Discovery of Potent, Selective, and Orally Bioavailable Inhibitors of USP7 with In Vivo Antitumor Activity von Leger, Paul R, Hu, Dennis X, Biannic, Berenger, Bui, Minna, Han, Xinping, Karbarz, Emily, Maung, Jack, Okano, Akinori, Osipov, Maksim, Shibuya, Grant M, Young, Kyle, Higgs, Christopher, Abraham, Betty, Bradford, Delia, Cho, Cynthia, Colas, Christophe, Jacobson, Scott, Ohol, Yamini M, Pookot, Deepa, Rana, Payal, Sanchez, Jerick, Shah, Niket, Sun, Michael, Wong, Steve, Brockstedt, Dirk G, Kassner, Paul D, Schwarz, Jacob B, Wustrow, David J

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Novel Piperidinyl-Azetidines as Potent and Selective CCR4 Antagonists Elicit Antitumor Response as a Single Agent and in Combination with Checkpoint Inhibitors von Robles, Omar, Jackson, Jeffrey J, Marshall, Lisa, Talay, Oezcan, Chian, David, Cutler, Gene, Diokno, Raymond, Hu, Dennis X, Jacobson, Scott, Karbarz, Emily, Kassner, Paul D, Ketcham, John M, McKinnell, Jenny, Meleza, Cesar, Reilly, Maureen K, Riegler, Erin, Shunatona, Hunter P, Wadsworth, Angela, Younai, Ashkaan, Brockstedt, Dirk G, Wustrow, David J, Zibinsky, Mikhail

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Potent GCN2 Inhibitor Capable of Reversing MDSC-Driven T Cell Suppression Demonstrates In Vivo Efficacy as a Single Agent and in Combination with Anti-Angiogenesis Therapy von Jackson, Jeffrey J., Shibuya, Grant M., Ravishankar, Buvana, Adusumilli, Lavanya, Bradford, Delia, Brockstedt, Dirk G., Bucher, Cyril, Bui, Minna, Cho, Cynthia, Colas, Christoph, Cutler, Gene, Dukes, Adrian, Han, Xinping, Hu, Dennis X., Jacobson, Scott, Kassner, Paul D., Katibah, George E., Ko, Michelle Yoo Min, Kolhatkar, Urvi, Leger, Paul R., Ma, Anqi, Marshall, Lisa, Maung, Jack, Ng, Andrew A., Okano, Akinori, Pookot, Deepa, Poon, Daniel, Ramana, Chandru, Reilly, Maureen K., Robles, Omar, Schwarz, Jacob B., Shakhmin, Anton A., Shunatona, Hunter P., Sreenivasan, Raashi, Tivitmahaisoon, Parcharee, Xu, Mengshu, Zaw, Thant, Wustrow, David J., Zibinsky, Mikhail

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Discovery of a Potent and Selective CCR4 Antagonist That Inhibits T reg Trafficking into the Tumor Microenvironment von Jackson, Jeffrey J, Ketcham, John M, Younai, Ashkaan, Abraham, Betty, Biannic, Berenger, Beck, Hilary P, Bui, Minna H T, Chian, David, Cutler, Gene, Diokno, Raymond, Hu, Dennis X, Jacobson, Scott, Karbarz, Emily, Kassner, Paul D, Marshall, Lisa, McKinnell, Jenny, Meleza, Cesar, Okal, Abood, Pookot, Deepa, Reilly, Maureen K, Robles, Omar, Shunatona, Hunter P, Talay, Oezcan, Walker, James R, Wadsworth, Angela, Wustrow, David J, Zibinsky, Mikhail

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Discovery of a Potent and Selective CCR4 Antagonist That Inhibits Treg Trafficking into the Tumor Microenvironment von Jackson, Jeffrey J, Ketcham, John M, Younai, Ashkaan, Abraham, Betty, Biannic, Berenger, Beck, Hilary P, Bui, Minna H. T, Chian, David, Cutler, Gene, Diokno, Raymond, Hu, Dennis X, Jacobson, Scott, Karbarz, Emily, Kassner, Paul D, Marshall, Lisa, McKinnell, Jenny, Meleza, Cesar, Okal, Abood, Pookot, Deepa, Reilly, Maureen K, Robles, Omar, Shunatona, Hunter P, Talay, Oezcan, Walker, James R, Wadsworth, Angela, Wustrow, David J, Zibinsky, Mikhail

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3-Substituted GABA analogs with central nervous system activity: A review von Bryans, Justin S., Wustrow, David J.

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Structure−Activity Relationships of Pregabalin and Analogues That Target the α2-δ Protein von Belliotti, Thomas R, Capiris, Thomas, Ekhato, I. Victor, Kinsora, Jack J, Field, Mark J, Heffner, Thomas G, Meltzer, Leonard T, Schwarz, Jacob B, Taylor, Charles P, Thorpe, Andrew J, Vartanian, Mark G, Wise, Lawrence D, Zhi-Su, Ti, Weber, Mark L, Wustrow, David J

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Oxadiazolone bioisosteres of pregabalin and gabapentin von Wustrow, David J., Belliotti, Thomas R., Capiris, Thomas, Kneen, Clare O., Bryans, Justin S., Field, Mark J., Williams, Dic, El-Kattan, Ayman, Buchholz, Lisa, Kinsora, Jack J., Lotarski, Susan M., Vartanian, Mark G., Taylor, Charles P., Donevan, Sean D., Thorpe, Andrew J., Schwarz, Jacob B.

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The design and synthesis of human branched-chain amino acid aminotransferase inhibitors for treatment of neurodegenerative diseases von Hu, Lain-Yen, Boxer, Peter A., Kesten, Suzanne R., Lei, Huangshu J., Wustrow, David J., Moreland, David W., Zhang, Liming, Ahn, Kay, Ryder, Todd R., Liu, Xiaohong, Rubin, John R., Fahnoe, Kelly, Carroll, Richard T., Dutta, Satavisha, Fahnoe, Douglass C., Probert, Albert W., Roof, Robin L., Rafferty, Michael F., Kostlan, Catherine R., Scholten, Jeffrey D., Hood, Molly, Ren, Xiao-Dan, Schielke, Gerald P., Su, Ti-Zhi, Taylor, Charles P., Mistry, Anil, McConnell, Patrick, Hasemann, Charles, Ohren, Jeffrey

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Discovery of a novel potent GABA(B) receptor agonist von Xu, Feng, Peng, Ge, Phan, Thu, Dilip, Usha, Chen, Jian Lu, Chernov-Rogan, Tania, Zhang, Xuexiang, Grindstaff, Kent, Annamalai, Thamil, Koller, Kerry, Gallop, Mark A, Wustrow, David J

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Discovery of a novel potent GABAB receptor agonist von Xu, Feng, Peng, Ge, Phan, Thu, Dilip, Usha, Chen, Jian Lu, Chernov-Rogan, Tania, Zhang, Xuexiang, Grindstaff, Kent, Annamalai, Thamil, Koller, Kerry, Gallop, Mark A, Wustrow, David J

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Isoindolinone enantiomers having affinity for the dopamine D4 receptor von BELLIOTTI, T. R, BRINK, W. A, WISE, L. D, KESTEN, S. R, RUBIN, J. R, WUSTROW, D. J, ZOSKI, K. T, WHETZEL, S. Z, CORBIN, A. E, PUGSLEY, T. A, HEFFNER, T. G

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Novel Cyclopropyl β-Amino Acid Analogues of Pregabalin and Gabapentin That Target the α2-δ Protein von Schwarz, Jacob B, Gibbons, Sian E, Graham, Shelley R, Colbry, Norman L, Guzzo, Peter R, Le, Van-Duc, Vartanian, Mark G, Kinsora, Jack J, Lotarski, Susan M, Li, Zheng, Dickerson, Melvin R, Su, Ti-Zhi, Weber, Mark L, El-Kattan, Ayman, Thorpe, Andrew J, Donevan, Sean D, Taylor, Charles P, Wustrow, David J

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1-Benzylbenzimidazoles : The discovery of a novel series of bradykinin B1 receptor antagonists von QIN GUO, CHANDRASEKHAR, Jayaraman, BROOM, Daniel, KERSHAW, Mark T, SIMMERMACHER-MAYER, Jean, YAO PENG, HODGETTS, Kevin J, IHLE, David, WUSTROW, David J, CHENARD, Bertrand L, KRAUSE, James E, HUTCHISON, Alan, ALDERMAN, Dawn, CHENG, Charles, CORTRIGHT, Daniel

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Heteroaromatic side-chain analogs of pregabalin von Schelkun, Robert M., Yuen, Po-wai, Wustrow, David J., Kinsora, Jack, Su, Ti-Zhi, Vartanian, Mark G.

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Aminopyrazine CB1 receptor inverse agonists von Wustrow, David J., Maynard, George D., Yuan, Jun, Zhao, He, Mao, Jianmin, Guo, Qin, Kershaw, Mark, Hammer, Jack, Brodbeck, Robbin M., Near, Kristen E., Zhou, Dan, Beers, David S., Chenard, Bertrand L., Krause, James E., Hutchison, Alan J.

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Carboxylate bioisosteres of gabapentin von Burgos-Lepley, Carmen E., Thompson, Lisa R., Kneen, Clare O., Osborne, Simon A., Bryans, Justin S., Capiris, Thomas, Suman-Chauhan, Nirmala, Dooley, David J., Donovan, Cindy M., Field, Mark J., Vartanian, Mark G., Kinsora, Jack J., Lotarski, Susan M., El-Kattan, Ayman, Walters, Karen, Cherukury, Madhu, Taylor, Charles P., Wustrow, David J., Schwarz, Jacob B.

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Carboxylate bioisosteres of pregabalin von Schwarz, Jacob B., Colbry, Norman L., Zhu, Zhijian, Nichelson, Brian, Barta, Nancy S., Lin, Kristin, Hudack, Raymond A., Gibbons, Sian E., Galatsis, Paul, DeOrazio, Russell J., Manning, David D., Vartanian, Mark G., Kinsora, Jack J., Lotarski, Susan M., Li, Zheng, Dickerson, Melvin R., El-Kattan, Ayman, Thorpe, Andrew J., Donevan, Sean D., Taylor, Charles P., Wustrow, David J.

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Synthesis of 4-alkyl-pyrrolidine-3-carboxylic acid stereoisomers von Ling, Rong, Ekhato, I.Victor, Rubin, J.Ronald, Wustrow, David J

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Structure-activity relationships of pregabalin and analogues that target the alpha(2)-delta protein von Belliotti, Thomas R, Capiris, Thomas, Ekhato, I Victor, Kinsora, Jack J, Field, Mark J, Heffner, Thomas G, Meltzer, Leonard T, Schwarz, Jacob B, Taylor, Charles P, Thorpe, Andrew J, Vartanian, Mark G, Wise, Lawrence D, Zhi-Su, Ti, Weber, Mark L, Wustrow, David J

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