Discovery of Ledipasvir (GS-5885): A Potent, Once-Daily Oral NS5A Inhibitor for the Treatment of Hepatitis C Virus Infection von Link, John O., Taylor, James G., Xu, Lianhong, Mitchell, Michael, Guo, Hongyan, Liu, Hongtao, Kato, Darryl, Kirschberg, Thorsten, Sun, Jianyu, Squires, Neil, Parrish, Jay, Keller, Terry, Yang, Zheng-Yu, Yang, Chris, Matles, Mike, Wang, Yujin, Wang, Kelly, Cheng, Guofeng, Tian, Yang, Mogalian, Erik, Mondou, Elsa, Cornpropst, Melanie, Perry, Jason, Desai, Manoj C.

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Discovery of an Oral Respiratory Syncytial Virus (RSV) Fusion Inhibitor (GS-5806) and Clinical Proof of Concept in a Human RSV Challenge Study von Mackman, Richard L, Sangi, Michael, Sperandio, David, Parrish, Jay P, Eisenberg, Eugene, Perron, Michel, Hui, Hon, Zhang, Lijun, Siegel, Dustin, Yang, Hai, Saunders, Oliver, Boojamra, Constantine, Lee, Gary, Samuel, Dharmaraj, Babaoglu, Kerim, Carey, Anne, Gilbert, Brian E, Piedra, Pedro A, Strickley, Robert, Iwata, Quynh, Hayes, Jaclyn, Stray, Kirsten, Kinkade, April, Theodore, Dorothy, Jordan, Robert, Desai, Manoj, Cihlar, Tomas

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Cobicistat (GS-9350): A Potent and Selective Inhibitor of Human CYP3A as a Novel Pharmacoenhancer von Xu, Lianhong, Liu, Hongtao, Murray, Bernard P, Callebaut, Christian, Lee, Melody S, Hong, Allen, Strickley, Robert G, Tsai, Luong K, Stray, Kirsten M, Wang, Yujin, Rhodes, Gerry R, Desai, Manoj C

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Discovery and optimization of novel pyridines as highly potent and selective glycogen synthase kinase 3 inhibitors von Ramurthy, Savithri, Pfister, Keith B., Boyce, Rustum S., Brown, Sean P., Costales, Abran Q., Desai, Manoj C., Fang, Eric, Levine, Barry H., Ng, Simon C., Nuss, John M., Ring, David B., Shafer, Cynthia M., Shu, Wei, Subramanian, Sharadha, Wagman, Allan S., Wang, Haixia, Bussiere, Dirksen E.

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Discovery of Dihydrobenzoxazepinone (GS-6615) Late Sodium Current Inhibitor (Late I Nai), a Phase II Agent with Demonstrated Preclinical Anti-Ischemic and Antiarrhythmic Properties von Zablocki, Jeff A, Elzein, Elfatih, Li, Xiaofen, Koltun, Dmitry O, Parkhill, Eric Q, Kobayashi, Tetsuya, Martinez, Ruben, Corkey, Britton, Jiang, Haibo, Perry, Thao, Kalla, Rao, Notte, Gregory T, Saunders, Oliver, Graupe, Michael, Lu, Yafan, Venkataramani, Chandru, Guerrero, Juan, Perry, Jason, Osier, Mark, Strickley, Robert, Liu, Gongxin, Wang, Wei-Qun, Hu, Lufei, Li, Xiao-Jun, El-Bizri, Nesrine, Hirakawa, Ryoko, Kahlig, Kris, Xie, Cheng, Li, Cindy Hong, Dhalla, Arvinder K, Rajamani, Sridharan, Mollova, Nevena, Soohoo, Daniel, Lepist, Eve-Irene, Murray, Bernard, Rhodes, Gerry, Belardinelli, Luiz, Desai, Manoj C

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Structure–activity relationships of diamine inhibitors of cytochrome P450 (CYP) 3A as novel pharmacoenhancers. Part II: P2/P3 region and discovery of cobicistat (GS-9350) von Xu, Lianhong, Liu, Hongtao, Hong, Allen, Vivian, Randy, Murray, Bernard P., Callebaut, Christian, Choi, You-Chul, Lee, Melody S., Chau, Jennifer, Tsai, Luong K., Stray, Kirsten M., Strickley, Robert G., Wang, Jianhong, Tong, Leah, Swaminathan, Swami, Rhodes, Gerry R., Desai, Manoj C.

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Structure–activity relationships of diamine inhibitors of cytochrome P450 (CYP) 3A as novel pharmacoenhancers, part I: Core region von Liu, Hongtao, Xu, Lianhong, Hui, Hon, Vivian, Randy, Callebaut, Christian, Murray, Bernard P., Hong, Allen, Lee, Melody S., Tsai, Luong K., Chau, Jennifer K., Stray, Kirsten M., Cannizzaro, Carina, Choi, You-Chul, Rhodes, Gerry R., Desai, Manoj C.

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HCV versus HIV drug discovery: Déjà vu all over again? von Watkins, William J., Desai, Manoj C.

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Synthesis and biological evaluation of phosphonate analogues of nevirapine von Parrish, Jay, Tong, Leah, Wang, Michael, Chen, Xiaowu, Lansdon, Eric B., Cannizzaro, Carina, Zheng, Xubin, Desai, Manoj C., Xu, Lianhong

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Correction to Discovery of Ledipasvir (GS-5885): A Potent, Once-Daily Oral NS5A Inhibitor for the Treatment of Hepatitis C Virus Infection von Link, John O, Taylor, James G, Xu, Lianhong, Mitchell, Michael, Guo, Hongyan, Liu, Hongtao, Kato, Darryl, Kirschberg, Thorsten, Sun, Jianyu, Squires, Neil, Parrish, Jay, Kellar, Terry, Yang, Zheng-Yu, Yang, Chris, Matles, Mike, Wang, Yujin, Wang, Kelly, Cheng, Guofeng, Tian, Yang, Mogalian, Erik, Mondou, Elsa, Cornpropst, Melanie, Perry, Jason, Desai, Manoj C

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Discovery of GS-9131: Design, synthesis and optimization of amidate prodrugs of the novel nucleoside phosphonate HIV reverse transcriptase (RT) inhibitor GS-9148 von Mackman, Richard L., Ray, Adrian S., Hui, Hon C., Zhang, Lijun, Birkus, Gabriel, Boojamra, Constantine G., Desai, Manoj C., Douglas, Janet L., Gao, Ying, Grant, Deborah, Laflamme, Genevieve, Lin, Kuei-Ying, Markevitch, David Y., Mishra, Ruchika, McDermott, Martin, Pakdaman, Rowchanak, Petrakovsky, Oleg V., Vela, Jennifer E., Cihlar, Tomas

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Correlating structure and function of drug-metabolizing enzymes: progress and ongoing challenges von Johnson, Eric F, Connick, J Patrick, Reed, James R, Backes, Wayne L, Desai, Manoj C, Xu, Lianhong, Estrada, D Fernando, Laurence, Jennifer S, Scott, Emily E

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Design, synthesis, and anti-HIV activity of 4′-modified carbocyclic nucleoside phosphonate reverse transcriptase inhibitors von Boojamra, Constantine G., Parrish, Jay P., Sperandio, David, Gao, Ying, Petrakovsky, Oleg V., Lee, Sharon K., Markevitch, David Y., Vela, Jennifer E., Laflamme, Genevieve, Chen, James M., Ray, Adrian S., Barron, Abraham C., Sparacino, Mark L., Desai, Manoj C., Kim, Choung U., Cihlar, Tomas, Mackman, Richard L.

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GS-9219—A Novel Acyclic Nucleotide Analogue with Potent Antineoplastic Activity in Dogs with Spontaneous Non–Hodgkin's Lymphoma von Reiser, Hans, Wang, Jianying, Chong, Lee, Watkins, William J, Ray, Adrian S, Shibata, Riri, Birkus, Gabriel, Cihlar, Tomas, Wu, Sylvia, Li, Bei, Liu, Xiaohong, Henne, Ilana N, Wolfgang, Grushenka H I, Desai, Manoj, Rhodes, Gerald R, Fridland, Arnold, Lee, William A, Plunkett, William, Vail, David, Thamm, Douglas H, Jeraj, Robert, Tumas, Daniel B

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The potential role of Sodium/Glucose Cotransporter 2 inhibitors in the treatment of cystinuria von Sui, Wilson, Yang, Heiko, Desai, Manoj, Chi, Thomas, Stoller, Marshall

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A Potent Nonpeptide Antagonist of the Substance P (NK$_1$) Receptor von Snider, R. Michael, Constantine, Jay W., Lowe, John A., Longo, Kelly P., Lebel, Wesley S., Woody, Heidi A., Drozda, Susan E., Desai, Manoj C., Vinick, Frederic J., Spencer, Robin W., Hess, Hans-Jürgen

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A novel and efficient synthesis of chiral C2-symmetric 1,4-diamines von Xu, Lianhong, Desai, Manoj C., Liu, Hongtao

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Synthesis and Antibacterial Activity of Novel C12 Vinyl Ketolides von Burger, Matthew T, Lin, Xiaodong, Chu, Daniel T, Hiebert, Christy, Rico, Alice C, Seid, Mehran, Carroll, Georgia L, Barker, Lynn, Huh, Kay, Langhorne, Mike, Shawar, Ribhi, Kidney, Jolene, Young, Kelly, Anderson, Scott, Desai, Manoj C, Plattner, Jacob J

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Discovery of a potent substance P antagonist: recognition of the key molecular determinant von Desai, Manoj C, Lefkowitz, Sheri L, Thadeio, Peter F, Longo, Kelly P, Snider, R. Michael

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Synthesis and antibacterial activity of novel C12 ethyl ketolides von BURGER, Matthew T, HIEBERT, Christy, SEID, Mehran, CHU, Daniel T, BARKER, Lynn, LANGHORNE, Mike, SHAWAR, Ribhi, KIDNEY, Jolene, DESAI, Manoj C, PLATTNER, Jacob J

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