Small molecule inhibitors of the LEDGF site of human immunodeficiency virus integrase identified by fragment screening and structure based design von Peat, Thomas S, Rhodes, David I, Vandegraaff, Nick, Le, Giang, Smith, Jessica A, Clark, Lisa J, Jones, Eric D, Coates, Jonathan A V, Thienthong, Neeranat, Newman, Janet, Dolezal, Olan, Mulder, Roger, Ryan, John H, Savage, G Paul, Francis, Craig L, Deadman, John J

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Interrogating HIV integrase for compounds that bind- a SAMPL challenge von Peat, Thomas S., Dolezal, Olan, Newman, Janet, Mobley, David, Deadman, John J.

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Parallel Screening of Low Molecular Weight Fragment Libraries: Do Differences in Methodology Affect Hit Identification? von Wielens, Jerome, Headey, Stephen J., Rhodes, David I., Mulder, Roger J., Dolezal, Olan, Deadman, John J., Newman, Janet, Chalmers, David K., Parker, Michael W., Peat, Thomas S., Scanlon, Martin J.

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Design of a series of bicyclic HIV-1 integrase inhibitors. Part 2: Azoles: Effective metal chelators von Le, Giang, Vandegraaff, Nick, Rhodes, David I., Jones, Eric D., Coates, Jonathan A.V., Thienthong, Neeranat, Winfield, Lisa J., Lu, Long, Li, Xinming, Yu, Changjiang, Feng, Xiao, Deadman, John J.

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Correction: Small Molecule Inhibitors of the LEDGF Site of Human Immunodeficiency Virus Integrase Identified by Fragment Screening and Structure Based Design von Peat, Thomas S., Rhodes, David I., Vandegraaff, Nick, Le, Giang, Smith, Jessica A., Clark, Lisa J., Jones, Eric D., Coates, Jonathan A. V., Thienthong, Neeranat, Newman, Janet, Dolezal, Olan, Mulder, Roger, Ryan, John H., Savage, G. Paul, Francis, Craig L., Deadman, John J.

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The discovery of allyltyrosine based tripeptides as selective inhibitors of the HIV-1 integrase strand-transfer reaction von Dalton, Neal, Gordon, Christopher P, Boyle, Timothy P, Vandegraaf, Nicholas, Deadman, John, Rhodes, David I, Coates, Jonathan A, Pyne, Stephen G, Keller, Paul A, Bremner, John B

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Microwave-mediated synthesis and manipulation of a 2-substituted-5-aminooxazole-4-carbonitrile library von Spencer, John, Patel, Hiren, Amin, Jahangir, Callear, Samantha K., Coles, Simon J., Deadman, John J., Furman, Christophe, Mansouri, Roxane, Chavatte, Philippe, Millet, Régis

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Synthesis and solid state study of pyridine- and pyrimidine-based fragment libraries von Spencer, John, Patel, Hiren, Callear, Samantha K., Coles, Simon J., Deadman, John J.

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Crystal Structures of Novel Allosteric Peptide Inhibitors of HIV Integrase Identify New Interactions at the LEDGF Binding Site von Rhodes, David I., Peat, Thomas S., Vandegraaff, Nick, Jeevarajah, Dharshini, Newman, Janet, Martyn, John, Coates, Jonathan A. V., Ede, Nicholas J., Rea, Philip, Deadman, John J.

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Design of a series of bicyclic HIV-1 integrase inhibitors. Part 1: Selection of the scaffold von Jones, Eric D., Vandegraaff, Nick, Le, Giang, Choi, Neil, Issa, William, Macfarlane, Katherine, Thienthong, Neeranat, Winfield, Lisa J., Coates, Jonathan A.V., Lu, Long, Li, Xinming, Feng, Xiao, Yu, Changjiang, Rhodes, David I., Deadman, John J.

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Fragment-Based Design of Ligands Targeting a Novel Site on the Integrase Enzyme of Human Immunodeficiency Virus 1 von Wielens, Jerome, Headey, Stephen J., Deadman, John J., Rhodes, David I., Parker, Michael W., Chalmers, David K., Scanlon, Martin J.

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Structural basis for a new mechanism of inhibition of HIV-1 integrase identified by fragment screening and structure-based design von Rhodes, David I, Peat, Thomas S, Vandegraaff, Nick, Jeevarajah, Dharshini, Le, Giang, Jones, Eric D, Smith, Jessica A, Coates, Jonathan A V, Winfield, Lisa J, Thienthong, Neeranat, Newman, Janet, Lucent, Del, Ryan, John H, Savage, G Paul, Francis, Craig L, Deadman, John J

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Discovery of potent HIV integrase inhibitors active against raltegravir resistant viruses von Le, Giang, Vandegraaff, Nick, Rhodes, David I., Jones, Eric D., Coates, Jonathan A.V., Lu, Long, Li, Xinming, Yu, Changjiang, Feng, Xiao, Deadman, John J.

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The unexpected but predictable tetrazole packing in flexible 1-benzyl-1H-tetrazole von Spencer, John, Patel, Hiren, Deadman, John J., Palmer, Rex A., Male, Louise, Coles, Simon J., Uzoh, Ogaga G., Price, Sarah L.

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A New Process for Synthesis of Apricitabine, 2-(R)-Hydroxymethyl-4-(R)-(cytosin-1′-yl)-1,3-oxathiolane, an Anti-HIV NRTI von Marcuccio, Sebastian M, Epa, Ruwan, White, Jonathan M, Deadman, John J

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Binaphthyl-anchored antibacterial tripeptide derivatives with hydrophobic C-terminal amino acid variations von Bremner, John B, Keller, Paul A, Pyne, Stephen G, Robertson, Mark J, Sakthivel, K, Somphol, Kittiya, Baylis, Dean, Coates, Jonathan A, Deadman, John, Jeevarajah, Dharshini, Rhodes, David I

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A structure-based design approach to advance the allyltyrosine-based series of HIV integrase inhibitors von Gordon, Christopher P., Dalton, Neal, Vandegraaff, Nicholas, Deadman, John, Rhodes, David I., Coates, Jonathan A., Pyne, Stephen G., Griffith, Renate, Bremner, John B., Keller, Paul A.

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Generation of Ligand Conformations in Continuum Solvent Consistent with Protein Active Site Topology:  Application to Thrombin von Greenidge, Paulette A, Mérette, Sandrine A. M, Beck, Richard, Dodson, Guy, Goodwin, Christopher A, Scully, Michael F, Spencer, John, Weiser, Jörg, Deadman, John J

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Assembly of Urokinase Receptor-Mediated Plasminogen Activation Complexes Involves Direct, Non-Active-Site Interactions between Urokinase and Plasminogen von Ellis, Vincent, Whawell, Simon A, Werner, Finn, Deadman, John J

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Crystal structure of the HIV-1 integrase core domain in complex with sucrose reveals details of an allosteric inhibitory binding site von Wielens, Jerome, Headey, Stephen J., Jeevarajah, Dharshini, Rhodes, David I., Deadman, John, Chalmers, David K., Scanlon, Martin J., Parker, Michael W.

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