SAR405838: A Novel and Potent Inhibitor of the MDM2:p53 Axis for the Treatment of Dedifferentiated Liposarcoma von Bill, Kate Lynn J, Garnett, Jeannine, Meaux, Isabelle, Ma, XiaoYen, Creighton, Chad J, Bolshakov, Svetlana, Barriere, Cedric, Debussche, Laurent, Lazar, Alexander J, Prudner, Bethany C, Casadei, Lucia, Braggio, Danielle, Lopez, Gonzalo, Zewdu, Abbie, Bid, Hemant, Lev, Dina, Pollock, Raphael E

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YAP1 is essential for malignant mesothelioma tumor maintenance von Calvet, Loreley, Dos-Santos, Odette, Spanakis, Emmanuel, Jean-Baptiste, Véronique, Le Bail, Jean-Christophe, Buzy, Armelle, Paul, Pascal, Henry, Christophe, Valence, Sandrine, Dib, Colette, Pollard, Jack, Sidhu, Sukhvinder, Moll, Jürgen, Debussche, Laurent, Valtingojer, Iris

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Production of the Bengamide Class of Marine Natural Products in Myxobacteria: Biosynthesis and Structure-Activity Relationships von Wenzel, Silke C., Hoffmann, Holger, Zhang, Jidong, Debussche, Laurent, Haag-Richter, Sabine, Kurz, Michael, Nardi, Frederico, Lukat, Peer, Kochems, Irene, Tietgen, Heiko, Schummer, Dietmar, Nicolas, Jean-Paul, Calvet, Loreley, Czepczor, Valerie, Vrignaud, Patricia, Mühlenweg, Agnes, Pelzer, Stefan, Müller, Rolf, Brönstrup, Mark

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TEAD Inhibitors Sensitize KRASG12C Inhibitors via Dual Cell Cycle Arrest in KRASG12C-Mutant NSCLC von Tammaccaro, Salvina Laura, Prigent, Philippe, Le Bail, Jean-Christophe, Dos-Santos, Odette, Dassencourt, Laurent, Eskandar, Myriam, Buzy, Armelle, Venier, Olivier, Guillemot, Jean-Claude, Veeranagouda, Yaligara, Didier, Michel, Spanakis, Emmanuel, Kanno, Tokuwa, Cesaroni, Matteo, Mathieu, Stephane, Canard, Luc, Casse, Alhassan, Windenberger, Fanny, Calvet, Loreley, Noblet, Laurence, Sidhu, Sukhvinder, Debussche, Laurent, Moll, Jurgen, Valtingojer, Iris

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Efficacy of the MDM2 Inhibitor SAR405838 in Glioblastoma Is Limited by Poor Distribution Across the Blood-Brain Barrier von Kim, Minjee, Ma, Daniel J, Calligaris, David, Zhang, Shuangling, Feathers, Ryan W, Vaubel, Rachael A, Meaux, Isabelle, Mladek, Ann C, Parrish, Karen E, Jin, Fang, Barriere, Cedric, Debussche, Laurent, Watters, James, Tian, Shulan, Decker, Paul A, Eckel-Passow, Jeanette E, Kitange, Gaspar J, Johnson, Aaron J, Parney, Ian F, Anastasiadis, Panos Z, Agar, Nathalie Y R, Elmquist, William F, Sarkaria, Jann N

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Significant Differences in the Development of Acquired Resistance to the MDM2 Inhibitor SAR405838 between In Vitro and In Vivo Drug Treatment von Hoffman-Luca, C Gianna, Yang, Chao-Yie, Lu, Jianfeng, Ziazadeh, Daniel, McEachern, Donna, Debussche, Laurent, Wang, Shaomeng

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SAR405838: an optimized inhibitor of MDM2-p53 interaction that induces complete and durable tumor regression von Wang, Shaomeng, Sun, Wei, Zhao, Yujun, McEachern, Donna, Meaux, Isabelle, Barrière, Cédric, Stuckey, Jeanne A, Meagher, Jennifer L, Bai, Longchuan, Liu, Liu, Hoffman-Luca, Cassandra Gianna, Lu, Jianfeng, Shangary, Sanjeev, Yu, Shanghai, Bernard, Denzil, Aguilar, Angelo, Dos-Santos, Odette, Besret, Laurent, Guerif, Stéphane, Pannier, Pascal, Gorge-Bernat, Dimitri, Debussche, Laurent

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Abstract 2125: Roles of KAT6A and KAT6B in the biology of estrogen positive breast cancer von Meaux, Isabelle, Gorge-Bernat, Dimitri, Paz, Angele, Geslin, Catherine, Debussche, Laurent, Moll, Jürgen, Henry, Christophe

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Definition of a p53 transactivation function-deficient mutant and characterization of two independent p53 transactivation subdomains von VENOT, C, MARATRAT, M, SIERRA, V, CONSEILLER, E, DEBUSSCHE, L

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p53 mediated death of cells overexpressing MDM2 by an inhibitor of MDM2 interaction with p53 von WASYLYK, C, SALVI, R, ARGENTINI, M, DUREUIL, C, DELUMEAU, I, ABECASSIS, J, DEBUSSCHE, L, WASYLYK, B

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A Ras-GTPase-activating protein SH3-domain-binding protein von Parker, Fabienne, Maurier, Florence, Delumeau, Isabelle, Duchesne, Marc, Faucher, Didier, Debussche, Laurent, Dugue, Anita, Schweighoffer, Fabien, Tocque, Bruno

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Discovery, Structure Elucidation, and Biological Characterization of Nannocystin A, a Macrocyclic Myxobacterial Metabolite with Potent Antiproliferative Properties von Hoffmann, Holger, Kogler, Herbert, Heyse, Winfried, Matter, Hans, Caspers, Michael, Schummer, Dietmar, Klemke-Jahn, Christine, Bauer, Armin, Penarier, Geraldine, Debussche, Laurent, Brönstrup, Mark

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SAR439859, a Novel Selective Estrogen Receptor Degrader (SERD), Demonstrates Effective and Broad Antitumor Activity in Wild-Type and Mutant ER-Positive Breast Cancer Models von Shomali, Maysoun, Cheng, Jane, Sun, Fangxian, Koundinya, Malvika, Guo, Zhuyan, Hebert, Andrew T, McManus, Jessica, Levit, Mikhail N, Hoffmann, Dietmar, Courjaud, Albane, Arrebola, Rosalia, Cao, Hui, Pollard, Jack, Lee, Joon Sang, Besret, Laurent, Caron, Anne, Bangari, Dinesh S, Abecassis, Pierre-Yves, Schio, Laurent, El-Ahmad, Youssef, Halley, Frank, Tabart, Michel, Certal, Victor, Thompson, Fabienne, McCort, Gary, Filoche-Rommé, Bruno, Cheng, Hong, Garcia-Echeverria, Carlos, Debussche, Laurent, Bouaboula, Monsif

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Abstract 4024: NAMPT inhibitor decreases NAMPT capture by an antibody directed against the 5-phosphoribosyl-1-pyrophosphate-binding loop: Rationale for an NAMPT occupancy assay von Shomali, Maysoun, Hilairet, Sandrine, Duhamel, Marianne, Nardi, Frederico, Bertrand, Thomas, Penarier, Geraldine, Debussche, Laurent, Bouaboula, Monsif

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Abstract 2437: Potency and selectivity evaluation of TEAD covalent inhibitors in living cells by two complementary mass spectrometry methods von Buzy, Armelle, Paul, Pascal, Hamon, Stephanie, Venier, Olivier, Guillemot, Jean-Claude, Mikol, Vincent, Moll, Jurgen, Debussche, Laurent, Valtingojer, Iris

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Abstract 2161: A transcriptomic signature for measuring YAP1 activity in patient samples and tumor models von Spanakis, Emmanuel, Calvet, Loreley, Santos, Odette Dos, Dib, Colette, Sidhu, Sukhvinder, Moll, Jurgen, Debussche, Laurent, Pollard, Jack, Valtingojer, Iris

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Abstract P4-02-08: Amcenestrant in combination with CDK4/6 inhibitor palbociclib demonstrates synergistic anti-tumor activity in ER+ endocrine-resistant breast cancer xenograft mod... von Shomali, Maysoun, Guo, Zhuyan, Cheng, Jane, Sullivan, Amy, El-Ahmad, Youssef, Sun, Fangxian, Sidhu, Sukhvinder, Lee, Joon Sang, Cai, Hui, Pollard, Jack, Debussche, Laurent, Soria, Chris, Bouaboula, Monsif

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Abstract 4868: In vitro and in cellulo mass spectrometry study of TEAD1 palmitoylation von Buzy, Armelle, Guichard, Olivier, Zacchayus, Jean-Luc, Venier, Olivier, Courtin, Olivier, Valtingojer, Iris, Debussche, Laurent, Mikol, Vincent, Guillemot, Jean-Claude

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Abstract PS17-16: Sar439859, a novel selective estrogen receptor degrader (serd), demonstrates effective and broad antitumor activity in wild-type and mutant er-positive breast can... von Shomali, Maysoun, Sun, Fangxian, Levit, Mikhail, Pollard, Jack, Lee, Joon Sang, Schio, Laurent, El-Ahmad, Youssef, Soria, Chris, Cohen, Patrick, Debussche, Laurent, Bouaboula, Monsif

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Elucidation of Acquired Resistance to Bcl-2 and MDM2 Inhibitors in Acute Leukemia In Vitro and In Vivo von Hoffman-Luca, C Gianna, Ziazadeh, Daniel, McEachern, Donna, Zhao, Yujun, Sun, Wei, Debussche, Laurent, Wang, Shaomeng

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