Host Cell Factor Requirement for Hepatitis C Virus Enzyme Maturation von Waxman, Lloyd, Whitney, Michael, Pollok, Brian A., Kuo, Lawrence C., Darke, Paul L.

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The Herpesvirus Proteases as Targets for Antiviral Chemotherapy von Waxman, Lloyd, Darke, Paul L

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L-735,524: An Orally Bioavailable Human Immunodeficiency Virus Type 1 Protease Inhibitor von Vacca, J. P., Dorsey, B. D., Schleif, W. A., Levin, R. B., McDaniel, S. L., Darke, P. L., Zugay, J., Quintero, J. C., Blahy, O. M., Roth, E., Sardana, V. V., Schlabach, A. J., Graham, P. I., Condra, J. H., Gotlib, L., Holloway, M. K., Lin, J., I.-W. Chen, Vastag, K., Ostovic, D., Anderson, P. S., Emini, E. A., Huff, J. R.

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Crystal structure of the Apo, unactivated insulin-like growth factor-1 receptor kinase. Implication for inhibitor specificity von Munshi, Sanjeev, Kornienko, Maria, Hall, Dawn L, Reid, John C, Waxman, Lloyd, Stirdivant, Steven M, Darke, Paul L, Kuo, Lawrence C

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L-735,524 : the design of a potent and orally bioavailable HIV protease inhibitor von DORSEY, B. D, LEVIN, R. B, LIN, J. H, CHEN, I.-W, HOLLOWAY, M. K, FITZGERALD, P. M. D, AXEL, M. G, OSTOVIC, D, ANDERSON, P. S, HUFF, J. R, MCDANIEL, S. L, VACCA, J. P, GUARE, J. P, DARKE, P. L, ZUGAY, J. A, EMINI, E. A, SCHLEIF, W. A, QUINTERO, J. C

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Biochemical and Structural Characterization of a Novel Class of Inhibitors of the Type 1 Insulin-like Growth Factor and Insulin Receptor Kinases von Bell, Ian M, Stirdivant, Steven M, Ahern, Janet, Culberson, J. Christopher, Darke, Paul L, Dinsmore, Christopher J, Drakas, Robert A, Gallicchio, Steven N, Graham, Samuel L, Heimbrook, David C, Hall, Dawn L, Hua, Jin, Kett, Nathan R, Kim, Annette S, Kornienko, Maria, Kuo, Lawrence C, Munshi, Sanjeev K, Quigley, Amy G, Reid, John C, Trotter, B. Wesley, Waxman, Lloyd H, Williams, Theresa M, Zartman, C. Blair

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Dimerization and Activation of the Herpes Simplex Virus Type 1 Protease von Schmidt, Uwe, Darke, Paul L.

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A priori prediction of activity for HIV-1 protease inhibitors employing energy minimization in the active site von Holloway, M. Katharine, Wai, Jenny M, Halgren, Thomas A, Fitzgerald, Paula M. D, Vacca, Joseph P, Dorsey, Bruce D, Levin, Rhonda B, Thompson, Wayne J, Chen, L. Jenny

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Identification of MK-944a:  A Second Clinical Candidate from the Hydroxylaminepentanamide Isostere Series of HIV Protease Inhibitors von Dorsey, Bruce D, McDonough, Colleen, McDaniel, Stacey L, Levin, Rhonda B, Newton, Christina L, Hoffman, Jacob M, Darke, Paul L, Zugay-Murphy, Joan A, Emini, Emilio A, Schleif, William A, Olsen, David B, Stahlhut, Mark W, Rutkowski, Carrie A, Kuo, Lawrence C, Lin, Jiunn H, Chen, I-W, Michelson, Stuart R, Holloway, M. Katharine, Huff, Joel R, Vacca, Joseph P

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An Orally Bioavailable Pyrrolinone Inhibitor of HIV-1 Protease:  Computational Analysis and X-ray Crystal Structure of the Enzyme Complex von Smith, Amos B, Hirschmann, Ralph, Pasternak, Alexander, Yao, Wenquing, Sprengeler, Paul A, Holloway, M. Katharine, Kuo, Lawrence C, Chen, Zhongguo, Darke, Paul L, Schleif, William A

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Active Human Cytomegalovirus Protease Is a Dimer (∗) von Darke, Paul L., Cole, James L., Waxman, Lloyd, Hall, Dawn L., Sardana, Mohinder K., Kuo, Lawrence C.

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Crystallographic analysis of a complex between human immunodeficiency virus type 1 protease and acetyl-pepstatin at 2.0-A resolution von FITZGERALD, P. M. D, MCKEEVER, B. M, VANMIDDLESWORTH, J. F, SPRINGER, J. P, HEIMBACH, J. C, CHIH-TAI LEU, HERBER, W. K, DIXON, R. A. F, DARKE, P. L

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Activation of the Herpes Simplex Virus Type 1 Protease von Hall, D L, Darke, P L

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Inhibition of hepatitis C virus NS2/3 processing by NS4A peptides. Implications for control of viral processing von Darke, P L, Jacobs, A R, Waxman, L, Kuo, L C

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A general procedure for the purification of human β-secretase expressed in Escherichia coli von Sardana, Vinod, Xu, Bei, Zugay-Murphy, Joan, Chen, Zhongguo, Sardana, Mohinder, Darke, Paul L, Munshi, Sanjeev, Kuo, Lawrence C

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L-735,524: The Design of a Potent and Orally Bioavailable HIV Protease Inhibitor von Dorsey, Bruce D, Levin, Rhonda B, McDaniel, Stacy L, Vacca, Joseph P, Guare, James P, Darke, Paul L, Zugay, Joan A, Emini, Emilio A, Schleif, William A

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SYNTHESIS AND ANTIVIRAL ACTIVITY OF A SERIES OF HIV-1 PROTEASE INHIBITORS WITH FUNCTIONALITY TETHERED TO THE P1 OR P1' PHENYL SUBSTITUENTS - X-RAY CRYSTAL-STRUCTURE ASSISTED DESIGN von THOMPSON, WJ, FITZGERALD, PMD, HOLLOWAY, MK, EMINI, EA, DARKE, PL, MCKEEVER, BM, SCHLEIF, WA, QUINTERO, JC, ZUGAY, JA, TUCKER, TJ, SCHWERING, JE, HOMNICK, CF, NUNBERG, J, SPRINGER, JP, HUFF

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Protein expression plasmids produced rapidly: streamlining cloning protocols and robotic handling von Kornienko, Maria, Montalvo, Allison, Carpenter, Brian E, Lenard, Michael, Abeywickrema, Pravien, Hall, Dawn L, Darke, Paul L, Kuo, Lawrence C

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Pyrrolinone-Based HIV Protease Inhibitors. Design, Synthesis, and Antiviral Activity: Evidence for Improved Transport von Smith, Amos B, Hirschmann, Ralph, Pasternak, Alexander, Guzman, Mark C, Yokoyama, Akihisa, Sprengeler, Paul A, Darke, Paul L, Emini, Emilio A, Schleif, William A

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HIV-1 protease specificity of peptide cleavage is sufficient for processing of gag and pol polyproteins von Darke, Paul L., Nutt, Ruth F., Brady, Stephen F., Garsky, Victor M., Ciccarone, Terrence M., Leu, Chih-Tai, Lumma, Patricia K., Freidinger, Roger M., Veber, Daniel F., Sigal, Irving S.

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