A trial of gantenerumab or solanezumab in dominantly inherited Alzheimer’s disease von Salloway, Stephen, Farlow, Martin, McDade, Eric, Clifford, David B., Wang, Guoqiao, Llibre-Guerra, Jorge J., Hitchcock, Janice M., Mills, Susan L., Santacruz, Anna M., Aschenbrenner, Andrew J., Hassenstab, Jason, Benzinger, Tammie L. S., Gordon, Brian A., Fagan, Anne M., Coalier, Kelley A., Cruchaga, Carlos, Goate, Alison A., Perrin, Richard J., Xiong, Chengjie, Li, Yan, Morris, John C., Snider, B. Joy, Mummery, Catherine, Surti, G. Mustafa, Hannequin, Didier, Wallon, David, Berman, Sarah B., Lah, James J., Jimenez-Velazquez, Ivonne Z., Roberson, Erik D., van Dyck, Christopher H., Honig, Lawrence S., Sánchez-Valle, Raquel, Brooks, William S., Gauthier, Serge, Galasko, Douglas R., Masters, Colin L., Brosch, Jared R., Hsiung, Ging-Yuek Robin, Jayadev, Suman, Formaglio, Maité, Masellis, Mario, Clarnette, Roger, Pariente, Jérémie, Dubois, Bruno, Pasquier, Florence, Jack, Clifford R., Koeppe, Robert, Snyder, Peter J., Aisen, Paul S., Thomas, Ronald G., Berry, Scott M., Wendelberger, Barbara A., Andersen, Scott W., Holdridge, Karen C., Mintun, Mark A., Yaari, Roy, Sims, John R., Baudler, Monika, Delmar, Paul, Doody, Rachelle S., Fontoura, Paulo, Giacobino, Caroline, Kerchner, Geoffrey A., Bateman, Randall J.

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A phase III randomized trial of gantenerumab in prodromal Alzheimer's disease von Ostrowitzki, Susanne, Lasser, Robert A, Dorflinger, Ernest, Scheltens, Philip, Barkhof, Frederik, Nikolcheva, Tania, Ashford, Elizabeth, Retout, Sylvie, Hofmann, Carsten, Delmar, Paul, Klein, Gregory, Andjelkovic, Mirjana, Dubois, Bruno, Boada, Mercè, Blennow, Kaj, Santarelli, Luca, Fontoura, Paulo

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Gantenerumab reduces amyloid-β plaques in patients with prodromal to moderate Alzheimer's disease: a PET substudy interim analysis von Klein, Gregory, Delmar, Paul, Voyle, Nicola, Rehal, Sunita, Hofmann, Carsten, Abi-Saab, Danielle, Andjelkovic, Mirjana, Ristic, Smiljana, Wang, Guoqiao, Bateman, Randall, Kerchner, Geoffrey A, Baudler, Monika, Fontoura, Paulo, Doody, Rachelle

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Bevacizumab in Combination With Chemotherapy As First-Line Therapy in Advanced Gastric Cancer: A Biomarker Evaluation From the AVAGAST Randomized Phase III Trial von VAN CUTSEM, Eric, DE HAAS, S. Anne, SHAH, Manish A, KANG, Yoon-Koo, OHTSU, Atsushi, TEBBUTT, Niall C, JIAN MING XU, WEI PENG YONG, LANGER, Bernd, DELMAR, Paul, SCHERER, Stefan J

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A model for predicting effect of treatment on progression-free survival using MRD as a surrogate end point in CLL von Dimier, Natalie, Delmar, Paul, Ward, Carol, Morariu-Zamfir, Rodica, Fingerle-Rowson, Günter, Bahlo, Jasmin, Fischer, Kirsten, Eichhorst, Barbara, Goede, Valentin, van Dongen, Jacques J.M., Ritgen, Matthias, Böttcher, Sebastian, Langerak, Anton W., Kneba, Michael, Hallek, Michael

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A novel cognitive disease progression model for clinical trials in autosomal‐dominant Alzheimer's disease von Wang, Guoqiao, Berry, Scott, Xiong, Chengjie, Hassenstab, Jason, Quintana, Melanie, McDade, Eric M., Delmar, Paul, Vestrucci, Matteo, Sethuraman, Gopalan, Bateman, Randall J.

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VEGF pathway genetic variants as biomarkers of treatment outcome with bevacizumab: an analysis of data from the AViTA and AVOREN randomised trials von Lambrechts, Diether, Prof, Claes, Bart, MSc, Delmar, Paul, PhD, Reumers, Joke, PhD, Mazzone, Massimiliano, Prof, Yesilyurt, Betül T, MSc, Devlieger, Roland, Prof, Verslype, Chris, Prof, Tejpar, Sabine, Prof, Wildiers, Hans, Prof, de Haas, Sanne, PhD, Carmeliet, Peter, Prof, Scherer, Stefan J, MD, Van Cutsem, Eric, Prof

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In silico exploration of amyloid‐related imaging abnormalities in the gantenerumab open‐label extension trials using a semi‐mechanistic model von Aldea, Roxana, Grimm, Hans Peter, Gieschke, Ronald, Hofmann, Carsten, Lott, Dominik, Bullain, Szofia, Delmar, Paul, Klein, Gregory, Lyons, Marco, Piazza, Fabrizio, Carare, Roxana O., Mazer, Norman A.

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Proportional constrained longitudinal data analysis models for clinical trials in sporadic Alzheimer's disease von Wang, Guoqiao, Liu, Lei, Li, Yan, Aschenbrenner, Andrew J., Bateman, Randall J., Delmar, Paul, Schneider, Lon S., Kennedy, Richard E., Cutter, Gary R., Xiong, Chengjie

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Overview of dominantly inherited AD and top‐line DIAN‐TU results of solanezumab and gantenerumab von Bateman, Randall J, Aschenbrenner, Andrew J., Benzinger, Tammie L.S., Clifford, David, Coalier, Kelley, Cruchaga, Carlos, Fagan, Anne M., Farlow, Martin R., Goate, Alison M., Gordon, Brian A., Hassenstab, Jason, Jack, Clifford R., Koeppe, Robert A., McDade, Eric, Mills, Susan, Morris, John C., Salloway, Stephen P., Santacruz, Anna, Snyder, Peter J., Wang, Guoqiao, Xiong, Chengjie, Snider, B. Joy, Mummery, Catherine J., Surti, Ghulam M., Hannequin, Didier, Wallon, David, Berman, Sarah, Lah, James J., Jiménez‐Velazquez, Ivonne Z., Roberson, Erik D., Dyck, Christopher H., Honig, Lawrence S., Sanchez‐Valle, Raquel, Brooks, William S., Gauthier, Serge, Masters, Colin L., Galasko, Doug R., Brosch, Jared R., Hsiung, Ging‐Yuek Robin, Jayadev, Suman, Formaglio, Maïté, Masellis, Mario, Clarnette, Roger, Pariente, Jeremie, Dubois, Bruno, Pasquier, Florence, Andersen, Scott W., Holdridge, Karen C., Mintun, Mark A., Sims, John R., Yaari, Roy, Baudler, Monika, Delmar, Paul, Doody, Rachelle, Fontoura, Paulo, Kerchner, Geoffrey A.

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Innovative methods for the identification of predictive biomarker signatures in oncology: Application to bevacizumab von Delmar, Paul, Irl, Cornelia, Tian, Lu

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The Transcriptional Coactivator Peroxisome Proliferator–Activated Receptor (PPAR)γ Coactivator-1α and the Nuclear Receptor PPARα Control the Expression of Glycerol Kinase and Metab... von Mazzucotelli, Anne, Viguerie, Nathalie, Tiraby, Claire, Annicotte, Jean-Sébastien, Mairal, Aline, Klimcakova, Eva, Lepin, Emmanuelle, Delmar, Paul, Dejean, Sébastien, Tavernier, Geneviève, Lefort, Corinne, Hidalgo, Juan, Pineau, Thierry, Fajas, Lluis, Clément, Karine, Langin, Dominique

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Correction to: A phase III randomized trial of gantenerumab in prodromal Alzheimer's disease von Ostrowitzki, Susanne, Lasser, Robert A, Dorflinger, Ernest, Scheltens, Philip, Barkhof, Frederik, Nikolcheva, Tania, Ashford, Elizabeth, Retout, Sylvie, Hofmann, Carsten, Delmar, Paul, Klein, Gregory, Andjelkovic, Mirjana, Dubois, Bruno, Boada, Mercè, Blennow, Kaj, Santarelli, Luca, Fontoura, Paulo

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Evaluating Digital Twins for Alzheimer’s Disease using Data from a Completed Phase 2 Clinical Trial von Walsh, Jonathan R., Roumpanis, Spyros, Bertolini, Daniele, Delmar, Paul

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An industry statistician's perspective on PHC drug development von Fridlyand, Jane, Yeh, Ru-Fang, Mackey, Howard, Bengtsson, Thomas, Delmar, Paul, Spaniolo, Greg, Lieberman, Grazyna

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Preclinical biomarkers for a cyclin-dependent kinase inhibitor translate to candidate pharmacodynamic biomarkers in phase I patients von Berkofsky-Fessler, Windy, Nguyen, Tri Q., Delmar, Paul, Molnos, Juliette, Kanwal, Charu, DePinto, Wanda, Rosinski, James, McLoughlin, Patricia, Ritland, Steve, DeMario, Mark, Tobon, Krishna, Reidhaar-Olson, John F., Rueger, Ruediger, Hilton, Holly

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Selecting appropriate meaningful change thresholds for trials of early (prodromal‐to‐mild) AD: A caregiver‐rated, anchor‐based analysis based on the Tauriel Study von Lansdall, Claire J, Teng, Edmond, McDougall, Fiona, Delmar, Paul, Smith, Janice, Manser, Paul T

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Associations of patient‐specific resting state variability with CSF and clinical biomarkers: Data from Alzheimer’s disease clinical trials von Gobbi, Susanna, Scelsi, Marzia A., Delmar, Paul, Bittner, Tobias, Klein, Gregory, Magon, Stefano

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GRADUATE I AND II: Factors that may influence participant response to subcutaneous gantenerumab von Thanasopoulou, Angeliki, Lane, Christopher, Delmar, Paul, Voyle, Nicola, Huang, Zhiyue, Schwab, Dietmar, Fox, Nick C, Smith, Janice, Doody, Rachelle S.

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Rejoinder to the letter: “Standard and reference‐based conditional mean imputation: Regulators and trial statisticians be aware!” von Wolbers, Marcel, Noci, Alessandro, Delmar, Paul, Yiu, Sean, Bartlett, Jonathan W.

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