Emerging molecular diversity from the intra-molecular Ugi reaction: iterative efficiency in medicinal chemistry von Hulme, Christopher, Dietrich, Justin

Volltext

The design, synthesis, and evaluation of 8 hybrid DFG-out allosteric kinase inhibitors: A structural analysis of the binding interactions of Gleevec®, Nexavar®, and BIRB-796 von Dietrich, Justin, Hulme, Christopher, Hurley, Laurence H.

Volltext

Reagent and Catalyst Capsules: A Chemical Delivery System for Reaction Screening and Parallel Synthesis von Borlinghaus, Niginia, Kaschel, Johannes, Klee, Johanna, Haller, Vanessa, Schetterl, Jasmin, Heitz, Stephanie, Lindner, Tanja, Dietrich, Justin D, Braje, Wilfried M, Jolit, Anais

Volltext

The EED protein–protein interaction inhibitor A-395 inactivates the PRC2 complex von He, Yupeng, Selvaraju, Sujatha, Curtin, Michael L, Jakob, Clarissa G, Zhu, Haizhong, Comess, Kenneth M, Shaw, Bailin, The, Juliana, Lima-Fernandes, Evelyne, Szewczyk, Magdalena M, Cheng, Dong, Klinge, Kelly L, Li, Huan-Qiu, Pliushchev, Marina, Algire, Mikkel A, Maag, David, Guo, Jun, Dietrich, Justin, Panchal, Sanjay C, Petros, Andrew M, Sweis, Ramzi F, Torrent, Maricel, Bigelow, Lance J, Senisterra, Guillermo, Li, Fengling, Kennedy, Steven, Wu, Qin, Osterling, Donald J, Lindley, David J, Gao, Wenqing, Galasinski, Scott, Barsyte-Lovejoy, Dalia, Vedadi, Masoud, Buchanan, Fritz G, Arrowsmith, Cheryl H, Chiang, Gary G, Sun, Chaohong, Pappano, William N

Volltext

Hydrophobic Pockets of HPMC Enable Extremely Short Reaction Times in Water von Petkova, Desislava, Borlinghaus, Niginia, Sharma, Sudripet, Kaschel, Johannes, Lindner, Tanja, Klee, Johanna, Jolit, Anais, Haller, Vanessa, Heitz, Stephanie, Britze, Katarina, Dietrich, Justin, Braje, Wilfried M, Handa, Sachin

Volltext

Identification and structure-based drug design of cell-active inhibitors of interleukin 17A at a novel C-terminal site von Goedken, Eric R., Argiriadi, Maria A., Dietrich, Justin D., Petros, Andrew M., Krishnan, Navasona, Panchal, Sanjay C., Qiu, Wei, Wu, Haihong, Zhu, Haizhong, Adams, Ashley M., Bodelle, Pierre M., Goguen, Lucas, Richardson, Paul L., Slivka, Peter F., Srikumaran, Myron, Upadhyay, Anup K., Wu, Bainan, Judge, Russell A., Vasudevan, Anil, Gopalakrishnan, Sujatha M., Cox, Philip B., Stoll, Vincent S., Sun, Chaohong

Volltext

Development of Orally Efficacious Allosteric Inhibitors of TNFα via Fragment-Based Drug Design von Dietrich, Justin D, Longenecker, Kenton L, Wilson, Noel S, Goess, Christian, Panchal, Sanjay C, Swann, Steven L, Petros, Andrew M, Hobson, Adrian D, Ihle, David, Song, Danying, Richardson, Paul, Comess, Kenneth M, Cox, Philip B, Dombrowski, Amanda, Sarris, Kathy, Donnelly-Roberts, Diana L, Duignan, David B, Gomtsyan, Arthur, Jung, Paul, Krueger, A Chris, Mathieu, Suzanne, McClure, Andrea, Stoll, Vincent S, Wetter, Jill, Mankovich, John A, Hajduk, Philip J, Vasudevan, Anil, Stoffel, Robert H, Sun, Chaohong

Volltext

Fragment-Based Discovery of an Apolipoprotein E4 (apoE4) Stabilizer von Petros, Andrew M, Korepanova, Alla, Jakob, Clarissa G, Qiu, Wei, Panchal, Sanjay C, Wang, Jie, Dietrich, Justin D, Brewer, Jason T, Pohlki, Frauke, Kling, Andreas, Wilcox, Kyle, Lakics, Viktor, Bahnassawy, Lamiaa, Reinhardt, Peter, Partha, Sarathy Karunan, Bodelle, Pierre M, Lake, Marc, Charych, Erik I, Stoll, Vincent S, Sun, Chaohong, Mohler, Eric G

Volltext

SAR of amino pyrrolidines as potent and novel protein-protein interaction inhibitors of the PRC2 complex through EED binding von Curtin, Michael L., Pliushchev, Marina A., Li, Huan-Qiu, Torrent, Maricel, Dietrich, Justin D., Jakob, Clarissa G., Zhu, Haizhong, Zhao, Hongyu, Wang, Ying, Ji, Zhiqin, Clark, Richard F., Sarris, Kathy A., Selvaraju, Sujatha, Shaw, Bailin, Algire, Mikkel A., He, Yupeng, Richardson, Paul L., Sweis, Ramzi F., Sun, Chaohong, Chiang, Gary G., Michaelides, Michael R.

Volltext

Targeting aPKC disables oncogenic signaling by both the EGFR and the proinflammatory cytokine TNFα in glioblastoma von Kusne, Yael, Carrera-Silva, Eugenio A, Perry, Anthony S, Rushing, Elisabeth J, Mandell, Edward K, Dietrich, Justin D, Errasti, Andrea E, Gibbs, Daniel, Berens, Michael E, Loftus, Joseph C, Hulme, Christopher, Yang, Weiwei, Lu, Zhimin, Aldape, Kenneth, Sanai, Nader, Rothlin, Carla V, Ghosh, Sourav

Volltext

Discovery and optimization of novel constrained pyrrolopyridone BET family inhibitors von Fidanze, Steven D., Liu, Dachun, Mantei, Robert A., Hasvold, Lisa A., Pratt, John K., Sheppard, George S., Wang, Le, Holms, James H., Dai, Yujia, Aguirre, Ana, Bogdan, Andrew, Dietrich, Justin D., Marjanovic, Jasmina, Park, Chang H., Hutchins, Charles W., Lin, Xiaoyu, Bui, Mai H., Huang, Xiaoli, Wilcox, Denise, Li, Leiming, Wang, Rongqi, Kovar, Peter, Magoc, Terrance J., Rajaraman, Ganesh, Albert, Daniel H., Shen, Yu, Kati, Warren M., McDaniel, Keith F.

Volltext

Quantitative assessment of uncertainties in modeled crater retention ages on Mars von Palucis, Marisa C., Jasper, Justin, Garczynski, Bradley, Dietrich, William E.

Volltext

ERK Crosstalks with 4EBP1 to Activate Cyclin D1 Translation during Quinol-Thioether-Induced Tuberous Sclerosis Renal Cell Carcinoma von Cohen, Jennifer D., Gard, Jaime M. C., Nagle, Raymond B., Dietrich, Justin D., Monks, Terrence J., Lau, Serrine S.

Volltext

Clinical presentation, management, and biomarkers of neurotoxicity after adoptive immunotherapy with CAR T cells von Karschnia, Philipp, Jordan, Justin T., Forst, Deborah A., Arrillaga-Romany, Isabel C., Batchelor, Tracy T., Baehring, Joachim M., Clement, Nathan F., Gonzalez Castro, L. Nicolas, Herlopian, Aline, Maus, Marcela V., Schwaiblmair, Michaela H., Soumerai, Jacob D., Takvorian, Ronald W., Hochberg, Ephraim P., Barnes, Jeffrey A., Abramson, Jeremy S., Frigault, Matthew J., Dietrich, Jorg

Volltext

Understanding stone tool-making skill acquisition: Experimental methods and evolutionary implications von Pargeter, Justin, Khreisheh, Nada, Stout, Dietrich

Volltext

A novel route to synthesize libraries of quinoxalines via Petasis methodology in two synthetic operations von Ayaz, Muhammad, Dietrich, Justin, Hulme, Christopher

Volltext

A simple, cheap alternative to ‘designer convertible isonitriles’ expedited with microwaves von Hulme, Christopher, Chappeta, Shashi, Dietrich, Justin

Volltext

2,4-Diphenyl-6-trifluoromethyl-2,3-dihydro-1H,5H-pyrrolo[3,4-c]pyrrole-1,3-dione von Sue A. Roberts, Guillermo Martinez-Ariza, Justin Dietrich, Christopher Hulme

Volltext

Knowledge vs. know-how? Dissecting the foundations of stone knapping skill von Pargeter, Justin, Khreisheh, Nada, Shea, John J., Stout, Dietrich

Volltext

Concise two-step solution phase syntheses of four novel dihydroquinazoline scaffolds von Dietrich, Justin, Kaiser, Christine, Meurice, Nathalie, Hulme, Christopher

Volltext