Inhibition of RAF Isoforms and Active Dimers by LY3009120 Leads to Anti-tumor Activities in RAS or BRAF Mutant Cancers von Peng, Sheng-Bin, Henry, James R., Kaufman, Michael D., Lu, Wei-Ping, Smith, Bryan D., Vogeti, Subha, Rutkoski, Thomas J., Wise, Scott, Chun, Lawrence, Zhang, Youyan, Van Horn, Robert D., Yin, Tinggui, Zhang, Xiaoyi, Yadav, Vipin, Chen, Shih-Hsun, Gong, Xueqian, Ma, Xiwen, Webster, Yue, Buchanan, Sean, Mochalkin, Igor, Huber, Lysiane, Kays, Lisa, Donoho, Gregory P., Walgren, Jennie, McCann, Denis, Patel, Phenil, Conti, Ilaria, Plowman, Gregory D., Starling, James J., Flynn, Daniel L.

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Novel MET/TIE2/VEGFR2 inhibitor altiratinib inhibits tumor growth and invasiveness in bevacizumab-resistant glioblastoma mouse models von Piao, Yuji, Park, Soon Young, Henry, Verlene, Smith, Bryan D, Tiao, Ningyi, Flynn, Daniel L, de Groot, John F

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Phase 1 dose-finding study of rebastinib (DCC-2036) in patients with relapsed chronic myeloid leukemia and acute myeloid leukemia von Cortes, Jorge, Talpaz, Moshe, Smith, Hedy P, Snyder, David S, Khoury, Jean, Bhalla, Kapil N, Pinilla-Ibarz, Javier, Larson, Richard, Mitchell, David, Wise, Scott C, Rutkoski, Thomas J, Smith, Bryan D, Flynn, Daniel L, Kantarjian, Hagop M, Rosen, Oliver, Van Etten, Richard A

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Targeted Inhibition of Multiple Receptor Tyrosine Kinases in Mesothelioma von Ou, Wen-Bin, Hubert, Christopher, Fletcher, Jonathan A, Corson, Joseph M, Bueno, Raphael, Flynn, Daniel L, Sugarbaker, David J

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Ripretinib (DCC-2618) Is a Switch Control Kinase Inhibitor of a Broad Spectrum of Oncogenic and Drug-Resistant KIT and PDGFRA Variants von Smith, Bryan D., Kaufman, Michael D., Lu, Wei-Ping, Gupta, Anu, Leary, Cynthia B., Wise, Scott C., Rutkoski, Thomas J., Ahn, Yu Mi, Al-Ani, Gada, Bulfer, Stacie L., Caldwell, Timothy M., Chun, Lawrence, Ensinger, Carol L., Hood, Molly M., McKinley, Arin, Patt, William C., Ruiz-Soto, Rodrigo, Su, Ying, Telikepalli, Hanumaiah, Town, Ajia, Turner, Benjamin A., Vogeti, Lakshminarayana, Vogeti, Subha, Yates, Karen, Janku, Filip, Abdul Razak, Albiruni Ryan, Rosen, Oliver, Heinrich, Michael C., Flynn, Daniel L.

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The Selective Tie2 Inhibitor Rebastinib Blocks Recruitment and Function of Tie2Hi Macrophages in Breast Cancer and Pancreatic Neuroendocrine Tumors von Harney, Allison S., Karagiannis, George S., Pignatelli, Jeanine, Smith, Bryan D., Kadioglu, Ece, Wise, Scott C., Hood, Molly M., Kaufman, Michael D., Leary, Cynthia B., Lu, Wei-Ping, Al-Ani, Gada, Chen, Xiaoming, Entenberg, David, Oktay, Maja H., Wang, Yarong, Chun, Lawrence, De Palma, Michele, Jones, Joan G., Flynn, Daniel L., Condeelis, John S.

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Ripretinib and MEK Inhibitors Synergize to Induce Apoptosis in Preclinical Models of GIST and Systemic Mastocytosis von Gupta, Anu, Singh, Jarnail, Garcia-Valverde, Alfonso, Serrano, Cesar, Flynn, Daniel L., Smith, Bryan D.

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Multipolymer Solution-Phase Reactions: Application to the Mitsunobu Reaction von Harned, Andrew M, He, Helen Song, Toy, Patrick H, Flynn, Daniel L, Hanson, Paul R

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A Phase I Study of LY3009120, a Pan-RAF Inhibitor, in Patients with Advanced or Metastatic Cancer von Sullivan, Ryan J., Hollebecque, Antoine, Flaherty, Keith T., Shapiro, Geoffrey I., Ahnert, Jordi Rodon, Millward, Michael J., Zhang, Wei, Gao, Ling, Sykes, Amanda, Willard, Melinda D., Yu, Danni, Schade, Andrew E., Crowe, KrisAnne, Flynn, Daniel L., Kaufman, Michael D., Henry, James R., Peng, Sheng-Bin, Benhadji, Karim A., Conti, Ilaria, Gordon, Michael S., Tiu, Ramon V., Hong, David S.

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Monomer-on-Monomer (MoM) Mitsunobu Reaction: Facile Purification Utilizing Surface-Initiated Sequestration von Maity, Pradip K, Rolfe, Alan, Samarakoon, Thiwanka B, Faisal, Saqib, Kurtz, Ryan D, Long, Toby R, Schätz, Alexander, Flynn, Daniel L, Grass, Robert N, Stark, Wendelin J, Reiser, Oliver, Hanson, Paul R

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Vimseltinib: A Precision CSF1R Therapy for Tenosynovial Giant Cell Tumors and Diseases Promoted by Macrophages von Smith, Bryan D., Kaufman, Michael D., Wise, Scott C., Ahn, Yu Mi, Caldwell, Timothy M., Leary, Cynthia B., Lu, Wei-Ping, Tan, Gege, Vogeti, Lakshminarayana, Vogeti, Subha, Wilky, Breelyn A., Davis, Lara E., Sharma, Maitreyi, Ruiz-Soto, Rodrigo, Flynn, Daniel L.

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High-Load, Oligomeric Dichlorotriazine: A Versatile ROMP-Derived Reagent and Scavenger von Rolfe, Alan, Probst, Donald A, Volp, Kelly A, Omar, Iman, Flynn, Daniel L, Hanson, Paul R

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Discovery of vimseltinib (DCC-3014), a highly selective CSF1R switch-control kinase inhibitor, in clinical development for the treatment of Tenosynovial Giant Cell Tumor (TGCT) von Caldwell, Timothy M., Ahn, Yu Mi, Bulfer, Stacie L., Leary, Cynthia B., Hood, Molly M., Lu, Wei-Ping, Vogeti, Lakshminarayana, Vogeti, Subha, Kaufman, Michael D., Wise, Scott C., Le Bourdonnec, Bertrand, Smith, Bryan D., Flynn, Daniel L.

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High-Load, Soluble Oligomeric Carbodiimide:  Synthesis and Application in Coupling Reactions von Zhang, Mianji, Vedantham, Punitha, Flynn, Daniel L, Hanson, Paul R

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Discovery of acyl ureas as highly selective small molecule CSF1R kinase inhibitors von Caldwell, Timothy M., Kaufman, Michael D., Wise, Scott C., Mi Ahn, Yu, Hood, Molly M., Lu, Wei-Ping, Patt, William C., Samarakoon, Thiwanka, Vogeti, Lakshminarayana, Vogeti, Subha, Yates, Karen M., Bulfer, Stacie L., Le Bourdonnec, Bertrand, Smith, Bryan D., Flynn, Daniel L.

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Conformational Control Inhibition of the BCR-ABL1 Tyrosine Kinase, Including the Gatekeeper T315I Mutant, by the Switch-Control Inhibitor DCC-2036 von Chan, Wayne W., Wise, Scott C., Kaufman, Michael D., Ahn, Yu Mi, Ensinger, Carol L., Haack, Torsten, Hood, Molly M., Jones, Jennifer, Lord, John W., Lu, Wei Ping, Miller, David, Patt, William C., Smith, Bryan D., Petillo, Peter A., Rutkoski, Thomas J., Telikepalli, Hanumaiah, Vogeti, Lakshminarayana, Yao, Tony, Chun, Lawrence, Clark, Robin, Evangelista, Peter, Gavrilescu, L. Cristina, Lazarides, Katherine, Zaleskas, Virginia M., Stewart, Lance J., Van Etten, Richard A., Flynn, Daniel L.

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Discovery of 1‑(3,3-Dimethylbutyl)-3-(2-fluoro-4-methyl-5-(7-methyl-2-(methylamino)­pyrido[2,3‑d]pyrimidin-6-yl)phenyl)urea (LY3009120) as a Pan-RAF Inhibitor with Minimal Paradoxi... von Henry, James R, Kaufman, Michael D, Peng, Sheng-Bin, Ahn, Yu Mi, Caldwell, Timothy M, Vogeti, Lakshminarayana, Telikepalli, Hanumaiah, Lu, Wei-Ping, Hood, Molly M, Rutkoski, Thomas J, Smith, Bryan D, Vogeti, Subha, Miller, David, Wise, Scott C, Chun, Lawrence, Zhang, Xiaoyi, Zhang, Youyan, Kays, Lisa, Hipskind, Philip A, Wrobleski, Aaron D, Lobb, Karen L, Clay, Julia M, Cohen, Jeffrey D, Walgren, Jennie L, McCann, Denis, Patel, Phenil, Clawson, David K, Guo, Sherry, Manglicmot, Danalyn, Groshong, Chris, Logan, Cheyenne, Starling, James J, Flynn, Daniel L

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Inhibition of ULK1/2 and KRASG12C controls tumor growth in preclinical models of lung cancer von Ghazi, Phaedra C, O'Toole, Kayla T, Srinivas Boggaram, Sanjana, Scherzer, Michael T, Silvis, Mark R, Zhang, Yun, Bogdan, Madhumita, Smith, Bryan D, Lozano, Guillermina, Flynn, Daniel L, Snyder, Eric L, Kinsey, Conan G, McMahon, Martin

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Altiratinib Inhibits Tumor Growth, Invasion, Angiogenesis, and Microenvironment-Mediated Drug Resistance via Balanced Inhibition of MET, TIE2, and VEGFR2 von Smith, Bryan D, Kaufman, Michael D, Leary, Cynthia B, Turner, Benjamin A, Wise, Scott C, Ahn, Yu Mi, Booth, R John, Caldwell, Timothy M, Ensinger, Carol L, Hood, Molly M, Lu, Wei-Ping, Patt, Tristan W, Patt, William C, Rutkoski, Thomas J, Samarakoon, Thiwanka, Telikepalli, Hanumaiah, Vogeti, Lakshminarayana, Vogeti, Subha, Yates, Karen M, Chun, Lawrence, Stewart, Lance J, Clare, Michael, Flynn, Daniel L

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Combining VPS34 inhibitors with STING agonists enhances type I interferon signaling and anti‐tumor efficacy von Yu, Yasmin, Bogdan, Madhumita, Noman, Muhammad Zaeem, Parpal, Santiago, Bartolini, Elisabetta, Van Moer, Kris, Kleinendorst, Simone Caroline, Bilgrav Saether, Kristine, Trésaugues, Lionel, Silvander, Camilla, Lindström, Johan, Simeon, Jodi, Timson, Mary Jane, Al‐Hashimi, Hikmat, Smith, Bryan D., Flynn, Daniel L., Alexeyenko, Andrey, Viklund, Jenny, Andersson, Martin, Martinsson, Jessica, Pokrovskaja Tamm, Katja, De Milito, Angelo, Janji, Bassam

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