Pharmacological validation of TDO as a target for Parkinson’s disease von Perez‐Pardo, Paula, Grobben, Yvonne, Willemsen‐Seegers, Nicole, Hartog, Mitch, Tutone, Michaela, Muller, Michelle, Adolfs, Youri, Pasterkamp, Ronald Jeroen, Vu‐Pham, Diep, Doornmalen, Antoon M., Cauter, Freek, Wit, Joeri, Gerard Sterrenburg, Jan, Uitdehaag, Joost C.M., Man, Jos, Buijsman, Rogier C., Zaman, Guido J.R., Kraneveld, Aletta D.

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Comparison of the cancer gene targeting and biochemical selectivities of all targeted kinase inhibitors approved for clinical use von Uitdehaag, Joost C M, de Roos, Jeroen A D M, van Doornmalen, Antoon M, Prinsen, Martine B W, de Man, Jos, Tanizawa, Yoshinori, Kawase, Yusuke, Yoshino, Kohichiro, Buijsman, Rogier C, Zaman, Guido J R

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A guide to picking the most selective kinase inhibitor tool compounds for pharmacological validation of drug targets von Uitdehaag, Joost CM, Verkaar, Folkert, Alwan, Husam, de Man, Jos, Buijsman, Rogier C, Zaman, Guido JR

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Structural insights into human Arginase-1 pH dependence and its inhibition by the small molecule inhibitor CB-1158 von Grobben, Yvonne, Uitdehaag, Joost C.M., Willemsen-Seegers, Nicole, Tabak, Werner W.A., de Man, Jos, Buijsman, Rogier C., Zaman, Guido J.R.

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Stable aneuploid tumors cells are more sensitive to TTK inhibition than chromosomally unstable cell lines von Libouban, Marion A A, de Roos, Jeroen A D M, Uitdehaag, Joost C M, Willemsen-Seegers, Nicole, Mainardi, Sara, Dylus, Jelle, de Man, Jos, Tops, Bastiaan, Meijerink, Jules P P, Storchová, Zuzana, Buijsman, Rogier C, Medema, René H, Zaman, Guido J R

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An improved synthesis of 2-oxa-7-azaspiro[3,5]nonane and analogs as novel reagents in medicinal chemistry von Xu, Ruo, Czarniecki, Michael, Man, Jos de, Pan, Jianping, Qiang, Li, Root, Yuriko, Ying, Shihong, Su, Jing, Sun, Xijun, Zhang, Yuping, Yu, Tao, Zhang, Yang, Hu, Tao, Chen, Shu-Hui

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Target Residence Time-Guided Optimization on TTK Kinase Results in Inhibitors with Potent Anti-Proliferative Activity von Uitdehaag, Joost C.M., de Man, Jos, Willemsen-Seegers, Nicole, Prinsen, Martine B.W., Libouban, Marion A.A., Sterrenburg, Jan Gerard, de Wit, Joeri J.P., de Vetter, Judith R.F., de Roos, Jeroen A.D.M., Buijsman, Rogier C., Zaman, Guido J.R.

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Abstract 1480: Comparative cancer cell panel profiling of kinase inhibitors approved for clinical use from 2018 to 2020 von Kooijman, Jeffrey J., van Riel, Wilhelmina E., Prinsen, Martine B., Dylus, Jelle, de Roos, Jeroen A., Grobben, Yvonne, Willemsen-Seegers, Nicole, Muller, Michelle, de Man, Jos, Narumi, Yugo, Kawase, Yusuke, Buijsman, Rogier C., van Gerwen, Suzanne J., Zaman, Guido J.

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Compound Selectivity and Target Residence Time of Kinase Inhibitors Studied with Surface Plasmon Resonance von Willemsen-Seegers, Nicole, Uitdehaag, Joost C.M., Prinsen, Martine B.W., de Vetter, Judith R.F., de Man, Jos, Sawa, Masaaki, Kawase, Yusuke, Buijsman, Rogier C., Zaman, Guido J.R.

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Abstract B065: TTK inhibitors as a targeted therapy for β-catenin mutant cancers von Zaman, Guido, de Roos, Jeroen, Libouban, Marion, Prinsen, Martine, de Man, Jos, Buijsman, Rogier, Uitdehaag, Joost

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Preclinical evaluation of LCK as a novel therapeutic target in YAP-activated and FGFR2-altered cholangiocarcinoma von Conboy, Caitlin, Yonkus, Jennifer, Buckarma, EeeLN, Mun, Dong-Gi, Werneburg, Nathan, Watkins, Ryan, Guo, Yi, Wang, Juan, O'Brien, Daniel, Buijsman, Rogier, Vu, Diep, De Man, Jos, Ilyas, Sumera, Truty, Mark J., Borad, Mitesh J., Pandey, Akhilesh, Gores, Gregory J., Smoot, Rory L.

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Pharmacological validation of TDO as a target for Parkinson’s disease von Perez-Pardo, Paula, Grobben, Yvonne, Willemsen-Seegers, Nicole, Hartog, Mitch, Tutone, Michaela, Muller, Michelle, Adolfs, Youri, Pasterkamp, Ronald Jeroen, Vu-Pham, Diep, van Doornmalen, Antoon M, van Cauter, Freek, de Wit, Joeri, Gerard Sterrenburg, Jan, Uitdehaag, Joost C.M, de Man, Jos, Buijsman, Rogier C, Zaman, Guido J.R, Kraneveld, Aletta D

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Abstract 279A: Cell panel profiling of 162 small molecule therapeutics identifies response biomarkers for PARP, BET-family and proteasome inhibitors von Uitdehaag, Joost C., Kooijman, Jeffrey J., Roos, Jeroen A.D.M. de, Prinsen, Martine B.W., Dylus, Jelle, Willemsen-Seegers, Nicole, Man, Jos de, Gerwen, Suzanne J.C. van, Buijsman, Rogier C., Zaman, Guido J.R.

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Abstract A141: Computational models of synergy contribute to efficient combination screening von Uitdehaag, Joost C.M., Prinsen, Martine B.W., Tilborg, Derek W. van, Kooijman, Jeffrey J., Dylus, Jelle, Roos, Jeroen A.D.M. de, Gerwen, Suzanne J.C. van, Man, Jos de, Buijsman, Rogier C., Zaman, Guido J.R.

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Combined Cellular and Biochemical Profiling to Identify Predictive Drug Response Biomarkers for Kinase Inhibitors Approved for Clinical Use between 2013 and 2017 von Uitdehaag, Joost C M, Kooijman, Jeffrey J, de Roos, Jeroen A D M, Prinsen, Martine B W, Dylus, Jelle, Willemsen-Seegers, Nicole, Kawase, Yusuke, Sawa, Masaaki, de Man, Jos, van Gerwen, Suzanne J C, Buijsman, Rogier C, Zaman, Guido J R

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Abstract 4907: Cell line panel profiling reveals novel drug response biomarkers for BTK and CDK4/6 inhibitors von Uitdehaag, Joost C., Kooijman, Jeffrey J., Roos, Jeroen A.D.M. de, Prinsen, Martine B.W., Dylus, Jelle, Vetter, Judith de, Willemsen-Seegers, Nicole, Man, Jos de, Gerwen, Suzanne J.C. van, Buijsman, Rogier C., Zaman, Guido J.R.

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Abstract 3457: Stable aneuploid cells are more sensitive to TTK inhibition than chromosome instable cell lines von Libouban, Marion A.A., Roos, Jeroen A.D.M. de, Uitdehaag, Joost C.M., Willemsen-Seegers, Nicole, Mainardi, Sara, Dylus, Jelle, Man, Jos de, Tops, Bastiaan, Meijerink, Jules P.P., Storchová, Zuzana, Buijsman, Rogier C., Medema, René H., Zaman, Guido J.R.

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Cell Panel Profiling Reveals Conserved Therapeutic Clusters and Differentiates the Mechanism of Action of Different PI3K/mTOR, Aurora Kinase and EZH2 Inhibitors von Uitdehaag, Joost C M, de Roos, Jeroen A D M, Prinsen, Martine B W, Willemsen-Seegers, Nicole, de Vetter, Judith R F, Dylus, Jelle, van Doornmalen, Antoon M, Kooijman, Jeffrey, Sawa, Masaaki, van Gerwen, Suzanne J C, de Man, Jos, Buijsman, Rogier C, Zaman, Guido J R

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Abstract 4635: Comparative cancer cell line profiling differentiates the mechanism of action of different PI3K/mTOR, Aurora kinase and EZH2 inhibitors von Uitdehaag, Joost C.M., de Roos, Jeroen A.D.M., Prinsen, Martine B.W., de Vetter, Judith R.F., Dylus, Jelle, van Doornmalen, Antoon M., van Gerwen, Suzanne J.C., de Man, Jos, Buijsman, Rogier C., Zaman, Guido J.R.

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High-Throughput Fluorescence-Based Screening Assays for Tryptophan-Catabolizing Enzymes von Seegers, Nicole, van Doornmalen, Antoon M., Uitdehaag, Joost C.M., de Man, Jos, Buijsman, Rogier C., Zaman, Guido J.R.

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