Combating Autoimmune Diseases With Retinoic Acid Receptor-Related Orphan Receptor‑γ (RORγ or RORc) Inhibitors: Hits and Misses von Pandya, Vrajesh B, Kumar, Sanjay, Sachchidanand, Sharma, Rajiv, Desai, Ranjit C

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Prolyl Hydroxylase Inhibitors: A Breakthrough in the Therapy of Anemia Associated with Chronic Diseases von Joharapurkar, Amit A., Pandya, Vrajesh B., Patel, Vishal J., Desai, Ranjit C., Jain, Mukul R.

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Discovery of a Potent and Orally Efficacious TGR5 Receptor Agonist von Agarwal, Sameer, Patil, Amit, Aware, Umesh, Deshmukh, Prashant, Darji, Brijesh, Sasane, Santosh, Sairam, Kalapatapu V. V. M, Priyadarsiny, Priyanka, Giri, Poonam, Patel, Harilal, Giri, Suresh, Jain, Mukul, Desai, Ranjit C

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ZYBT1, a potent, irreversible Bruton’s Tyrosine Kinase (BTK) inhibitor that inhibits the C481S BTK with profound efficacy against arthritis and cancer von Ghoshdastidar, Krishnarup, Patel, Hoshang, Bhayani, Hitesh, Patel, Ankit, Thakkar, Kinjal, Patel, Dinesh, Sharma, Manoranjan, Singh, Jaideep, Mohapatra, Jogeswar, Chatterjee, Abhijit, Patel, Dipam, Bahekar, Rajesh, Sharma, Rajiv, Gupta, Lakshmikant, Patel, Nirmal, Giri, Poonam, Srinivas, Nuggehally R., Jain, Mukul, Bandyopadhyay, Debdutta, Patel, Pankaj R., Desai, Ranjit C.

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Discovery of 1,3-dihydro-2H-imidazo[4,5-c]quinolin-2-ones based novel, potent and PI3Kδ selective inhibitors von Bahekar, Rajesh, Dave, Bhushan, Soman, Shubhangi, Patel, Dipam, Chopade, Rajendra, Funde, Radhika, Kumar, Jeevan, Sachchidanand, S., Giri, Poonam, Chatterjee, Abhijit, Mahapatra, Jogeswar, Vyas, Purvi, Ghoshdastidar, Krishnarup, Bandyopadhyay, Debdutta, Desai, Ranjit C.

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Identification and preclinical characterization of a novel and potent poly (ADP-ribose) polymerase (PARP) inhibitor ZYTP1 von Jain, Mukul R., Mohapatra, Jogeswar, Bandhyopadhyay, Debdutta, Chatterjee, Abhijit, Ghoshdastidar, Krishnarup, Patel, Dinesh, Patel, Ankit, Bhayani, Hitesh, Srivastava, Brijesh Kumar, Shedage, Sandeep A., Kadam, Pravin, Sundar, Rajesh, Patel, Harilal, Giri, Poonam, Patel, Prakash, Gupta, Laxmikant, Srinivas, Nuggehally R., Patel, Pankaj R., Desai, Ranjit C.

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ZY15557, a novel, long acting inhibitor of dipeptidyl peptidase‐4, for the treatment of Type 2 diabetes mellitus von Jain, Mukul R, Joharapurkar, Amit A, Kshirsagar, Samadhan G, Patel, Vishal J, Bahekar, Rajesh H, Patel, Harilal V, Jadav, Pradip A, Patel, Pankaj R, Desai, Ranjit C

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Discovery of diaminopyrimidine-carboxamide derivatives as JAK3 inhibitors von Bahekar, Rajesh, Panchal, Nandini, Soman, Shubhangi, Desai, Jigar, Patel, Dipam, Argade, Anil, Gite, Archana, Gite, Sanjay, Patel, Bhaumin, Kumar, Jeevan, S, Sachchidanand, Patel, Harilal, Sundar, Rajesh, Chatterjee, Abhijit, Mahapatra, Jogeswar, Patel, Hoshang, Ghoshdastidar, Krishnarup, Bandyopadhyay, Debdutta, Desai, Ranjit C.

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Identification of an Orally Efficacious GPR40/FFAR1 Receptor Agonist von Agarwal, Sameer, Sasane, Santosh, Deshmukh, Prashant, Rami, Bhadresh, Bandyopadhyay, Debdutta, Giri, Poonam, Giri, Suresh, Jain, Mukul, Desai, Ranjit C

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A sensitive assay for ZYAN1 in human whole blood and urine utilizing positive LC-MS/MS electrospray ionization von Patel, Harilal, Soni, Krunal, Trivedi, Rucha, Heading, Heather, Geue, Jason, Kansagra, Kevinkumar, Gupta, Rahul J, Pandya, Vrajesh B, Srinivas, Nuggehally R, Patel, Pankaj R, Desai, Ranjit C

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In vitro metabolism of a new oxazolidinedione hypoglycemic agent utilizing liver microsomes and recombinant human cytochrome P450 enzymes von Agrawal, Arun K., Hop, Cornelis E.C.A., Pang, Jianmei, Silva Elipe, Maria V., Desai, Ranjit C., Leung, Kwan H., Franklin, Ronald B.

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Pharmacological characterization of ZYDPLA1, a novel long-acting dipeptidyl peptidase-4 inhibitor von Jain, Mukul R., Joharapurkar, Amit A., Bahekar, Rajesh H., Patel, Harilal, Jadav, Pradip, Kshirsagar, Samadhan G., Patel, Vishal J., Patel, Kartikkumar N., Ramanathan, Vikram K., Patel, Pankaj R., Desai, Ranjit C.

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5-Aryl thiazolidine-2,4-diones: discovery of PPAR dual α/γ agonists as antidiabetic agents von Desai, Ranjit C., Han, Wei, Metzger, Edward J., Bergman, Jeffrey P., Gratale, Dominick F., MacNaul, Karen L., Berger, Joel P., Doebber, Thomas W., Leung, Kwan, Moller, David E., Heck, James V., Sahoo, Soumya P.

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(2R)-2-Ethylchromane-2-carboxylic Acids:  Discovery of Novel PPARα/γ Dual Agonists as Antihyperglycemic and Hypolipidemic Agents von Koyama, Hiroo, Miller, Daniel J, Boueres, Julia K, Desai, Ranjit C, Jones, A. Brian, Berger, Joel P, MacNaul, Karen L, Kelly, Linda J, Doebber, Thomas W, Wu, Margaret S, Zhou, Gaochao, Wang, Pei-ran, Ippolito, Marc C, Chao, Yu-Sheng, Agrawal, Arun K, Franklin, Ronald, Heck, James V, Wright, Samuel D, Moller, David E, Sahoo, Soumya P

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Design and synthesis of potent and subtype-selective PPARα agonists von Desai, Ranjit C., Metzger, Edward, Santini, Conrad, Meinke, Peter T., Heck, James V., Berger, Joel P., MacNaul, Karen L., Cai, Tian-quan, Wright, Samuel D., Agrawal, Arun, Moller, David E., Sahoo, Soumya P.

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A Convenient Synthesis of the Novel Hypoglycemic Agent SDZ PGU 693 von Desai, Ranjit C

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Aryloxazolidinediones: Identification of potent orally active PPAR dual α/γ agonists von DESAI, Ranjit C, GRATALE, Dominick F, FRANKLIN, Ronald, MOLLER, David E, HECK, James V, SAHOO, Soumya P, WEI HAN, KOYAMA, Hiroo, METZGER, Edward, LOMBARDO, Victoria K, MACNAUL, Karen L, DOEBBER, Thomas W, BERGER, Joel P, LEUNG, Kwan

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Expeditious synthesis of tri-substituted cyclopentane derivatives von Desai, Ranjit C, Cicala, Peter, Meurer, Laura C, Finke, Paul E

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ZYDG2, a Potent, Selective, and Safe GPR40 Agonist for Treatment of Type 2 Diabetes von JAIN, MUKUL R., GIRI, SURESH R., TRIVEDI, CHITRANG J., BHOI, BIBHUTI B., RATH, AKSHYAYA CHANDAN, RATHOD, ROHAN MANUBHAI, SUNDAR, RAJESH, BANDYOPADHYAY, DEBDUTTA, RAMDHAVE, RASHMI, PATEL, GAUTAM D., SRIVASTAVA, BRIJESH KUMAR, DESAI, RANJIT C.

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Synthesis of chiral β-methyl tryptamine-derived GnRH antagonists von Simeone, Joseph P, Bugianesi, Robert L, Ponpipom, Mitree M, Goulet, Mark T, Levorse, Mark S, Desai, Ranjit C

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