Establishing in vitro in vivo correlations to screen monoclonal antibodies for physicochemical properties related to favorable human pharmacokinetics von Avery, Lindsay B, Wade, Jason, Wang, Mengmeng, Tam, Amy, King, Amy, Piche-Nicholas, Nicole, Kavosi, Mania S, Penn, Steve, Cirelli, David, Kurz, Jeffrey C, Zhang, Minlei, Cunningham, Orla, Jones, Rhys, Fennell, Brian J, McDonnell, Barry, Sakorafas, Paul, Apgar, James, Finlay, William J, Lin, Laura, Bloom, Laird, O'Hara, Denise M

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Recommendations for the validation of flow cytometric testing during drug development: II assays von O'Hara, Denise M., Xu, Yuanxin, Liang, Zhiyan, Reddy, Manjula P., Wu, Dianna Y., Litwin, Virginia

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Utility of a human FcRn transgenic mouse model in drug discovery for early assessment and prediction of human pharmacokinetics of monoclonal antibodies von Avery, Lindsay B, Wang, Mengmeng, Kavosi, Mania S, Joyce, Alison, Kurz, Jeffrey C, Fan, Yao-Yun, Dowty, Martin E, Zhang, Minlei, Zhang, Yiqun, Cheng, Aili, Hua, Fei, Jones, Hannah M, Neubert, Hendrik, Polzer, Robert J, O'Hara, Denise M

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Glyco-engineered Long Acting FGF21 Variant with Optimal Pharmaceutical and Pharmacokinetic Properties to Enable Weekly to Twice Monthly Subcutaneous Dosing von Weng, Yan, Ishino, Tetsuya, Sievers, Annette, Talukdar, Saswata, Chabot, Jeffrey R., Tam, Amy, Duan, Weili, Kerns, Kelvin, Sousa, Eric, He, Tao, Logan, Alison, Lee, Darwin, Li, Dongmei, Zhou, Yingjiang, Bernardo, Barbara, Joyce, Alison, Kavosi, Mania, O’Hara, Denise M., Clark, Tracey, Guo, Jie, Giragossian, Craig, Stahl, Mark, Calle, Roberto A., Kriz, Ron, Somers, Will, Lin, Laura

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One Mouse, One Pharmacokinetic Profile: Quantitative Whole Blood Serial Sampling for Biotherapeutics von Joyce, Alison P., Wang, Mengmeng, Lawrence-Henderson, Rosemary, Filliettaz, Cynthia, Leung, Sheldon S., Xu, Xin, O’Hara, Denise M.

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Engineering a Monomeric Fc Domain Modality by N-Glycosylation for the Half-life Extension of Biotherapeutics von Ishino, Tetsuya, Wang, Mengmeng, Mosyak, Lidia, Tam, Amy, Duan, Weili, Svenson, Kristine, Joyce, Alison, O'Hara, Denise M., Lin, Laura, Somers, William S., Kriz, Ronald

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Comparison of Succinimidyl [125I]Iodobenzoate with Iodogen Iodination Methods to Study Pharmacokinetics and ADME of Biotherapeutics von Chen, Jianqing, Wang, Mengmeng, Joyce, Alison, DeFranco, David, Kavosi, Mania, Xu, Xin, O’Hara, Denise M.

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Faster in vivo clearance of human embryonic kidney than Chinese hamster ovary cell derived protein: Role of glycan mediated clearance von Wang, Mengmeng, Ishino, Tetsuya, Joyce, Alison, Tam, Amy, Duan, Weili, Lin, Laura, Somers, William S., Kriz, Ronald, O'Hara, Denise M.

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Changes in complementarity-determining regions significantly alter IgG binding to the neonatal Fc receptor (FcRn) and pharmacokinetics von Piche-Nicholas, Nicole M, Avery, Lindsay B, King, Amy C, Kavosi, Mania, Wang, Mengmeng, O'Hara, Denise M, Tchistiakova, Lioudmila, Katragadda, Madan

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Challenges in Selectivity, Specificity and Quantitation Range of Ligand-Binding Assays: Case Studies Using A Microfluidics Platform von Yang, Tong-Yuan, Uhlinger, David J, Ayers, Stephen A, O’Hara, Denise M, Joyce, Alison P

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Human FcRn Tissue Expression Profile and Half-Life in PBMCs von Fan, Yao-Yun, Farrokhi, Vahid, Caiazzo, Teresa, Wang, Mengmeng, O'Hara, Denise M, Neubert, Hendrik

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Understanding Lung Deposition of Alpha-1 Antitrypsin in Acute Experimental Mouse Lung Injury Model Using Fluorescence Microscopy von Wang, Mengmeng, Zhan, Yutian, Chen, Jianqing, Rong, Haojing, O’Neil, Shawn P., Ghosh, Brahma, Nguyen, Vuong, Owens, Jane, Li, Xianfeng, O’Hara, Denise M.

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Ligand Binding Assays in the 21st Century Laboratory: Recommendations for Characterization and Supply of Critical Reagents von O’Hara, Denise M., Theobald, Valerie, Egan, Adrienne Clements, Usansky, Joel, Krishna, Murli, TerWee, Julie, Maia, Mauricio, Spriggs, Frank P., Kenney, John, Safavi, Afshin, Keefe, Jeannine

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Physiologically relevant binding affinity quantification of monoclonal antibody PF‐00547659 to mucosal addressin cell adhesion molecule for in vitro in vivo correlation von Wang, Mengmeng, Kussrow, Amanda K, Ocana, Mireia Fernandez, Chabot, Jeffrey R, Lepsy, Christopher S, Bornhop, Darryl J, O'Hara, Denise M

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Tissue expression profile of human neonatal Fc receptor (FcRn) in Tg32 transgenic mice von Fan, Yao-Yun, Avery, Lindsay B., Wang, Mengmeng, O'Hara, Denise M., Leung, Sheldon, Neubert, Hendrik

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Quantitative biodistribution of biotherapeutics at whole body, organ and cellular levels by autoradiography von Wang, Mengmeng, Zhan, Yutian, O'Neil, Shawn P, Harris, Stephen, Henson, Claire, McEwen, Andrew, Webster, Rob, O'Hara, Denise M

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Bioanalytical platform comparison using a generic human IgG PK assay format von Leary, Beth A., Lawrence-Henderson, Rosemary, Mallozzi, Carolyn, Fernandez Ocaña, Mireia, Duriga, Nicole, O’Hara, Denise M., Kavosi, Mania, Qu, Qiang, Joyce, Alison P.

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Placental transfer of 125iodinated humanized immunoglobulin G2Δa in the cynomolgus monkey von Catlin, Natasha R., Mitchell, Andrea Z., Potchoiba, Michael J., O'Hara, Denise M., Wang, Mengmeng, Zhang, Minlei, Weinbauer, Gerhard F., Bowman, Christopher J.

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Placental transfer of 125 iodinated humanized immunoglobulin G2Δa in the cynomolgus monkey von Catlin, Natasha R, Mitchell, Andrea Z, Potchoiba, Michael J, O'Hara, Denise M, Wang, Mengmeng, Zhang, Minlei, Weinbauer, Gerhard F, Bowman, Christopher J

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