P137 - A novel method for the isolation of NR8383 lysosomes and measurement of intralysosomal drug concentrations von Francis, Laura, Hallifax, David, Harrell, Andrew, Galetin, Aleksandra

Volltext

Primary Hepatocytes: Current Understanding of the Regulation of Metabolic Enzymes and Transporter Proteins, and Pharmaceutical Practice for the Use of Hepatocytes in Metabolism, En... von Hewitt, Nicola J., Gómez Lechón, María José, Houston, J. Brian, Hallifax, David, Brown, Hayley S., Maurel, Patrick, Kenna, J. Gerald, Gustavsson, Lena, Lohmann, Christina, Skonberg, Christian, Guillouzo, Andre, Tuschl, Gregor, Li, Albert P., LeCluyse, Edward, Groothuis, Geny M. M., Hengstler, Jan G.

Volltext

The impact of lysosomal sequestration on desipramine cellular disposition and metabolic drug–drug interactions in rat and human hepatocytes von Ufuk, Ayşe, Matsunaga, Norikazu, Hallifax, David, Galetin, Aleksandra

Volltext

Use of segregated hepatocyte scaling factors and cross-species relationships to resolve clearance dependence in the prediction of human hepatic clearance von Hallifax, David, Houston, James

Volltext

Utilising Magnetically Isolated Lysosomes for Direct Quantification of Intralysosomal Drug Concentrations by LC-MS/MS Analysis: An Investigatory Study With Imipramine von Francis, Laura, Harrell, Andrew, Hallifax, David, Galetin, Aleksandra

Volltext

Utilising magnetically isolated lysosomes for direct quantification of intralysosomal drug concentrations by LC MS/MS analysis: An investigatory study with imipramine von Francis, Laura, Harrell, Andrew, Hallifax, David, Galetin, Aleksandra

Volltext

Prediction of Human Metabolic Clearance from In Vitro Systems: Retrospective Analysis and Prospective View von Hallifax, David, Foster, Joanne A, Houston, J. Brian

Volltext

Exploring the Boundaries for In Vitro–In Vivo Extrapolation: Use of Isolated Rat Hepatocytes in Co-culture and Impact of Albumin Binding Properties in the Prediction of Clearance o... von Francis, Laura, Ogungbenro, Kayode, De Bruyn, Tom, Houston, J. Brian, Hallifax, David

Volltext

Evaluation of Hepatic Clearance Prediction Using In Vitro Data: Emphasis on Fraction Unbound in Plasma and Drug Ionisation Using a Database of 107 Drugs von Hallifax, David, Houston, J. Brian

Volltext

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of... von Godoy, Patricio, Hewitt, Nicola J., Albrecht, Ute, Andersen, Melvin E., Ansari, Nariman, Bhattacharya, Sudin, Bode, Johannes Georg, Bolleyn, Jennifer, Borner, Christoph, Böttger, Jan, Braeuning, Albert, Budinsky, Robert A., Burkhardt, Britta, Cameron, Neil R., Camussi, Giovanni, Cho, Chong-Su, Choi, Yun-Jaie, Craig Rowlands, J., Dahmen, Uta, Damm, Georg, Dirsch, Olaf, Donato, María Teresa, Dong, Jian, Dooley, Steven, Drasdo, Dirk, Eakins, Rowena, Ferreira, Karine Sá, Fonsato, Valentina, Fraczek, Joanna, Gebhardt, Rolf, Gibson, Andrew, Glanemann, Matthias, Goldring, Chris E. P., Gómez-Lechón, María José, Groothuis, Geny M. M., Gustavsson, Lena, Guyot, Christelle, Hallifax, David, Hammad, Seddik, Hayward, Adam, Häussinger, Dieter, Hellerbrand, Claus, Hewitt, Philip, Hoehme, Stefan, Holzhütter, Hermann-Georg, Houston, J. Brian, Hrach, Jens, Ito, Kiyomi, Jaeschke, Hartmut, Keitel, Verena, Kelm, Jens M., Kevin Park, B., Kordes, Claus, Kullak-Ublick, Gerd A., LeCluyse, Edward L., Lu, Peng, Luebke-Wheeler, Jennifer, Lutz, Anna, Maltman, Daniel J., Matz-Soja, Madlen, McMullen, Patrick, Merfort, Irmgard, Messner, Simon, Meyer, Christoph, Mwinyi, Jessica, Naisbitt, Dean J., Nussler, Andreas K., Olinga, Peter, Pampaloni, Francesco, Pi, Jingbo, Pluta, Linda, Przyborski, Stefan A., Ramachandran, Anup, Rogiers, Vera, Rowe, Cliff, Schelcher, Celine, Schmich, Kathrin, Schwarz, Michael, Singh, Bijay, Stelzer, Ernst H. K., Stieger, Bruno, Stöber, Regina, Sugiyama, Yuichi, Tetta, Ciro, Thasler, Wolfgang E., Vanhaecke, Tamara, Vinken, Mathieu, Weiss, Thomas S., Widera, Agata, Woods, Courtney G., Xu, Jinghai James, Yarborough, Kathy M., Hengstler, Jan G.

Volltext

Use of segregated hepatocyte scaling factors and cross-species relationship to resolve clearance-dependency in prediction of human hepatic clearance von Hallifax, David, Houston, James Brian

Volltext

SP268IMPACT OF CHRONIC KIDNEY DISEASE ON THE DRUGS ELIMINATED PREDOMINANTLY THROUGH A NON-RENAL ROUTE: A PROOF OF CONCEPT STUDY WITH CITALOPRAM von Chinnadurai, Rajkumar, Al-Qassabi, Jokha, Darwich, Adam, Murphy, Susan, Hallifax, David, Rostami, Amin, Kalra, Philip

Volltext

Comparison of cryopreserved HepaRG cells with cryopreserved human hepatocytes for prediction of clearance for 26 drugs von Zanelli, Ugo, Caradonna, Nicola Pasquale, Hallifax, David, Turlizzi, Elisa, Houston, J Brian

Volltext

Importance of the Unstirred Water Layer and Hepatocyte Membrane Integrity In Vitro for Quantification of Intrinsic Metabolic Clearance von Wood, Francesca L., Houston, J. Brian, Hallifax, David

Volltext

Exploring the boundaries for in vitro-in vivo extrapolation: Use of isolated hepatocytes in co-culture and impact of albumin binding properties in the prediction of clearance of va... von Francis, Laura, Ogungbenro, Kayode, De Bruyn, Tom, Houston, J Brian, Hallifax, David

Volltext

Evaluation of Hepatic Clearance Prediction Using In Vitro Data: Emphasis on Fraction Unbound in Plasma and Drug lonisation Using a Database of 107 Drugs von HALLIFAX, David, HOUSTON, J. Brian

Volltext

Prediction of in vivo drug-drug interactions from in vitro data : Factors affecting prototypic drug-drug interactions involving CYP2C9, CYP2D6 and CYP3A4 von BROWN, Hayley S, GALETIN, Aleksandra, HALLIFAX, David, HOUSTON, J. Brian

Volltext

Clearance-dependent underprediction of in vivo intrinsic clearance from human hepatocytes: Comparison with permeabilities from artificial membrane (PAMPA) assay, in silico and caco... von Hallifax, David, Turlizzi, Elisa, Zanelli, Ugo, Houston, J. Brian

Volltext

Predicting P-glycoprotein effects on oral absorption: correlation of transport in Caco-2 with drug pharmacokinetics in wild-type and mdr1a(-/-) mice in vivo von Collett, Andrew, Tanianis-Hughes, Jolanta, Hallifax, David, Warhurst, Geoff

Volltext

Metabolite formation kinetics and intrinsic clearance of phenacetin, tolbutamide, alprazolam, and midazolam in adenoviral cytochrome P450-transfected HepG2 cells and comparison wit... von Donato, M Teresa, Hallifax, David, Picazo, Laura, Castell, José V, Houston, J Brian, Gomez-Lechón, M José, Lahoz, Agustin

Volltext