mGlu2/3 receptor agonist (LY354740) in anxiety von Schoepp, Darryle D.

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Activation of mGlu2/3 receptors as a new approach to treat schizophrenia: a randomized Phase 2 clinical trial von Martenyi, Ferenc, Monn, James A, Patil, Sandeep T, Zhang, Lu, Lowe, Stephen L, Jackson, Kimberley A, Andreev, Boris V, Avedisova, Alla S, Bardenstein, Leonid M, Gurovich, Issak Y, Morozova, Margarita A, Mosolov, Sergey N, Neznanov, Nikolai G, Reznik, Alexander M, Smulevich, Anatoly B, Tochilov, Vladimir A, Johnson, Bryan G, Schoepp, Darryle D

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Efficacy and Tolerability of an mGlu2 3 Agonist in the Treatment of Generalized Anxiety Disorder von Dunayevich, Eduardo, Erickson, Janelle, Levine, Louise, Landbloom, Ronald, Schoepp, Darryle D, Tollefson, Gary D

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CNS distribution of metabotropic glutamate 2 and 3 receptors: Transgenic mice and [3H]LY459477 autoradiography von Wright, Rebecca A., Johnson, Bryan G., Zhang, Ce, Salhoff, Craig, Kingston, Ann E., Calligaro, David O., Monn, James A., Schoepp, Darryle D., Marek, Gerard J.

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Metabotropic glutamate receptors as novel targets for anxiety and stress disorders von Schoepp, Darryle D, Swanson, Chad J, Bures, Mark, Johnson, Michael P, Linden, Anni-Maija, Monn, James A

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Where will new neuroscience therapies come from? von Schoepp, Darryle D

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Synaptic Activity Regulates Interstitial Fluid Amyloid-β Levels In Vivo von Cirrito, John R., Yamada, Kelvin A., Finn, Mary Beth, Sloviter, Robert S., Bales, Kelly R., May, Patrick C., Schoepp, Darryle D., Paul, Steven M., Mennerick, Steven, Holtzman, David M.

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Regulation of Neurotransmitter Release by Metabotropic Glutamate Receptors von Cartmell, Jayne, Schoepp, Darryle D.

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In vivo pharmacological characterization of the structurally novel, potent, selective mGlu2/3 receptor agonist LY404039 in animal models of psychiatric disorders von RORICK-KEHN, Linda M, JOHNSON, Bryan G, SCHOEPP, Darryle D, KNITOWSKI, Karen M, SALHOFF, Craig R, WITKIN, Jeffrey M, PERRY, Kenneth W, GRIFFEY, Kelly I, TIZZANO, Joseph P, MONN, James A, MCKINZIE, David L

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Metabotropic glutamate receptors, 5 years on von Collingridge, Graham L., Manahan-Vaughan, Denise, Nicoletti, Ferdinando, Schoepp, Darryle D.

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Alzheimer's disease research and development: a call for a new research roadmap von Feldman, Howard H., Haas, Magali, Gandy, Sam, Schoepp, Darryle D., Cross, Alan J., Mayeux, Richard, Sperling, Reisa A., Fillit, Howard, van de Hoef, Diana L., Dougal, Sonya, Nye, Jeffrey S.

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Metabotropic glutamate 2 receptor potentiators: receptor modulation, frequency-dependent synaptic activity, and efficacy in preclinical anxiety and psychosis model(s) von Johnson, Michael P, Barda, David, Britton, Thomas C, Emkey, Renee, Hornback, William J, Jagdmann, G Erik, McKinzie, David L, Nisenbaum, Eric S, Tizzano, Joseph P, Schoepp, Darryle D

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Pharmacological agents acting at subtypes of metabotropic glutamate receptors von Schoepp, Darryle D., Jane, David E., Monn, James A.

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Discovery of Allosteric Potentiators for the Metabotropic Glutamate 2 Receptor:  Synthesis and Subtype Selectivity of N-(4-(2-Methoxyphenoxy)phenyl)-N-(2,2,2− trifluoroethylsulfony... von Johnson, Michael P, Baez, Melvyn, Jagdmann, G. Erik, Britton, Thomas C, Large, Thomas H, Callagaro, David O, Tizzano, Joseph P, Monn, James A, Schoepp, Darryle D

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Effects of mGlu2 or mGlu3 receptor deletions on mGlu2/3 receptor agonist (LY354740)-induced brain c-Fos expression: Specific roles for mGlu2 in the amygdala and subcortical nuclei,... von Linden, Anni-Maija, Baez, Melvin, Bergeron, Marcelle, Schoepp, Darryle D.

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Synthesis, Pharmacological Characterization, and Molecular Modeling of Heterobicyclic Amino Acids Related to (+)-2-Aminobicyclo[3.1.0]hexane- 2,6-dicarboxylic Acid (LY354740):  Ide... von Monn, James A, Valli, Matthew J, Massey, Steven M, Hansen, Marvin M, Kress, Thomas J, Wepsiec, James P, Harkness, Allen R, Grutsch, John L, Wright, Rebecca A, Johnson, Bryan G, Andis, Sherri L, Kingston, Ann, Tomlinson, Rosemarie, Lewis, Richard, Griffey, Kelly R, Tizzano, Joseph P, Schoepp, Darryle D

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The metabotropic glutamate 2/3 receptor agonist LY404039 reduces alcohol-seeking but not alcohol self-administration in alcohol-preferring (P) rats von Rodd, Zachary A., McKinzie, David L., Bell, Richard L., McQueen, Victoria K., Murphy, James M., Schoepp, Darryle D., McBride, William J.

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Design, Synthesis, and Pharmacological Characterization of (+)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY354740):  A Potent, Selective, and Orally Active Group 2 Metabot... von Monn, James A, Valli, Matthew J, Massey, Steven M, Wright, Rebecca A, Salhoff, Craig R, Johnson, Bryan G, Howe, Trevor, Alt, Charles A, Rhodes, Gary A, Robey, Roger L, Griffey, Kelly R, Tizzano, Joseph P, Kallman, Mary J, Helton, David R, Schoepp, Darryle D

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LY354740, an mGlu2/3 Receptor Agonist as a Novel Approach to Treat Anxiety/Stress von Schoepp, Darryle D., Wright, Rebecca A., Levine, Louise R., Gaydos, Brenda, Potter, William Z.

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Synthesis and Metabotropic Glutamate Receptor Activity of S-Oxidized Variants of (−)-4-Amino-2-thiabicyclo-[3.1.0]hexane-4,6-dicarboxylate:  Identification of Potent, Selective, an... von Monn, James A., Massey, Steven M., Valli, Matthew J., Henry, Steven S., Stephenson, Gregory A., Bures, Mark, Hérin, Marc, Catlow, John, Giera, Deborah, Wright, Rebecca A., Johnson, Bryan G., Andis, Sherri L., Kingston, Ann, Schoepp, Darryle D.

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