Coronaviruses lacking exoribonuclease activity are susceptible to lethal mutagenesis: evidence for proofreading and potential therapeutics von Smith, Everett Clinton, Blanc, Hervé, Surdel, Matthew C, Vignuzzi, Marco, Denison, Mark R

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The coronavirus proofreading exoribonuclease mediates extensive viral recombination von Gribble, Jennifer, Stevens, Laura J., Agostini, Maria L., Anderson-Daniels, Jordan, Chappell, James D., Lu, Xiaotao, Pruijssers, Andrea J., Routh, Andrew L., Denison, Mark R.

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Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV von Sheahan, Timothy P., Sims, Amy C., Leist, Sarah R., Schäfer, Alexandra, Won, John, Brown, Ariane J., Montgomery, Stephanie A., Hogg, Alison, Babusis, Darius, Clarke, Michael O., Spahn, Jamie E., Bauer, Laura, Sellers, Scott, Porter, Danielle, Feng, Joy Y., Cihlar, Tomas, Jordan, Robert, Denison, Mark R., Baric, Ralph S.

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Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen von Pallesen, Jesper, Wang, Nianshuang, Corbett, Kizzmekia S., Wrapp, Daniel, Kirchdoerfer, Robert N., Turner, Hannah L., Cottrell, Christopher A., Becker, Michelle M., Wang, Lingshu, Shi, Wei, Kong, Wing-Pui, Andres, Erica L., Kettenbach, Arminja N., Denison, Mark R., Chappell, James D., Graham, Barney S., Ward, Andrew B., McLellan, Jason S.

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Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease von Agostini, Maria L, Andres, Erica L, Sims, Amy C, Graham, Rachel L, Sheahan, Timothy P, Lu, Xiaotao, Smith, Everett Clinton, Case, James Brett, Feng, Joy Y, Jordan, Robert, Ray, Adrian S, Cihlar, Tomas, Siegel, Dustin, Mackman, Richard L, Clarke, Michael O, Baric, Ralph S, Denison, Mark R

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The Coronavirus helicase in replication von Grimes, Samantha L., Denison, Mark R.

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Infidelity of SARS-CoV Nsp14-exonuclease mutant virus replication is revealed by complete genome sequencing von Eckerle, Lance D, Becker, Michelle M, Halpin, Rebecca A, Li, Kelvin, Venter, Eli, Lu, Xiaotao, Scherbakova, Sana, Graham, Rachel L, Baric, Ralph S, Stockwell, Timothy B, Spiro, David J, Denison, Mark R

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Murine Hepatitis Virus nsp14 Exoribonuclease Activity Is Required for Resistance to Innate Immunity von Case, James Brett, Li, Yize, Elliott, Ruth, Lu, Xiaotao, Graepel, Kevin W, Sexton, Nicole R, Smith, Everett Clinton, Weiss, Susan R, Denison, Mark R

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Distinct patterns of IFITM-mediated restriction of filoviruses, SARS coronavirus, and influenza A virus von Huang, I-Chueh, Bailey, Charles C, Weyer, Jessica L, Radoshitzky, Sheli R, Becker, Michelle M, Chiang, Jessica J, Brass, Abraham L, Ahmed, Asim A, Chi, Xiaoli, Dong, Lian, Longobardi, Lindsay E, Boltz, Dutch, Kuhn, Jens H, Elledge, Stephen J, Bavari, Sina, Denison, Mark R, Choe, Hyeryun, Farzan, Michael

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Stabilized coronavirus spike stem elicits a broadly protective antibody von Hsieh, Ching-Lin, Werner, Anne P., Leist, Sarah R., Stevens, Laura J., Falconer, Ester, Goldsmith, Jory A., Chou, Chia-Wei, Abiona, Olubukola M., West, Ande, Westendorf, Kathryn, Muthuraman, Krithika, Fritch, Ethan J., Dinnon, Kenneth H., Schäfer, Alexandra, Denison, Mark R., Chappell, James D., Baric, Ralph S., Graham, Barney S., Corbett, Kizzmekia S., McLellan, Jason S.

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Importance of Neutralizing Monoclonal Antibodies Targeting Multiple Antigenic Sites on the Middle East Respiratory Syndrome Coronavirus Spike Glycoprotein To Avoid Neutralization E... von Wang, Lingshu, Shi, Wei, Chappell, James D, Joyce, M Gordon, Zhang, Yi, Kanekiyo, Masaru, Becker, Michelle M, van Doremalen, Neeltje, Fischer, Robert, Wang, Nianshuang, Corbett, Kizzmekia S, Choe, Misook, Mason, Rosemarie D, Van Galen, Joseph G, Zhou, Tongqing, Saunders, Kevin O, Tatti, Kathleen M, Haynes, Lia M, Kwong, Peter D, Modjarrad, Kayvon, Kong, Wing-Pui, McLellan, Jason S, Denison, Mark R, Munster, Vincent J, Mascola, John R, Graham, Barney S

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Coronaviruses: An RNA proofreading machine regulates replication fidelity and diversity von Denison, Mark R., Graham, Rachel L., Donaldson, Eric F., Eckerle, Lance D., Baric, Ralph S.

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Seeking membranes: positive-strand RNA virus replication complexes von Denison, Mark R

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A mutation in the coronavirus nsp13-helicase impairs enzymatic activity and confers partial remdesivir resistance von Grimes, Samantha L, Choi, Young J, Banerjee, Anoosha, Small, Gabriel, Anderson-Daniels, Jordan, Gribble, Jennifer, Pruijssers, Andrea J, Agostini, Maria L, Abu-Shmais, Alexandra, Lu, Xiaotao, Darst, Seth A, Campbell, Elizabeth, Denison, Mark R

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High Fidelity of Murine Hepatitis Virus Replication Is Decreased in nsp14 Exoribonuclease Mutants von ECKERLE, Lance D, XIAOTAO LU, SPERRY, Steven M, CHOI, Leena, DENISON, Mark R

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Reovirus RNA Recombination Is Sequence Directed and Generates Internally Deleted Defective Genome Segments during Passage von Smith, Sydni Caet, Gribble, Jennifer, Diller, Julia R., Wiebe, Michelle A., Thoner, Timothy W., Denison, Mark R., Ogden, Kristen M.

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Chimeric Exchange of Coronavirus nsp5 Proteases (3CLpro) Identifies Common and Divergent Regulatory Determinants of Protease Activity von Stobart, Christopher C, Sexton, Nicole R, Munjal, Havisha, Lu, Xiaotao, Molland, Katrina L, Tomar, Sakshi, Mesecar, Andrew D, Denison, Mark R

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Structural Definition of a Neutralization-Sensitive Epitope on the MERS-CoV S1-NTD von Wang, Nianshuang, Rosen, Osnat, Wang, Lingshu, Turner, Hannah L., Stevens, Laura J., Corbett, Kizzmekia S., Bowman, Charles A., Pallesen, Jesper, Shi, Wei, Zhang, Yi, Leung, Kwanyee, Kirchdoerfer, Robert N., Becker, Michelle M., Denison, Mark R., Chappell, James D., Ward, Andrew B., Graham, Barney S., McLellan, Jason S.

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Mutations across murine hepatitis virus nsp4 alter virus fitness and membrane modifications von Beachboard, Dia C, Anderson-Daniels, Jordan M, Denison, Mark R

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Evaluation of Serologic and Antigenic Relationships Between Middle Eastern Respiratory Syndrome Coronavirus and Other Coronaviruses to Develop Vaccine Platforms for the Rapid Respo... von Agnihothram, Sudhakar, Gopal, Robin, Yount, Boyd L., Donaldson, Eric F., Menachery, Vineet D., Graham, Rachel L., Scobey, Trevor D., Gralinski, Lisa E., Denison, Mark R., Zambon, Maria, Baric, Ralph S.

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