Acute gamma-secretase inhibition improves contextual fear conditioning in the Tg2576 mouse model of Alzheimer's disease von Comery, Thomas A, Martone, Robert L, Aschmies, Suzan, Atchison, Kevin P, Diamantidis, George, Gong, Xiaohai, Zhou, Hua, Kreft, Anthony F, Pangalos, Menelas N, Sonnenberg-Reines, June, Jacobsen, J Steven, Marquis, Karen L

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Discovery of Begacestat, a Notch-1-Sparing γ-Secretase Inhibitor for the Treatment of Alzheimer’s Disease von Mayer, Scott C, Kreft, Anthony F, Harrison, Boyd, Abou-Gharbia, Magid, Antane, Madelene, Aschmies, Suzan, Atchison, Kevin, Chlenov, Michael, Cole, Derek C, Comery, Thomas, Diamantidis, George, Ellingboe, John, Fan, Kristi, Galante, Rocco, Gonzales, Cathleen, Ho, Douglas M, Hoke, Molly E, Hu, Yun, Huryn, Donna, Jain, Uday, Jin, Mei, Kremer, Kenneth, Kubrak, Dennis, Lin, Melissa, Lu, Peimin, Magolda, Ron, Martone, Robert, Moore, William, Oganesian, Aram, Pangalos, Menelas N, Porte, Alex, Reinhart, Peter, Resnick, Lynn, Riddell, David R, Sonnenberg-Reines, June, Stock, Joseph R, Sun, Shaiu-Ching, Wagner, Erik, Wang, Ting, Woller, Kevin, Xu, Zheng, Zaleska, Margaret M, Zeldis, Joseph, Zhang, Minsheng, Zhou, Hua, Jacobsen, J. Steven

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N-Hydroxy-3-phenyl-2-propenamides as Novel Inhibitors of Human Histone Deacetylase with in Vivo Antitumor Activity:  Discovery of (2E)-N-Hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1H-indol... von Remiszewski, Stacy W, Sambucetti, Lidia C, Bair, Kenneth W, Bontempo, John, Cesarz, David, Chandramouli, Nagarajan, Chen, Ru, Cheung, Min, Cornell-Kennon, Susan, Dean, Karl, Diamantidis, George, France, Dennis, Green, Michael A, Howell, Kobporn Lulu, Kashi, Rina, Kwon, Paul, Lassota, Peter, Martin, Mary S, Mou, Yin, Perez, Lawrence B, Sharma, Sushil, Smith, Troy, Sorensen, Eric, Taplin, Francis, Trogani, Nancy, Versace, Richard, Walker, Heather, Weltchek-Engler, Susan, Wood, Alexander, Wu, Arthur, Atadja, Peter

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Novel pyrazolopyrimidines as highly potent B-Raf inhibitors von Di Grandi, Martin J., Berger, Dan M., Hopper, Darrin W., Zhang, Chunchun, Dutia, Minu, Dunnick, Alejandro L., Torres, Nancy, Levin, Jeremy I., Diamantidis, George, Zapf, Christoph W., Bloom, Jonathan D., Hu, YongBo, Powell, Dennis, Wojciechowicz, Donald, Collins, Karen, Frommer, Eileen

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Discovery of a novel series of Notch-sparing γ-secretase inhibitors von Kreft, Anthony, Harrison, Boyd, Aschmies, Suzan, Atchison, Kevin, Casebier, David, Cole, Derek C., Diamantidis, George, Ellingboe, John, Hauze, Diane, Hu, Yun, Huryn, Donna, Jin, Mei, Kubrak, Dennis, Lu, Peimin, Lundquist, Joseph, Mann, Charles, Martone, Robert, Moore, William, Oganesian, Aram, Porte, Alex, Riddell, Dave R., Sonnenberg-Reines, June, Stock, Joseph R., Sun, Shaiu-Ching, Wagner, Erik, Woller, Kevin, Xu, Zheng, Zhou, Hua, Steven Jacobsen, J.

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( S) -N-(5-Chlorothiophene-2-sulfonyl)-β,β-diethylalaninol a Notch-1-sparing γ-secretase inhibitor von Cole, Derek C., Stock, Joseph R., Kreft, Anthony F., Antane, Madelene, Aschmies, Suzan H., Atchison, Kevin P., Casebier, David S., Comery, Thomas A., Diamantidis, George, Ellingboe, John W., Harrison, Boyd L., Hu, Yun, Jin, Mei, Kubrak, Dennis M., Lu, Peimin, Mann, Charles W., Martone, Robert L., Moore, William J., Oganesian, Aram, Riddell, David R., Sonnenberg-Reines, June, Sun, Shaiu-Ching, Wagner, Erik, Wang, Zheng, Woller, Kevin R., Xu, Zheng, Zhou, Hua, Jacobsen, J. Steven

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Synthesis and structure–activity relationship of a novel series of heterocyclic sulfonamide γ-secretase inhibitors von Pu, Jun, Kreft, Anthony F., Aschmies, Suzan H., Atchison, Kevin P., Berkowitz, Joshua, Caggiano, Thomas J., Chlenov, Micheal, Diamantidis, George, Harrison, Boyd L., Hu, Yun, Huryn, Donna, Steven Jacobsen, J., Jin, Mei, Lipinski, Kerri, Lu, Peimin, Martone, Robert L., Morris, Koi, Sonnenberg-Reines, June, Riddell, Dave R., Sabalski, Joan, Sun, Shaiu-Ching, Wagner, Erik, Wang, Yiqun, Xu, Zheng, Zhou, Hua, Resnick, Lynn

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Asymmetric synthesis of novel α-amino acids with β-branched side chains von Zhang, Minsheng, Porte, Alex, Diamantidis, George, Sogi, Kimberly, Kubrak, Dennis, Resnick, Lynn, Mayer, Scott C., Wang, Zheng, Kreft, Anthony F., Harrison, Boyd L.

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Synthesis and pharmacological evaluation of 4,4-disubstituted piperidines von Colapret, John A, Diamantidis, George, Spencer, H. Kenneth, Spaulding, Ted C, Rudo, Frieda G

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P2-337: Characterization of the affinity of GSI-953 for binding to gamma-secretase and comparison to benchmark gamma-secretase inhibitors von Kreft, Anthony F, Abou-Gharbia, Magid A, Aulabaugh, Ann E, Atchison, Kevin P, Diamantidis, George, Harrison, Boyd L, Hirst, Warren D, Huang, Xinyi, Kubrak, Dennis M, Lipinski, Kerri, Magolda, Ronald L, Martone, Robert L, May, Michael K, Mayer, Scott C, Pangalos, Menelas N, Porte, Alex M, Reinhart, Peter H, Resnick, Lynn, Zhou, Hua, Jacobsen, J. Steven

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N-hydroxy-3-phenyl-2-propenamides as novel inhibitors of human histone deacetylase with in vivo antitumor activity: Discovery of (2E)-N-hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1H-indol-... von REMISZEWSKI, Stacy W, SAMBUCETTI, Lidia C, DIAMANTIDIS, George, FRANCE, Dennis, GREEN, Michael A, HOWELL, Kobporn Lulu, KASHI, Rina, KWON, Paul, LASSOTA, Peter, MARTIN, Mary S, YIN MOU, PEREZ, Lawrence B, BAIR, Kenneth W, SHARMA, Sushil, SMITH, Troy, SORENSEN, Eric, TAPLIN, Francis, TROGANI, Nancy, VERSACE, Richard, WALKER, Heather, WELTCHEK-ENGLER, Susan, WOOD, Alexander, WU, Arthur, BONTEMPO, John, ATADJA, Peter, CESARZ, David, CHANDRAMOULI, Nagarajan, RU CHEN, MIN CHEUNG, CORNELL-KENNON, Susan, DEAN, Karl

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Acute {gamma}-Secretase Inhibition Improves Contextual Fear Conditioning in the Tg2576 Mouse Model of Alzheimer's Disease von Comery, Thomas A, Martone, Robert L, Aschmies, Suzan, Atchison, Kevin P, Diamantidis, George, Gong, Xiaohai, Zhou, Hua, Kreft, Anthony F, Pangalos, Menelas N, Sonnenberg-Reines, June, Jacobsen, J. Steven, Marquis, Karen L

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PHENYLSULFONAMIDE-SUBSTITUTED, PYRAZOLO[1, 5-A]PYRIMIDINES, METHODS FOR PREPARATION AND USES THEREOF von DUTIA, MINU DHANJISHA, DIAMANTIDIS, GEORGE, BERGER, DAN MAARTEN, NORTON, EMILY BOUCHER, LEVIN, JEREMY IAN

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FUSED TRICYCLIC PYRAZOLO[1, 5-A]PYRIMIDINES, METHODS FOR PREPARATION AND USES THEREOF von DIAMANTIDIS, GEORGE, ZAPF, CHRISTOPH, WOLFGANG, BLOOM, JONATHAN, DAVID, LEVIN, JEREMY, IAN

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Asymmetric Synthesis of Novel α-Amino Acids with β-Branched Side Chains von Zhang, Minsheng, Porte, Alex, Diamantidis, George, Sogi, Kimberly, Kubrak, Dennis, Resnick, Lynn, Mayer, Scott C., Wang, Zheng, Kreft, Anthony F., Harrison, Boyd L.

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Heterocyclic Sulfonamide Inhibitors of Beta Amyloid Production von WOLLER KEVIN R, STOCK JOSEPH R, KUTTERER KRISTINA M, COLE DEREK C, DIAMANTIDIS GEORGE, MOORE WILLIAM J, CASEBIER DAVID S, KUBRAK DENNIS M, KREFT ANTHONY F

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FLUORO-AND TRIFLUOROALKYL-CONTAINING HETEROCYCLIC SULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION AND DERIVATIVES THEREOF von MAYER SCOTT CHRISTIAN, GALANTE ROCCO JOHN, HOKE MOLLY, DIAMANTIDIS GEORGE, COLE DEREK CECIL, TINGZHONG WANG, RESNICK LYNN, MINSHENG ZHANG, HARRISON BOYD LYNN, KREFT ANTHONY FRANK

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Fluoro- and trifluoroalkyl-containing heterocyclic sulfonamide inhibitors of beta amyloid production and derivatives thereof von Kreft, Anthony Frank, Resnick, Lynn, Mayer, Scott Christian, Diamantidis, George, Cole, Derek Cecil, Harrison, Boyd Lynn, Zhang, Minsheng, Hoke, Molly, Wang, Tingzhong, Galante, Rocco John

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Fluoro- and trifluoroalkyl-containing heterocyclic sulfonamide inhibitors of beta amyloid production and derivatives thereof von MAYER SCOTT CHRISTIAN, HOKE MOLLY, GALANTE ROCCO JOHN, WANG TINGZHONG, ZHANG MINSHENG, DIAMANTIDIS GEORGE, COLE DEREK CECIL, RESNICK LYNN, HARRISON BOYD LYNN, KREFT ANTHONY FRANK

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Fluoro-and trifluoroalkyl-containing heterocyclic sulfonamide inhibitors of beta amyloid production and derivatives thereof von LYNN RESNICK, SCOTT CHRISTIAN MAYER, MOLLY HOKE, BOYD LYNN HARRISON, TINGZHONG WANG, GEORGE DIAMANTIDIS, ANTHONY FRANK KREFT, MINSHENG ZHANG, ROCCO JOHN GALANTE, DEREK CECIL COLE

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