Structural and Physicochemical Features of Oral PROTACs von Schade, Markus, Scott, James S., Hayhow, Thomas G., Pike, Andy, Terstiege, Ina, Ahlqvist, Marie, Johansson, Johan R., Diene, Coura R., Fallan, Charlene, Balazs, Amber Y. S., Chiarparin, Elisabetta, Wilson, David

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A Buchwald–Hartwig Protocol to Enable Rapid Linker Exploration of Cereblon E3‐Ligase PROTACs von Hayhow, Thomas G., Borrows, Rachel E. A., Diène, Coura R., Fairley, Gary, Fallan, Charlene, Fillery, Shaun M., Scott, James S., Watson, David W.

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Access to a Diverse Array of Bridged Benzo[1,5]oxazocine and Benzo[1,4]diazepine Structures von Sherborne, Grant J, Diène, Coura, Kemmitt, Paul, Smith, Andrew D

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Discovery of a Series of Orally Bioavailable Androgen Receptor Degraders for the Treatment of Prostate Cancer von Bagal, Sharan K., Astles, Peter C., Diène, Coura, Argyrou, Argyrides, Crafter, Claire, Cassar, Doyle J., Fallan, Charlene, Hock, Andreas, Jones, Thomas, Moreau, Kevin, Lamont, Gillian M., Lamont, Scott, Michaloglou, Chrysiis, Packer, Martin J., Pike, Andy, Ramos-Montoya, Antonio, Scott, James S., Shaw, Joseph, Shologu, Ziyanda

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Pd-, Ni-, Fe-, and Co-Catalyzed Cross-Couplings Using Functionalized Zn-, Mg-, Fe-, and In-Organometallics von Knochel, Paul, Thaler, Tobias, Diene, Coura

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Stereoselective C-Glycosylation Reactions with Arylzinc Reagents von Lemaire, Sébastien, Houpis, Ioannis N, Xiao, Tingting, Li, Juanjuan, Digard, Eric, Gozlan, Charlotte, Liu, Renmao, Gavryushin, Andrey, Diène, Coura, Wang, Youchu, Farina, Vittorio, Knochel, Paul

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Optimization of Pan-Pim Kinase Activity and Oral Bioavailability Leading to Diaminopyrazole (GDC-0339) for the Treatment of Multiple Myeloma von Wang, Xiaojing, Blackaby, Wesley, Allen, Vivienne, Chan, Grace Ka Yan, Chang, Jae H, Chiang, Po-Chang, Diène, Coura, Drummond, Jason, Do, Steven, Fan, Eric, Harstad, Eric B, Hodges, Alastair, Hu, Huiyong, Jia, Wei, Kofie, William, Kolesnikov, Aleksandr, Lyssikatos, Joseph P, Ly, Justin, Matteucci, Mizio, Moffat, John G, Munugalavadla, Veerendra, Murray, Jeremy, Nash, David, Noland, Cameron L, Del Rosario, Geoff, Ross, Leanne, Rouse, Craig, Sharpe, Andrew, Slaga, Dionysos, Sun, Minghua, Tsui, Vickie, Wallweber, Heidi, Yu, Shang-Fan, Ebens, Allen J

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Preparation of 2′-Deoxy-2′-spirocyclopropylcytidine via an Alternative Cyclopropanation Reaction von Lemaire, Sébastien, Diène, Coura, Gavryushin, Andrei, Du Jourdin, Xavier Mollat, Paolini, Léa, Jusseau, Xavier, Knochel, Paul, Farina, Vittorio

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Identification and optimisation of a pyrimidopyridone series of IRAK4 inhibitors von Cumming, Iain A., Degorce, Sébastien L., Aagaard, Anna, Braybrooke, Erin L., Davies, Nichola L., Diène, Coura R., Eatherton, Andrew J., Felstead, Hannah R., Groombridge, Sam D., Lenz, Eva M., Li, Yunxia, Nai, Youfeng, Pearson, Stuart, Robb, Graeme R., Scott, James S., Steward, Oliver R., Wu, Chengyan, Xue, Yafeng, Zhang, Lanping, Zhang, Yanxiu

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Improving metabolic stability and removing aldehyde oxidase liability in a 5-azaquinazoline series of IRAK4 inhibitors von Degorce, Sébastien L., Aagaard, Anna, Anjum, Rana, Cumming, Iain A., Diène, Coura R., Fallan, Charlene, Johnson, Tony, Leuchowius, Karl-Johan, Orton, Alexandra L., Pearson, Stuart, Robb, Graeme R., Rosen, Alan, Scarfe, Graeme B., Scott, James S., Smith, James M., Steward, Oliver R., Terstiege, Ina, Tucker, Michael J., Turner, Paul, Wilkinson, Stephen D., Wrigley, Gail L., Xue, Yafeng

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Isoxazole-Embedded Allylic Zinc Reagent for the Diastereoselective Preparation of Highly Functionalized Aldol-Type Derivatives Bearing a Stereocontrolled Quaternary Center von Klier, Lydia, Diène, Coura R., Schickinger, Manuel, Metzger, Albrecht, Wagner, Andreas J., Karaghiosoff, Konstantin, Marek, Ilan, Knochel, Paul

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Preparation of Polyfunctional Zinc Organometallics Using an Fe- or Co-Catalyzed Cl/Zn-Exchange von Melzig, Laurin, Diène, Coura R, Rohbogner, Christoph J, Knochel, Paul

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Cobalt-Catalyzed Sulfonate/Copper Exchange for the Preparation of Highly Functionalized Electron-Deficient Aryl Copper Reagents von Rohbogner, Christoph J, Diène, Coura R, Korn, Tobias J, Knochel, Paul

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Preparation of functionalized Zn and Mg-organometallics. Application to the performance of diastereoselective cross-couplings von Knochel, Paul, Diène, Coura

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Discovery and In Vivo Efficacy of AZ-PRMT5i-1, a Novel PRMT5 Inhibitor with High MTA Cooperativity von Smith, James M., Barlaam, Bernard, Beattie, David, Bradshaw, Lauren, Chan, Ho Man, Chiarparin, Elisabetta, Collingwood, Olga, Cooke, Sophie L., Cronin, Anna, Cumming, Iain, Dean, Emma, Debreczeni, Judit É., del Barco Barrantes, Iván, Diene, Coura, Gianni, Davide, Guerot, Carine, Guo, Xiaoxiao, Guven, Sinem, Hayhow, Thomas G., Hong, Ted, Kemmitt, Paul D., Lamont, Gillian M., Lamont, Scott, Lynch, James T., McWilliams, Lisa, Moore, Shaun, Raubo, Piotr, Robb, Graeme R., Robinson, James, Scott, James S., Srinivasan, Bharath, Steward, Oliver, Stubbs, Christopher J., Syson, Karl, Tan, Lixiang, Turner, Oliver, Underwood, Elizabeth, Urosevic, Jelena, Vazquez-Chantada, Mercedes, Whittaker, Amy L., Wilson, David M., Winter-Holt, Jon J.

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Metabolism-driven in vitro/in vivo disconnect of an oral ERɑ VHL-PROTAC von Hayhow, Thomas G., Williamson, Beth, Lawson, Mandy, Cureton, Natalie, Braybrooke, Erin L., Campbell, Andrew, Carbajo, Rodrigo J., Cheraghchi-Bashi, Azadeh, Chiarparin, Elisabetta, Diène, Coura R., Fallan, Charlene, Fisher, David I., Goldberg, Frederick W., Hopcroft, Lorna, Hopcroft, Philip, Jackson, Anne, Kettle, Jason G., Klinowska, Teresa, Künzel, Ulrike, Lamont, Gillian, Lewis, Hilary J., Maglennon, Gareth, Martin, Scott, Gutierrez, Pablo Morentin, Morrow, Christopher J., Nikolaou, Myria, Nissink, J. Willem M., O’Shea, Patrick, Polanski, Radoslaw, Schade, Markus, Scott, James S., Smith, Aaron, Weber, Judith, Wilson, Joanne, Yang, Bin, Crafter, Claire

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ChemInform Abstract: Isoxazole-Embedded Allylic Zinc Reagent for the Diastereoselective Preparation of Highly Functionalized Aldol-Type Derivatives Bearing a Stereocontrolled Quate... von Klier, Lydia, Diene, Coura R., Schickinger, Manuel, Metzger, Albrecht, Wagner, Andreas J., Karaghiosoff, Konstantin, Marek, Ilan, Knochel, Paul

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ChemInform Abstract: Preparation of Functionalized Zn and Mg Organometallics - Application to the Performance of Diastereoselective Cross-Couplings von Knochel, Paul, Diene, Coura

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Estrogen receptor degrading protacs von SCOTT, James Stewart, DIENE, Coura, NISSINK, Johannes Wilhelmus Maria, FALLAN, Charlene, YANG, Bin, HAYHOW, Thomas George Christopher, BARLAAM, Bernard Christophe

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COMPOUNDS AND THEIR USE IN TREATING CANCER von SCOTT, James, GINGIPALLI, Lakshmaiah, DIENE, Coura Rosalie, NISSINK, Johannes Wilhelmus Maria, KAWATKAR, Sameer Pralhad, YE, Qing, PACKER, Martin John, FALLAN, Charlene, BAGAL, Sharanjeet Kaur, CASSAR, Doyle Joseph, ASTLES, Peter

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