Small-Molecule ONC201/TIC10 Targets Chemotherapy-Resistant Colorectal Cancer Stem-like Cells in an Akt/Foxo3a/TRAIL-Dependent Manner von Prabhu, Varun V, Allen, Joshua E, Dicker, David T, El-Deiry, Wafik S

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Role of Dopamine Receptors in the Anticancer Activity of ONC201 von Kline, Christina Leah B., Ralff, Marie D., Lulla, Amriti R., Wagner, Jessica M., Abbosh, Phillip H., Dicker, David T., Allen, Joshua E., El-Deiry, Wafik S.

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miR-6883 Family miRNAs Target CDK4/6 to Induce G1 Phase Cell-Cycle Arrest in Colon Cancer Cells von Lulla, Amriti R., Slifker, Michael J., Zhou, Yan, Lev, Avital, Einarson, Margret B., Dicker, David T., El-Deiry, Wafik S.

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P53-independent partial restoration of the p53 pathway in tumors with mutated p53 through ATF4 transcriptional modulation by ERK1/2 and CDK9 von Tian, Xiaobing, Ahsan, Nagib, Lulla, Amriti, Lev, Avital, Abbosh, Philip, Dicker, David T., Zhang, Shengliang, El-Deiry, Wafik S.

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Small-Molecule NSC59984 Restores p53 Pathway Signaling and Antitumor Effects against Colorectal Cancer via p73 Activation and Degradation of Mutant p53 von Zhang, Shengliang, Zhou, Lanlan, Hong, Bo, van den Heuvel, A Pieter J, Prabhu, Varun V, Warfel, Noel A, Kline, Christina Leah B, Dicker, David T, Kopelovich, Levy, El-Deiry, Wafik S

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Flexible micro spring array device for high-throughput enrichment of viable circulating tumor cells von Harouaka, Ramdane A, Zhou, Ming-Da, Yeh, Yin-Ting, Khan, Waleed J, Das, Avisnata, Liu, Xin, Christ, Christine C, Dicker, David T, Baney, Tara S, Kaifi, Jussuf T, Belani, Chandra P, Truica, Cristina I, El-Deiry, Wafik S, Allerton, Jeffrey P, Zheng, Si-Yang

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Anti-cancer efficacy including Rb-deficient tumors and VHL-independent HIF1α proteasomal destabilization by dual targeting of CDK1 or CDK4/6 and HSP90 von Zhao, Shuai, Zhou, Lanlan, Dicker, David T., Lev, Avital, Zhang, Shengliang, Ross, Eric, El-Deiry, Wafik S.

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The Deubiquitinase Inhibitor PR-619 Sensitizes Normal Human Fibroblasts to Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL)-mediated Cell Death von Crowder, Roslyn N., Dicker, David T., El-Deiry, Wafik S.

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A subset of CB002 xanthine analogs bypass p53-signaling to restore a p53 transcriptome and target an S-phase cell cycle checkpoint in tumors with mutated-p53 von Borrero, Liz Hernandez, Dicker, David T., Santiago, John, Sanders, Jennifer, Tian, Xiaobing, Ahsan, Nagib, Lev, Avital, Zhou, Lanlan, El-Deiry, Wafik S.

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Sorafenib sensitizes solid tumors to Apo2L/TRAIL and Apo2L/TRAIL receptor agonist antibodies by the Jak2-Stat3-Mcl1 axis von Abdulghani, Junaid, Allen, Joshua E, Dicker, David T, Liu, Yingqiu Yvette, Goldenberg, David, Smith, Charles D, Humphreys, Robin, El-Deiry, Wafik S

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Genetic and Pharmacological Screens Converge in Identifying FLIP, BCL2, and IAP Proteins as Key Regulators of Sensitivity to the TRAIL-Inducing Anticancer Agent ONC201/TIC10 von Allen, Joshua E, Prabhu, Varun V, Talekar, Mala, van den Heuvel, A Pieter J, Lim, Bora, Dicker, David T, Fritz, Jennifer L, Beck, Adam, El-Deiry, Wafik S

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Reduction of TRAIL-Induced Mcl-1 and cIAP2 by c-Myc or Sorafenib Sensitizes Resistant Human Cancer Cells to TRAIL-Induced Death von Ricci, M. Stacey, Kim, Seok-Hyun, Ogi, Kazuhiro, Plastaras, John P., Ling, Jianhua, Wang, Wenge, Jin, Zhaoyu, Liu, Yingqiu Y., Dicker, David T., Chiao, Paul J., Flaherty, Keith T., Smith, Charles D., El-Deiry, Wafik S.

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Anti-pancreatic cancer activity of ONC212 involves the unfolded protein response (UPR) and is reduced by IGF1-R and GRP78/BIP von Lev, Avital, Lulla, Amriti R, Wagner, Jessica, Ralff, Marie D, Kiehl, Joshua B, Zhou, Yan, Benes, Cyril H, Prabhu, Varun V, Oster, Wolfgang, Astsaturov, Igor, Dicker, David T, El-Deiry, Wafik S

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Deficient Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) Death Receptor Transport to the Cell Surface in Human Colon Cancer Cells Selected for Resistance to TRAIL-... von Jin, Zhaoyu, McDonald, 3rd, E Robert, Dicker, David T, El-Deiry, Wafik S

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Direct Repression of FLIP Expression by c-myc Is a Major Determinant of TRAIL Sensitivity von Ricci, M. Stacey, Jin, Zhaoyu, Dews, Michael, Yu, Duonan, Thomas-Tikhonenko, Andrei, Dicker, David T., El-Deiry, Wafik S.

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Human colon cancer stem cells are enriched by insulin-like growth factor-1 and are sensitive to figitumumab von Hart, Lori S., Dolloff, Nathan G., Dicker, David T., Koumenis, Constantinos, Christensen, James G., Grimberg, Adda, El-Deiry, Wafik S.

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The angular structure of ONC201, a TRAIL pathway-inducing compound, determines its potent anti-cancer activity von Wagner, Jessica, Kline, Christina Leah, Pottorf, Richard S, Nallaganchu, Bhaskara Rao, Olson, Gary L, Dicker, David T, Allen, Joshua E, El-Deiry, Wafik S

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Silencing of the Novel p53 Target Gene Snk/Plk2 Leads to Mitotic Catastrophe in Paclitaxel (Taxol)-Exposed Cells von Burns, Timothy F, Fei, Peiwen, Scata, Kimberly A, Dicker, David T, El-Deiry, Wafik S

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Bnip3L is induced by p53 under hypoxia, and its knockdown promotes tumor growth von Fei, Peiwen, Wang, Wenge, Kim, Seok-hyun, Wang, Shulin, Burns, Timothy F., Sax, Joanna K., Buzzai, Monica, Dicker, David T., McKenna, W.Gillies, Bernhard, Eric J., El-Deiry, Wafik S.

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Circulating tumor cells: silent predictors of metastasis von Zhou, LanLan, Dicker, David T, Matthew, Elizabeth, El-Deiry, Wafik S, Alpaugh, R Katherine

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