A Simple Method for Discovering Druggable, Specific Glycosaminoglycan-Protein Systems. Elucidation of Key Principles from Heparin/Heparan Sulfate-Binding Proteins von Sarkar, Aurijit, Desai, Umesh R

Volltext

Discovering small-molecule therapeutics against SARS-CoV-2 von Tiwari, Vaibhav, Beer, Jacob C., Sankaranarayanan, Nehru Viji, Swanson-Mungerson, Michelle, Desai, Umesh R.

Volltext

So you think computational approaches to understanding glycosaminoglycan–protein interactions are too dry and too rigid? Think again von Sankaranarayanan, Nehru Viji, Nagarajan, Balaji, Desai, Umesh R

Volltext

Solution NMR characterization of chemokine CXCL8/IL-8 monomer and dimer binding to glycosaminoglycans: structural plasticity mediates differential binding interactions von Joseph, Prem Raj B, Mosier, Philip D, Desai, Umesh R, Rajarathnam, Krishna

Volltext

Structural Insights Into How Proteoglycans Determine Chemokine-CXCR1/CXCR2 Interactions: Progress and Challenges von Rajarathnam, Krishna, Desai, Umesh R

Volltext

The alphaherpesvirus conserved pUS10 is important for natural infection and its expression is regulated by the conserved Herpesviridae protein kinase (CHPK) von Ponnuraj, Nagendraprabhu, Akbar, Haji, Arrington, Justine V, Spatz, Stephen J, Nagarajan, Balaji, Desai, Umesh R, Jarosinski, Keith W

Volltext

Molecular dynamics simulations to understand glycosaminoglycan interactions in the free- and protein-bound states von Nagarajan, Balaji, Holmes, Samuel G., Sankaranarayanan, Nehru Viji, Desai, Umesh R.

Volltext

Synthesis and Reactivity of Masked Organic Sulfates von Kumar Villuri, Bharath, Desai, Umesh R.

Volltext

Glycosaminoglycan microarrays for studying glycosaminoglycan–protein systems von Chittum, John E., Thompson, Ally, Desai, Umesh R.

Volltext

Enzyme immobilization offers a robust tool to scale up the production of longer, diverse, natural glycosaminoglycan oligosaccharides von Alabbas, Alhumaidi, Desai, Umesh R

Volltext

Molecular Basis of Chemokine CXCL5-Glycosaminoglycan Interactions von Sepuru, Krishna Mohan, Nagarajan, Balaji, Desai, Umesh R., Rajarathnam, Krishna

Volltext

Structural basis, stoichiometry, and thermodynamics of binding of the chemokines KC and MIP2 to the glycosaminoglycan heparin von Sepuru, Krishna Mohan, Nagarajan, Balaji, Desai, Umesh R., Rajarathnam, Krishna

Volltext

A molecular dynamics-based algorithm for evaluating the glycosaminoglycan mimicking potential of synthetic, homogenous, sulfated small molecules von Nagarajan, Balaji, Sankaranarayanan, Nehru Viji, Patel, Bhaumik B, Desai, Umesh R

Volltext

Chemical sulfation of small molecules—advances and challenges von Al-Horani, Rami A., Desai, Umesh R.

Volltext

Toward a robust computational screening strategy for identifying glycosaminoglycan sequences that display high specificity for target proteins von Sankaranarayanan, Nehru Viji, Desai, Umesh R

Volltext

Recent Advances on Plasmin Inhibitors for the Treatment of Fibrinolysis-Related Disorders von Al-Horani, Rami A., Desai, Umesh R.

Volltext

Designing Smaller, Synthetic, Functional Mimetics of Sulfated Glycosaminoglycans as Allosteric Modulators of Coagulation Factors von Abdelfadiel, Elsamani I., Gunta, Rama, Villuri, Bharath Kumar, Afosah, Daniel K., Sankaranarayanan, Nehru Viji, Desai, Umesh R.

Volltext

Rigorous analysis of free solution glycosaminoglycan dynamics using simple, new tools von Nagarajan, Balaji, Sankaranarayanan, Nehru Viji, Desai, Umesh R

Volltext

Designing Allosteric Inhibitors of Factor XIa. Lessons from the Interactions of Sulfated Pentagalloylglucopyranosides von Al-Horani, Rami A, Desai, Umesh R

Volltext

Metabolic engineering of non-pathogenic Escherichia coli strains for the controlled production of low molecular weight heparosan and size-specific heparosan oligosaccharides von Roy, Anindita, Miyai, Yuma, Rossi, Alessandro, Paraswar, Krishna, Desai, Umesh R., Saijoh, Yukio, Kuberan, Balagurunathan

Volltext