A novel hierarchical prognostic model of AML solely based on molecular mutations von Grossmann, Vera, Schnittger, Susanne, Kohlmann, Alexander, Eder, Christiane, Roller, Andreas, Dicker, Frank, Schmid, Christoph, Wendtner, Clemens-Martin, Staib, Peter, Serve, Hubert, Kreuzer, Karl-Anton, Kern, Wolfgang, Haferlach, Torsten, Haferlach, Claudia

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Minimal residual disease levels assessed by NPM1 mutation–specific RQ-PCR provide important prognostic information in AML von Schnittger, Susanne, Kern, Wolfgang, Tschulik, Claudia, Weiss, Tamara, Dicker, Frank, Falini, Brunangelo, Haferlach, Claudia, Haferlach, Torsten

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Detection of recurrent and of novel fusion transcripts in myeloid malignancies by targeted RNA sequencing von Stengel, Anna, Nadarajah, Niroshan, Haferlach, Torsten, Dicker, Frank, Kern, Wolfgang, Meggendorfer, Manja, Haferlach, Claudia

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Next-Generation Sequencing Technology Reveals a Characteristic Pattern of Molecular Mutations in 72.8% of Chronic Myelomonocytic Leukemia by Detecting Frequent Alterations in TET2,... von KOHLMANN, Alexander, GROSSMANN, Vera, HAFERLACH, Claudia, HAFERLACH, Torsten, KLEIN, Hans-Ulrich, SCHINDELA, Sonja, WEISS, Tamara, KAZAK, Beray, DICKER, Frank, SCHNITTGER, Susanne, DUGAS, Martin, KERN, Wolfgang

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Effect of Whole Bowel Irrigation for Ingested Lead-Containing Foreign Bodies: A Pediatric Case Series von Dicker, Frank, Mullins, Michael, Liss, David

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Molecular subtypes of NPM1 mutations have different clinical profiles, specific patterns of accompanying molecular mutations and varying outcomes in intermediate risk acute myeloid... von Alpermann, Tamara, Schnittger, Susanne, Eder, Christiane, Dicker, Frank, Meggendorfer, Manja, Kern, Wolfgang, Schmid, Christoph, Aul, Carlo, Staib, Peter, Wendtner, Clemens-Martin, Schmitz, Norbert, Haferlach, Claudia, Haferlach, Torsten

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ZAP-70 directly enhances IgM signaling in chronic lymphocytic leukemia von Chen, Liguang, Apgar, John, Huynh, Lang, Dicker, Frank, Giago-McGahan, Teresa, Rassenti, Laura, Weiss, Arthur, Kipps, Thomas J.

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Development and validation of a real-time quantification assay to detect and monitor BRAFV600E mutations in hairy cell leukemia von Schnittger, Susanne, Bacher, Ulrike, Haferlach, Torsten, Wendland, Nicole, Ulke, Madlen, Dicker, Frank, Grossmann, Vera, Haferlach, Claudia, Kern, Wolfgang

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P694: RISK ASSESSMENT ACCORDING TO IPSS‐M IS SUPERIOR TO AML ELN 2022 RISK CLASSIFICATION IN MDS/AML PATIENTS DEFINED BY ICC – IS AN INCLUSION INTO AML TRIALS JUSTIFIED? von Huber, Sandra, Baer, Constance, Hutter, Stephan, Dicker, Frank, Meggendorfer, Manja, Pohlkamp, Christian, Kern, Wolfgang, Haferlach, Torsten, Haferlach, Claudia, Hoermann, Gregor

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Proximally biased V(D)J recombination in the clonal evolution of IGH alleles in KMT2A::AFF1 BCP‐ALL of all age classes von Müller, Heiko, Dicker, Frank, Bär, Constance, Walter, Wencke, Hutter, Stephan, Nadarajah, Niroshan, Meggendorfer, Manja, Gao, Qingsong, Iacobucci, Ilaria, Mullighan, Charles G., Kern, Wolfgang, Haferlach, Torsten, Haferlach, Claudia

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Mutations of JAK2 and TET2, but not CBL are detectable in a high portion of patients with refractory anemia with ring sideroblasts and thrombocytosis von FLACH, Johanna, DICKER, Frank, SCHNITTGER, Susanne, KOHLMANN, Alexander, HAFERLACH, Torsten, HAFERLACH, Claudia

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Use of CBL exon 8 and 9 mutations in diagnosis of myeloproliferative neoplasms and myelodysplastic/myeloproliferative disorders: an analysis of 636 cases von SCHNITTGER, Susanne, BACHER, Ulrike, KERN, Wolfgang, HAFERLACH, Claudia, HAFERLACH, Torsten, ALPERMANN, Tamara, REITER, Andreas, ULKE, Madlen, DICKER, Frank, EDER, Christiane, KOHLMANN, Alexander, GROSSMANN, Vera, KOWARSCH, Andreas

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Molecular analyses of 15,542 patients with suspected BCR-ABL1-negative myeloproliferative disorders allow to develop a stepwise diagnostic workflow von SCHNITTGER, Susanne, BACHER, Ulrike, EDER, Christiane, DICKER, Frank, ALPERMANN, Tamara, GROSSMANN, Vera, KOHLMANN, Alexander, KERN, Wolfgang, HAFERLACH, Claudia, HAFERLACH, Torsten

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Young Man with Sore Throat, Headache, and Rash von Dicker, Frank, BS, Walsh, Ryan, MD, MC, USA, May, Ian C., MD, MC, USA

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Fas-ligand (CD178) and TRAIL synergistically induce apoptosis of CD40-activated chronic lymphocytic leukemia B cells von Dicker, Frank, Kater, Arnon P., Fukuda, Tetsuya, Kipps, Thomas J.

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Rare coincident NPM1 and RUNX1 mutations in intermediate risk acute myeloid leukemia display similar patterns to single mutated cases von Fasan, Annette, Haferlach, Claudia, Kohlmann, Alexander, Dicker, Frank, Eder, Christiane, Kern, Wolfgang, Haferlach, Torsten, Schnittger, Susanne

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AML classification in the year 2023: How to avoid a Babylonian confusion of languages von Huber, Sandra, Baer, Constance, Hutter, Stephan, Dicker, Frank, Meggendorfer, Manja, Pohlkamp, Christian, Kern, Wolfgang, Haferlach, Torsten, Haferlach, Claudia, Hoermann, Gregor

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RUNX1 mutations are frequent in de novo AML with noncomplex karyotype and confer an unfavorable prognosis von Schnittger, Susanne, Dicker, Frank, Kern, Wolfgang, Wendland, Nicole, Sundermann, Jana, Alpermann, Tamara, Haferlach, Claudia, Haferlach, Torsten

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Treatment-free remission after third-line therapy with asciminib in chronic myeloid leukemia with an atypical e19a2 BCR::ABL1 transcript and T315I mutation von Ernst, Philipp, Rinke, Jenny, Franke, Georg-Nikolaus, Dicker, Frank, Haferlach, Torsten, Ernst, Thomas, Hochhaus, Andreas

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CD154 induces p73 to overcome the resistance to apoptosis of chronic lymphocytic leukemia cells lacking functional p53 von Dicker, Frank, Kater, Arnon P., Prada, Carlos E., Fukuda, Tetsuya, Castro, Januario E., Sun, Guizhen, Wang, Jean Y., Kipps, Thomas J.

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