CELL RECEPTORS: Multiple Molecular Solutions to Self, Nonself Discrimination von Natarajan, Kannan, Dimasi, Nazzareno, Wang, Jian, Mariuzza, Roy A, Margulies, David H

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Straightforward Glycoengineering Approach to Site-Specific Antibody–Pyrrolobenzodiazepine Conjugates von Thompson, Pamela, Ezeadi, Ebele, Hutchinson, Ian, Fleming, Ryan, Bezabeh, Binyam, Lin, Jia, Mao, Shenlan, Chen, Cui, Masterson, Luke, Zhong, Haihong, Toader, Dorin, Howard, Philip, Wu, Herren, Gao, Changshou, Dimasi, Nazzareno

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Structure and Dynamics of a Site-Specific Labeled Fc Fragment with Altered Effector Functions von Gallagher, D. Travis, McCullough, Chris, Brinson, Robert G., Ahn, Joomi, Marino, John P., Dimasi, Nazzareno

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Characterization and in vitro data of antibody drug conjugates (ADCs) derived from heterotrifunctional linker designed for the site-specific preparation of dual ADCs von Kumar, Amit, Kinneer, Krista, Masterson, Luke, Ezeadi, Ebele, Howard, Philip, Wu, Herren, Gao, Changshou, Dimasi, Nazzareno

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Characterization of oxidation end product of plasma albumin ‘in vivo’ von Musante, Luca, Bruschi, Maurizio, Candiano, Giovanni, Petretto, Andrea, Dimasi, Nazzareno, Boccio, Piero Del, Urbani, Andrea, Rialdi, Giovanni, Ghiggeri, Gian Marco

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Binding Specificity of Multiprotein Signaling Complexes Is Determined by Both Cooperative Interactions and Affinity Preferences von Houtman, Jon C. D, Higashimoto, Yuichiro, Dimasi, Nazzareno, Cho, Sangwoo, Yamaguchi, Hiroshi, Bowden, Brent, Regan, Carole, Malchiodi, Emilio L, Mariuzza, Roy, Schuck, Peter, Appella, Ettore, Samelson, Lawrence E

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Synthesis of a heterotrifunctional linker for the site-specific preparation of antibody-drug conjugates with two distinct warheads von Kumar, Amit, Kinneer, Krista, Masterson, Luke, Ezeadi, Ebele, Howard, Philip, Wu, Herren, Gao, Changshou, Dimasi, Nazzareno

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Abstract 660: Engineering strategies to control stoichiometry, site of conjugation, serum stability and effector functions of antibody-drug conjugates von Dimasi, Nazzareno, Fleming, Ryan

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Generation of bispecific antibodies using chemical conjugation methods von Dimasi, Nazzareno, Kumar, Amit, Gao, Changshou

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The Crystal Structure of the Extracellular Domain of the Inhibitor Receptor Expressed on Myeloid Cells IREM-1 von Márquez, José Antonio, Galfré, Elena, Dupeux, Florine, Flot, David, Moran, Oscar, Dimasi, Nazzareno

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