Opportunities and challenges in developing stearoyl-coenzyme A desaturase-1 inhibitors as novel therapeutics for human disease von Zhang, Zaihui, Dales, Natalie A, Winther, Michael D

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An orally available, brain penetrant, small molecule lowers huntingtin levels by enhancing pseudoexon inclusion von Keller, Caroline Gubser, Shin, Youngah, Monteys, Alex Mas, Renaud, Nicole, Beibel, Martin, Teider, Natalia, Peters, Thomas, Faller, Thomas, St-Cyr, Sophie, Knehr, Judith, Roma, Guglielmo, Reyes, Alejandro, Hild, Marc, Lukashev, Dmitriy, Theil, Diethilde, Dales, Natalie, Cha, Jang-Ho, Borowsky, Beth, Dolmetsch, Ricardo, Davidson, Beverly L., Sivasankaran, Rajeev

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ACE2 X-Ray Structures Reveal a Large Hinge-bending Motion Important for Inhibitor Binding and Catalysis von Towler, Paul, Staker, Bart, Prasad, Sridhar G., Menon, Saurabh, Tang, Jin, Parsons, Thomas, Ryan, Dominic, Fisher, Martin, Williams, David, Dales, Natalie A., Patane, Michael A., Pantoliano, Michael W.

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A molecular glue degrader of the WIZ transcription factor for fetal hemoglobin induction von Ting, Pamela Y, Borikar, Sneha, Kerrigan, John Ryan, Thomsen, Noel M, Aghania, Eamon, Hinman, Amelia E, Reyes, Alejandro, Pizzato, Nicolas, Fodor, Barna D, Wu, Fabian, Belew, Muluken S, Mao, Xiaohong, Wang, Jian, Chitnis, Shripad, Niu, Wei, Hachey, Amanda, Cobb, Jennifer S, Savage, Nikolas A, Burke, Ashley, Paulk, Joshiawa, Dovala, Dustin, Lin, James, Clifton, Matthew C, Ornelas, Elizabeth, Ma, Xiaolei, Ware, Nathaniel F, Sanchez, Carina C, Taraszka, John, Terranova, Remi, Knehr, Judith, Altorfer, Marc, Barnes, S Whitney, Beckwith, Rohan E J, Solomon, Jonathan M, Dales, Natalie A, Patterson, Andrew W, Wagner, Jürgen, Bouwmeester, Tewis, Dranoff, Glenn, Stevenson, Susan C, Bradner, James E

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Systematic evaluation of amide bioisosteres leading to the discovery of novel and potent thiazolylimidazolidinone inhibitors of SCD1 for the treatment of metabolic diseases von Sun, Shaoyi, Zhang, Zaihui, Kodumuru, Vishnumurthy, Pokrovskaia, Natalia, Fonarev, Julia, Jia, Qi, Leung, Po-Yee, Tran, Jennifer, Ratkay, Leslie G., McLaren, David G., Radomski, Chris, Chowdhury, Sultan, Fu, Jianmin, Hubbard, Brian, Winther, Michael D., Dales, Natalie A.

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Opportunities and Challenges in Developing Stearoyl-Coenzyme A Desaturase‑1 Inhibitors as Novel Therapeutics for Human Disease: Miniperspective von Zhang, Zaihui, Dales, Natalie A, Winther, Michael D

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Pharmacological Inhibition of Stearoyl CoA Desaturase in the Skin Induces Atrophy of the Sebaceous Glands von Meingassner, Josef G., Aschauer, Heinrich, Winiski, Anthony P., Dales, Natalie, Yowe, David, Winther, Michael D., Zhang, Zaihui, Stütz, Anton, Billich, Andreas

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Substrate-Based Design of the First Class of Angiotensin-Converting Enzyme-Related Carboxypeptidase (ACE2) Inhibitors von Dales, Natalie A, Gould, Alexandra E, Brown, James A, Calderwood, Emily F, Guan, Bing, Minor, Charles A, Gavin, James M, Hales, Paul, Kaushik, Virendar K, Stewart, Michael, Tummino, Peter J, Vickers, Chad S, Ocain, Timothy D, Patane, Michael A

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Discovery of triazolone derivatives as novel, potent stearoyl-CoA desaturase-1 (SCD1) inhibitors von Sun, Shaoyi, Zhang, Zaihui, Pokrovskaia, Natalia, Chowdhury, Sultan, Jia, Qi, Chang, Elaine, Khakh, Kuldip, Kwan, Rainbow, McLaren, David G., Radomski, Chris C., Ratkay, Leslie G., Fu, Jianmin, Dales, Natalie A., Winther, Michael D.

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Design and Synthesis of Unsymmetrical Peptidyl Urea Inhibitors of Aspartic Peptidases von Dales, Natalie A, Bohacek, Regine S, Satyshur, Kenneth A, Rich, Daniel H

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BET bromodomain inhibitors regulate keratinocyte plasticity von Schutzius, Gabi, Kolter, Christian, Bergling, Sebastian, Tortelli, Federico, Fuchs, Florian, Renner, Steffen, Guagnano, Vito, Cotesta, Simona, Rueeger, Heinrich, Faller, Michael, Bouchez, Laure, Salathe, Adrian, Nigsch, Florian, Richards, Shola M., Louis, Malvina, Gruber, Viktoria, Aebi, Alexandra, Turner, Jonathan, Grandjean, Frederic, Li, Jun, Dimitri, Chris, Thomas, Jason R., Schirle, Markus, Blank, Jutta, Drueckes, Peter, Vaupel, Andrea, Tiedt, Ralph, Manley, Paul W., Klopp, Julia, Hemmig, Rene, Zink, Florence, Leroy, Nelly, Carbone, Walter, Roma, Guglielmo, Keller, Caroline Gubser, Dales, Natalie, Beyerbach, Armin, Zimmerlin, Alfred, Bonenfant, Debora, Terranova, Remi, Berwick, Amy, Sahambi, Sukhdeep, Reynolds, Aimee, Jennings, Lori L., Ruffner, Heinz, Tarsa, Peter, Bouwmeester, Tewis, Driver, Vickie, Frederiksen, Mathias, Lohmann, Felix, Kirkland, Susan

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Discovery of thiazolylpyridinone SCD1 inhibitors with preferential liver distribution and reduced mechanism-based adverse effects von Sun, Shaoyi, Zhang, Zaihui, Raina, Vandna, Pokrovskaia, Natalia, Hou, Duanjie, Namdari, Rostam, Khakh, Kuldip, Ratkay, Leslie G., McLaren, David G., Mork, Monica, Fu, Jianmin, Ferreira, Suzie, Hubbard, Brian, Winther, Michael D., Dales, Natalie

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Correction: Corrigendum: SMN2 splice modulators enhance U1–pre-mRNA association and rescue SMA mice von Palacino, James, Swalley, Susanne E, Song, Cheng, Cheung, Atwood K, Shu, Lei, Zhang, Xiaolu, Van Hoosear, Mailin, Shin, Youngah, Chin, Donovan N, Keller, Caroline Gubser, Beibel, Martin, Renaud, Nicole A, Smith, Thomas M, Salcius, Michael, Shi, Xiaoying, Hild, Marc, Servais, Rebecca, Jain, Monish, Deng, Lin, Bullock, Caroline, McLellan, Michael, Schuierer, Sven, Murphy, Leo, Blommers, Marcel J J, Blaustein, Cecile, Berenshteyn, Frada, Lacoste, Arnaud, Thomas, Jason R, Roma, Guglielmo, Michaud, Gregory A, Tseng, Brian S, Porter, Jeffery A, Myer, Vic E, Tallarico, John A, Hamann, Lawrence G, Curtis, Daniel, Fishman, Mark C, Dietrich, William F, Dales, Natalie A, Sivasankaran, Rajeev

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Corrigendum: SMN2 splice modulators enhance U1-pre-mRNA association and rescue SMA mice von Palacino, James, Swalley, Susanne E, Song, Cheng, Cheung, Atwood K, Shu, Lei, Zhang, Xiaolu, Van Hoosear, Mailin, Shin, Youngah, Chin, Donovan N, Keller, Caroline Gubser, Beibel, Martin, Renaud, Nicole A, Smith, Thomas M, Salcius, Michael, Shi, Xiaoying, Hild, Marc, Servais, Rebecca, Jain, Monish, Deng, Lin, Bullock, Caroline, McLellan, Michael, Schuierer, Sven, Murphy, Leo, Blommers, Marcel J J, Blaustein, Cecile, Berenshteyn, Frada, Lacoste, Arnaud, Thomas, Jason R, Roma, Guglielmo, Michaud, Gregory A, Tseng, Brian S, Porter, Jeffery A, Myer, Vic E, Tallarico, John A, Hamann, Lawrence G, Curtis, Daniel, Fishman, Mark C, Dietrich, William F, Dales, Natalie A, Sivasankaran, Rajeev

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Erratum: Corrigendum: SMN2 splice modulators enhance U1-pre-mRNA association and rescue SMA mice von Palacino, James, Swalley, Susanne E, Song, Cheng, Cheung, Atwood K, Shu, Lei, Zhang, Xiaolu, Van Hoosear, Mailin, Shin, Youngah, Chin, Donovan N, Keller, Caroline Gubser, Beibel, Martin, Renaud, Nicole A, Smith, Thomas M, Salcius, Michael, Shi, Xiaoying, Hild, Marc, Servais, Rebecca, Jain, Monish, Deng, Lin, Bullock, Caroline, McLellan, Michael, Schuierer, Sven, Murphy, Leo, Blommers, Marcel J J, Blaustein, Cecile, Berenshteyn, Frada, Lacoste, Arnaud, Thomas, Jason R, Roma, Guglielmo, Michaud, Gregory A, Tseng, Brian S, Porter, Jeffery A, Myer, Vic E, Tallarico, John A, Hamann, Lawrence G, Curtis, Daniel, Fishman, Mark C, Dietrich, William F, Dales, Natalie A, Sivasankaran, Rajeev

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THIADIAZOLE ANALOGS AND THEIR USE FOR TREATING DISEASES ASSOCIATED WITH A DEFICIENCY OF SMN MOTOR NEURONS von DALES, Natalie, AXFORD, Jake, SUNG, Moo Je

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THIADIAZOLE ANALOGS AND THEIR USE FOR TREATING DISEASES ASSOCIATED WITH A DEFICIENCY OF SMN MOTOR NEURONS von DALES, Natalie, AXFORD, Jake, SUNG, Moo Je

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Pnigalio Schrank, 1802

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Eurytoma Illiger, 1807

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Sycophila flavicollis (Walker, 1834)

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