Antibody-drug conjugates targeting TROP-2 and incorporating SN-38: A case study of anti-TROP-2 sacituzumab govitecan von Goldenberg, David M., Sharkey, Robert M.

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Sacituzumab Govitecan-hziy in Refractory Metastatic Triple-Negative Breast Cancer von Bardia, Aditya, Mayer, Ingrid A, Vahdat, Linda T, Tolaney, Sara M, Isakoff, Steven J, Diamond, Jennifer R, O’Shaughnessy, Joyce, Moroose, Rebecca L, Santin, Alessandro D, Abramson, Vandana G, Shah, Nikita C, Rugo, Hope S, Goldenberg, David M, Sweidan, Ala M, Iannone, Robert, Washkowitz, Sarah, Sharkey, Robert M, Wegener, William A, Kalinsky, Kevin

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Sacituzumab Govitecan in Metastatic Triple-Negative Breast Cancer von Bardia, Aditya, Hurvitz, Sara A, Tolaney, Sara M, Loirat, Delphine, Punie, Kevin, Oliveira, Mafalda, Brufsky, Adam, Sardesai, Sagar D, Kalinsky, Kevin, Zelnak, Amelia B, Weaver, Robert, Traina, Tiffany, Dalenc, Florence, Aftimos, Philippe, Lynce, Filipa, Diab, Sami, Cortés, Javier, O’Shaughnessy, Joyce, Diéras, Véronique, Ferrario, Cristiano, Schmid, Peter, Carey, Lisa A, Gianni, Luca, Piccart, Martine J, Loibl, Sibylle, Goldenberg, David M, Hong, Quan, Olivo, Martin S, Itri, Loretta M, Rugo, Hope S

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Sacituzumab Govitecan (IMMU-132), an Anti-Trop-2/SN-38 Antibody–Drug Conjugate: Characterization and Efficacy in Pancreatic, Gastric, and Other Cancers von Cardillo, Thomas M., Govindan, Serengulam V., Sharkey, Robert M., Trisal, Preeti, Arrojo, Roberto, Liu, Donglin, Rossi, Edmund A., Chang, Chien-Hsing, Goldenberg, David M.

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Humanized Anti-Trop-2 IgG-SN-38 Conjugate for Effective Treatment of Diverse Epithelial Cancers: Preclinical Studies in Human Cancer Xenograft Models and Monkeys von CARDILLO, Thomas M, GOVINDAN, Serengulam V, SHARKEY, Robert M, TRISAL, Preeti, GOLDENBERG, David M

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First-in-Human Trial of a Novel Anti-Trop-2 Antibody-SN-38 Conjugate, Sacituzumab Govitecan, for the Treatment of Diverse Metastatic Solid Tumors von Starodub, Alexander N, Ocean, Allyson J, Shah, Manish A, Guarino, Michael J, Picozzi, Jr, Vincent J, Vahdat, Linda T, Thomas, Sajeve S, Govindan, Serengulam V, Maliakal, Pius P, Wegener, William A, Hamburger, Steven A, Sharkey, Robert M, Goldenberg, David M

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Milatuzumab-SN-38 conjugates for the treatment of CD74+ cancers von Govindan, Serengulam V, Cardillo, Thomas M, Sharkey, Robert M, Tat, Fatma, Gold, David V, Goldenberg, David M

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Antibody Pretargeting Advances Cancer Radioimmunodetection and Radioimmunotherapy von GOLDENBERG, David M, SHARKEY, Robert M, PAGANELLI, Giovanni, BARBET, Jacques, CHATAL, Jean-Francois

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Expression patterns of CEACAM5 and CEACAM6 in primary and metastatic cancers von Blumenthal, Rosalyn D, Leon, Evelyn, Hansen, Hans J, Goldenberg, David M

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Safety analyses from the phase 3 ASCENT trial of sacituzumab govitecan in metastatic triple-negative breast cancer von Rugo, Hope S., Tolaney, Sara M., Loirat, Delphine, Punie, Kevin, Bardia, Aditya, Hurvitz, Sara A., O’Shaughnessy, Joyce, Cortés, Javier, Diéras, Véronique, Carey, Lisa A., Gianni, Luca, Piccart, Martine J., Loibl, Sibylle, Goldenberg, David M., Hong, Quan, Olivo, Martin, Itri, Loretta M., Kalinsky, Kevin

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Initial clinical trial of epratuzumab (humanized anti-CD22 antibody) for immunotherapy of systemic lupus erythematosus von Dörner, Thomas, Kaufmann, Joerg, Wegener, William A, Teoh, Nick, Goldenberg, David M, Burmester, Gerd R

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CD74: A New Candidate Target for the Immunotherapy of B-Cell Neoplasms von STEIN, Rhona, MATTES, M. Jules, CARDILLO, Thomas M, HANSEN, Hans J, CHANG, Chien-Hsing, BURTON, Jack, GOVINDAN, Serengulam, GOLDENBERG, David M

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The emergence of trophoblast cell-surface antigen 2 (TROP-2) as a novel cancer target von Goldenberg, David M, Stein, Rhona, Sharkey, Robert M

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Anti-CD22/CD20 Bispecific antibody with enhanced trogocytosis for treatment of Lupus von Rossi, Edmund A, Chang, Chien-Hsing, Goldenberg, David M

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Chemoimmunotherapy Reinduction With Epratuzumab in Children With Acute Lymphoblastic Leukemia in Marrow Relapse: A Children's Oncology Group Pilot Study von RAETZ, Elizabeth A, CAIRO, Mitchell S, ADAMSON, Peter C, BOROWITZ, Michael J, BLANEY, Susan M, KRAILO, Mark D, LEIL, Tarek A, REID, Joel M, GOLDENBERG, David M, WEGENER, William A, CARROLL, William L

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Inhibition of adhesion, invasion, and metastasis by antibodies targeting CEACAM6 (NCA-90) and CEACAM5 (Carcinoembryonic Antigen) von BLUMENTHAL, Rosalyn D, HANSEN, Hans J, GOLDENBERG, David M

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Stably Tethered Multifunctional Structures of Defined Composition Made by the Dock and Lock Method for Use in Cancer Targeting von Rossi, Edmund A., Goldenberg, David M., Cardillo, Thomas M., McBride, William J., Sharkey, Robert M., Chang, Chien-Hsing

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IL-8 secreted in a macrophage migration-inhibitory factor- and CD74-dependent manner regulates B cell chronic lymphocytic leukemia survival von Binsky, Inbal, Haran, Michal, Starlets, Diana, Gore, Yael, Lantner, Frida, Harpaz, Nurit, Leng, Lin, Goldenberg, David M, Shvidel, Lev, Berrebi, Alain, Bucala, Richard, Shachar, Idit

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Humanized Anti-CD20 Antibody, Veltuzumab, in Refractory/Recurrent Non-Hodgkin's Lymphoma: Phase I/II Results von MORSCHHAUSER, Franck, LEONARD, John P, WEGENER, William A, GOLDENBERG, David M, FAYAD, Luis, COIFFIER, Bertrand, PETILLON, Marie-Odile, COLEMAN, Morton, SCHUSTER, Stephen J, DYER, Martin J. S, HORNE, Heather, TEOH, Nick

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Antibody Conjugates of 7-Ethyl-10-hydroxycamptothecin (SN-38) for Targeted Cancer Chemotherapy von Moon, Sung-Ju, Govindan, Serengulam V, Cardillo, Thomas M, D’Souza, Christopher A, Hansen, Hans J, Goldenberg, David M

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