Multispecific drugs herald a new era of biopharmaceutical innovation von Deshaies, Raymond J.

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Proteotoxic crisis, the ubiquitin-proteasome system, and cancer therapy von Deshaies, Raymond J

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Protein degradation: Prime time for PROTACs von Deshaies, Raymond J

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Prime time for PROTACs von Deshaies, Raymond J

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Harnessing the Power of Proteolysis for Targeted Protein Inactivation von Verma, Rati, Mohl, Dane, Deshaies, Raymond J.

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Cand1 Promotes Assembly of New SCF Complexes through Dynamic Exchange of F Box Proteins von Pierce, Nathan W., Lee, J. Eugene, Liu, Xing, Sweredoski, Michael J., Graham, Robert L.J., Larimore, Elizabeth A., Rome, Michael, Zheng, Ning, Clurman, Bruce E., Hess, Sonja, Shan, Shu-ou, Deshaies, Raymond J.

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Multimodal Activation of the Ubiquitin Ligase SCF by Nedd8 Conjugation von Saha, Anjanabha, Deshaies, Raymond J.

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Essential Role for Ubiquitin-Ubiquitin-Conjugating Enzyme Interaction in Ubiquitin Discharge from Cdc34 to Substrate von Saha, Anjanabha, Lewis, Steven, Kleiger, Gary, Kuhlman, Brian, Deshaies, Raymond J.

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RING domain E3 ubiquitin ligases von Deshaies, Raymond J, Joazeiro, Claudio A P

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Function and regulation of cullin-RING ubiquitin ligases von Petroski, Matthew D, Deshaies, Raymond J

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2.3 Å resolution cryo-EM structure of human p97 and mechanism of allosteric inhibition von Banerjee, Soojay, Bartesaghi, Alberto, Merk, Alan, Rao, Prashant, Bulfer, Stacie L., Yan, Yongzhao, Green, Neal, Mroczkowski, Barbara, Neitz, R. Jeffrey, Wipf, Peter, Falconieri, Veronica, Deshaies, Raymond J., Milne, Jacqueline L. S., Huryn, Donna, Arkin, Michelle, Subramaniam, Sriram

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Composition and Regulation of the Cellular Repertoire of SCF Ubiquitin Ligases von Reitsma, Justin M., Liu, Xing, Reichermeier, Kurt M., Moradian, Annie, Sweredoski, Michael J., Hess, Sonja, Deshaies, Raymond J.

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Ribosomal proteins produced in excess are degraded by the ubiquitin-proteasome system von Sung, Min-Kyung, Reitsma, Justin M, Sweredoski, Michael J, Hess, Sonja, Deshaies, Raymond J

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Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4 von Skrott, Zdenek, Mistrik, Martin, Andersen, Klaus Kaae, Friis, Søren, Majera, Dusana, Gursky, Jan, Ozdian, Tomas, Bartkova, Jirina, Turi, Zsofia, Moudry, Pavel, Kraus, Marianne, Michalova, Martina, Vaclavkova, Jana, Dzubak, Petr, Vrobel, Ivo, Pouckova, Pavla, Sedlacek, Jindrich, Miklovicova, Andrea, Kutt, Anne, Li, Jing, Mattova, Jana, Driessen, Christoph, Dou, Q. Ping, Olsen, Jørgen, Hajduch, Marian, Cvek, Boris, Deshaies, Raymond J., Bartek, Jiri

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p97-dependent retrotranslocation and proteolytic processing govern formation of active Nrf1 upon proteasome inhibition von Radhakrishnan, Senthil K, den Besten, Willem, Deshaies, Raymond J

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Multisystem Proteinopathy Mutations in VCP/p97 Increase NPLOC4·UFD1L Binding and Substrate Processing von Blythe, Emily E., Gates, Stephanie N., Deshaies, Raymond J., Martin, Andreas

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Cand1-Mediated Adaptive Exchange Mechanism Enables Variation in F-Box Protein Expression von Liu, Xing, Reitsma, Justin M., Mamrosh, Jennifer L., Zhang, Yaru, Straube, Ronny, Deshaies, Raymond J.

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Glutamine Triggers Acetylation-Dependent Degradation of Glutamine Synthetase via the Thalidomide Receptor Cereblon von Van Nguyen, Thang, Lee, J. Eugene, Sweredoski, Michael J., Yang, Seung-Joo, Jeon, Seung-Je, Harrison, Joseph S., Yim, Jung-Hyuk, Lee, Sang Ghil, Handa, Hiroshi, Kuhlman, Brian, Jeong, Ji-Seon, Reitsma, Justin M., Park, Chul-Seung, Hess, Sonja, Deshaies, Raymond J.

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Transcription Factor Nrf1 Mediates the Proteasome Recovery Pathway after Proteasome Inhibition in Mammalian Cells von Radhakrishnan, Senthil K., Lee, Candy S., Young, Patrick, Beskow, Anne, Chan, Jefferson Y., Deshaies, Raymond J.

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Vms1 and ANKZF1 peptidyl-tRNA hydrolases release nascent chains from stalled ribosomes von Verma, Rati, Reichermeier, Kurt M., Burroughs, A. Maxwell, Oania, Robert S., Reitsma, Justin M., Aravind, L., Deshaies, Raymond J.

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