Antitumor Efficacy of PKI-587, a Highly Potent Dual PI3K/mTOR Kinase Inhibitor von MALLON, Robert, FELDBERG, Larry R, HOLLANDER, Irwin, LUCAS, Judy, CHAUDHARY, Inder, DEHNHARDT, Christoph, DELOS SANTOS, Efren, ZECHENG CHEN, DOS SANTOS, Osvaldo, AYRAL-KALOUSTIAN, Semiramis, VENKATESAN, Aranapakam

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Bis(morpholino-1,3,5-triazine) Derivatives: Potent Adenosine 5′-Triphosphate Competitive Phosphatidylinositol-3-kinase/Mammalian Target of Rapamycin Inhibitors: Discovery of Compou... von Venkatesan, Aranapakam M, Dehnhardt, Christoph M, Delos Santos, Efren, Chen, Zecheng, Dos Santos, Osvaldo, Ayral-Kaloustian, Semiramis, Khafizova, Gulnaz, Brooijmans, Natasja, Mallon, Robert, Hollander, Irwin, Feldberg, Larry, Lucas, Judy, Yu, Ker, Gibbons, James, Abraham, Robert T, Chaudhary, Inder, Mansour, Tarek S

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Stereoselective Synthesis of an Active Metabolite of the Potent PI3 Kinase Inhibitor PKI-179 von Chen, Zecheng, Venkatesan, Aranapakam M, Dos Santos, Osvaldo, Delos Santos, Efren, Dehnhardt, Christoph M, Ayral-Kaloustian, Semiramis, Ashcroft, Joseph, McDonald, Leonard A, Mansour, Tarek S

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PKI-179: An orally efficacious dual phosphatidylinositol-3-kinase (PI3K)/mammalian target of rapamycin (mTOR) inhibitor von Venkatesan, Aranapakam M., Chen, Zecheng, Santos, Osvaldo Dos, Dehnhardt, Christoph, Santos, Efren Delos, Ayral-Kaloustian, Semiramis, Mallon, Robert, Hollander, Irwin, Feldberg, Larry, Lucas, Judy, Yu, Ker, Chaudhary, Inder, Mansour, Tarek S.

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Antitumor efficacy profile of PKI-402, a dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor von Mallon, Robert, Hollander, Irwin, Feldberg, Larry, Lucas, Judy, Soloveva, Veronica, Venkatesan, Aranapakam, Dehnhardt, Christoph, Delos Santos, Efren, Chen, Zecheng, Dos Santos, Osvaldo, Ayral-Kaloustian, Semiramis, Gibbons, Jay

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2,4-Diamino-quinazolines as inhibitors of β-catenin/Tcf-4 pathway: Potential treatment for colorectal cancer von Chen, Zecheng, Venkatesan, Aranapakam M., Dehnhardt, Christoph M., Santos, Osvaldo Dos, Santos, Efren Delos, Ayral-Kaloustian, Semiramis, Chen, Lei, Geng, Yi, Arndt, Kim T., Lucas, Judy, Chaudhary, Inder, Mansour, Tarek S.

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Structure–activity study of novel tricyclic benzazepine arginine vasopressin antagonists von Sum, Fuk-Wah, Dusza, John, Santos, Efren Delos, Grosu, George, Reich, Marvin, Du, Xumei, Albright, J.Donald, Chan, Peter, Coupet, Joseph, Ru, Xun, Mazandarani, Hossein, Saunders, Trina

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Novel purine and pyrazolo[3,4- d]pyrimidine inhibitors of PI3 kinase-α: Hit to lead studies von Gilbert, Adam M., Nowak, Pawel, Brooijmans, Natasja, Bursavich, Matthew G., Dehnhardt, Christoph, Santos, Efren Delos, Feldberg, Larry R., Hollander, Irwin, Kim, Stephen, Lombardi, Sabrina, Park, Kaapjoo, Venkatesan, Aranapakam M., Mallon, Robert

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Novel imidazolopyrimidines as dual PI3-Kinase/mTOR inhibitors von Venkatesan, Aranapakam M., Dehnhardt, Christoph M., Chen, Zecheng, Santos, Efren Delos, Dos Santos, Osvaldo, Bursavich, Matthew, Gilbert, Adam M., Ellingboe, John W., Ayral-Kaloustian, Semiramis, Khafizova, Gulnaz, Brooijmans, Natasja, Mallon, Robert, Hollander, Irwin, Feldberg, Larry, Lucas, Judy, Yu, Ker, Gibbons, Jay, Abraham, Robert, Mansour, Tarek S.

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5-Fluoro-2-methyl-N-[4-(5H-pyrrolo[2,1-c]- [1,4]benzodiazepin-10(11H)-ylcarbonyl)-3- chlorophenyl]benzamide (VPA-985):  An Orally Active Arginine Vasopressin Antagonist with Select... von Albright, J. Donald, Reich, Marvin F, Delos Santos, Efren G, Dusza, John P, Sum, Fuk-Wah, Venkatesan, Aranapakam M, Coupet, Joseph, Chan, Peter S, Ru, Xun, Mazandarani, Hossein, Bailey, Trina

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Benzodiazepine inhibitors of the MMPs and TACE von NELSON, Frances C, DELOS SANTOS, Efren, GUIXIAN JIN, ROTH, Catherine E, ALBRIGHT, J. Donald, LEVIN, Jeremy I, CHEN, James M, SKOTNICKI, Jerauld S, DIJOSEPH, John F, SHARR, Michele A, SUNG, Amy, KILLAR, Loran M, COWLING, Rebecca

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Lead Optimization of N-3-Substituted 7-Morpholinotriazolopyrimidines as Dual Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Inhibitors: Discovery of PKI-402 von Dehnhardt, Christoph M, Venkatesan, Aranapakam M, Delos Santos, Efren, Chen, Zecheng, Santos, Osvaldo, Ayral-Kaloustian, Semiramis, Brooijmans, Natasja, Mallon, Robert, Hollander, Irwin, Feldberg, Larry, Lucas, Judy, Chaudhary, Inder, Yu, Ker, Gibbons, Jay, Abraham, Robert, Mansour, Tarek S

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Identification of 2-oxatriazines as highly potent pan-PI3K/mTOR dual inhibitors von Dehnhardt, Christoph M., Venkatesan, Aranapakam M., Chen, Zecheng, Delos-Santos, Efren, Ayral-Kaloustian, Semiramis, Brooijmans, Natasja, Yu, Ker, Hollander, Irwin, Feldberg, Larry, Lucas, Judy, Mallon, Robert

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Design and Synthesis of Novel Diaminoquinazolines with in Vivo Efficacy for β-Catenin/T-Cell Transcriptional Factor 4 Pathway Inhibition von Dehnhardt, Christoph M, Venkatesan, Aranapakam M, Chen, Zecheng, Ayral-Kaloustian, Semiramis, Dos Santos, Osvaldo, Delos Santos, Efren, Curran, Kevin, Follettie, Max T, Diesl, Veronica, Lucas, Judy, Geng, Yi, DeJoy, Susan Quinn, Petersen, Rosanne, Chaudhary, Inder, Brooijmans, Natasja, Mansour, Tarek S, Arndt, Kim, Chen, Lei

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5-Fluoro-2-methyl- N -[4-(5 H -pyrrolo[2,1- c ]- [1,4]benzodiazepin-10(11 H )-ylcarbonyl)-3- chlorophenyl]benzamide (VPA-985):  An Orally Active Arginine Vasopressin Antagonist wit... von Albright, J. Donald, Reich, Marvin F., Delos Santos, Efren G., Dusza, John P., Sum, Fuk-Wah, Venkatesan, Aranapakam M., Coupet, Joseph, Chan, Peter S., Ru, Xun, Mazandarani, Hossein, Bailey, Trina

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Abstract 723: Beyond temsirolimus: Discovery of PKI-587 a highly efficacious dual PI3K/mTOR inhibitor von Venkatesan, Aranapakam M., Dehnhardt, Christoph M., Santos, Efren Delos, Chen, Zecheng, Santos, Osvaldo Dos, Ayral-Kaloustian, Semiramis, Mallon, Robert, Hollander, Irwin, Feldberg, Larry, Lucas, Judy, Yu, Ker, Brooijmans, Natasja, Bard, Joel, Gibbons, James, Abraham, Robert T., Mansour, Tarek S.

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Novel purine and pyrazolo[3,4-d]pyrimidine inhibitors of PI3 kinase-a: Hit to lead studies von Gilbert, Adam M, Nowak, Pawel, Brooijmans, Natasja, Bursavich, Matthew G, Dehnhardt, Christoph, Santos, Efren Delos, Feldberg, Larry R, Hollander, Irwin, Kim, Stephen, Lombardi, Sabrina, Park, Kaapjoo, Venkatesan, Aranapakam M, Mallon, Robert

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2,4-Diamino-quinazolines as inhibitors of b-catenin/Tcf-4 pathway: Potential treatment for colorectal cancer von Chen, Zecheng, Venkatesan, Aranapakam M, Dehnhardt, Christoph M, Dos Santos, Osvaldo, Santos, Efren Delos, Ayral-Kaloustian, Semiramis, Chen, Lei, Geng, Yi, Arndt, Kim T, Lucas, Judy, Chaudhary, Inder, Mansour, Tarek S

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Benzodiazepine inhibitors of the MMPs and TACE. Part 2 von Levin, Jeremy I, Nelson, Frances C, Delos Santos, Efren, Du, Mila T, MacEwan, Gloria, Chen, James M, Ayral-Kaloustian, Semiramis, Xu, Jun, Jin, Guixian, Cummons, Terri, Barone, Dauphine

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5-fluoro-2-methyl-N-[5-(5 H-pyrrolo[2,1- c][1,4]benzodiazepine-10(11 H)-yl carbonyl)-2-pyridinyl]benzamide (CL-385004) and analogs as orally active arginine vasopressin receptor an... von Aranapakam, Venkatesan, Albright, J.Donald, Grosu, George T., Delos Santos, Efren G., Chan, Peter S., Coupet, Joseph, Ru, Xun, Saunders, Trina, Mazandarani, H.

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