Substrate Recognition and Activity Regulation of the Escherichia coli mRNA Endonuclease MazF von Zorzini, Valentina, Mernik, Andrej, Lah, Jurij, Sterckx, Yann G.J., De Jonge, Natalie, Garcia-Pino, Abel, De Greve, Henri, Versées, Wim, Loris, Remy

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Camelid Ig V genes reveal significant human homology not seen in therapeutic target genes, providing for a powerful therapeutic antibody platform von Klarenbeek, Alex, Mazouari, Khalil El, Desmyter, Aline, Blanchetot, Christophe, Hultberg, Anna, de Jonge, Natalie, Roovers, Rob C, Cambillau, Christian, Spinelli, Sylvia, Del-Favero, Jurgen, Verrips, Theo, de Haard, Hans J, Achour, Ikbel

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VEGFR-1/Flt-1 inhibition increases angiogenesis and improves muscle function in a mouse model of Duchenne muscular dystrophy von Bosco, Jennifer, Zhou, Zhiwei, Gabriëls, Sofie, Verma, Mayank, Liu, Nan, Miller, Brian K., Gu, Sheng, Lundberg, Dianna M., Huang, Yan, Brown, Eilish, Josiah, Serene, Meiyappan, Muthuraman, Traylor, Matthew J., Chen, Nancy, Asakura, Atsushi, De Jonge, Natalie, Blanchetot, Christophe, de Haard, Hans, Duffy, Heather S., Keefe, Dennis

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Driving Forces of Gyrase Recognition by the Addiction Toxin CcdB von Simic, Mario, De Jonge, Natalie, Loris, Remy, Vesnaver, Gorazd, Lah, Jurij

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The NHance® Mutation-Equipped Anti-MET Antibody ARGX-111 Displays Increased Tissue Penetration and Anti-Tumor Activity in Advanced Cancer Patients von Aftimos, Philippe, Rolfo, Christian, Rottey, Sylvie, Barthélémy, Philippe, Borg, Christophe, Park, Keunchil, Oh, Do-Youn, Kim, Sang-We, De Jonge, Natalie, Hanssens, Valérie, Zwanenpoel, Karen, Molthoff, Carla, Vugts, Daniëlle, Dreier, Torsten, Verheesen, Peter, van Dongen, Guus A.M.S., Jacobs, Julie, Van Rompaey, Luc, Hultberg, Anna, Michieli, Paolo, Pauwels, Patrick, Fung, Samson, Thibault, Alain, de Haard, Hans, Leupin, Nicolas, Awada, Ahmad

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Structural and Thermodynamic Characterization of Vibrio fischeri CcdB von De Jonge, Natalie, Hohlweg, Walter, Garcia-Pino, Abel, Respondek, Michal, Buts, Lieven, Haesaerts, Sarah, Lah, Jurij, Zangger, Klaus, Loris, Remy

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Rejuvenation of CcdB-Poisoned Gyrase by an Intrinsically Disordered Protein Domain von De Jonge, Natalie, Garcia-Pino, Abel, Buts, Lieven, Haesaerts, Sarah, Charlier, Daniel, Zangger, Klaus, Wyns, Lode, De Greve, Henri, Loris, Remy

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Energetic Basis of Uncoupling Folding from Binding for an Intrinsically Disordered Protein von Drobnak, Igor, De Jonge, Natalie, Haesaerts, Sarah, Vesnaver, Gorazd, Loris, Remy, Lah, Jurij

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Structural Mimicry of Receptor Interaction by Antagonistic Interleukin-6 (IL-6) Antibodies von Blanchetot, Christophe, De Jonge, Natalie, Desmyter, Aline, Ongenae, Nico, Hofman, Erik, Klarenbeek, Alex, Sadi, Ava, Hultberg, Anna, Kretz-Rommel, Anke, Spinelli, Silvia, Loris, Remy, Cambillau, Christian, de Haard, Hans

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Four individually druggable MET hotspots mediate HGF-driven tumor progression von Basilico, Cristina, Hultberg, Anna, Blanchetot, Christophe, de Jonge, Natalie, Festjens, Els, Hanssens, Valérie, Osepa, Sjudry-Ilona, De Boeck, Gitte, Mira, Alessia, Cazzanti, Manuela, Morello, Virginia, Dreier, Torsten, Saunders, Michael, de Haard, Hans, Michieli, Paolo

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Depleting MET-Expressing Tumor Cells by ADCC Provides a Therapeutic Advantage over Inhibiting HGF/MET Signaling von Hultberg, Anna, Morello, Virginia, Huyghe, Leander, De Jonge, Natalie, Blanchetot, Christophe, Hanssens, Valérie, De Boeck, Gitte, Silence, Karen, Festjens, Els, Heukers, Raimond, Roux, Benjamin, Lamballe, Fabienne, Ginestier, Christophe, Charafe-Jauffret, Emmanuelle, Maina, Flavio, Brouckaert, Peter, Saunders, Michael, Thibault, Alain, Dreier, Torsten, de Haard, Hans, Michieli, Paolo

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Dual anti-idiotypic purification of a novel, native-format biparatopic anti-MET antibody with improved in vitro and in vivo efficacy von Godar, Marie, Morello, Virginia, Sadi, Ava, Hultberg, Anna, De Jonge, Natalie, Basilico, Cristina, Hanssens, Valérie, Saunders, Michael, Lambrecht, Bart N., El Khattabi, Mohamed, de Haard, Hans, Michieli, Paolo, Blanchetot, Christophe

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A phase I, first-in-human study of argx-111, a monoclonal antibody targeting c-met in patients with solid tumors von Aftimos, Philippe G., Barthelemy, Philippe, Rolfo, Christian D., Hanssens, Valerie, De Jonge, Natalie, Silence, Karen, Dreier, Torsten, de Haard, Hans, Peeters, Marc, Thibault, Alain, Awada, Ahmad

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ARGX-111 shows activity in MET-amplified patients in a phase-I study and in preclinical models of myeloid-derived suppressor cell (MDSC) depletion in the tumor microenvironment von Rolfo, Christian Diego, Aftimos, Philippe Georges, Pallandre, Jean-Rene, Morello, Virginia, Bouard, Adeline, Cazzanti, Manuela, Barthelemy, Philippe, Rottey, Sylvie, Awada, Ahmad, Hanssens, Valerie, De Jonge, Natalie, Van Rompaey, Luc, Fung, Samson Sau-Sing, Michieli, Paolo, Borg, Christophe

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Dual anti-idiotypic purification of a novel, native-format biparatopic anti-MET antibody with improved in vitro and in vivo efficacy von Godar, Marie, Morello, Virginia, Sadi, Ava, Hultberg, Anna, De Jonge, Natalie, Basilico, Cristina, Hanssens, Valérie, Saunders, Michael, Lambrecht, Bart, El Khattabi, Mohamed, de Haard, Hans, Michieli, Paolo, Blanchetot, Christophe

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Alternative interactions define gyrase specificity in the CcdB family von De Jonge, Natalie, Simic, Mario, Buts, Lieven, Haesaerts, Sarah, Roelants, Kim, Garcia-Pino, Abel, Sterckx, Yann, De Greve, Henri, Lah, Jurij, Loris, Remy

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The NHance® mutation-equipped anti-MET antibody ARGX-111 displays increased tissue penetration and anti-tumor activity in advanced cancer patients von Aftimos, Philippe, Rolfo, Christian, Rottey, Sylvie, Barthélémy, Philippe, Borg, Christophe, Park, Keunchil, Oh, Do-Youn, Kim, Sang-We, De Jonge, Natalie, Hanssens, Valérie, Zwanenpoel, Karen, Molthoff, Carla, Vugts, Daniëlle, Dreier, Torsten, Verheesen, Peter, van Dongen, Guus A.M.S, Jacobs, Julie, Van Rompaey, Luc, Hultberg, Anna, Michieli, Paolo, Pauwels, Patrick, Fung, Samson, Thibault, Alain, de Haard, Hans, Leupin, Nicolas, Awada, Ahmad

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Rejuvenation Of CcdB-poisoned Gyrase By An Intrinsically Disordered Protein Domain von De Jonge, Natalie, Lieven, Buts, Garcia-Pino, Abel, De Greve, Henri, Wyns, Lode, Loris, Remy

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Anti-Flt-1 antibodies for treating duchenne muscular dystrophy von De Haard, Hans, Keefe, Dennis, Gabriels, Sofie, De Jonge, Natalie

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Anti-Flt-1 antibodies for treating duchenne muscular dystrophy von De Haard, Hans, Keefe, Dennis, Gabriels, Sofie, De Jonge, Natalie

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