Novel mutant-selective EGFR kinase inhibitors against EGFR T790M von Yun, Cai-Hong, Chirieac, Lucian, Iacob, Roxana E, Padera, Robert, Zhou, Wenjun, Eck, Michael J, Engen, John R, Chen, Liang, Gray, Nathanael S, Jänne, Pasi A, Li, Danan, Capelletti, Marzia, Cortot, Alexis B, Ercan, Dalia, Wong, Kwok-Kin

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An ErbB3 Antibody, MM-121, Is Active in Cancers with Ligand-Dependent Activation von SCHOEBERL, Birgit, FABER, Anthony C, FULGHAM, Aaron, SONG, Youngchul, NIELSEN, Ulrik B, ENGELMAN, Jeffrey A, WONG, Kwok-Kin, DANAN LI, LIANG, Mei-Chih, CROSBY, Katherine, ONSUM, Matthew, BURENKOVA, Olga, PACE, Emily, WALTON, Zandra, LIN NIE

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Compromised CDK1 activity sensitizes BRCA-proficient cancers to PARP inhibition von Johnson, Neil, Li, Yu-Chen, Walton, Zandra E, Cheng, Katherine A, Li, Danan, Rodig, Scott J, Moreau, Lisa A, Unitt, Christine, Bronson, Roderick T, Thomas, Huw D, Newell, David R, D'Andrea, Alan D, Curtin, Nicola J, Wong, Kwok-Kin, Shapiro, Geoffrey I

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Differential induction of apoptosis in HER2 and EGFR addicted cancers following PI3K inhibition von Faber, Anthony C, Li, Danan, Song, YoungChul, Liang, Mei-Chih, Yeap, Beow Y, Bronson, Roderick T, Lifshits, Eugene, Chen, Zhao, Maira, Sauveur-Michel, García-Echeverría, Carlos, Wong, Kwok-Kin, Engelman, Jeffrey A

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Exploiting Cancer Cell Vulnerabilities to Develop a Combination Therapy for Ras-Driven Tumors von De Raedt, Thomas, Walton, Zandra, Yecies, Jessica L., Li, Danan, Chen, Yimei, Malone, Clare F., Maertens, Ophélia, Jeong, Seung Min, Bronson, Roderick T., Lebleu, Valerie, Kalluri, Raghu, Normant, Emmanuel, Haigis, Marcia C., Manning, Brendan D., Wong, Kwok-Kin, Macleod, Kay F., Cichowski, Karen

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Ganetespib (STA-9090), a Nongeldanamycin HSP90 Inhibitor, Has Potent Antitumor Activity in In Vitro and In Vivo Models of Non―Small Cell Lung Cancer von SHIMAMURA, Takeshi, PERERA, Samanthi A, SINHA, Papiya, CAREY, Christopher D, BORGMAN, Christa L, JIMENEZ, John-Paul, MEYERSON, Matthew, WEIWEN YING, BARSOUM, James, WONG, Kwok-Kin, SHAPIRO, Geoffrey I, FOLEY, Kevin P, JIM SANG, RODIG, Scott J, INOUE, Takayo, LIANG CHEN, DANAN LI, CARRETERO, Julian, LI, Yu-Chen

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LKB1 modulates lung cancer differentiation and metastasis von Castrillon, Diego H, Lindeman, Neal I, Kwiatkowski, David J, Johnson, Bruce E, Wu, Michael C, Ramsey, Matthew R, McNamara, Kate, Li, Danan, Ji, Hongbin, Kozlowski, Piotr, Sharpless, Norman E, Shapiro, Geoffrey I, Bronson, Roderick T, Bao, Lei, Naumov, George N, Bardeesy, Nabeel, Meyerson, Matthew, Koivunen, Jussi, Krishnamurthy, Janakiraman, Contreras, Cristina M, Jänne, Pasi A, Padera, Robert F, Chen, Liang, Fan, Cheng, Chirieac, Lucian R, Torrice, Chad, Shimamura, Takeshi, Lin, Xihong, Hayes, D. Neil, Perera, Samanthi A, Cai, Dongpo, Liang, Mei-Chih, Wong, Kwok-Kin, Christiani, David C

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Inhibition of ALK, PI3K/MEK, and HSP90 in Murine Lung Adenocarcinoma Induced by EML4-ALK Fusion Oncogene von ZHAO CHEN, SASAKI, Takaaki, HYUN JOO LEE, RODIG, Scott J, BORGMAN, Christa, PARK, Seung-Il, HYEONG RYUL KIM, PADERA, Robert, MARTO, Jarrod A, GRAY, Nathanael S, KUNG, Andrew L, SHAPIRO, Geoffrey I, XIAOHONG TAN, JÄNNE, Pasi A, WONG, Kwok-Kin, CARRETERO, Julian, SHIMAMURA, Takeshi, DANAN LI, CHUNXIAO XU, YUCHUAN WANG, ADELMANT, Guillaume O, CAPELLETTI, Marzia

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Primary Tumor Genotype Is an Important Determinant in Identification of Lung Cancer Propagating Cells von Curtis, Stephen J., Sinkevicius, Kerstin W., Li, Danan, Lau, Allison N., Roach, Rebecca R., Zamponi, Raffaella, Woolfenden, Amber E., Kirsch, David G., Wong, Kwok-Kin, Kim, Carla F.

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The impact of human EGFR kinase domain mutations on lung tumorigenesis and in vivo sensitivity to EGFR-targeted therapies von Ji, Hongbin, Li, Danan, Chen, Liang, Shimamura, Takeshi, Kobayashi, Susumu, McNamara, Kate, Mahmood, Umar, Mitchell, Albert, Sun, Yangping, Al-Hashem, Ruqayyah, Chirieac, Lucian R., Padera, Robert, Bronson, Roderick T., Kim, William, Jänne, Pasi A., Shapiro, Geoffrey I., Tenen, Daniel, Johnson, Bruce E., Weissleder, Ralph, Sharpless, Norman E., Wong, Kwok-Kin

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Bronchial and Peripheral Murine Lung Carcinomas Induced by T790M-L858R Mutant EGFR Respond to HKI-272 and Rapamycin Combination Therapy von Li, Danan, Shimamura, Takeshi, Ji, Hongbin, Chen, Liang, Haringsma, Henry J., McNamara, Kate, Liang, Mei-Chih, Perera, Samanthi A., Zaghlul, Sara, Borgman, Christa L., Kubo, Shigeto, Takahashi, Masaya, Sun, Yanping, Chirieac, Lucian R., Padera, Robert F., Lindeman, Neal I., Jänne, Pasi A., Thomas, Roman K., Meyerson, Matthew L., Eck, Michael J., Engelman, Jeffrey A., Shapiro, Geoffrey I., Wong, Kwok-Kin

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Epidermal Growth Factor Receptor Variant III Mutations in Lung Tumorigenesis and Sensitivity to Tyrosine Kinase Inhibitors von Ji, Hongbin, Zhao, Xiaojun, Yuza, Yuki, Shimamura, Takeshi, Li, Danan, Protopopov, Alexei, Jung, Boonim L., McNamara, Kate, Xia, Huili, Glatt, Karen A., Thomas, Roman K., Sasaki, Hidefumi, Horner, James W., Eck, Michael, Mitchell, Albert, Sun, Yangping, Al-Hashem, Ruqayyah, Bronson, Roderick T., Rabindran, Sridhar K., Discafani, Carolyn M., Maher, Elizabeth, Shapiro, Geoffrey I., Meyerson, Matthew, Wong, Kwok-Kin

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Hsp90 inhibition suppresses mutant EGFR-T790M signaling and overcomes kinase inhibitor resistance von Shimamura, Takeshi, Li, Danan, Ji, Hongbin, Haringsma, Henry J, Liniker, Elizabeth, Borgman, Christa L, Lowell, April M, Minami, Yuko, McNamara, Kate, Perera, Samanthi A, Zaghlul, Sara, Thomas, Roman K, Greulich, Heidi, Kobayashi, Susumu, Chirieac, Lucian R, Padera, Robert F, Kubo, Shigeto, Takahashi, Masaya, Tenen, Daniel G, Meyerson, Matthew, Wong, Kwok-Kin, Shapiro, Geoffrey I

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Mutations in BRAF and KRAS converge on activation of the mitogen-activated protein kinase pathway in lung cancer mouse models von HONGBIN JI, ZHENXIONG WANG, AL-HASHEM, Ruqayyah, CHIRIEAC, Lucian R, PADERA, Robert, BRONSON, Roderick T, THOMAS, Roman K, GARRAWAY, Levi A, JINNE, Pasi A, JOHNSON, Bruce E, CHIN, Lynda, WONG, Kwok-Kin, PERERA, Samanthi A, DANAN LI, LIANG, Mei-Chih, ZAGHLUL, Sara, MCNAMARA, Kate, LIANG CHEN, ALBERT, Mitchell, YANPING SUN

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Regression of Drug-Resistant Lung Cancer by the Combination of Rosiglitazone and Carboplatin von GIRNUN, Geoffrey D, LIANG CHEN, NASERI, Elnaz, BUCKLEY, Stephanie, DANAN LI, FORCE, Jeremy, MCNAMARA, Kate, DEMETRI, George, SPIEGELMAN, Bruce M, WONG, Kwok-Kin, SILVAGGI, Jessica, DRAPKIN, Ronny, CHIRIEAC, Lucian R, PADERA, Robert F, UPADHYAY, Rabi, VAFAI, Scott B, WEISSLEDER, Ralph, MAHMOOD, Umar

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A dual role for the immune response in a mouse model of inflammation-associated lung cancer von Dougan, Michael, Li, Danan, Neuberg, Donna, Mihm, Martin, Googe, Paul, Wong, Kwok-Kin, Dranoff, Glenn

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PEST domain mutations in Notch receptors comprise an oncogenic driver segment in triple-negative breast cancer sensitive to a γ-secretase inhibitor von Wang, Kai, Zhang, Qin, Li, Danan, Ching, Keith, Zhang, Cathy, Zheng, Xianxian, Ozeck, Mark, Shi, Stephanie, Li, Xiaorong, Wang, Hui, Rejto, Paul, Christensen, James, Olson, Peter

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A Genome-wide RNAi Screen Identifies Multiple Synthetic Lethal Interactions with the Ras Oncogene von Luo, Ji, Emanuele, Michael J., Li, Danan, Creighton, Chad J., Schlabach, Michael R., Westbrook, Thomas F., Wong, Kwok-Kin, Elledge, Stephen J.

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A dual role for the immune response in a mouse model of inflammation-associated lung cancer von Dougan, Michael, Li, Danan, Neuberg, Donna, Mihm, Martin, Googe, Paul, Wong, Kwok-Kin, Dranoff, Glenn

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Preparation, solution characteristics and displacement performances of a novel acrylamide copolymer for enhanced oil recovery (EOR) von Zhang, Peng, Bai, Shixun, Chen, Shilan, Li, Danan, Jia, Zhenfu, Zhou, Chengyu

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