Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF -mutant melanoma von Marimuthu, Adhirai, D'Andrea, Kurt, Lin, Paul S, Puzanov, Igor, Chapman, Paul B, Zhang, Jiazhong, Tsai, James, Ibrahim, Prabha N, Cho, Hanna, West, Brian L, Nathanson, Katherine L, Zhang, Kam Y. J, Zhang, Ying, Nolop, Keith, Schlessinger, Joseph, Grippo, Joseph, Shellooe, Rafe, Zhang, Chao, Flaherty, Keith T, Tsang, Garson, Powell, Ben, Kim, Kevin B, Wong, Bernice, Stumm, Michael, Ribas, Antoni, Spevak, Wayne, Higgins, Brian, Sosman, Jeffrey A, Artis, Dean R, Habets, Gaston, Hirth, Peter, Burton, Elizabeth A, Iyer, Raman, Su, Fei, Koehler, Astrid, Lee, Richard J, Bollag, Gideon, Nguyen, Hoa, McArthur, Grant A, Xu, Xiaowei

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Design and pharmacology of a highly specific dual FMS and KIT kinase inhibitor von Zhang, Chao, Ibrahim, Prabha N., Zhang, Jiazhong, Burton, Elizabeth A., Habets, Gaston, Zhang, Ying, Powell, Ben, West, Brian L., Matusow, Bernice, Tsang, Garson, Shellooe, Rafe, Carias, Heidi, Nguyen, Hoa, Marimuthu, Adhirai, Zhang, Kam Y. J., Oh, Angela, Bremer, Ryan, Hurt, Clarence R., Artis, Dean R., Wu, Guoxian, Nespi, Marika, Spevak, Wayne, Lin, Paul, Nolop, Keith, Hirth, Peter, Tesch, Greg H., Bollag, Gideon

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Scaffold-based discovery of indeglitazar, a PPAR pan-active anti-diabetic agent von Artis, Dean R, Lin, Jack J, Zhang, Chao, Wang, Weiru, Mehra, Upasana, Perreault, Mylene, Erbe, David, Krupka, Heike I, England, Bruce P, Arnold, James, Plotnikov, Alexander N, Marimuthu, Adhirai, Nguyen, Hoa, Will, Sarah, Signaevsky, Maxime, Kral, John, Cantwell, John, Settachatgull, Calvin, Yan, Douglas S, Fong, Daniel, Oh, Angela, Shi, Shenghua, Womack, Patrick, Powell, Benjamin, Habets, Gaston, West, Brian L, Zhang, Kam Y.J, Milburn, Michael V, Vlasuk, George P, Hirth, K. Peter, Nolop, Keith, Bollag, Gideon, Ibrahim, Prabha N, Tobin, James F

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Design and synthesis of thiophene dihydroisoquinolines as novel BACE1 inhibitors von Xu, Ying-zi, Yuan, Shendong, Bowers, Simeon, Hom, Roy K., Chan, Wayman, Sham, Hing L., Zhu, Yong L., Beroza, Paul, Pan, Hu, Brecht, Eric, Yao, Nanhua, Lougheed, Julie, Yan, Jiangli, Tam, Danny, Ren, Zhao, Ruslim, Lany, Bova, Michael P., Artis, Dean R.

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Including Explicit Water Molecules as Part of the Protein Structure in MM/PBSA Calculations von Zhu, Yong-Liang, Beroza, Paul, Artis, Dean R

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Design and synthesis of a novel, orally active, brain penetrant, tri-substituted thiophene based JNK inhibitor von Bowers, Simeon, Truong, Anh P., Neitz, R. Jeffrey, Neitzel, Martin, Probst, Gary D., Hom, Roy K., Peterson, Brian, Galemmo, Robert A., Konradi, Andrei W., Sham, Hing L., Tóth, Gergley, Pan, Hu, Yao, Nanhua, Artis, Dean R., Brigham, Elizabeth F., Quinn, Kevin P., Sauer, John-Michael, Powell, Kyle, Ruslim, Lany, Ren, Zhao, Bard, Frédérique, Yednock, Ted A., Griswold-Prenner, Irene

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Discovery of a Selective Inhibitor of Oncogenic B-Raf Kinase with Potent Antimelanoma Activity von Tsai, James, Lee, John T., Wang, Weiru, Zhang, Jiazhong, Cho, Hanna, Mamo, Shumeye, Bremer, Ryan, Gillette, Sam, Kong, Jun, Haass, Nikolas K., Sproesser, Katrin, Li, Ling, Smalley, Keiran S. M., Fong, Daniel, Zhu, Yong-Liang, Marimuthu, Adhirai, Nguyen, Hoa, Lam, Billy, Liu, Jennifer, Cheung, Ivana, Rice, Julie, Suzuki, Yoshihisa, Luu, Catherine, Settachatgul, Calvin, Shellooe, Rafe, Cantwell, John, Kim, Sung-Hou, Schlessinger, Joseph, Zhang, Kam Y. J., West, Brian L., Powell, Ben, Habets, Gaston, Zhang, Chao, Ibrahim, Prabha N., Hirth, Peter, Artis, Dean R., Herlyn, Meenhard, Bollag, Gideon

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Conformations of Thioamide-Containing Dipeptides:  A Computational Study von Artis, Dean R, Lipton, Mark A

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Selective and Brain-Permeable Polo-like Kinase-2 (Plk-2) Inhibitors That Reduce α-Synuclein Phosphorylation in Rat Brain von Aubele, Danielle L., Hom, Roy K., Adler, Marc, Galemmo Jr, Robert A., Bowers, Simeon, Truong, Anh P., Pan, Hu, Beroza, Paul, Neitz, R. Jeffrey, Yao, Nanhua, Lin, May, Tonn, George, Zhang, Heather, Bova, Michael P., Ren, Zhao, Tam, Danny, Ruslim, Lany, Baker, Jeanne, Diep, Linnea, Fitzgerald, Kent, Hoffman, Jennifer, Motter, Ruth, Fauss, Donald, Tanaka, Pearl, Dappen, Michael, Jagodzinski, Jacek, Chan, Wayman, Konradi, Andrei W., Latimer, Lee, Zhu, Yong L., Sham, Hing L., Anderson, John P., Bergeron, Marcelle, Artis, Dean R.

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Correction: Label Free Fragment Screening Using Surface Plasmon Resonance as a Tool for Fragment Finding РAnalyzing Parkin, a Difficult CNS Target von Regnstr̦m, Karin, Yan, Jiangli, Nguyen, Lan, Callaway, Kari, Yang, Yanli, Diep, Linnea, Xing, Weimei, Adhikari, Anirban, Beroza, Paul, Hom, Roy K., Riley, Brigit, Rudolph, Don, Jobling, Michael F., Baker, Jeanne, Johnston, Jennifer, Konradi, Andrei, Bova, Michael P., Artis, Dean R.

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Oxidative Radical Cyclization of (.omega.-Iodoalkyl)indoles and Pyrroles. Synthesis of (-)-Monomorine and Three Diastereomers von Artis, Dean R, Cho, In-Seop, Jaime-Figueroa, Saul, Muchowski, Joseph M

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Design and synthesis of disubstituted thiophene and thiazole based inhibitors of JNK von Hom, Roy K., Bowers, Simeon, Sealy, Jennifer M., Truong, Anh P., Probst, Gary D., Neitzel, Martin L., Neitz, R. Jeffrey, Fang, Larry, Brogley, Louis, Wu, Jing, Konradi, Andrei W., Sham, Hing L., Tóth, Gergely, Pan, Hu, Yao, Nanhua, Artis, Dean R., Quinn, Kevin, Sauer, John-Michael, Powell, Kyle, Ren, Zhao, Bard, Frédérique, Yednock, Ted A., Griswold-Prenner, Irene

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Development of a Novel β-Secretase Binding Assay Using the AlphaScreen Platform von Ren, Zhao, Tam, Danny, Xu, Ying-Zi, Wone, David, Yuan, Shendong, Sham, Hing L., Cheung, Harry, Regnstrom, Karin, Chen, Xiaohua, Rudolph, Donald, Jobling, Michael F., Artis, Dean R., Bova, Michael P.

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Improving the permeability of the hydroxyethylamine BACE-1 inhibitors: Structure–activity relationship of P2′ substituents von Truong, Anh P., Probst, Gary D., Aquino, Jose, Fang, Larry, Brogley, Louis, Sealy, Jennifer M., Hom, Roy K., Tucker, John A., John, Varghese, Tung, Jay S., Pleiss, Michael A., Konradi, Andrei W., Sham, Hing L., Dappen, Michael S., Tóth, Gergley, Yao, Nanhua, Brecht, Eric, Pan, Hu, Artis, Dean R., Ruslim, Lany, Bova, Michael P., Sinha, Sukanto, Yednock, Ted A., Zmolek, Wes, Quinn, Kevin P., Sauer, John-Michael

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Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: Structure–activity relationship of the aryl region von Probst, Gary D., Bowers, Simeon, Sealy, Jennifer M., Stupi, Brian, Dressen, Darren, Jagodzinska, Barbara M., Aquino, Jose, Gailunas, Andrea, Truong, Anh P., Tso, Luke, Xu, Ying-Zi, Hom, Roy K., John, Varghese, Tung, Jay S., Pleiss, Michael A., Tucker, John A., Konradi, Andrei W., Sham, Hing L., Jagodzinski, Jacek, Toth, Gergely, Brecht, Eric, Yao, Nanhua, Pan, Hu, Lin, May, Artis, Dean R., Ruslim, Lany, Bova, Michael P., Sinha, Sukanto, Yednock, Ted A., Gauby, Shawn, Zmolek, Wes, Quinn, Kevin P., Sauer, John-Michael

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Classical Complement Activation in Lupus Nephritis Correlates with Disease Biomarkers: Results from Two Observational Studies: SA-PO931 von Chang, Edmund, Low, Julian, Yousefpour, Noosha, Bao, Min, Osterloh, Jeannette, Chang, Qing, Artis, Dean R., Kroon, Henk-Andre, Andrews-Zwilling, Yaisa, Dall'Era, Maria, Yednock, Ted, Mongan, Ann

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Results of Single-Arm, Phase 1b Study of Anti-C1q Treatment (ANX009) Show that the Classical Pathway Is a Key Driver of Complement Activation and Consumption in Patients with Activ... von Bao, Min, Lichauco, Juan, Chen, Hsiang, Gomez, Harold, Tee, Michael L., Arroyo, Caroline, Lan, Joung-Liang, Fang, Yao-Fan, Chang, Edmund, Yousefpour, Noosha, Low, Julian, Chang, Qing, Osterloh, Jeannette, Manser, Paul, Mongan, Ann, Yednock, Ted, Artis, Dean R., Kroon, Henk-Andre, Andrews-Zwilling, Yaisa, Dall'Era, Maria

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Radical-based syntheses of 5-benzoyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid (ketorolac) von Artis, Dean R, Cho, In-Seop, Muchowski, Joseph M

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Potent α4β1 Peptide Antagonists as Potential Anti-Inflammatory Agents von Jackson, David Y, Quan, Clifford, Artis, Dean R, Rawson, Thomas, Blackburn, Brent, Struble, Martin, Fitzgerald, Geraldine, Chan, Kathryn, Mullins, Sheldon, Burnier, J. P, Fairbrother, Wayne J, Clark, Kevin, Berisini, Maureen, Chui, Henry, Renz, Mark, Jones, Susan, Fong, Sherman

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Structure-based design of six novel classes of nonpeptide antagonists of the bradykinin B2 receptor von ARTIS, Dean R, BROTHERTON-PLEISS, Christine, PEASE, Joseph H. B, LIN, Clara J, FERLA, Steve W, NEWMAN, Sherry R, BHAKTA, Sunil, OSTRELICH, Helene, JARNAGIN, Kurt

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