CTNNA3 and SEMA3D : Promising loci for asthma exacerbation identified through multiple genome-wide association studies von McGeachie, Michael J., PhD, Wu, Ann C., MD, Tse, Sze Man, MD, Clemmer, George L., MS, Sordillo, Joanne, ScD, Himes, Blanca E., PhD, Lasky-Su, Jessica, PhD, Chase, Robert P., MS, Martinez, Fernando D., MD, Weeke, Peter, MD, Shaffer, Christian M., BS, Xu, Hua, PhD, Denny, Josh C., MD, Roden, Dan M., MD, Panettieri, Reynold A., MD, Raby, Benjamin A., MD, Weiss, Scott T., MD, Tantisira, Kelan G., MD

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The use of a DNA biobank linked to electronic medical records to characterize pharmacogenomic predictors of tacrolimus dose requirement in kidney transplant recipients von BIRDWELL, Kelly A, GRADY, Ben, RICHARDSON, Danielle M, ROBINSON, Melanie P, ALP IKIZLER, Talat, RITCHIE, Marylyn D, STEIN, Charles Michael, HAAS, David W, CHOI, Leena, HUA XU, AIHUA BIAN, DENNY, Josh C, MIN JIANG, VRANIC, Gayle, BASFORD, Melissa, COWAN, James D

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Lossless integration of multiple electronic health records for identifying pleiotropy using summary statistics von Li, Ruowang, Duan, Rui, Zhang, Xinyuan, Lumley, Thomas, Pendergrass, Sarah, Bauer, Christopher, Hakonarson, Hakon, Carrell, David S., Smoller, Jordan W., Wei, Wei-Qi, Carroll, Robert, Velez Edwards, Digna R., Wiesner, Georgia, Sleiman, Patrick, Denny, Josh C., Mosley, Jonathan D., Ritchie, Marylyn D., Chen, Yong, Moore, Jason H.

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Genome-Wide Association Study of Serum Creatinine Levels during Vancomycin Therapy von Van Driest, Sara L, McGregor, Tracy L, Velez Edwards, Digna R, Saville, Ben R, Kitchner, Terrie E, Hebbring, Scott J, Brilliant, Murray, Jouni, Hayan, Kullo, Iftikhar J, Creech, C Buddy, Kannankeril, Prince J, Vear, Susan I, Brothers, Kyle B, Bowton, Erica A, Shaffer, Christian M, Patel, Neelam, Delaney, Jessica T, Bradford, Yuki, Wilson, Sarah, Olson, Lana M, Crawford, Dana C, Potts, Amy L, Ho, Richard H, Roden, Dan M, Denny, Josh C

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Integrating EMR-linked and in vivo functional genetic data to identify new genotype-phenotype associations von Mosley, Jonathan D, Van Driest, Sara L, Weeke, Peter E, Delaney, Jessica T, Wells, Quinn S, Bastarache, Lisa, Roden, Dan M, Denny, Josh C

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Mechanistic phenotypes: an aggregative phenotyping strategy to identify disease mechanisms using GWAS data von Mosley, Jonathan D, Van Driest, Sara L, Larkin, Emma K, Weeke, Peter E, Witte, John S, Wells, Quinn S, Karnes, Jason H, Guo, Yan, Bastarache, Lisa, Olson, Lana M, McCarty, Catherine A, Pacheco, Jennifer A, Jarvik, Gail P, Carrell, David S, Larson, Eric B, Crosslin, David R, Kullo, Iftikhar J, Tromp, Gerard, Kuivaniemi, Helena, Carey, David J, Ritchie, Marylyn D, Denny, Josh C, Roden, Dan M

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Electronic health record design and implementation for pharmacogenomics: a local perspective von Peterson, Josh F., Bowton, Erica, Field, Julie R., Beller, Marc, Mitchell, Jennifer, Schildcrout, Jonathan, Gregg, William, Johnson, Kevin, Jirjis, Jim N., Roden, Dan M., Pulley, Jill M., Denny, Josh C.

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Uterine fibroid polygenic risk score (PRS) associates and predicts risk for uterine fibroid von Piekos, Jacqueline A., Hellwege, Jacklyn N., Zhang, Yanfei, Torstenson, Eric S., Jarvik, Gail P., Dikilitas, Ozan, Kullo, Iftikhar J., Schaid, Daniel J., Crosslin, David R., Pendergrass, Sarah A., Lee, Ming Ta Michael, Roden, Dan, Denny, Josh C., Edwards, Todd L., Velez Edwards, Digna R.

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Probing the Virtual Proteome to Identify Novel Disease Biomarkers von Mosley, Jonathan D, Benson, Mark D, Smith, J Gustav, Melander, Olle, Ngo, Debby, Shaffer, Christian M, Ferguson, Jane F, Herzig, Matthew S, McCarty, Catherine A, Chute, Christopher G, Jarvik, Gail P, Gordon, Adam S, Palmer, Melody R, Crosslin, David R, Larson, Eric B, Carrell, David S, Kullo, Iftikhar J, Pacheco, Jennifer A, Peissig, Peggy L, Brilliant, Murray H, Kitchner, Terrie E, Linneman, James G, Namjou, Bahram, Williams, Marc S, Ritchie, Marylyn D, Borthwick, Kenneth M, Kiryluk, Krzysztof, Mentch, Frank D, Sleiman, Patrick M, Karlson, Elizabeth W, Verma, Shefali S, Zhu, Yineng, Vasan, Ramachandran S, Yang, Qiong, Denny, Josh C, Roden, Dan M, Gerszten, Robert E, Wang, Thomas J

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Effect of CYP4F2, VKORC1, and CYP2C9 in Influencing Coumarin Dose: A Single‐Patient Data Meta‐Analysis in More Than 15,000 Individuals von Danese, Elisa, Raimondi, Sara, Montagnana, Martina, Tagetti, Angela, Langaee, Taimour, Borgiani, Paola, Ciccacci, Cinzia, Carcas, Antonio J., Borobia, Alberto M., Tong, Hoi Y., Dávila‐Fajardo, Cristina, Rodrigues Botton, Mariana, Bourgeois, Stephane, Deloukas, Panos, Caldwell, Michael D., Burmester, Jim K., Berg, Richard L., Cavallari, Larisa H., Drozda, Katarzyna, Huang, Min, Zhao, Li‐Zi, Cen, Han‐Jing, Gonzalez‐Conejero, Rocio, Roldan, Vanessa, Nakamura, Yusuke, Mushiroda, Taisei, Gong, Inna Y., Kim, Richard B., Hirai, Keita, Itoh, Kunihiko, Isaza, Carlos, Beltrán, Leonardo, Jiménez‐Varo, Enrique, Cañadas‐Garre, Marisa, Giontella, Alice, Kringen, Marianne K., Haug, Kari Bente Foss, Gwak, Hye Sun, Lee, Kyung Eun, Minuz, Pietro, Lee, Ming Ta Michael, Lubitz, Steven A., Scott, Stuart, Mazzaccara, Cristina, Sacchetti, Lucia, Genç, Ece, Özer, Mahmut, Pathare, Anil, Krishnamoorthy, Rajagopal, Paldi, Andras, Siguret, Virginie, Loriot, Marie‐Anne, Kutala, Vijay Kumar, Suarez‐Kurtz, Guilherme, Perini, Jamila, Denny, Josh C., Ramirez, Andrea H., Mittal, Balraj, Rathore, Saurabh Singh, Sagreiya, Hersh, Altman, Russ, Shahin, Mohamed Hossam A., Khalifa, Sherief I., Limdi, Nita A., Rivers, Charles, Shendre, Aditi, Dillon, Chrisly, Suriapranata, Ivet M., Zhou, Hong‐Hao, Tan, Sheng‐Lan, Tatarunas, Vacis, Lesauskaite, Vaiva, Zhang, Yumao, Maitland‐van der Zee, Anke H., Verhoef, Talitha I., Boer, Anthonius, Taljaard, Monica, Zambon, Carlo Federico, Pengo, Vittorio, Zhang, Jieying Eunice, Pirmohamed, Munir, Johnson, Julie A., Fava, Cristiano

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Rare Variants in the Gene ALPL That Cause Hypophosphatasia Are Strongly Associated With Ovarian and Uterine Disorders von Dahir, Kathryn M, Tilden, Daniel R, Warner, Jeremy L, Bastarache, Lisa, Smith, Derek K, Gifford, Aliya, Ramirez, Andrea H, Simmons, Jill S, Black, Margo M, Newman, John H, Denny, Josh C

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Heritability and genome-wide association study of benign prostatic hyperplasia (BPH) in the eMERGE network von Hellwege, Jacklyn N., Stallings, Sarah, Torstenson, Eric S., Carroll, Robert, Borthwick, Kenneth M., Brilliant, Murray H., Crosslin, David, Gordon, Adam, Hripcsak, George, Jarvik, Gail P., Linneman, James G., Devi, Parimala, Peissig, Peggy L., Sleiman, Patrick A. M., Hakonarson, Hakon, Ritchie, Marylyn D., Verma, Shefali Setia, Shang, Ning, Denny, Josh C., Roden, Dan M., Velez Edwards, Digna R., Edwards, Todd L.

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Clinical Features Associated With Nascent Left Ventricular Diastolic Dysfunction in a Population Aged 40 to 55 Years von Mosley, Jonathan D., Levinson, Rebecca T., Brittain, Evan L., Gupta, Deepak K., Farber-Eger, Eric, Shaffer, Christian M., Denny, Josh C., Roden, Dan M., Wells, Quinn S.

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A study paradigm integrating prospective epidemiologic cohorts and electronic health records to identify disease biomarkers von Mosley, Jonathan D., Feng, QiPing, Wells, Quinn S., Van Driest, Sara L., Shaffer, Christian M., Edwards, Todd L., Bastarache, Lisa, Wei, Wei-Qi, Davis, Lea K., McCarty, Catherine A., Thompson, Will, Chute, Christopher G., Jarvik, Gail P., Gordon, Adam S., Palmer, Melody R., Crosslin, David R., Larson, Eric B., Carrell, David S., Kullo, Iftikhar J., Pacheco, Jennifer A., Peissig, Peggy L., Brilliant, Murray H., Linneman, James G., Namjou, Bahram, Williams, Marc S., Ritchie, Marylyn D., Borthwick, Kenneth M., Verma, Shefali S., Karnes, Jason H., Weiss, Scott T., Wang, Thomas J., Stein, C. Michael, Denny, Josh C., Roden, Dan M.

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Syntactic parsing of clinical text: guideline and corpus development with handling ill-formed sentences von Fan, Jung-wei, Yang, Elly W, Jiang, Min, Prasad, Rashmi, Loomis, Richard M, Zisook, Daniel S, Denny, Josh C, Xu, Hua, Huang, Yang

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Extracting and integrating data from entire electronic health records for detecting colorectal cancer cases von Xu, Hua, Fu, Zhenming, Shah, Anushi, Chen, Yukun, Peterson, Neeraja B, Chen, Qingxia, Mani, Subramani, Levy, Mia A, Dai, Qi, Denny, Josh C

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Evaluation of the F2R IVS-14A/T PAR1 polymorphism with subsequent cardiovascular events and bleeding in patients who have undergone percutaneous coronary intervention von Friedman, Eitan A., Texeira, Luisa, Delaney, Jessica, Weeke, Peter E., Lynch, Donald R., Kasasbeh, Ehab, Song, Yanna, Harrell, Frank E., Denny, Josh C., Hamm, Heidi E., Roden, Dan M., Cleator, John H.

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Defining a Contemporary Ischemic Heart Disease Genetic Risk Profile Using Historical Data von Mosley, Jonathan D, van Driest, Sara L, Wells, Quinn S, Shaffer, Christian M, Edwards, Todd L, Bastarache, Lisa, McCarty, Catherine A, Thompson, Will, Chute, Christopher G, Jarvik, Gail P, Crosslin, David R, Larson, Eric B, Kullo, Iftikhar J, Pacheco, Jennifer A, Peissig, Peggy L, Brilliant, Murray H, Linneman, James G, Denny, Josh C, Roden, Dan M

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Investigating the Genetic Architecture of the PR Interval Using Clinical Phenotypes von Mosley, Jonathan D, Shoemaker, M Benjamin, Wells, Quinn S, Darbar, Dawood, Shaffer, Christian M, Edwards, Todd L, Bastarache, Lisa, McCarty, Catherine A, Thompson, Will, Chute, Christopher G, Jarvik, Gail P, Crosslin, David R, Larson, Eric B, Kullo, Iftikhar J, Pacheco, Jennifer A, Peissig, Peggy L, Brilliant, Murray H, Linneman, James G, Witte, John S, Denny, Josh C, Roden, Dan M

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Extracting semantic lexicons from discharge summaries using machine learning and the C-Value method von Jiang, Min, Denny, Josh C, Tang, Buzhou, Cao, Hongxin, Xu, Hua

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