Beyond the Rule of 5: Lessons Learned from AbbVie's Drugs and Compound Collection von DeGoey, David A, Chen, Hui-Ju, Cox, Philip B, Wendt, Michael D

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Antiviral Drug Discovery for the Treatment of COVID-19 Infections von Ng, Teresa I, Correia, Ivan, Seagal, Jane, DeGoey, David A, Schrimpf, Michael R, Hardee, David J, Noey, Elizabeth L, Kati, Warren M

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Discovery of ABT-267, a Pan-Genotypic Inhibitor of HCV NS5A von DeGoey, David A., Randolph, John T., Liu, Dachun, Pratt, John, Hutchins, Charles, Donner, Pamela, Krueger, A. Chris, Matulenko, Mark, Patel, Sachin, Motter, Christopher E., Nelson, Lissa, Keddy, Ryan, Tufano, Michael, Caspi, Daniel D., Krishnan, Preethi, Mistry, Neeta, Koev, Gennadiy, Reisch, Thomas J., Mondal, Rubina, Pilot-Matias, Tami, Gao, Yi, Beno, David W. A., Maring, Clarence J., Molla, Akhter, Dumas, Emily, Campbell, Andrew, Williams, Laura, Collins, Christine, Wagner, Rolf, Kati, Warren M.

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Development of a sensitive high-throughput enzymatic assay capable of measuring sub-nanomolar inhibitors of SARS-CoV2 Mpro von Kovar, Peter, Richardson, Paul L, Korepanova, Alla, Afanador, Gustavo A, Stojkovic, Vladimir, Li, Tao, Schrimpf, Michael R, Ng, Teresa I, Degoey, David A, Gopalakrishnan, Sujatha M, Chen, Jun

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Implications of the Conformationally Flexible, Macrocyclic Structure of the First-Generation, Direct-Acting Anti-Viral Paritaprevir on Its Solid Form Complexity and Chameleonic Beh... von Sheikh, Ahmad Y., Mattei, Alessandra, Miglani Bhardwaj, Rajni, Hong, Richard S., Abraham, Nathan S., Schneider-Rauber, Gabriela, Engstrom, Kenneth M., Diwan, Moiz, Henry, Rodger F., Gao, Yi, Juarez, Vivian, Jordan, Erin, DeGoey, David A., Hutchins, Charles W.

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Prodrug Strategies to Improve the Solubility of the HCV NS5A Inhibitor Pibrentasvir (ABT-530) von Randolph, John T, Voight, Eric A, Greszler, Stephen N, Uno, Brice E, Newton, James N, Gleason, Kenneth M, Stolarik, DeAnne, Van Handel, Cecilia, Bow, Daniel A. J, DeGoey, David A

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Enantioselective Synthesis of Antiinfluenza Compound A-315675 von DeGoey, David A, Chen, Hui-Ju, Flosi, William J, Grampovnik, David J, Yeung, Clinton M, Klein, Larry L, Kempf, Dale J

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Desymmetrization of pibrentasvir for efficient prodrug synthesis von Voight, Eric A, Greszler, Stephen N, Hartung, John, Ji, Jianguo, Klix, Russell C, Randolph, John T, Shelat, Bhadra H, Waters, Jan E, DeGoey, David A

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Beyond the Rule of 5: Lessons Learned from AbbVie’s Drugs and Compound Collection: Miniperspective von DeGoey, David A, Chen, Hui-Ju, Cox, Philip B, Wendt, Michael D

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Discovery of (R)-(3-fluoropyrrolidin-1-yl)(6-((5-(trifluoromethyl)pyridin-2-yl)oxy)quinolin-2-yl)methanone (ABBV-318) and analogs as small molecule Nav1.7/ Nav1.8 blockers for the... von Patel, Meena V., Peltier, Hillary M., Matulenko, Mark A., Koenig, John R., C. Scanio, Marc J., Gum, Rebecca J., El-Kouhen, Odile F., Fricano, Meagan M., Lundgaard, Greta L., Neelands, Torben, Zhang, Xu-Feng, Zhan, Cenchen, Pai, Madhavi, Ghoreishi-Haack, Nayereh, Hudzik, Thomas, Gintant, Gary, Martin, Ruth, McGaraughty, Steve, Xu, Jun, Bow, Daniel, Kalvass, John C., Kym, Philip R., DeGoey, David A., Kort, Michael E.

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Discovery of 2-aminoisobutyric acid ethyl ester (AIBEE) phosphoramidate prodrugs for delivering nucleoside HCV NS5B polymerase inhibitors von Randolph, John T., Li, Tongmei, Chris Krueger, A., Heyman, Howard R., Chen, Hui-Ju, Bow, Daniel A.J., Van Handel, Cecilia, Peterkin, Vincent, Carr, Robert A., Stolarik, DeAnne, Dekhtyar, Tatyana, Irvin, Michelle, Krishnan, Preethi, Wagner, Rolf, DeGoey, David A.

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Discovery of pyrido[2,3-d]pyrimidine-based inhibitors of HCV NS5A von DeGoey, David A., Betebenner, David A., Grampovnik, David J., Liu, Dachun, Pratt, John K., Tufano, Michael D., He, Wenping, Krishnan, Preethi, Pilot-Matias, Tami J., Marsh, Kennan C., Molla, Akhteruzzaman, Kempf, Dale J., Maring, Clarence J.

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Synthesis and evaluation of 2′-dihalo ribonucleotide prodrugs with activity against hepatitis C virus von Chris Krueger, A., Chen, Hui-Ju, Randolph, John T., Brown, Brian S., Halvorsen, Geoff T., Heyman, Howard R., Li, Tongmei, Marvin, Christopher C., Shanley, Jason P., Voight, Eric A., Bow, Daniel A.J., Van Handel, Cecilia, Peterkin, Vincent, Carr, Robert A., Stolarik, DeAnne, Dekhtyar, Tatyana, Irvin, Michelle L., Krishnan, Preethi, Henry, Rodger F., Wagner, Rolf, DeGoey, David A.

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Substituted Indazoles as Nav1.7 Blockers for the Treatment of Pain von Frost, Jennifer M, DeGoey, David A, Shi, Lei, Gum, Rebecca J, Fricano, Meagan M, Lundgaard, Greta L, El-Kouhen, Odile F, Hsieh, Gin C, Neelands, Torben, Matulenko, Mark A, Daanen, Jerome F, Pai, Madhavi, Ghoreishi-Haack, Nayereh, Zhan, Cenchen, Zhang, Xu-Feng, Kort, Michael E

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Characterization of a Novel Human Immunodeficiency Virus Type 1 Protease Inhibitor, A-790742 von Dekhtyar, Tatyana, Ng, Teresa I, Lu, Liangjun, Masse, Sherie, DeGoey, David A, Flosi, William J, Grampovnik, David J, Klein, Larry L, Kempf, Dale J, Molla, Akhteruzzaman

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Practical Preclinical Model for Assessing the Potential for Unconjugated Hyperbilirubinemia Produced by Human Immunodeficiency Virus Protease Inhibitors von KEMPF, Dale J, WARING, Jeffrey F, MARSH, Kennan, MORFITT, David C, WERNER, Paige, EBERT, Brian, MITTEN, Michael, NGUYEN, Bach, RANDOLPH, John T, DEGOEY, David A, KLEIN, Larry L

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Water-Soluble Prodrugs of the Human Immunodeficiency Virus Protease Inhibitors Lopinavir and Ritonavir von DeGoey, David A, Grampovnik, David J, Flosi, William J, Marsh, Kennan C, Wang, Xiu C, Klein, Larry L, McDaniel, Keith F, Liu, Yaya, Long, Michelle A, Kati, Warren M, Molla, Akhteruzzaman, Kempf, Dale J

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Aryl uracil inhibitors of hepatitis C virus NS5B polymerase: Synthesis and characterization of analogs with a fused 5,6-bicyclic ring motif von Krueger, A. Chris, Randolph, John T., DeGoey, David A., Donner, Pamela L., Flentge, Charles A., Hutchinson, Douglas K., Liu, Dachun, Motter, Christopher E., Rockway, Todd W., Wagner, Rolf, Beno, David W.A., Koev, Gennadiy, Lim, Hock B., Beyer, Jill M., Mondal, Rubina, Liu, Yaya, Kati, Warren M., Longenecker, Kenton L., Molla, Akhteruzzaman, Stewart, Kent D., Maring, Clarence J.

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P1-Substituted Symmetry-Based Human Immunodeficiency Virus Protease Inhibitors with Potent Antiviral Activity against Drug-Resistant Viruses von DeGoey, David A, Grampovnik, David J, Chen, Hui-Ju, Flosi, William J, Klein, Larry L, Dekhtyar, Tatyana, Stoll, Vincent, Mamo, Mulugeta, Molla, Akhteruzzaman, Kempf, Dale J

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KCNQ2/3 openers show differential selectivity and site of action across multiple KCNQ channels von Zhang, Di, Thimmapaya, Rama, Zhang, Xu-Feng, Anderson, David J., Baranowski, John L., Scanio, Marc, Perez-Medrano, Arturo, Peddi, Sridhar, Wang, Zhi, Patel, Jyoti R., DeGoey, David A., Gopalakrishnan, Murali, Honore, Prisca, Yao, Betty B., Surowy, Carol S.

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