ExoSTING, an extracellular vesicle loaded with STING agonists, promotes tumor immune surveillance von Jang, Su Chul, Economides, Kyriakos D., Moniz, Raymond J., Sia, Chang Ling, Lewis, Nuruddeen, McCoy, Christine, Zi, Tong, Zhang, Kelvin, Harrison, Rane A., Lim, Joanne, Dey, Joyoti, Grenley, Marc, Kirwin, Katherine, Ross, Nikki L., Bourdeau, Raymond, Villiger-Oberbek, Agata, Estes, Scott, Xu, Ke, Sanchez-Salazar, Jorge, Dooley, Kevin, Dahlberg, William K., Williams, Douglas E., Sathyanarayanan, Sriram

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Albumin-bound nanoparticle (nab) paclitaxel exhibits enhanced paclitaxel tissue distribution and tumor penetration von Chen, Nianhang, Brachmann, Carrie, Liu, Xiping, Pierce, Daniel W., Dey, Joyoti, Kerwin, William S., Li, Yan, Zhou, Simon, Hou, Shihe, Carleton, Michael, Klinghoffer, Richard A., Palmisano, Maria, Chopra, Rajesh

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A Distinct Smoothened Mutation Causes Severe Cerebellar Developmental Defects and Medulloblastoma in a Novel Transgenic Mouse Model von Dey, Joyoti, Ditzler, Sally, Knoblaugh, Sue E., Hatton, Beryl A., Schelter, Janell M., Cleary, Michele A., Mecham, Brig, Rorke-Adams, Lucy B., Olson, James M.

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603 Targeted STAT3 degradation leads to remodeling of an immunosuppressive tumor microenvironment and subsequent sensitization to immune checkpoint therapy von Dey, Joyoti, Liu, Phillip, Mayo, Michele, Karnik, Rahul, Yang, Bin, Dixit, Vaishali, Jeong, Jieun, Gollob, Jared, Savi, Chris De

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A Platform for Rapid, Quantitative Assessment of Multiple Drug Combinations Simultaneously in Solid Tumors In Vivo von Dey, Joyoti, Kerwin, William S, Grenley, Marc O, Casalini, Joseph R, Tretyak, Ilona, Ditzler, Sally H, Thirstrup, Derek J, Frazier, Jason P, Pierce, Daniel W, Carleton, Michael, Klinghoffer, Richard A

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Fundamental differences in promoter CpG island DNA hypermethylation between human cancer and genetically engineered mouse models of cancer von Diede, Scott J, Yao, Zizhen, Keyes, C Chip, Tyler, Ashlee E, Dey, Joyoti, Hackett, Christopher S, Elsaesser, Katrina, Kemp, Christopher J, Neiman, Paul E, Weiss, William A, Olson, James M, Tapscott, Stephen J

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Phase 1 study of KT-333, a targeted protein degrader, in patients with relapsed or refractory lymphomas, large granular lymphocytic leukemia, and solid tumors von Starodub, Alexander, Gollerkeri, Ashwin, De savi, Chris, Dey, Joyoti, Agarwal, Sagar, Donohue, Sean, Perea, Rachelle, Klaus, Christine, Gollob, Jared

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A biobank of patient-derived pediatric brain tumor models von Brabetz, Sebastian, Leary, Sarah E. S., Gröbner, Susanne N., Nakamoto, Madison W., Şeker-Cin, Huriye, Girard, Emily J., Cole, Bonnie, Strand, Andrew D., Bloom, Karina L., Hovestadt, Volker, Mack, Norman L., Pakiam, Fiona, Schwalm, Benjamin, Korshunov, Andrey, Balasubramanian, Gnana Prakash, Northcott, Paul A., Pedro, Kyle D., Dey, Joyoti, Hansen, Stacey, Ditzler, Sally, Lichter, Peter, Chavez, Lukas, Jones, David T. W., Koster, Jan, Pfister, Stefan M., Kool, Marcel, Olson, James M.

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Voruciclib, a clinical stage oral CDK9 inhibitor, represses MCL-1 and sensitizes high-risk Diffuse Large B-cell Lymphoma to BCL2 inhibition von Dey, Joyoti, Deckwerth, Thomas L., Kerwin, William S., Casalini, Joseph R., Merrell, Angela J., Grenley, Marc O., Burns, Connor, Ditzler, Sally H., Dixon, Chantel P., Beirne, Emily, Gillespie, Kate C., Kleinman, Edward F., Klinghoffer, Richard A.

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Leveraging Pre-Clinical Animal Model of CTCL to Explore Therapeutic Potential of a Novel STAT3 Degrader von Ivanova, Ellie, Tegla, Cosmin A, Novikova, Ekaterina, Herrera, Alberto M, Mullins, Briana, Latkowski, Jo-Ann, Hymes, Kenneth B., Dey, Joyoti, Yang, Bin, Gollerkeri, Ashwin, Gollob, Jared, Koralov, Sergei B.

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A Phase 1 Study of KT-333, a Targeted Protein Degrader of STAT3, in Patients with Relapsed or Refractory Lymphomas, Large Granular Lymphocytic Leukemia, and Solid Tumors von Smith, Stephen D, Starodub, Alexander, Stevens, Don A., Shastri, Aditi, Porcu, Pierluigi, Feldman, Tatyana, Ewesuedo, Reggie, DeSavi, Chris, Dey, Joyoti, Agarwal, Sagar, Donohue, Sean, Perea, Rachelle, Klaus, Christine, Gollob, Jared

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A STAT3 Degrader Demonstrates Pre-Clinical Efficacy in Venetoclax Resistant Acute Myeloid Leukemia von Chakraborty, Samarpana, Morganti, Claudia, Dey, Joyoti, Zhang, Hui, Aluri, Srinivas, Gitego, Nadege, Pradhan, Kith, Rivera, Bianca, Chutake, Yogesh, Skwarska, Anna, Mantzaris, Ioannis, Goldfinger, Mendel, Feldman, Eric J, Choudhary, Gaurav S, Hubner, Stefan, Qiu, Yihua, Brown, Brandon D., Verma, Amit, Gavathiotis, Evripidis, Konopleva, Marina Y., Kornblau, Steven M., Gollob, Jared, Ito, Keisuke, Shastri, Aditi

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Preliminary Safety, Pharmacokinetics, Pharmacodynamics and Clinical Activity of KT-333, a Targeted Protein Degrader of STAT3, in Patients with Relapsed or Refractory Lymphomas, Lar... von Shastri, Aditi, Feldman, Eric J, Starodub, Alexander N, Feldman, Tatyana, Rodriguez, Cristina P, Epstein-Peterson, Zachary D., Stevens, Don A., Olszewski, Adam J, Huen, Auris O, Porcu, Pierluigi, Reneau, John C, Barta, Stefan K., Marchi, Enrica, Mattour, Ahmad H, Pinter-Brown, Lauren C., Perea, Rachelle, Donohue, Sean, Dey, Joyoti, Agarwal, Sagar, Karnik, Rahul, Gollerkeri, Ashwin, Gollob, Jared, Smith, Stephen D

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A First-in-Class STAT3 Degrader KT-333 in Development for Treatment of Hematologic Cancers von Liu, Phillip CC, Dixit, Vaishali, Mayo, Michele, Dey, Joyoti, Yuan, Karen, Karnik, Rahul, Walther, Dirk, Shi, Yatao, Sharma, Kirti, Rong, Haojing, Yang, Bin, Gollerkeri, Ashwin, Gollob, Jared, DeSavi, Chris

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Mechanisms of the Anti-Tumor Activity of STAT3 Degraders in Lymphoma von Rong, Haojing, Sharma, Kirti, Csibi, Fred, Yang, Bin, Rusin, Scott, Shi, Yatao, Dey, Joyoti, Karnik, Rahul, Mayo, Michele, Yuan, Karen, Chutake, Yogesh, McDonald, Alice, Zhu, Sean, Ji, Nan, Liu, Phillip, Li, Henry, Walker, Duncan, Gollob, Jared, Mainolfi, Nello, Desavi, Chris

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Abstract 4136: Direct intratumoral microdosing via the CIVO® platform reveals anti-tumor immune responses induced by the SUMO inhibitor TAK-981 von Hatton, Beryl A., Grenley, Marc, Garnsey, James, Shinde, Vaishali, Huszar, Dennis, Burns, Connor, Ditzler, Sally, Merrell, Angela, Dey, Joyoti, Beirne, Emily, Klinghoffer, Richard A.

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Induction of the Phase II Detoxification Pathway Suppresses Neuron Loss in Drosophila Models of Parkinson's Disease von Trinh, Kien, Moore, Katherine, Wes, Paul D, Muchowski, Paul J, Dey, Joyoti, Andrews, Laurie, Pallanck, Leo J

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Selective STAT3 Degraders Dissect Peripheral T-Cell Lymphomas Vulnerabilities Empowering Personalized Regimens von Astone, Giuseppina, Cappelli, Luca Vincenzo, Chiu, William, Kayembe, Clarisse, Wang, Rui, Yang, Bin, Sharma, Kirti, Dey, Joyoti, Karnik, Rahul, Brambilla, Lara, Levy, David, Yoffe, Liron, Boccalatte, Francesco, Hernaez, Javier Rodriguez, Tsirigos, Aristotelis, Zumbo, Paul, Betel, Doron, Verma, Akanksha, Elemento, Olivier, Cumerlato, Michela, Piva, Roberto, Horwitz, Steven M., Epstein-Peterson, Zachary D., Gollob, Jared, DeSavi, Chris, Liu, Phillip CC, Inghirami, Giorgio

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Abstract 2835: Voruciclib, a clinical stage oral CDK inhibitor, sensitizes triple negative breast cancer xenografts to proteasome inhibition von Dey, Joyoti, Casalini, Joseph, Ditzler, Sally, Biery, Matt, Merrell, Angela, Thirstrup, Derek, Grenley, Marc, Klinghoffer, Richard

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Multiplexed Evaluation of Microdosed Antineoplastic Agents In Situ in the Tumor Microenvironment of Patients with Soft Tissue Sarcoma von Gundle, Kenneth R, Deutsch, Gary B, Goodman, Howard J, Pollack, Seth M, Thompson, Matthew J, Davis, Jessica L, Lee, Mee-Young, Ramirez, Daniel C, Kerwin, William, Bertout, Jessica A, Grenley, Marc O, Sottero, Kimberly H W, Beirne, Emily, Frazier, Jason, Dey, Joyoti, Ellison, Micah, Klinghoffer, Richard A, Maki, Robert G

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