Phthalimide conjugation as a strategy for in vivo target protein degradation von Winter, Georg E., Buckley, Dennis L., Paulk, Joshiawa, Roberts, Justin M., Souza, Amanda, Dhe-Paganon, Sirano, Bradner, James E.

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Small-Molecule Control of Intracellular Protein Levels through Modulation of the Ubiquitin Proteasome System von Buckley, Dennis L., Crews, Craig M.

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YY1 Is a Structural Regulator of Enhancer-Promoter Loops von Weintraub, Abraham S., Li, Charles H., Zamudio, Alicia V., Sigova, Alla A., Hannett, Nancy M., Day, Daniel S., Abraham, Brian J., Cohen, Malkiel A., Nabet, Behnam, Buckley, Dennis L., Guo, Yang Eric, Hnisz, Denes, Jaenisch, Rudolf, Bradner, James E., Gray, Nathanael S., Young, Richard A.

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A Chemoproteomic Approach to Query the Degradable Kinome Using a Multi-kinase Degrader von Huang, Hai-Tsang, Dobrovolsky, Dennis, Paulk, Joshiawa, Yang, Guang, Weisberg, Ellen L., Doctor, Zainab M., Buckley, Dennis L., Cho, Joong-Heui, Ko, Eunhwa, Jang, Jaebong, Shi, Kun, Choi, Hwan Geun, Griffin, James D., Li, Ying, Treon, Steven P., Fischer, Eric S., Bradner, James E., Tan, Li, Gray, Nathanael S.

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Rapid and direct control of target protein levels with VHL-recruiting dTAG molecules von Nabet, Behnam, Ferguson, Fleur M., Seong, Bo Kyung A., Kuljanin, Miljan, Leggett, Alan L., Mohardt, Mikaela L., Robichaud, Amanda, Conway, Amy S., Buckley, Dennis L., Mancias, Joseph D., Bradner, James E., Stegmaier, Kimberly, Gray, Nathanael S.

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Mutant NPM1 Maintains the Leukemic State through HOX Expression von Brunetti, Lorenzo, Gundry, Michael C., Sorcini, Daniele, Guzman, Anna G., Huang, Yung-Hsin, Ramabadran, Raghav, Gionfriddo, Ilaria, Mezzasoma, Federica, Milano, Francesca, Nabet, Behnam, Buckley, Dennis L., Kornblau, Steven M., Lin, Charles Y., Sportoletti, Paolo, Martelli, Maria Paola, Falini, Brunangelo, Goodell, Margaret A.

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Degradation of the BAF Complex Factor BRD9 by Heterobifunctional Ligands von Remillard, David, Buckley, Dennis L., Paulk, Joshiawa, Brien, Gerard L., Sonnett, Matthew, Seo, Hyuk‐Soo, Dastjerdi, Shiva, Wühr, Martin, Dhe‐Paganon, Sirano, Armstrong, Scott A., Bradner, James E.

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BET Bromodomain Proteins Function as Master Transcription Elongation Factors Independent of CDK9 Recruitment von Winter, Georg E., Mayer, Andreas, Buckley, Dennis L., Erb, Michael A., Roderick, Justine E., Vittori, Sarah, Reyes, Jaime M., di Iulio, Julia, Souza, Amanda, Ott, Christopher J., Roberts, Justin M., Zeid, Rhamy, Scott, Thomas G., Paulk, Joshiawa, Lachance, Kate, Olson, Calla M., Dastjerdi, Shiva, Bauer, Sophie, Lin, Charles Y., Gray, Nathanael S., Kelliher, Michelle A., Churchman, L. Stirling, Bradner, James E.

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The dTAG system for immediate and target-specific protein degradation von Nabet, Behnam, Roberts, Justin M., Buckley, Dennis L., Paulk, Joshiawa, Dastjerdi, Shiva, Yang, Annan, Leggett, Alan L., Erb, Michael A., Lawlor, Matthew A., Souza, Amanda, Scott, Thomas G., Vittori, Sarah, Perry, Jennifer A., Qi, Jun, Winter, Georg E., Wong, Kwok-Kin, Gray, Nathanael S., Bradner, James E.

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Prostate cancer–associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4 von Dai, Xiangpeng, Gan, Wenjian, Li, Xiaoning, Wang, Shangqian, Zhang, Wei, Huang, Ling, Liu, Shengwu, Zhong, Qing, Guo, Jianping, Zhang, Jinfang, Chen, Ting, Shimizu, Kouhei, Beca, Francisco, Blattner, Mirjam, Vasudevan, Divya, Buckley, Dennis L, Qi, Jun, Buser, Lorenz, Liu, Pengda, Inuzuka, Hiroyuki, Beck, Andrew H, Wang, Liewei, Wild, Peter J, Garraway, Levi A, Rubin, Mark A, Barbieri, Christopher E, Wong, Kwok-Kin, Muthuswamy, Senthil K, Huang, Jiaoti, Chen, Yu, Bradner, James E, Wei, Wenyi

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Plasticity in binding confers selectivity in ligand-induced protein degradation von Nowak, Radosław P., DeAngelo, Stephen L., Buckley, Dennis, He, Zhixiang, Donovan, Katherine A., An, Jian, Safaee, Nozhat, Jedrychowski, Mark P., Ponthier, Charles M., Ishoey, Mette, Zhang, Tinghu, Mancias, Joseph D., Gray, Nathanael S., Bradner, James E., Fischer, Eric S.

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Targeting the von Hippel–Lindau E3 Ubiquitin Ligase Using Small Molecules To Disrupt the VHL/HIF-1α Interaction von Buckley, Dennis L, Van Molle, Inge, Gareiss, Peter C, Tae, Hyun Seop, Michel, Julien, Noblin, Devin J, Jorgensen, William L, Ciulli, Alessio, Crews, Craig M

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Targetable BET proteins- and E2F1-dependent transcriptional program maintains the malignancy of glioblastoma von Xu, Liang, Chen, Ye, Mayakonda, Anand, Koh, Lynnette, Chong, Yuk Kien, Buckley, Dennis L., Sandanaraj, Edwin, Lim, See Wee, Lin, Ruby Yu-Tong, Ke, Xin-Yu, Huang, Mo-Li, Chen, Jianxiang, Sun, Wendi, Wang, Ling-Zhi, Goh, Boon Cher, Dinh, Huy Q., Kappei, Dennis, Winter, Georg E., Ding, Ling-Wen, Ang, Beng Ti, Berman, Benjamin P., Bradner, James E., Tang, Carol, Koeffler, H. Phillip

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Small-Molecule-Mediated Degradation of the Androgen Receptor through Hydrophobic Tagging von Gustafson, Jeffrey L., Neklesa, Taavi K., Cox, Carly S., Roth, Anke G., Buckley, Dennis L., Tae, Hyun Seop, Sundberg, Thomas B., Stagg, D. Blake, Hines, John, McDonnell, Donald P., Norris, John D., Crews, Craig M.

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Catalytic in vivo protein knockdown by small-molecule PROTACs von Bondeson, Daniel P, Mares, Alina, Smith, Ian E D, Ko, Eunhwa, Campos, Sebastien, Miah, Afjal H, Mulholland, Katie E, Routly, Natasha, Buckley, Dennis L, Gustafson, Jeffrey L, Zinn, Nico, Grandi, Paola, Shimamura, Satoko, Bergamini, Giovanna, Faelth-Savitski, Maria, Bantscheff, Marcus, Cox, Carly, Gordon, Deborah A, Willard, Ryan R, Flanagan, John J, Casillas, Linda N, Votta, Bartholomew J, den Besten, Willem, Famm, Kristoffer, Kruidenier, Laurens, Carter, Paul S, Harling, John D, Churcher, Ian, Crews, Craig M

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Transcription control by the ENL YEATS domain in acute leukaemia von Erb, Michael A., Scott, Thomas G., Li, Bin E., Xie, Huafeng, Paulk, Joshiawa, Seo, Hyuk-Soo, Souza, Amanda, Roberts, Justin M., Dastjerdi, Shiva, Buckley, Dennis L., Sanjana, Neville E., Shalem, Ophir, Nabet, Behnam, Zeid, Rhamy, Offei-Addo, Nana K., Dhe-Paganon, Sirano, Zhang, Feng, Orkin, Stuart H., Winter, Georg E., Bradner, James E.

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HaloPROTACS: Use of Small Molecule PROTACs to Induce Degradation of HaloTag Fusion Proteins von Buckley, Dennis L, Raina, Kanak, Darricarrere, Nicole, Hines, John, Gustafson, Jeffrey L, Smith, Ian E, Miah, Afjal H, Harling, John D, Crews, Craig M

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Functional TRIM24 degrader via conjugation of ineffectual bromodomain and VHL ligands von Gechijian, Lara N., Buckley, Dennis L., Lawlor, Matthew A., Reyes, Jaime M., Paulk, Joshiawa, Ott, Christopher J., Winter, Georg E., Erb, Michael A., Scott, Thomas G., Xu, Mousheng, Seo, Hyuk-Soo, Dhe-Paganon, Sirano, Kwiatkowski, Nicholas P., Perry, Jennifer A., Qi, Jun, Gray, Nathanael S., Bradner, James E.

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Small-Molecule Inhibitors of the Interaction between the E3 Ligase VHL and HIF1α von Buckley, Dennis L., Gustafson, Jeffrey L., Van Molle, Inge, Roth, Anke G., Tae, Hyun Seop, Gareiss, Peter C., Jorgensen, William L., Ciulli, Alessio, Crews, Craig M.

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MELK is not necessary for the proliferation of basal-like breast cancer cells von Huang, Hai-Tsang, Seo, Hyuk-Soo, Zhang, Tinghu, Wang, Yubao, Jiang, Baishan, Li, Qing, Buckley, Dennis L, Nabet, Behnam, Roberts, Justin M, Paulk, Joshiawa, Dastjerdi, Shiva, Winter, Georg E, McLauchlan, Hilary, Moran, Jennifer, Bradner, James E, Eck, Michael J, Dhe-Paganon, Sirano, Zhao, Jean J, Gray, Nathanael S

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