In Vitro Activity and Preclinical Profile of TMC435350, a Potent Hepatitis C Virus Protease Inhibitor von LIN, Tse-I, LENZ, Oliver, VRANG, Lotta, DE KOCK, Herman, WIGERINCK, Piet, RABOISSON, Pierre, SIMMEN, Kenneth, FANNING, Gregory, VERBINNEN, Thierry, DELOUVROY, Frédéric, SCHOLLIERS, Annick, VERMEIREN, Katrien, ROSENQUIST, Asa, EDLUND, Michael, SAMUELSSON, Bertil

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Structure–activity relationship study on a novel series of cyclopentane-containing macrocyclic inhibitors of the hepatitis C virus NS3/4A protease leading to the discovery of TMC43... von Raboisson, Pierre, de Kock, Herman, Rosenquist, Åsa, Nilsson, Magnus, Salvador-Oden, Lourdes, Lin, Tse-I, Roue, Natalie, Ivanov, Vladimir, Wähling, Horst, Wickström, Kristina, Hamelink, Elizabeth, Edlund, Michael, Vrang, Lotta, Vendeville, Sandrine, Van de Vreken, Wim, McGowan, David, Tahri, Abdellah, Hu, Lili, Boutton, Carlo, Lenz, Oliver, Delouvroy, Frederic, Pille, Geert, Surleraux, Dominique, Wigerinck, Piet, Samuelsson, Bertil, Simmen, Kenneth

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1,5-Benzodiazepines, a Novel Class of Hepatitis C Virus Polymerase Nonnucleoside Inhibitors von NYANGUILE, Origene, PAUWELS, Frederik, DEHERTOGH, Pascale, CUMMINGS, Maxwell D, BONFANTI, Jean-Francois, SIMMEN, Kenneth A, RABOISSON, Pierre, VAN DEN BROECK, Walter, BOUTTON, Carlo W, QUIRYNEN, Ludo, IVENS, Tania, VAN DER HELM, Liesbet, VANDERCRUYSSEN, Geneviève, MOSTMANS, Wendy, DELOUVROY, Frédéric

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1a/1b Subtype Profiling of Nonnucleoside Polymerase Inhibitors of Hepatitis C Virus von NYANGUILE, Origène, DEVOGELAERE, Benoit, VANDERCRUYSSEN, Geneviève, VERMEIREN, Katrien, MOSTMANS, Wendy, DEHERTOGH, Pascale, DELOUVROY, Frédéric, VENDEVILLE, Sandrine, VANDYCK, Koen, DOCKX, Koen, CLEIREN, Ema, RABOISSON, Pierre, VIJGEN, Leen, SIMMEN, Kenneth A, FANNING, Gregory C, VAN DEN BROECK, Walter, PAUWELS, Frederik, CUMMINGS, Maxwell D, DE BONDT, Hendrik L, VOS, Ann M, BERKE, Jan M, LENZ, Oliver

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Synthesis and evaluation of novel HCV replication inhibitors von McGowan, David C., Khamlichi, Mourad D., De Groot, Alex, Pauwels, Frederik, Delouvroy, Frédéric, Van Emelen, Kristof, Simmen, Kenneth, Raboisson, Pierre

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Evaluation of the anti-hepatitis C virus effect of novel potent, selective, and orally bioavailable JNK and VEGFR kinase inhibitors von Raboisson, Pierre, Lenz, Oliver, Lin, Tse-I, Surleraux, Dominique, Chakravarty, Sarvajit, Scholliers, Annick, Vermeiren, Katrien, Delouvroy, Frederic, Verbinnen, Thierry, Simmen, Kenneth

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1,5-Benzodiazepine inhibitors of HCV NS5B polymerase von McGowan, David, Nyanguile, Origène, Cummings, Maxwell D., Vendeville, Sandrine, Vandyck, Koen, Van den Broeck, Walter, Boutton, Carlo W., De Bondt, Hendrik, Quirynen, Ludo, Amssoms, Katie, Bonfanti, Jean-François, Last, Stefaan, Rombauts, Klara, Tahri, Abdellah, Hu, Lili, Delouvroy, Frédéric, Vermeiren, Katrien, Vandercruyssen, Geneviève, Van der Helm, Liesbet, Cleiren, Erna, Mostmans, Wendy, Lory, Pedro, Pille, Geert, Van Emelen, Kristof, Fanning, Gregory, Pauwels, Frederik, Lin, Tse-I, Simmen, Kenneth, Raboisson, Pierre

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ambr™ Mini-bioreactor as a high-throughput tool for culture process development to accelerate transfer to stainless steel manufacturing scale: comparability study from process perf... von Delouvroy, Frédéric, Siriez, Gaetan, Tran, An-Vy, Mukankurayija, Larissa, Kochanowski, Nadine, Malphettes, Laetitia

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From Clone Selection to 80L Bioreactor Production: Better, Faster, Leaner von Clincke, Marie-Françoise, Delouvroy, Frédéric, Révérend, Guillaume L, Stofferis, Jimmy, Hinchliffe, Matthew, Malphettes, Laetitia

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Discovery of novel potent and selective dipeptide hepatitis C virus NS3/4A serine protease inhibitors von Raboisson, Pierre, Lin, Tse-I, Kock, Herman de, Vendeville, Sandrine, Vreken, Wim Van de, McGowan, David, Tahri, Abdellah, Hu, Lili, Lenz, Oliver, Delouvroy, Frederic, Surleraux, Dominique, Wigerinck, Piet, Nilsson, Magnus, Rosenquist, Åsa, Samuelsson, Bertil, Simmen, Kenneth

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Discovery of novel, potent and bioavailable proline-urea based macrocyclic HCV NS3/4A protease inhibitors von VENDEVILLE, Sandrine, NILSSON, Magnus, ENEROTH, Anders, WIKSTROM, Kristina, VRANG, Lotta, EDLUND, Michael, LINDSTRÖM, Stefan, VAN DE VREKEN, Wim, MCGOWAN, David, TAHRI, Abdellah, LILI HU, LENZ, Oliver, DE KOCK, Herman, DELOUVROY, Frederic, VAN DOOREN, Marleen, KINDERMANS, Natalie, SURLERAUX, Dominique, WIGERINCK, Piet, ROSENQUIST, Asa, SAMUELSSON, Bertil, SIMMENA, Kenneth, RABOISSON, Pierre, LINA, Tse-I, ANTONOV, Dmitry, CLASSON, Björn, AYESA, Susana, IVANOV, Vladimir, JOHANSSON, Per-Ola, KAHNBERG, Pia

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Evaluation of the advanced micro-scale bioreactor (ambr™) as a highthroughput tool for cell culture process development von Delouvroy, Frédéric, Le Reverend, Guillaume, Fessler, Boris, Mathy, Gregory, Harmsen, Mareike, Kochanowski, Nadine, Malphettes, Laetitia

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