Differential Activation of Innate Immune Pathways by Distinct Islet Amyloid Polypeptide (IAPP) Aggregates von Westwell-Roper, Clara, Denroche, Heather C., Ehses, Jan A., Verchere, C.Bruce

Volltext

A human antibody against pathologic IAPP aggregates protects beta cells in type 2 diabetes models von Wirth, Fabian, Heitz, Fabrice D., Seeger, Christine, Combaluzier, Ioana, Breu, Karin, Denroche, Heather C., Thevenet, Julien, Osto, Melania, Arosio, Paolo, Kerr-Conte, Julie, Verchere, C. Bruce, Pattou, François, Lutz, Thomas A., Donath, Marc Y., Hock, Christoph, Nitsch, Roger M., Grimm, Jan

Volltext

IL-1 mediates amyloid-associated islet dysfunction and inflammation in human islet amyloid polypeptide transgenic mice von Westwell-Roper, Clara Y., Chehroudi, Cyrus A., Denroche, Heather C., Courtade, Jaques A., Ehses, Jan A., Verchere, C. Bruce

Volltext

The role of leptin in glucose homeostasis von Denroche, Heather C, Huynh, Frank K, Kieffer, Timothy J

Volltext

T cells accumulate in non-diabetic islets during ageing von Denroche, Heather C, Miard, Stéphanie, Sallé-Lefort, Sandrine, Picard, Frédéric, Verchere, C Bruce

Volltext

Insulin Knockout Mice Have Extended Survival but Volatile Blood Glucose Levels on Leptin Therapy von Neumann, Ursula H, Denroche, Heather C, Mojibian, Majid, Covey, Scott D, Kieffer, Timothy J

Volltext

Disruption of Hepatic Leptin Signaling Protects Mice From Age- and Diet-Related Glucose Intolerance von HUYNH, Frank K, LEVI, Jasna, DENROCHE, Heather C, GRAY, Sarah L, VOSHOL, Peter J, NEUMANN, Ursula H, SPECK, Madeleine, CHUA, Streamson C, COVEY, Scott D, KIEFFER, Timothy J

Volltext

IL-33 Reverses an Obesity-Induced Deficit in Visceral Adipose Tissue ST2+ T Regulatory Cells and Ameliorates Adipose Tissue Inflammation and Insulin Resistance von Han, Jonathan M, Wu, Dan, Denroche, Heather C, Yao, Yu, Verchere, C Bruce, Levings, Megan K

Volltext

Leptin induces fasting hypoglycaemia in a mouse model of diabetes through the depletion of glycerol von Denroche, Heather C., Kwon, Michelle M., Quong, Whitney L., Neumann, Ursula H., Kulpa, Jerzy E., Karunakaran, Subashini, Clee, Susanne M., Brownsey, Roger W., Covey, Scott D., Kieffer, Timothy J.

Volltext

IAPP and type 1 diabetes: implications for immunity, metabolism and islet transplants von Denroche, Heather C, Verchere, C Bruce

Volltext

Circulating miR-375 as a Biomarker of β-Cell Death and Diabetes in Mice von Erener, Suheda, Mojibian, Majid, Fox, Jessica K, Denroche, Heather C, Kieffer, Timothy J

Volltext

Leptin Administration Enhances Islet Transplant Performance in Diabetic Mice von DENROCHE, Heather C, QUONG, Whitney L, BRUIN, Jennifer E, TUDURI, Eva, ASADI, Ali, GLAVAS, Maria M, FOX, Jessica K, KIEFFER, Timothy J

Volltext

Impaired Ca2+ Signaling in β-Cells Lacking Leptin Receptors by Cre-loxP Recombination von Tudurí, Eva, Bruin, Jennifer E., Denroche, Heather C., Fox, Jessica K., Johnson, James D., Kieffer, Timothy J.

Volltext

The role of autonomic efferents and uncoupling protein 1 in the glucose-lowering effect of leptin therapy von Denroche, Heather C, Kwon, Michelle M, Glavas, Maria M, Tudurí, Eva, Philippe, Marion, Quong, Whitney L, Kieffer, Timothy J

Volltext

Impaired Ca(2+) signaling in β-cells lacking leptin receptors by Cre-loxP recombination von Tudurí, Eva, Bruin, Jennifer E, Denroche, Heather C, Fox, Jessica K, Johnson, James D, Kieffer, Timothy J

Volltext

When beta cells talk back von Denroche, Heather C., Nackiewicz, Dominika, Verchere, C. Bruce

Volltext

Leptin Therapy Reverses Hyperglycemia in Mice With Streptozotocin-Induced Diabetes, Independent of Hepatic Leptin Signaling von DENROCHE, Heather C, LEVI, Jasna, WIDEMAN, Rhonda D, SEQUEIRA, Roveena M, HUYNH, Frank K, COVEY, Scott D, KIEFFER, Timothy J

Volltext

AAV8 Ins1-Cre can produce efficient β-cell recombination but requires consideration of off-target effects von Ramzy, Adam, Tudurí, Eva, Glavas, Maria M., Baker, Robert K., Mojibian, Majid, Fox, Jessica K., O’Dwyer, Shannon M., Dai, Derek, Hu, Xiaoke, Denroche, Heather C., Edeer, Nazde, Gray, Sarah L., Verchere, Cameron B., Johnson, James D., Kieffer, Timothy J.

Volltext

Disrupted Leptin Signaling in the Lateral Hypothalamus and Ventral Premammillary Nucleus Alters Insulin and Glucagon Secretion and Protects Against Diet-Induced Obesity von Denroche, Heather C, Glavas, Maria M, Tudurí, Eva, Karunakaran, Subashini, Quong, Whitney L, Philippe, Marion, Britton, Heidi M, Clee, Susanne M, Kieffer, Timothy J

Volltext

Partial ablation of leptin signaling in mouse pancreatic α-cells does not alter either glucose or lipid homeostasis von Tudurí, Eva, Denroche, Heather C, Kara, Jenna A, Asadi, Ali, Fox, Jessica K, Kieffer, Timothy J

Volltext