Antagonism of Nerve Growth Factor-TrkA Signaling and the Relief of Pain von MANTYH, Patrick W, KOLTZENBURG, Martin, MENDELL, Lorne M, TIVE, Leslie, SHELTON, David L

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Tanezumab for the Treatment of Pain from Osteoarthritis of the Knee von Lane, Nancy E, Schnitzer, Thomas J, Birbara, Charles A, Mokhtarani, Masoud, Shelton, David L, Smith, Mike D, Brown, Mark T

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Molecular Basis of Valine-Citrulline-PABC Linker Instability in Site-Specific ADCs and Its Mitigation by Linker Design von Dorywalska, Magdalena, Dushin, Russell, Moine, Ludivine, Farias, Santiago E, Zhou, Dahui, Navaratnam, Thayalan, Lui, Victor, Hasa-Moreno, Adela, Casas, Meritxell Galindo, Tran, Thomas-Toan, Delaria, Kathy, Liu, Shu-Hui, Foletti, Davide, O'Donnell, Christopher J, Pons, Jaume, Shelton, David L, Rajpal, Arvind, Strop, Pavel

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Characterization of Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Trafficking Reveals a Novel Lysosomal Targeting Mechanism via Amyloid Precursor-like Protein 2 (APLP2) von DeVay, Rachel M., Shelton, David L., Liang, Hong

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Novel class of pain drugs based on antagonism of NGF von Hefti, Franz F., Rosenthal, Arnon, Walicke, Patricia A., Wyatt, Sean, Vergara, German, Shelton, David L., Davies, Alun M.

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Proprotein convertase substilisin/kexin type 9 antagonism reduces low-density lipoprotein cholesterol in statin-treated hypercholesterolemic nonhuman primates von Liang, Hong, Chaparro-Riggers, Javier, Strop, Pavel, Geng, Tao, Sutton, Janette E, Tsai, Daniel, Bai, Lanfang, Abdiche, Yasmina, Dilley, Jeanette, Yu, Jessica, Wu, Si, Chin, S Michael, Lee, Nicole A, Rossi, Andrea, Lin, John C, Rajpal, Arvind, Pons, Jaume, Shelton, David L

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Site-Dependent Degradation of a Non-Cleavable Auristatin-Based Linker-Payload in Rodent Plasma and Its Effect on ADC Efficacy von Dorywalska, Magdalena, Strop, Pavel, Melton-Witt, Jody A, Hasa-Moreno, Adela, Farias, Santiago E, Galindo Casas, Meritxell, Delaria, Kathy, Lui, Victor, Poulsen, Kris, Sutton, Janette, Bolton, Gary, Zhou, Dahui, Moine, Ludivine, Dushin, Russell, Tran, Thomas-Toan, Liu, Shu-Hui, Rickert, Mathias, Foletti, Davide, Shelton, David L, Pons, Jaume, Rajpal, Arvind

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Anti-NGF therapy profoundly reduces bone cancer pain and the accompanying increase in markers of peripheral and central sensitization von Sevcik, Molly A., Ghilardi, Joseph R., Peters, Christopher M., Lindsay, Theodore H., Halvorson, Kyle G., Jonas, Beth M., Kubota, Kazufumi, Kuskowski, Michael A., Boustany, Leila, Shelton, David L., Mantyh, Patrick W.

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Common Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Epitopes Mediate Multiple Routes for Internalization and Function von DeVay, Rachel M, Yamamoto, Lynn, Shelton, David L, Liang, Hong

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A blocking antibody to nerve growth factor attenuates skeletal pain induced by prostate tumor cells growing in bone von HALVORSON, Kyle G, KUBOTA, Kazufumi, SEVCIK, Molly A, LINDSAY, Theodore H, SOTILLO, Julio E, GHILARDI, Joseph R, ROSOL, Thomas J, BOUSTANY, Leila, SHELTON, David L, MANTYH, Patrick W

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Effects of Monoclonal Antibodies against Nerve Growth Factor on Healthy Bone and Joint Tissues in Mice, Rats, and Monkeys: Histopathologic, Biomarker, and Microcomputed Tomographic... von Gropp, Kathryn E., Carlson, Cathy S., Evans, Mark G., Bagi, Cedo M., Reagan, William J., Hurst, Susan I., Shelton, David L., Zorbas, Mark A.

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Nerve growth factor mediates hyperalgesia and cachexia in auto-immune arthritis von Shelton, David L., Zeller, Jörg, Ho, Wei-Hsien, Pons, Jaume, Rosenthal, Arnon

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First-in-human randomized clinical trials of the safety and efficacy of tanezumab for treatment of chronic knee osteoarthritis pain or acute bunionectomy pain von Walicke, Patricia A., Hefti, Franz, Bales, Roxanne, Lu, Shiao-Ping, Ruckle, Jon L., Brown, Mark T., West, Christine R., Shelton, David L.

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Site-specific conjugation improves therapeutic index of antibody drug conjugates with high drug loading von Strop, Pavel, Delaria, Kathy, Foletti, Davide, Witt, Jody Melton, Hasa-Moreno, Adela, Poulsen, Kris, Casas, Meritxell Galindo, Dorywalska, Magdalena, Farias, Santiago, Pios, Ariel, Lui, Victor, Dushin, Russell, Zhou, Dahui, Navaratnam, Thayalan, Tran, Thomas-Toan, Sutton, Janette, Lindquist, Kevin C, Han, Bora, Liu, Shu-Hui, Shelton, David L, Pons, Jaume, Rajpal, Arvind

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Neutralization of endogenous NGF prevents the sensitization of nociceptors supplying inflamed skin von Koltzenburg, Martin, Bennett, David L. H., Shelton, David L., McMahon, Stephen B.

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Effect of Attachment Site on Stability of Cleavable Antibody Drug Conjugates von Dorywalska, Magdalena, Strop, Pavel, Melton-Witt, Jody A, Hasa-Moreno, Adela, Farias, Santiago E, Galindo Casas, Meritxell, Delaria, Kathy, Lui, Victor, Poulsen, Kris, Loo, Carole, Krimm, Stellanie, Bolton, Gary, Moine, Ludivine, Dushin, Russell, Tran, Thomas-Toan, Liu, Shu-Hui, Rickert, Mathias, Foletti, Davide, Shelton, David L, Pons, Jaume, Rajpal, Arvind

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The biological effects of endogenous nerve growth factor on adult sensory neurons revealed by a trkA-IgG fusion molecule von Mcmahon, Stephen B, Bennett, David L.H, Priestley, John V, Shelton, David L

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Mass Spectrometric Characterization of Transglutaminase Based Site-Specific Antibody–Drug Conjugates von Farias, Santiago E, Strop, Pavel, Delaria, Kathy, Galindo Casas, Meritxell, Dorywalska, Magdalena, Shelton, David L, Pons, Jaume, Rajpal, Arvind

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Engineering Highly Potent and Selective Microproteins against Nav1.7 Sodium Channel for Treatment of Pain von Shcherbatko, Anatoly, Rossi, Andrea, Foletti, Davide, Zhu, Guoyun, Bogin, Oren, Galindo Casas, Meritxell, Rickert, Mathias, Hasa-Moreno, Adela, Bartsevich, Victor, Crameri, Andreas, Steiner, Alexander R., Henningsen, Robert, Gill, Avinash, Pons, Jaume, Shelton, David L., Rajpal, Arvind, Strop, Pavel

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The Glial Cell Line-Derived Neurotrophic Factor Family Receptor Components Are Differentially Regulated within Sensory Neurons after Nerve Injury von Bennett, David L. H, Boucher, Timothy J, Armanini, Mark P, Poulsen, Kris T, Michael, Gregory J, Priestley, John V, Phillips, Heidi S, McMahon, Stephen B, Shelton, David L

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