Redirected T Cell Cytotoxicity in Cancer Therapy von Clynes, Raphael A, Desjarlais, John R

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Enhanced antibody half-life improves in vivo activity von Zalevsky, Jonathan, Chamberlain, Aaron K, Horton, Holly M, Karki, Sher, Leung, Irene W L, Sproule, Thomas J, Lazar, Greg A, Roopenian, Derry C, Desjarlais, John R

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Targeting Multiple Myeloma with AMG 424, a Novel Anti-CD38/CD3 Bispecific T-cell-recruiting Antibody Optimized for Cytotoxicity and Cytokine Release von Zuch de Zafra, Christina L, Fajardo, Flordeliza, Zhong, Wendy, Bernett, Matthew J, Muchhal, Umesh S, Moore, Gregory L, Stevens, Jennitte, Case, Ryan, Pearson, Joshua T, Liu, Siyuan, McElroy, Patricia L, Canon, Jude, Desjarlais, John R, Coxon, Angela, Balazs, Mercedesz, Nolan-Stevaux, Olivier

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A robust heterodimeric Fc platform engineered for efficient development of bispecific antibodies of multiple formats von Moore, Gregory L., Bernett, Matthew J., Rashid, Rumana, Pong, Erik W., Nguyen, Duc-Hanh T., Jacinto, Jonathan, Eivazi, Araz, Nisthal, Alex, Diaz, Juan E., Chu, Seung Y., Muchhal, Umesh S., Desjarlais, John R.

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Modulation of antibody effector function von Desjarlais, John R., Lazar, Greg A.

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AMG 509 (Xaluritamig), an Anti-STEAP1 XmAb 2+1 T-cell Redirecting Immune Therapy with Avidity-Dependent Activity against Prostate Cancer von Nolan-Stevaux, Olivier, Li, Cong, Liang, Lingming, Zhan, Jinghui, Estrada, Juan, Osgood, Tao, Li, Fei, Zhang, Hanzhi, Case, Ryan, Murawsky, Christopher M, Estes, Bram, Moore, Gregory L, Bernett, Matthew J, Muchhal, Umesh, Desjarlais, John R, Staley, Binnaz K, Stevens, Jennitte, Cooke, Keegan S, Aeffner, Famke, Thomas, Oliver, Stieglmaier, Julia, Lee, Jae-Lyun, Coxon, Angela, Bailis, Julie M

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Potent In vitro and In vivo Activity of an Fc-Engineered Anti-CD19 Monoclonal Antibody against Lymphoma and Leukemia von HORTON, Holly M, BERNETT, Matthew J, DESJARLAIS, John R, ZHUKOVSKY, Eugene A, PONG, Erik, PEIPP, Matthias, KARKI, Sher, CHU, Seung Y, RICHARDS, John O, VOSTIAR, Igor, JOYCE, Patrick F, REPP, Roland

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Reduction of total IgE by targeted coengagement of IgE B-cell receptor and FcγRIIb with Fc-engineered antibody von Chu, Seung Y., PhD, Horton, Holly M., PhD, Pong, Erik, MS, Leung, Irene W.L., PhD, Chen, Hsing, MS, Nguyen, Duc-Hanh, BS, Bautista, Cristina, BS, Muchhal, Umesh S., PhD, Bernett, Matthew J., PhD, Moore, Gregory L., PhD, Szymkowski, David E., PhD, Desjarlais, John R., PhD

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Translational PK/PD and the first-in-human dose selection of a PD1/IL15: an engineered recombinant targeted cytokine for cancer immunotherapy von Yadav, Rajbharan, Schubbert, Suzanne, Holder, Patrick G, Chiang, Eugene Y, Kiabi, Nargess, Bogaert, Liz, Leung, Irene, Rashid, Rumana, Avery, Kendra N, Bonzon, Christine, Desjarlais, John R, Sanjabi, Shomyseh, Sharma, Amy, Lepherd, Michelle, Shelton, Amy, Chan, Pam, Liu, Yanqiu, Joslyn, Louis, Hosseini, Iraj, Stefanich, Eric G, Kamath, Amrita V, Bernett, Matthew J, Shivva, Vittal

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Antibody-mediated coengagement of FcγRIIb and B cell receptor complex suppresses humoral immunity in systemic lupus erythematosus von Horton, Holly M, Chu, Seung Y, Ortiz, Elizabeth C, Pong, Erik, Cemerski, Saso, Leung, Irene W L, Jacob, Noam, Zalevsky, Jonathan, Desjarlais, John R, Stohl, William, Szymkowski, David E

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Suppression of Rheumatoid Arthritis B Cells by XmAb5871, an Anti‐CD19 Antibody That Coengages B Cell Antigen Receptor Complex and Fcγ Receptor IIb Inhibitory Receptor von Chu, Seung Y., Yeter, Karen, Kotha, Roshan, Pong, Erik, Miranda, Yvonne, Phung, Sheryl, Chen, Hsing, Lee, Sung‐Hyung, Leung, Irene, Bonzon, Christine, Desjarlais, John R., Stohl, William, Szymkowski, David E.

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Optimizing engagement of the immune system by anti-tumor antibodies: an engineer's perspective von Desjarlais, John R., Lazar, Greg A., Zhukovsky, Eugene A., Chu, Seung Y.

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Fc-engineered anti-CD40 antibody enhances multiple effector functions and exhibits potent in vitro and in vivo antitumor activity against hematologic malignancies von Horton, Holly M., Bernett, Matthew J., Peipp, Matthias, Pong, Erik, Karki, Sher, Chu, Seung Y., Richards, John O., Chen, Hsing, Repp, Roland, Desjarlais, John R., Zhukovsky, Eugene A.

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CD19 targeting of chronic lymphocytic leukemia with a novel Fc-domain–engineered monoclonal antibody von Awan, Farrukh T., Lapalombella, Rosa, Trotta, Rossana, Butchar, Jonathan P., Yu, Bo, Benson, Don M., Roda, Julie M., Cheney, Carolyn, Mo, Xiaokui, Lehman, Amy, Jones, Jeffrey, Flynn, Joseph, Jarjoura, David, Desjarlais, John R., Tridandapani, Susheela, Caligiuri, Michael A., Muthusamy, Natarajan, Byrd, John C.

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Optimization of antibody binding to FcγRIIa enhances macrophage phagocytosis of tumor cells von Richards, John O., Karki, Sher, Lazar, Greg A., Chen, Hsing, Dang, Wei, Desjarlais, John R.

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Dissecting strategies to tune the therapeutic potential of SARS-CoV-2-specific monoclonal antibody CR3022 von Atyeo, Caroline, Slein, Matthew D, Fischinger, Stephanie, Burke, John, Schäfer, Alexandra, Leist, Sarah R, Kuzmina, Natalia A, Mire, Chad, Honko, Anna, Johnson, Rebecca, Storm, Nadia, Bernett, Matthew, Tong, Pei, Zuo, Teng, Lin, Junrui, Zuiani, Adam, Linde, Caitlyn, Suscovich, Todd, Wesemann, Duane R, Griffiths, Anthony, Desjarlais, John R, Juelg, Boris D, Goudsmit, Jaap, Bukreyev, Alexander, Baric, Ralph, Alter, Galit

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Increasing FcγRIIa affinity of an FcγRIII-optimized anti-EGFR antibody restores neutrophil-mediated cytotoxicity von Derer, Stefanie, Glorius, Pia, Schlaeth, Martin, Lohse, Stefan, Klausz, Katja, Muchhal, Umesh, Desjarlais, John R, Humpe, Andreas, Valerius, Thomas, Peipp, Matthias

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Indigineering: Engineering Through Indigenous Knowledge and Mino Pimachisowin/Nehinaw Osihcikewin: Nehinaw Kiskenitamowin Eyapatak Mena Mino Pimachisowin von Desjarlais, John

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Potent in vitro and in vivo activity of an Fc-engineered humanized anti-HM1.24 antibody against multiple myeloma via augmented effector function von Tai, Yu-Tzu, Horton, Holly M., Kong, Sun-Young, Pong, Erik, Chen, Hsing, Cemerski, Saso, Bernett, Matthew J., Nguyen, Duc-Hanh T., Karki, Sher, Chu, Seung Y., Lazar, Greg A., Munshi, Nikhil C., Desjarlais, John R., Anderson, Kenneth C., Muchhal, Umesh S.

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A molecular immunology approach to antibody humanization and functional optimization von Lazar, Greg A., Desjarlais, John R., Jacinto, Jonathan, Karki, Sher, Hammond, Philip W.

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