Structure−Activity Studies and Analgesic Efficacy of N-(3-Pyridinyl)-Bridged Bicyclic Diamines, Exceptionally Potent Agonists at Nicotinic Acetylcholine Receptors von Bunnelle, William H, Daanen, Jerome F, Ryther, Keith B, Schrimpf, Michael R, Dart, Michael J, Gelain, Arianna, Meyer, Michael D, Frost, Jennifer M, Anderson, David J, Buckley, Michael, Curzon, Peter, Cao, Ying-Jun, Puttfarcken, Pamela, Searle, Xenia, Ji, Jianguo, Putman, C. Brent, Surowy, Carol, Toma, Lucio, Barlocco, Daniela

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Pharmacology of modality-specific transient receptor potential vanilloid-1 antagonists that do not alter body temperature von Reilly, Regina M, McDonald, Heath A, Puttfarcken, Pamela S, Joshi, Shailen K, Lewis, LaGeisha, Pai, Madhavi, Franklin, Pamela H, Segreti, Jason A, Neelands, Torben R, Han, Ping, Chen, Jun, Mantyh, Patrick W, Ghilardi, Joseph R, Turner, Teresa M, Voight, Eric A, Daanen, Jerome F, Schmidt, Robert G, Gomtsyan, Arthur, Kort, Michael E, Faltynek, Connie R, Kym, Philip R

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Stereoselective Synthesis of a Dipyridyl Transient Receptor Potential Vanilloid‑3 (TRPV3) Antagonist von Voight, Eric A, Daanen, Jerome F, Schmidt, Robert G, Gomtsyan, Arthur, Dart, Michael J, Kym, Philip R

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Gram Scale Synthesis of the Glucuronide Metabolite of ABT-724 von Engstrom, Kenneth M, Daanen, Jerome F, Wagaw, Seble, Stewart, Andrew O

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Substituted Indazoles as Nav1.7 Blockers for the Treatment of Pain von Frost, Jennifer M, DeGoey, David A, Shi, Lei, Gum, Rebecca J, Fricano, Meagan M, Lundgaard, Greta L, El-Kouhen, Odile F, Hsieh, Gin C, Neelands, Torben, Matulenko, Mark A, Daanen, Jerome F, Pai, Madhavi, Ghoreishi-Haack, Nayereh, Zhan, Cenchen, Zhang, Xu-Feng, Kort, Michael E

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Discovery of (R)‑1-(7-Chloro-2,2-bis(fluoromethyl)chroman-4-yl)-3-(3-methylisoquinolin-5-yl)urea (A-1165442): A Temperature-Neutral Transient Receptor Potential Vanilloid‑1 (TRPV1)... von Voight, Eric A, Gomtsyan, Arthur R, Daanen, Jerome F, Perner, Richard J, Schmidt, Robert G, Bayburt, Erol K, DiDomenico, Stanley, McDonald, Heath A, Puttfarcken, Pamela S, Chen, Jun, Neelands, Torben R, Bianchi, Bruce R, Han, Ping, Reilly, Regina M, Franklin, Pamela H, Segreti, Jason A, Nelson, Richard A, Su, Zhi, King, Andrew J, Polakowski, James S, Baker, Scott J, Gauvin, Donna M, Lewis, LaGeisha R, Mikusa, Joseph P, Joshi, Shailen K, Faltynek, Connie R, Kym, Philip R, Kort, Michael E

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Repeated dosing of ABT-102, a potent and selective TRPV1 antagonist, enhances TRPV1-mediated analgesic activity in rodents, but attenuates antagonist-induced hyperthermia von Honore, Prisca, Chandran, Prasant, Hernandez, Gricelda, Gauvin, Donna M., Mikusa, Joseph P., Zhong, Chengmin, Joshi, Shailen K., Ghilardi, Joseph R., Sevcik, Molly A., Fryer, Ryan M., Segreti, Jason A., Banfor, Patricia N., Marsh, Kennan, Neelands, Torben, Bayburt, Erol, Daanen, Jerome F., Gomtsyan, Arthur, Lee, Chih-Hung, Kort, Michael E., Reilly, Regina M., Surowy, Carol S., Kym, Philip R., Mantyh, Patrick W., Sullivan, James P., Jarvis, Michael F., Faltynek, Connie R.

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Synthesis of Oxazolo[4,5-c]quinoline TRPV1 Antagonists von Voight, Eric A, Daanen, Jerome F, Kort, Michael E

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Chroman and tetrahydroquinoline ureas as potent TRPV1 antagonists von Schmidt, Robert G., Bayburt, Erol K., Latshaw, Steven P., Koenig, John R., Daanen, Jerome F., McDonald, Heath A., Bianchi, Bruce R., Zhong, Chengmin, Joshi, Shailen, Honore, Prisca, Marsh, Kennan C., Lee, Chih-Hung, Faltynek, Connie R., Gomtsyan, Arthur

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Capsaicin-induced inhibition of platelet aggregation is not mediated by transient receptor potential vanilloid type 1 von Mittelstadt, Scott W, Nelson, Richard A, Daanen, Jerome F, King, Andrew J, Kort, Michael E, Kym, Philip R, Lubbers, Nathan L, Cox, Bryan F, Lynch, James J

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TRPV1 ligands with hyperthermic, hypothermic and no temperature effects in rats von Gomtsyan, Arthur, McDonald, Heath A, Schmidt, Robert G, Daanen, Jerome F, Voight, Eric A, Segreti, Jason A, Puttfarcken, Pamela S, Reilly, Regina M, Kort, Michael E, Dart, Michael J, Kym, Philip R

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Efficient and general asymmetric syntheses of ( R)-chroman-4-amine salts von Voight, Eric A., Daanen, Jerome F., Hannick, Steven M., Shelat, Bhadra H., Kerdesky, Francis A., Plata, Daniel J., Kort, Michael E.

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Discovery of 2-(4-Pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole (ABT-724), a Dopaminergic Agent with a Novel Mode of Action for the Potential Treatment of Erectile Dysfunction von Cowart, Marlon, Latshaw, Steven P, Bhatia, Pramila, Daanen, Jerome F, Rohde, Jeffrey, Nelson, Sherry L, Patel, Meena, Kolasa, Teodozyi, Nakane, Masaki, Uchic, Marie E, Miller, Loan N, Terranova, Marc A, Chang, Renjie, Donnelly-Roberts, Diana L, Namovic, Marian T, Hollingsworth, Peter R, Martino, Brenda R, Lynch, James J, Sullivan, James P, Hsieh, Gin C, Moreland, Robert B, Brioni, Jorge D, Stewart, Andrew O

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Synthesis and evaluation of 3-aryl piperidine analogs as potent and efficacious dopamine D4 receptor agonists von XUEQING WANG, BHATIA, Pramila A, MILLER, Loan N, RENJIE CHANG, MORELAND, Robert B, BRIONI, Jorge D, STEWART, Andrew O, DAANEN, Jerome F, LATSAW, Steve P, ROHDE, Jeffrey, KOLASA, Teodozyi, HAKEEM, Ahmed A, MATULENKO, Mark A, NAKANE, Masaki, UCHIC, Marie E

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Synthesis and Structure−Activity Relationships of 3,8-Diazabicyclo[4.2.0]octane Ligands, Potent Nicotinic Acetylcholine Receptor Agonists von Frost (née Pac, Jennifer M, Bunnelle, William H, Tietje, Karin R, Anderson, David J, Rueter, Lynne E, Curzon, Peter, Surowy, Carol S, Ji, Jianquo, Daanen, Jerome F, Kohlhaas, Kathy L, Buckley, Michael J, Henry, Rodger F, Dyhring, Tino, Ahring, Philip K, Meyer, Michael D

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Dopamine D4 Ligands and Models of Receptor Activation:  2-(4-Pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole and Related Heteroarylmethylarylpiperazines Exhibit a Substituent Ef... von Stewart, Andrew O, Cowart, Marlon D, Moreland, Robert B, Latshaw, Steve P, Matulenko, Mark A, Bhatia, Pramila A, Wang, Xueqing, Daanen, Jerome F, Nelson, Sherry L, Terranova, Marc A, Namovic, Marian T, Donnelly-Roberts, Diana L, Miller, Loan N, Nakane, Masaki, Sullivan, James P, Brioni, Jorge D

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Nitroaromatic Amino Acids as Inhibitors of Neuronal Nitric Oxide Synthase von Cowart, Marlon, Kowaluk, Elizabeth A, Daanen, Jerome F, Kohlhaas, Kathy L, Alexander, Karen M, Wagenaar, Frank L, Kerwin, James F

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Synthesis and Pharmacology of (Pyridin-2-yl)methanol Derivatives as Novel and Selective Transient Receptor Potential Vanilloid 3 Antagonists von Gomtsyan, Arthur, Schmidt, Robert G, Bayburt, Erol K, Gfesser, Gregory A, Voight, Eric A, Daanen, Jerome F, Schmidt, Diana L, Cowart, Marlon D, Liu, Huaqing, Altenbach, Robert J, Kort, Michael E, Clapham, Bruce, Cox, Phil B, Shrestha, Anurupa, Henry, Rodger, Whittern, David N, Reilly, Regina M, Puttfarcken, Pamela S, Brederson, Jill-Desiree, Song, Ping, Li, Bin, Huang, Susan M, McDonald, Heath A, Neelands, Torben R, McGaraughty, Steve P, Gauvin, Donna M, Joshi, Shailen K, Banfor, Patricia N, Segreti, Jason A, Shebley, Mohamad, Faltynek, Connie R, Dart, Michael J, Kym, Philip R

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Synthesis and biological evaluation of clitocine analogues as adenosine kinase inhibitors von Lee, Chih-Hung, Daanen, Jerome F, Jiang, Meiqun, Yu, Haixia, Kohlhaas, Kathy L, Alexander, Karen, Jarvis, Michael F, Kowaluk, Elizabeth L, Bhagwat, Shripad S

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Substituted Indazoles as Na v 1.7 Blockers for the Treatment of Pain von Frost, Jennifer M., DeGoey, David A., Shi, Lei, Gum, Rebecca J., Fricano, Meagan M., Lundgaard, Greta L., El-Kouhen, Odile F., Hsieh, Gin C., Neelands, Torben, Matulenko, Mark A., Daanen, Jerome F., Pai, Madhavi, Ghoreishi-Haack, Nayereh, Zhan, Cenchen, Zhang, Xu-Feng, Kort, Michael E.

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