Clonal selection drives genetic divergence of metastatic medulloblastoma von Wu, Xiaochong, Northcott, Paul A., Dubuc, Adrian, Dupuy, Adam J., Shih, David J. H., Witt, Hendrik, Croul, Sidney, Bouffet, Eric, Fults, Daniel W., Eberhart, Charles G., Garzia, Livia, Van Meter, Timothy, Zagzag, David, Jabado, Nada, Schwartzentruber, Jeremy, Majewski, Jacek, Scheetz, Todd E., Pfister, Stefan M., Korshunov, Andrey, Li, Xiao-Nan, Scherer, Stephen W., Cho, Yoon-Jae, Akagi, Keiko, MacDonald, Tobey J., Koster, Jan, McCabe, Martin G., Sarver, Aaron L., Collins, V. Peter, Weiss, William A., Largaespada, David A., Collier, Lara S., Taylor, Michael D.

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Role of DNA repair defects in predicting immunotherapy response von Zhang, Jing, Shih, David J. H., Lin, Shiaw-Yih

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The IL6/JAK/STAT3 signaling axis is a therapeutic vulnerability in SMARCB1-deficient bladder cancer von Amara, Chandra Sekhar, Kami Reddy, Karthik Reddy, Yuntao, Yang, Chan, Yuen San, Piyarathna, Danthasinghe Waduge Badrajee, Dobrolecki, Lacey Elizabeth, Shih, David J. H., Shi, Zhongcheng, Xu, Jun, Huang, Shixia, Ellis, Matthew J., Apolo, Andrea B., Ballester, Leomar Y., Gao, Jianjun, Hansel, Donna E., Lotan, Yair, Hodges, H. Courtney, Lerner, Seth P., Creighton, Chad J., Sreekumar, Arun, Zheng, W. Jim, Msaouel, Pavlos, Kavuri, Shyam M., Putluri, Nagireddy

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A Hematogenous Route for Medulloblastoma Leptomeningeal Metastases von Garzia, Livia, Kijima, Noriyuki, Morrissy, A. Sorana, De Antonellis, Pasqualino, Guerreiro-Stucklin, Ana, Holgado, Borja L., Wu, Xiaochong, Wang, Xin, Parsons, Michael, Zayne, Kory, Manno, Alex, Kuzan-Fischer, Claudia, Nor, Carolina, Donovan, Laura K., Liu, Jessica, Qin, Lei, Garancher, Alexandra, Liu, Kun-Wei, Mansouri, Sheila, Luu, Betty, Thompson, Yuan Yao, Ramaswamy, Vijay, Peacock, John, Farooq, Hamza, Skowron, Patryk, Shih, David J.H., Li, Angela, Ensan, Sherine, Robbins, Clinton S., Cybulsky, Myron, Mitra, Siddhartha, Ma, Yussanne, Moore, Richard, Mungall, Andy, Cho, Yoon-Jae, Weiss, William A., Chan, Jennifer A., Hawkins, Cynthia E., Massimino, Maura, Jabado, Nada, Zapotocky, Michal, Sumerauer, David, Bouffet, Eric, Dirks, Peter, Tabori, Uri, Sorensen, Poul H.B., Brastianos, Priscilla K., Aldape, Kenneth, Jones, Steven J.M., Marra, Marco A., Woodgett, James R., Wechsler-Reya, Robert J., Fults, Daniel W., Taylor, Michael D.

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Biophysical Reviews special issue call: quantitative methods to decipher cellular heterogeneity — from single-cell to spatial omic methods von Ho, Joshua W. K., Chen, Xi, He, Mu, Huang, Yuanhua, Mar, Jessica C., Shih, David J. H., Wu, Angela R.

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Proteome Instability Is a Therapeutic Vulnerability in Mismatch Repair-Deficient Cancer von McGrail, Daniel J., Garnett, Jeannine, Yin, Jun, Dai, Hui, Shih, David J.H., Lam, Truong Nguyen Anh, Li, Yang, Sun, Chaoyang, Li, Yongsheng, Schmandt, Rosemarie, Wu, Ji Yuan, Hu, Limei, Liang, Yulong, Peng, Guang, Jonasch, Eric, Menter, David, Yates, Melinda S., Kopetz, Scott, Lu, Karen H., Broaddus, Russell, Mills, Gordon B., Sahni, Nidhi, Lin, Shiaw-Yih

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CNGPLD: case–control copy-number analysis using Gaussian process latent difference von Shih, David J H, Li, Ruoxing, Müller, Peter, Zheng, W Jim, Do, Kim-Anh, Lin, Shiaw-Yih, Carter, Scott L

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TERT promoter mutations are highly recurrent in SHH subgroup medulloblastoma von Remke, Marc, Ramaswamy, Vijay, Peacock, John, Shih, David J. H., Koelsche, Christian, Northcott, Paul A., Hill, Nadia, Cavalli, Florence M. G., Kool, Marcel, Wang, Xin, Mack, Stephen C., Barszczyk, Mark, Morrissy, A. Sorana, Wu, Xiaochong, Agnihotri, Sameer, Luu, Betty, Jones, David T. W., Garzia, Livia, Dubuc, Adrian M., Zhukova, Nataliya, Vanner, Robert, Kros, Johan M., French, Pim J., Van Meir, Erwin G., Vibhakar, Rajeev, Zitterbart, Karel, Chan, Jennifer A., Bognár, László, Klekner, Almos, Lach, Boleslaw, Jung, Shin, Saad, Ali G., Liau, Linda M., Albrecht, Steffen, Zollo, Massimo, Cooper, Michael K., Thompson, Reid C., Delattre, Oliver O., Bourdeaut, Franck, Doz, François F., Garami, Miklós, Hauser, Peter, Carlotti, Carlos G., Van Meter, Timothy E., Massimi, Luca, Fults, Daniel, Pomeroy, Scott L., Kumabe, Toshiro, Ra, Young Shin, Leonard, Jeffrey R., Elbabaa, Samer K., Mora, Jaume, Rubin, Joshua B., Cho, Yoon-Jae, McLendon, Roger E., Bigner, Darell D., Eberhart, Charles G., Fouladi, Maryam, Wechsler-Reya, Robert J., Faria, Claudia C., Croul, Sidney E., Huang, Annie, Bouffet, Eric, Hawkins, Cynthia E., Dirks, Peter B., Weiss, William A., Schüller, Ulrich, Pollack, Ian F., Rutkowski, Stefan, Meyronet, David, Jouvet, Anne, Fèvre-Montange, Michelle, Jabado, Nada, Perek-Polnik, Marta, Grajkowska, Wieslawa A., Kim, Seung-Ki, Rutka, James T., Malkin, David, Tabori, Uri, Pfister, Stefan M., Korshunov, Andrey, von Deimling, Andreas, Taylor, Michael D.

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Tumour mutational burden is overestimated by target cancer gene panels von Fang, Hu, Bertl, Johanna, Zhu, Xiaoqiang, Lam, Tai Chung, Wu, Song, Shih, David J.H., Wong, Jason W.H.

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The impact of the multi-disciplinary molecular tumour board and integrative next generation sequencing on clinical outcomes in advanced solid tumours von El Helali, Aya, Lam, Tai-Chung, Ko, Elaine Yee-Ling, Shih, David J.H., Chan, Chun Kau, Wong, Charlene H.L., Wong, Jason W.H., Cheung, Lydia W.T., Lau, Johnny K.S., Liu, Anthony P.Y., Chan, Ann S.Y., Loong, Herbert H., Lam, Stephen Tak Sum, Chan, Godfrey Chi-Fung, Lee, Victor H.F., Yuen, Kwok Keung, Ng, Wai-Tong, Lee, Anne W.M., Ma, Edmond S.K.

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Exploiting induced vulnerability to overcome PARPi resistance and clonal heterogeneity in BRCA mutant triple-negative inflammatory breast cancer von Shih, David J H, Chen, Mei-Kuang, Yin, Jun, McGrail, Daniel J, Dai, Hui, Wei, Rongbin, Zhang, Jing, Zheng, Wenjin Jim, Do, Kim-Anh, Yang, Liuqing, Hung, Mien-Chie, Lin, Shiaw-Yih

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Genomic characterization of human brain metastases identifies drivers of metastatic lung adenocarcinoma von Shih, David J. H., Nayyar, Naema, Bihun, Ivanna, Dagogo-Jack, Ibiayi, Gill, Corey M., Aquilanti, Elisa, Bertalan, Mia, Kaplan, Alexander, D’Andrea, Megan R., Chukwueke, Ugonma, Ippen, Franziska Maria, Alvarez-Breckenridge, Christopher, Camarda, Nicholas D., Lastrapes, Matthew, McCabe, Devin, Kuter, Ben, Kaufman, Benjamin, Strickland, Matthew R., Martinez-Gutierrez, Juan Carlos, Nagabhushan, Deepika, De Sauvage, Magali, White, Michael D., Castro, Brandyn A., Hoang, Kaitlin, Kaneb, Andrew, Batchelor, Emily D., Paek, Sun Ha, Park, Sun Hye, Martinez-Lage, Maria, Berghoff, Anna S., Merrill, Parker, Gerstner, Elizabeth R., Batchelor, Tracy T., Frosch, Matthew P., Frazier, Ryan P., Borger, Darrell R., Iafrate, A. John, Johnson, Bruce E., Santagata, Sandro, Preusser, Matthias, Cahill, Daniel P., Carter, Scott L., Brastianos, Priscilla K.

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Divergent clonal selection dominates medulloblastoma at recurrence von Garzia, Livia, Zuyderduyn, Scott, Huang, Xi, Skowron, Patryk, Remke, Marc, Cavalli, Florence M. G., Ramaswamy, Vijay, Lindsay, Patricia E., Jelveh, Salomeh, Donovan, Laura K., Wang, Xin, Luu, Betty, Zayne, Kory, Thiessen, Nina, Mercier, Eloi, Mungall, Karen L., Ma, Yusanne, Tse, Kane, Shumansky, Karey, Roth, Andrew J. L., Shah, Sohrab, Farooq, Hamza, Holgado, Borja L., Liu, Jessica, Mack, Stephen C., Nor, Carolina, Rolider, Adi, Thompson, Yuan Y., Wu, Xiaochong, Pugh, Trevor, Ally, Adrian, Bilenky, Mikhail, Cheng, Young, Corbett, Richard D., He, An, Li, Haiyan I., Long, William, Mayo, Michael, Plettner, Patrick, Qian, Jenny Q., Schein, Jacqueline E., Tam, Angela, Wong, Tina, Zhao, Yongjun, Pimentel, José, Shalaby, Tarek, Hamilton, Ronald L., Li, Xiao-Nan, Bendel, Anne E., Fults, Daniel W., Walter, Andrew W., Kumabe, Toshihiro, Tominaga, Teiji, Collins, V. Peter, Cho, Yoon-Jae, Hoffman, Caitlin, Garvin, James H., Stearns, Duncan S., Schüller, Ulrich, Zitterbart, Karel, Puget, Stephanie, Ayrault, Olivier, Dunn, Sandra E., Tirapelli, Daniela P. C., Hallahan, Andrew R., Ingram, Wendy, MacDonald, Tobey J., Olson, Jeffrey J., Van Meir, Erwin G., Lee, Ji-Yeoun, Wang, Kyu-Chang, Kim, Seung-Ki, Cho, Byung-Kyu, Pietsch, Torsten, Fleischhack, Gudrun, Tippelt, Stephan, Lindsey, Janet C., Clifford, Steven C., Cooper, Michael K., Packer, Roger J., Massimino, Maura, Garre, Maria Luisa, Bartels, Ute, Dirks, Peter, Bouffet, Eric, Rutka, James T., Wechsler-Reya, Robert J., Weiss, William A., Collier, Lara S., Dupuy, Adam J., Korshunov, Andrey, Jones, David T. W., Kool, Marcel, Northcott, Paul A., Moore, Richard A., Jabado, Nada, Jones, Steven J. M., Malkin, David, Marra, Marco A., Taylor, Michael D.

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Prognostic value of medulloblastoma extent of resection after accounting for molecular subgroup: a retrospective integrated clinical and molecular analysis von Thompson, Eric M, MD, Hielscher, Thomas, MSc, Bouffet, Eric, Prof, Remke, Marc, MD, Luu, Betty, BSc, Gururangan, Sridharan, Prof, McLendon, Roger E, Prof, Bigner, Darell D, Prof, Lipp, Eric S, MD, Perreault, Sebastien, MD, Cho, Yoon-Jae, MD, Grant, Gerald, MD, Kim, Seung-Ki, Prof, Lee, Ji Yeoun, MD, Rao, Amulya A Nageswara, MD, Li, Kay Ka Wai, MD, Ng, Ho-Keung, Prof, Yao, Yu, MD, Kumabe, Toshihiro, MD, Tominaga, Teiji, Prof, Grajkowska, Wieslawa A, Prof, Perek-Polnik, Marta, Prof, Low, David C Y, MBBCh, Seow, Wan Tew, MBBS, Chang, Kenneth T E, MBBCh, Mora, Jaume, Prof, Pollack, Ian F, Prof, Hamilton, Ronald L, MD, Leary, Sarah, MD, Moore, Andrew S, PhD, Ingram, Wendy J, PhD, Hallahan, Andrew R, MBBS, Jouvet, Anne, MD, Fèvre-Montange, Michelle, PhD, Vasiljevic, Alexandre, MD, Faure-Conter, Cecile, MD, Shofuda, Tomoko, PhD, Hashimoto, Naoya, MD, Jabado, Nada, MD, Weil, Alexander G, MD, Gayden, Tenzin, PhD, Wataya, Takafumi, MD, Shalaby, Tarek, MD, Grotzer, Michael, Prof, Zitterbart, Karel, PhD, Sterba, Jaroslav, Prof, Kren, Leos, MD, Hortobágyi, Tibor, Prof, Klekner, Almos, PhD, László, Bognár, Prof, Pócza, Tímea, MSc, Hauser, Peter, MD, Schüller, Ulrich, MD, Jung, Shin, Prof, Jang, Woo-Youl, MD, French, Pim J, Prof, Kros, Johan M, Prof, van Veelen, Marie-Lise C, MD, Massimi, Luca, MD, Leonard, Jeffrey R, Prof, Rubin, Joshua B, MD, Vibhakar, Rajeev, MD, Chambless, Lola B, MD, Cooper, Michael K, MD, Thompson, Reid C, Prof, Carvalho, Alice, MD, Nunes, Sofia, MD, Pimentel, José, MD, Fan, Xing, MD, Lyden, David, Prof, Garzia, Livia, PhD, Shih, David J H, PhD, Kijima, Noriyuki, MD, Schneider, Christian, MD, Adamski, Jennifer, PhD, Northcott, Paul A, PhD, Kool, Marcel, PhD, Jones, David T W, PhD, Chan, Jennifer A, MD, Nikolic, Ana, MD, Garre, Maria Luisa, MD, Van Meir, Erwin G, Prof, Osuka, Satoru, MD, Olson, Jeffrey J, Prof, Jahangiri, Arman, BSc, Castro, Brandyn A, BSc, Gupta, Nalin, MD, Moxon-Emre, Iska, MSc, Mabbott, Donald J, PhD, Lassaletta, Alvaro, MD, Hawkins, Cynthia E, Prof, Tabori, Uri, MD, Drake, James, Prof, Kulkarni, Abhaya, Prof, Dirks, Peter, Prof, Rutka, James T, Prof, Pfister, Stefan M, Prof, Packer, Roger J, Prof, Ramaswamy, Vijay, MD, Taylor, Michael D, Dr Prof

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Abstract NG14: Proteome instability is an immunogenic therapeutic vulnerability in mismatch repair deficient cancer von Sahni, Nidhi, McGrail, Daniel J., Garnett, Jeannine, Yin, Jun, Dai, Hui, Shih, David J. H., Peng, Guang, Menter, David, Yates, Melinda S., Kopetz, Scott, Lu, Karen, Broaddus, Russell, Mills, Gordon B., Lin, Shiaw Y.

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Abstract 1445: Integrative genomics identifies actionable targets for therapy in medulloblastoma subgroups von Northcott, Paul A., Shih, David J. H., Taylor, Michael D.

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Divergent clonal selection dominates medulloblastoma at recurrence von Morrissy, A Sorana, Garzia, Livia, Shih, David J H, Zuyderduyn, Scott, Huang, Xi, Skowron, Patryk, Remke, Marc, Cavalli, Florence M G, Ramaswamy, Vijay, Lindsay, Patricia E, Jelveh, Salomeh, Donovan, Laura K, Wang, Xin, Luu, Betty, Zayne, Kory, Li, Yisu, Mayoh, Chelsea, Thiessen, Nina, Mercier, Eloi, Mungall, Karen L, Ma, Yusanne, Tse, Kane, Zeng, Thomas, Shumansky, Karey, Roth, Andrew J L, Shah, Sohrab, Farooq, Hamza, Kijima, Noriyuki, Holgado, Borja L, Lee, John J Y

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Synthetic carbapenem antibiotics III. 1-Methyl thienamycin von Shih, David H., Cama, Lovji, Christensen, Burton G.

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Prognostic Value of Medulloblastoma Extent of Resection After Accounting for Molecular Subgroup: An Integrated Clinical and Molecular Analysis von Thompson, Eric M, Hielscher, Thomas, Bouffet, Eric, Remke, Marc, Luu, Betty, Gururangan, Sridharan, McLendon, Roger E, Bigner, Darell D, Lipp, Eric S, Perreault, Sebastien, Cho, Yoon-Jae, Grant, Gerald, Kim, Seung-Ki, Lee, Seung-Ki Kim Ji Yeoun, Rao, Amulya A Nageswara, Giannini, Caterina, Li, Kay Ka Wai, Ng, Ho-Keung, Yao, Yu, Kumabe, Toshihiro, Tominaga, Teiji, Grajkowska, Wieslawa A, Perek-Polnik, Marta, Low, David CY, Seow, Wan Tew, Chang, Kenneth TE, Mora, Jaume, Pollack, Ian F, Hamilton, Ronald L, Leary, Sarah, Moore, Andrew S., Ingram, Wendy J., Hallahan, Andrew R., Jouvet, Anne, Fèvre-Montange, Michelle, Vasiljevic, Alexandre, Faure-Conter, Cecile, Shofuda, Tomoko, Kagawa, Naoki, Hashimoto, Naoya, Jabado, Nada, Weil, Alexander G, Gayden, Tenzin, Wataya, Takafumi, Shalaby, Tarek, Grotzer, Michael, Zitterbart, Karel, Sterba, Jaroslav, Kren, Leos, Hortobágyi, Tibor, Klekner, Almos, László, Bognár, Pócza, Tímea, Hauser, Peter, Schüller, Ulrich, Jung, Shin, Jang, Woo-Youl, French, Pim J, Kros, Johan M, van Veelen, Marie-Lise C, Massimi, Luca, Leonard, Jeffrey R, Rubin, Joshua B, Vibhakar, Rajeev, Chambless, Lola B, Cooper, Michael K, Thompson, Reid C, Faria, Claudia C, Carvalho, Alice, Nunes, Sofia, Pimentel, José, Fan, Xing, Muraszko, Karin M, López-Aguilar, Enrique, Lyden, David, Garzia, Livia, Shih, David JH, Kijima, Noriyuki, Schneider, Christian, Adamski, Jennifer, Northcott, Paul A, Kool, Marcel, Jones, David TW, Chan, Jennifer A, Nikolic, Ana, Garre, Maria Luisa, Van Meir, Erwin G, Osuka, Satoru, Olson, Jeffrey J, Jahangiri, Arman, Castro, Brandyn A., Gupta, Nalin, Weiss, William A, Moxon-Emre, Iska, Mabbott, Donald J, Lassaletta, Alvaro, Hawkins, Cynthia E, Tabori, Uri, Drake, James, Kulkarni, Abhaya

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TERT promoter mutations are highly recurrent in SHH subgroup medulloblastoma von Remke, Marc, Ramaswamy, Vijay, Peacock, John, Shih, David J. H, Koelsche, Christian, Northcott, Paul A, Hill, Nadia, Cavalli, Florence M. G, Kool, Marcel, Wang, Xin, Mack, Stephen C, Barszczyk, Mark, Morrissy, A. Sorana, Wu, Xiaochong, Agnihotri, Sameer, Luu, Betty, Jones, David T. W, Garzia, Livia, Dubuc, Adrian M, Zhukova, Nataliya, Vanner, Robert, Kros, Johan M, French, Pim J, Van Meir, Erwin G, Vibhakar, Rajeev, Zitterbart, Karel, Chan, Jennifer A, Bognár, László, Klekner, Almos, Lach, Boleslaw, Jung, Shin, Saad, Ali G, Liau, Linda M, Albrecht, Steffen, Zollo, Massimo, Cooper, Michael K, Thompson, Reid C, Delattre, Oliver O, Bourdeaut, Franck, Doz, François F, Garami, Miklós, Hauser, Peter, Carlotti, Carlos G, Van Meter, Timothy E, Massimi, Luca, Fults, Daniel, Pomeroy, Scott L, Kumabe, Toshiro, Ra, Young Shin, Leonard, Jeffrey R, Elbabaa, Samer K, Mora, Jaume, Rubin, Joshua B, Cho, Yoon-Jae, McLendon, Roger E, Bigner, Darell D, Eberhart, Charles G, Fouladi, Maryam, Wechsler-Reya, Robert J, Faria, Claudia C, Croul, Sidney E, Huang, Annie, Bouffet, Eric, Hawkins, Cynthia E, Dirks, Peter B, Weiss, William A, Schüller, Ulrich, Pollack, Ian F, Rutkowski, Stefan, Meyronet, David, Jouvet, Anne, Fèvre-Montange, Michelle, Jabado, Nada, Perek-Polnik, Marta, Grajkowska, Wieslawa A, Kim, Seung-Ki, Rutka, James T, Malkin, David, Tabori, Uri, Pfister, Stefan M, Korshunov, Andrey, von Deimling, Andreas, Taylor, Michael D

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