Highly efficient multiplex human T cell engineering without double-strand breaks using Cas9 base editors von Webber, Beau R., Lonetree, Cara-lin, Kluesner, Mitchell G., Johnson, Matthew J., Pomeroy, Emily J., Diers, Miechaleen D., Lahr, Walker S., Draper, Garrett M., Slipek, Nicholas J., Smeester, Branden A., Lovendahl, Klaus N., McElroy, Amber N., Gordon, Wendy R., Osborn, Mark J., Moriarity, Branden S.

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Author Correction: Highly efficient multiplex human T cell engineering without double-strand breaks using Cas9 base editors von Webber, Beau R., Lonetree, Cara-lin, Kluesner, Mitchell G., Johnson, Matthew J., Pomeroy, Emily J., Diers, Miechaleen D., Lahr, Walker S., Draper, Garrett M., Slipek, Nicholas J., Smeester, Branden A., Lovendahl, Klaus N., McElroy, Amber N., Gordon, Wendy R., Osborn, Mark J., Moriarity, Branden S.

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Internal checkpoint regulates T cell neoantigen reactivity and susceptibility to PD1 blockade von Palmer, Douglas C, Webber, Beau R, Patel, Yogin, Johnson, Matthew J, Kariya, Christine M, Lahr, Walker S, Parkhurst, Maria R, Gartner, Jared J, Prickett, Todd D, Lowery, Frank J, Kishton, Rigel J, Gurusamy, Devikala, Franco, Zulmarie, Vodnala, Suman K, Diers, Miechaleen D, Wolf, Natalie K, Slipek, Nicholas J, McKenna, David H, Sumstad, Darin, Viney, Lydia, Henley, Tom, Bürckstümmer, Tilmann, Baker, Oliver, Hu, Ying, Yan, Chunhua, Meerzaman, Daoud, Padhan, Kartik, Lo, Winnie, Malekzadeh, Parisa, Jia, Li, Deniger, Drew C, Patel, Shashank J, Robbins, Paul F, McIvor, R Scott, Choudhry, Modassir, Rosenberg, Steven A, Moriarity, Branden S, Restifo, Nicholas P

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Cas9-induced targeted integration of large DNA payloads in primary human T cells via homology-mediated end-joining DNA repair von Webber, Beau R, Johnson, Matthew J, Skeate, Joseph G, Slipek, Nicholas J, Lahr, Walker S, DeFeo, Anthony P, Mills, Lauren J, Qiu, Xiaohong, Rathmann, Blaine, Diers, Miechaleen D, Wick, Bryce, Henley, Tom, Choudhry, Modassir, Starr, Timothy K, McIvor, R Scott, Moriarity, Branden S

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RAS oncogene suppression induces apoptosis followed by more differentiated and less myelosuppressive disease upon relapse of acute myeloid leukemia von Kim, Won-Il, Matise, Ilze, Diers, Miechaleen D., Largaespada, David A.

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Whole-body sleeping beauty mutagenesis can cause penetrant leukemia/lymphoma and rare high-grade glioma without associated embryonic lethality von Collier, Lara S, Adams, David J, Hackett, Christopher S, Bendzick, Laura E, Akagi, Keiko, Davies, Michael N, Diers, Miechaleen D, Rodriguez, Fausto J, Bender, Aaron M, Tieu, Christina, Matise, Ilze, Dupuy, Adam J, Copeland, Neal G, Jenkins, Nancy A, Hodgson, J Graeme, Weiss, William A, Jenkins, Robert B, Largaespada, David A

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Stat5 is critical for the development and maintenance of myeloproliferative neoplasm initiated by Nf1 deficiency von Sachs, Zohar, Been, Raha A, DeCoursin, Krista J, Nguyen, Hanh T, Mohd Hassan, Nurul A, Noble-Orcutt, Klara E, Eckfeldt, Craig E, Pomeroy, Emily J, Diaz-Flores, Ernesto, Geurts, Jennifer L, Diers, Miechaleen D, Hasz, Diane E, Morgan, Kelly J, MacMillan, Margaret L, Shannon, Kevin M, Largaespada, David A, Wiesner, Stephen M

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NRASG12V oncogene facilitates self-renewal in a murine model of acute myelogenous leukemia von Sachs, Zohar, LaRue, Rebecca S., Nguyen, Hanh T., Sachs, Karen, Noble, Klara E., Mohd Hassan, Nurul Azyan, Diaz-Flores, Ernesto, Rathe, Susan K., Sarver, Aaron L., Bendall, Sean C., Ha, Ngoc A., Diers, Miechaleen D., Nolan, Garry P., Shannon, Kevin M., Largaespada, David A.

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An insertional mutagenesis screen identifies genes that cooperate with Mll-AF9 in a murine leukemogenesis model von Bergerson, Rachel J., Collier, Lara S., Sarver, Aaron L., Been, Raha A., Lugthart, Sanne, Diers, Miechaleen D., Zuber, Johannes, Rappaport, Amy R., Nixon, Molly J., Silverstein, Kevin A.T., Fan, Danhua, Lamblin, Anne-Francoise J., Wolff, Linda, Kersey, John H., Delwel, Ruud, Lowe, Scott W., O'Sullivan, M. Gerard, Kogan, Scott C., Adams, David J., Largaespada, David A.

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333 Targeting the apical intracellular checkpoint CISH unleashes T cell neoantigen reactivity and effector program von Palmer, Douglas, Webber, Beau, Patel, Yogin, Johnson, Matthew, Kariya, Christine, Lahr, Walker, Parkhurst, Maria, Gartner, Jared, Prickett, Todd, Lowery, Frank, Kishton, Rigel, Gurusamy, Devikala, Franco, Zulmarie, Vodnala, Suman, Diers, Miechaleen, Wolf, Natalie, Slipek, Nicholas, McKenna, David, Sumstad, Darin, Viney, Lydia, Henley, Tom, Bürckstümmer, Tilmann, Baker, Oliver, Hu, Ying, Yan, Chunhua, Meerzaman, Daoud, Padhan, Kartik, Lo, Winnie, Malekzadeh, Parisa, Jia, Li, Deniger, Drew, Patel, Shashank, Robbins, Paul, Scott McIvor, R, Choudhry, Modassir, Rosenberg, Steven, Moriarity, Branden, Restifo, Nicholas

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β common receptor inactivation attenuates myeloproliferative disease in Nf1 mutant mice von Kim, Andrew, Morgan, Kelly, Hasz, Diane E., Wiesner, Stephen M., Lauchle, Jennifer O., Geurts, Jennifer L., Diers, Miechaleen D., Le, Doan T., Kogan, Scott C., Parada, Luis F., Shannon, Kevin, Largaespada, David A.

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Nf1 mutant mice with p19ARF gene loss develop accelerated hematopoietic disease resembling acute leukemia with a variable phenotype von Wiesner, Stephen M., Geurts, Jennifer L., Diers, Miechaleen D., Bergerson, Rachel J., Hasz, Diane E., Morgan, Kelly J., Largaespada, David A.

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Multiplex Human T Cell Engineering without Double-Strand Break Induction Using the Cas9 Base Editor System von Webber, Beau, Lonetree, Cara-lin, Diers, Miechaleen, Lahr, Walker S, Mitchell, Kluesner, Johnson, Matthew J, Moriarity, Branden S

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Abstract A036: Multiplex human T-cell engineering by Cas9 base editor technology von Lonetree, Cara, Webber, Beau R., Diers, Miechaleen D., Lahr, Walker S., Kluesner, Mitchell, Osborn, Mark J., Johnson, Matthew J., Moriarity, Branden S.

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35 Targeted non-viral integration of large cargo in primary human T cells by CRISPR/Cas9 guided homology mediated end joining von Webber, Beau, Johnson, Matthew, Slipek, Nicholas, Walker Lahr, Qiu, Xiaohong, Rathmann, Blaine, Diers, Miechaleen, Wick, Bryce, McIvor, R Scott, Moriarity, Branden

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Abstract 4176: Activated NRAS mediates self-renewal capacity in AML von Sachs, Zohar, Rathe, Susan K., Diaz-Flores, Ernesto, Diers, Miechaleen D., Shannon, Kevin, Largaespada, David A.

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Cellular Intrinsic Mechanism Affecting The Outcome Of AML Treatment With Ara-C In a Syngeneic Mouse Model von Chen, Zheng, Tan, Dongming, Zhao, Wenjun, Su, Guangsong, Zheng, Yanwen, He, Chao, Diers, Miechaleen D, Mao, Zhengwei, Singleton, Timothy, Largaespada, David A., Yin, Bin

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Methotrexate accumulates to similar levels in animals transplanted with normal versus drug-resistant transgenic marrow von BELUR, Lalitha R, BOELK-GALVAN, Debra, DIERS, Miechaleen D, MCLVOR, R. Scott, ZIMMERMAN, Cheryl L

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Abstract B15: NRASG12V oncogene mediates self-renewal in a murine model of acute myelogenous leukemia von Sachs, Zohar, LaRue, Rebecca S., Nguyen, Hanh T., Sachs, Karen, Hassan, Nurul Azyan Mohd, Diaz-Flores, Ernesto, Rathe, Susan K., Sarver, Aaron L., Bendall, Sean C., Ha, Ngoc A., Diers, Miechaleen D., Nolan, Garry P., Shannon, Kevin M., Largaespada, David A.

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Delineating Critical Effectors of Remission Induction in a Mouse Model of AML von Sachs, Zohar, Rathe, Susan K., Diaz-Flores, Ernesto, Diers, Miechaleen D, Shannon, Kevin M., Largaespada, David A.

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