A sensory neuron–expressed IL-31 receptor mediates T helper cell–dependent itch: Involvement of TRPV1 and TRPA1 von Cevikbas, Ferda, PhD, Wang, Xidao, PhD, Akiyama, Tasuku, PhD, Kempkes, Cordula, PhD, Savinko, Terhi, PhD, Antal, Attila, MD, Kukova, Gabriela, MD, Buhl, Timo, MD, Ikoma, Akihiko, MD, PhD, Buddenkotte, Joerg, PhD, Soumelis, Vassili, MD, Feld, Micha, PhD, Alenius, Harri, PhD, Dillon, Stacey R., PhD, Carstens, Earl, PhD, Homey, Bernhard, MD, Basbaum, Allan, PhD, Steinhoff, Martin, MD, PhD

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The pruritus- and TH2-associated cytokine IL-31 promotes growth of sensory nerves von Feld, Micha, Garcia, Richard, Buddenkotte, Jörg, Katayama, Shintaro, Lewis, Katherine, Muirhead, Gareth, Hevezi, Peter, Plesser, Kristin, Schrumpf, Holger, Krjutskov, Kaarel, Sergeeva, Olga, Müller, Hans Werner, Tsoka, Sophia, Kere, Juha, Dillon, Stacey R, Steinhoff, Martin, Homey, Bernhard

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RNA sequencing atopic dermatitis transcriptome profiling provides insights into novel disease mechanisms with potential therapeutic implications von Suárez-Fariñas, Mayte, PhD, Ungar, Benjamin, BA, Correa da Rosa, Joel, PhD, Ewald, David A., MSc, Rozenblit, Mariya, BA, Gonzalez, Juana, PhD, Xu, Hui, MSc, Zheng, Xiuzhong, MSc, Peng, Xiangyu, MSc, Estrada, Yeriel D., MSc, Dillon, Stacey R., PhD, Krueger, James G., MD, PhD, Guttman-Yassky, Emma, MD, PhD

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Cutting Edge: The Dependence of Plasma Cells and Independence of Memory B Cells on BAFF and APRIL von Benson, Micah J, Dillon, Stacey R, Castigli, Emanuela, Geha, Raif S, Xu, Shengli, Lam, Kong-Peng, Noelle, Randolph J

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The engineered CD80 variant fusion therapeutic davoceticept combines checkpoint antagonism with conditional CD28 costimulation for anti-tumor immunity von Maurer, Mark F., Lewis, Katherine E., Kuijper, Joseph L., Ardourel, Dan, Gudgeon, Chelsea J., Chandrasekaran, Siddarth, Mudri, Sherri L., Kleist, Kayla N., Navas, Chris, Wolfson, Martin F., Rixon, Mark W., Swanson, Ryan, Dillon, Stacey R., Levin, Steven D., Kimbung, Yengo Raymond, Akutsu, Masato, Logan, Derek T., Walse, Björn, Swiderek, Kristine M., Peng, Stanford L.

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Acazicolcept (ALPN-101), a dual ICOS/CD28 antagonist, demonstrates efficacy in systemic sclerosis preclinical mouse models von Orvain, Cindy, Cauvet, Anne, Prudent, Alexis, Guignabert, Christophe, Thuillet, Raphaël, Ottaviani, Mina, Tu, Ly, Duhalde, Fanny, Nicco, Carole, Batteux, Frédéric, Avouac, Jérôme, Wang, NingXin, Seaberg, Michelle A, Dillon, Stacey R, Allanore, Yannick

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Povetacicept, an Enhanced Dual APRIL/BAFF Antagonist That Modulates B Lymphocytes and Pathogenic Autoantibodies for the Treatment of Lupus and Other B Cell–Related Autoimmune Disea... von Evans, Lawrence S., Lewis, Katherine E., DeMonte, Daniel, Bhandari, Janhavi G., Garrett, Logan B., Kuijper, Joseph L., Ardourel, Daniel, Wolfson, Martin F., Debrot, Susan, Mudri, Sherri, Kleist, Kayla, Griffin, Luana L., Hebb, LuAnne, Sanderson, Russell J., Wang, NingXin, Seaberg, Michelle, Chunyk, Allison G., Yang, Jing, Hong, Youji, Maria, Zahra, Messenheimer, David J., Holland, Pamela M., Peng, Stanford L., Rixon, Mark W., Dillon, Stacey R.

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IL‐31 transgenic mice show reduced allergen‐induced lung inflammation von Neuper, Theresa, Neureiter, Daniel, Sarajlic, Muamera, Strandt, Helen, Bauer, Renate, Schwarz, Harald, Suchanek, Patrick, Korotchenko, Evgeniia, Dillon, Stacey R., Hammerl, Peter, Stoecklinger, Angelika, Weiss, Richard, Horejs‐Hoeck, Jutta

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Non‐Redundant Roles of T Cell Costimulation Pathways in Inflammatory Arthritis Revealed by Dual Blockade of ICOS and CD28 with Acazicolcept (ALPN‐101) von Dillon, Stacey R., Evans, Lawrence S., Lewis, Katherine E., Debrot, Susan, Blair, Tiffany C., Mudri, Sherri, Kleist, Kayla, Levin, Steven D., Bhandari, Janhavi G., Garrett, Logan, Wolfson, Martin F., Holland, Pamela M., Rixon, Mark W., Peng, Stanford L.

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An APRIL to remember: novel TNF ligands as therapeutic targets von Dillon, Stacey R, Gross, Jane A, Ansell, Stephen M, Novak, Anne J

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A first‐in‐human, randomized study of the safety, pharmacokinetics and pharmacodynamics of povetacicept, an enhanced dual BAFF/APRIL antagonist, in healthy adults von Davies, Rupert, Peng, Stanford L., Lickliter, Jason, McLendon, Kristi, Enstrom, Amanda, Chunyk, Allison G., Blanchfield, Lori, Wang, NingXin, Blair, Tiffany, Thomas, Heather M., Smith, Alina, Dillon, Stacey R.

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Interleukin-21 combined with PD-1 or CTLA-4 blockade enhances antitumor immunity in mouse tumor models von Lewis, Katherine E., Selby, Mark J., Masters, Gregg, Valle, Jose, Dito, Gennaro, Curtis, Wendy R., Garcia, Richard, Mink, Kathy A., Waggie, Kimberly S., Holdren, Matthew S., Grosso, Joseph F., Korman, Alan J., Jure-Kunkel, Maria, Dillon, Stacey R.

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Correction: IL-31-Driven Skin Remodeling Involves Epidermal Cell Proliferation and Thickening That Lead to Impaired Skin-Barrier Function von Singh, Brijendra, Jegga, Anil G, Shanmukhappa, Kumar S, Edukulla, Ramakrishna, Khurana Hershey, Gurjit Kaur, Medvedovic, Mario, Dillon, Stacey R, Madala, Satish K

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Hodgkin lymphoma cells express TACI and BCMA receptors and generate survival and proliferation signals in response to BAFF and APRIL von Chiu, April, Xu, Weifeng, He, Bing, Dillon, Stacey R., Gross, Jane A., Sievers, Eric, Qiao, Xugang, Santini, Paul, Hyjek, Elizabeth, Lee, Joong-won, Cesarman, Ethel, Chadburn, Amy, Knowles, Daniel M., Cerutti, Andrea

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TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease von Gross, Jane A, Johnston, Janet, Mudri, Sherri, Enselman, Rachel, Dillon, Stacey R, Madden, Karen, Xu, Wenfeng, Parrish-Novak, Julia, Foster, Don, Lofton-Day, Cathy, Moore, Margaret, Littau, Alisa, Grossman, Angelika, Haugen, Harald, Foley, Kevin, Blumberg, Hal, Harrison, Kim, Kindsvogel, Wayne, Clegg, Christopher H

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Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function von Foster, Don, Parrish-Novak, Julia, Dillon, Stacey R, Nelson, Andrew, Hammond, Angie, Sprecher, Cindy, Gross, Jane A, Johnston, Janet, Madden, Karen, Xu, Wenfeng, West, Jim, Schrader, Sara, Burkhead, Steve, Heipel, Mark, Brandt, Cameron, Kuijper, Joseph L, Kramer, Janet, Conklin, Darrell, Presnell, Scott R, Berry, Jon, Shiota, Faith, Bort, Susan, Hambly, Kevin, Mudri, Sherri, Clegg, Chris, Moore, Margaret, Grant, Francis J, Lofton-Day, Catherine, Gilbert, Teresa, Raymond, Fenella, Ching, Andrew, Yao, Lena, Smith, Deb, Webster, Philippa, Whitmore, Theodore, Maurer, Mark, Kaushansky, Kenneth, Holly, Rick D

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Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice von Gross, Jane A, Dillon, Stacey R, Sprecher, Cindy, Hammond, Angela, Bilsborough, Janine, Rosenfeld-Franklin, Maryland, Presnell, Scott R, Haugen, Harald S, Maurer, Mark, Harder, Brandon, Johnston, Janet, Bort, Susan, Mudri, Sherri, Kuijper, Joseph L, Bukowski, Tom, Shea, Pamela, Dong, Dennis L, Dasovich, Maria, Grant, Francis J, Lockwood, Luann, Levin, Steven D, LeCiel, Cosette, Waggie, Kim, Day, Heather, Topouzis, Stavros, Kramer, Janet, Kuestner, Rolf, Chen, Zhi, Foster, Don, Parrish-Novak, Julia

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The C104R mutant impairs the function of transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI) through haploinsufficiency von Lee, John J., MD, Jabara, Haifa H., BS, Garibyan, Lilit, MD, PhD, Rauter, Ingrid, PhD, Sannikova, Tatyana, BS, Dillon, Stacey R., PhD, Bram, Richard, MD, PhD, Geha, Raif S., MD

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B-lymphocyte stimulator/a proliferation-inducing ligand heterotrimers are elevated in the sera of patients with autoimmune disease and are neutralized by atacicept and B-cell matur... von Dillon, Stacey R, Harder, Brandon, Lewis, Kenneth B, Moore, Margaret D, Liu, Hong, Bukowski, Thomas R, Hamacher, Nels B, Lantry, Megan M, Maurer, Mark, Krejsa, Cecile M, Ellsworth, Jeff L, Pederson, Susan, Elkon, Keith B, Wener, Mark H, Dall'Era, Maria, Gross, Jane A

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Conditioned media from the renal cell carcinoma cell line 786.O drives human blood monocytes to a monocytic myeloid-derived suppressor cell phenotype von Okada, Shannon L., Simmons, Randi M., Franke-Welch, Secil, Nguyen, Thuy H., Korman, Alan J., Dillon, Stacey R., Gilbertson, Debra G.

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