COBRA™: a highly potent conditionally active T cell engager engineered for the treatment of solid tumors von Panchal, Anand, Seto, Pui, Wall, Russell, Hillier, Brian J, Zhu, Ying, Krakow, Jessica, Datt, Aakash, Pongo, Elizabeth, Bagheri, Andisheh, Chen, Tseng-Hui T, Degenhardt, Jeremiah D, Culp, Patricia A, Dettling, Danielle E, Vinogradova, Maia V, May, Chad, DuBridge, Robert B

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Regression of EGFR positive established solid tumors in mice with the conditionally active T cell engager TAK-186 von Dettling, Danielle E, Kwok, Eilene, Quach, Lucy, Datt, Aakash, Degenhardt, Jeremiah D, Panchal, Anand, Seto, Pui, Krakow, Jessica L, Wall, Russell, Hillier, Brian J, Zhu, Ying, Vinogradova, Maia, DuBridge, Robert B, May, Chad

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Allogeneic FLT3 CAR T Cells with an Off-Switch Exhibit Potent Activity against AML and Can Be Depleted to Expedite Bone Marrow Recovery von Sommer, Cesar, Cheng, Hsin-Yuan, Nguyen, Duy, Dettling, Danielle, Yeung, Yik Andy, Sutton, Janette, Hamze, Moustafa, Valton, Julien, Smith, Julianne, Djuretic, Ivana, Chaparro-Riggers, Javier, Sasu, Barbra J.

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4-(Alkylthio)- and 4-(arylthio)-benzonitrile derivatives as androgen receptor antagonists for the topical suppression of sebum production von Mitchell, Lorna, Wang, Zhi, Hu, Lain-Yen, Kostlan, Catherine, Carroll, Matthew, Dettling, Danielle, Du, Daniel, Pocalyko, David, Wade, Kimberly

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Rational Design and Synthesis of 4-((1R,2R)-2-Hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile (PF-998425), a Novel, Nonsteroidal Androgen Receptor Antagonist Devoid of Phototoxic... von Li, Jie Jack, Iula, Donna M, Nguyen, Maria N, Hu, Lain-Yen, Dettling, Danielle, Johnson, Theodore R, Du, Daniel Y, Shanmugasundaram, Veerabahu, Van Camp, Jennifer A, Wang, Zhi, Harter, William G, Yue, Wen-Song, Boys, Mark L, Wade, Kimberly J, Drummond, Elena M, Samas, Brian M, Lefker, Bruce A, Hoge, Garrett S, Lovdahl, Mark J, Asbill, Jeffrey, Carroll, Matthew, Meade, Mary Ann, Ciotti, Susan M, Krieger-Burke, Theresa

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An Optimized Full-Length FLT3/CD3 Bispecific Antibody Demonstrates Potent Anti-leukemia Activity and Reversible Hematological Toxicity von Yeung, Yik Andy, Krishnamoorthy, Veena, Dettling, Danielle, Sommer, Cesar, Poulsen, Kris, Ni, Irene, Pham, Amber, Chen, Wei, Liao-Chan, Sindy, Lindquist, Kevin, Chin, S. Michael, Chunyk, Allison Given, Hu, Wenyue, Sasu, Barbra, Chaparro-Riggers, Javier, Djuretic, Ivana

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Diphenyl ethers as androgen receptor antagonists for the topical suppression of sebum production von Mitchell, Lorna H., Hu, Lain-Yen, Nguyen, Maria, Fakhoury, Stephen, Smith, Yvonne, Iula, Donna, Kostlan, Catherine, Carroll, Matthew, Dettling, Danielle, Du, Daniel, Pocalyko, David, Wade, Kimberly, Lefker, Bruce

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Preparation of 4-aryl-2-trifluoromethylbenzonitrile derivatives as androgen receptor antagonists for topical suppression of sebum production von Van Camp, Jennifer A., Hu, Lain-Yen, Kostlan, Catherine, Lefker, Bruce, Li, Jie, Mitchell, Lorna, Wang, Zhi, Yue, Wen-Song, Carroll, Matthew, Dettling, Danielle, Du, Daniel, Pocalyko, David, Wade, Kimberly

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Abstract 557: COBRA: A novel conditionally active bispecific antibody that regresses established solid tumors in mice von Dettling, Danielle, Kwok, Eilene, Quach, Lucy, Datt, Aakash, Degenhardt, Jeremiah D., Vinogradova, Maia, Panchal, Anand, Seto, Pui, Krakow, Jessica L., Wall, Russell, Hillier, Brian J., Zhu, Ying, DuBridge, Robert B., May, Chad

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A Novel Full Length Anti-FLT3 CD3 Bispecific Antibody for the Treatment of Acute Myeloid Leukemia von Djuretic, Ivana, Krishnamoorthy, Veena, Sommer, Cesar, Dettling, Danielle E., Poulsen, Kris, Chen, Wei, Hu, Wenyue, Given Chunyk, Allison, Lindquist, Kevin, Potluri, Shobha, Rickert, Robert C, Sasu, Barbra, Chaparro-Riggers, Javier, Yeung, Yik Andy

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Molecular Characterization of Familial Hypercholesterolemia in a North American Cohort von Garg, Abhimanyu, Fazio, Sergio, Duell, P Barton, Baass, Alexis, Udata, Chandrasekhar, Joh, Tenshang, Riel, Tom, Sirota, Marina, Dettling, Danielle, Liang, Hong, Garzone, Pamela D, Gumbiner, Barry, Wan, Hong

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Development of a long acting human growth hormone analog suitable for once a week dosing von Palanki, Moorthy S.S., Bhat, Abhijit, Bolanos, Ben, Brunel, Florence, Del Rosario, Joselyn, Dettling, Danielle, Horn, Mark, Lappe, Rodney, Preston, Ryan, Sievers, Annette, Stankovic, Nebojsa, Woodnut, Gary, Chen, Gang

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Comprehensive mechanism-based antibody pharmacokinetic modeling von Chabot, J. R., Dettling, D. E., Jasper, P. J., Gomes, B. C.

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Pantolactams as androgen receptor antagonists for the topical suppression of sebum production von Sexton, Karen E., Barrett, Stephen, Bridgwood, Katy, Carroll, Matthew, Dettling, Danielle, Du, Daniel, Fakhoury, Stephen, Fedij, Victor, Hu, Lain-Yen, Kostlan, Catherine, Pocalyko, David, Raheja, Neil, Smith, Yvonne, Shanmugasundaram, Veerabahu, Wade, Kimberly

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Smoothened antagonists for hair inhibition von Li, Jie Jack, Shanmugasundaram, Veerabahu, Reddy, Satya, Fleischer, Laura L., Wang, Zenquan, Smith, Yvonne, Harter, William G., Yue, Wen-Song, Swaroop, Manju, Li, Ling, Ji, Christy Xiaodong, Dettling, Danielle, Osak, Bella, Fitzgerald, Laura R., Conradi, Robert

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Synthesis and biological evaluation of amino-pyridines as androgen receptor antagonists for stimulating hair growth and reducing sebum production von Hu, Lain-Yen, Lei, Huangshu John, Du, Daniel, Johnson, Theodore R., Fedij, Victor, Kostlan, Catherine, Yue, Wen Song, Lovdahl, Mark, Li, Jie Jack, Carroll, Mathew, Dettling, Danielle, Asbill, Jeffrey, Fan, Conglin, Wade, Kimberly, Pocalyko, David, Lapham, Kimberly, Yalamanchili, Radhika, Samas, Brian, Vrieze, Derek, Ciotti, Susan, Krieger-Burke, Teresa, Sliskovic, Drago, Welgus, Howard

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Chimeric antigen receptors targeting FLT3 von Hamze, Moustafa Marc, Dettling, Danielle Elizabeth, Sommer, Cesar Adolfo, Sasu, Barbra Johnson, Yeung, Yik Andy

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(1 R ,2 S )-4-(2-Cyano-cyclohexyl-oxy)-2-trifluoromethyl-benzonitrile, a potent androgen receptor antagonist for stimulating hair growth and reducing sebum production von Hu, Lain-Yen, Du, Daniel, Hoffman, Jennifer, Smith, Yvonne, Fedij, Victor, Kostlan, Catherine, Johnson, Theodore R., Huang, Yun, Kesten, Steve, Harter, William, Yue, Wen Song, Li, Jie Jack, Barvian, Nicole, Mitchell, Lorna, Lei, Huangshu John, Lefker, Bruce, Carroll, Mathew, Dettling, Danielle, Krieger-Burke, Teresa, Samas, Brian, Yalamanchili, Radhika, Lapham, Kimberly, Pocalyko, David, Sliskovic, Drago, Ciotti, Susan, Stoller, Brenda, Hena, Mostofa A., Ding, Qizhu, Maiti, Samarendra N., Stier, Michael, Welgus, Howard

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ANTIBODIES SPECIFIC FOR FLT3 AND THEIR USES von DETTLING, Danielle Elizabeth, YEUNG, Yik Andy, SOMMER, Cesar Adolfo, KRISHNAMOORTHY, Veena, POULSEN, Kristian Todd

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Chimeric antigen receptors targeting flt3 von Hamze, Moustafa Marc, Dettling, Danielle Elizabeth, Sommer, Cesar Adolfo, Yeung, Yik Andy, Sasu, Barbra Johnson

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