Induction of ER Stress in Acute Lymphoblastic Leukemia Cells by the Deubiquitinase Inhibitor VLX1570 von Pellegrini, Paola, Selvaraju, Karthik, Faustini, Elena, Mofers, Arjan, Zhang, Xiaonan, Ternerot, Jens, Schubert, Alice, Linder, Stig, D Arcy, Pádraig

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Identification of proteasome inhibitors using analysis of gene expression profiles von Mofers, Arjan, Selvaraju, Karthik, Gubat, Johannes, D'Arcy, Padraig, Linder, Stig

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Induction of mitochondrial dysfunction as a strategy for targeting tumour cells in metabolically compromised microenvironments von Zhang, Xiaonan, Fryknäs, Mårten, Hernlund, Emma, Fayad, Walid, De Milito, Angelo, Olofsson, Maria Hägg, Gogvadze, Vladimir, Dang, Long, Påhlman, Sven, Schughart, Leoni A. Kunz, Rickardson, Linda, D′Arcy, Padraig, Gullbo, Joachim, Nygren, Peter, Larsson, Rolf, Linder, Stig

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Comprehensive Target Screening and Cellular Profiling of the Cancer-Active Compound b-AP15 Indicate Abrogation of Protein Homeostasis and Organelle Dysfunction as the Primary Mecha... von Gubat, Johannes, Selvaraju, Karthik, Sjöstrand, Linda, Kumar Singh, Dhananjay, Turkina, Maria V, Schmierer, Bernhard, Sabatier, Pierre, Zubarev, Roman A, Linder, Stig, D'Arcy, Pádraig

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Proteasome-associated deubiquitinases and cancer von Mofers, Arjan, Pellegrini, Paola, Linder, Stig, D’Arcy, Pádraig

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Identifying Essential Deubiquitinase Interactions and Targeting Protein Ubiquitination in Cancer von Gubat, Johannes

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The tumor suppressor p53 is a negative regulator of the carcinoma-associated transcription factor FOXQ1 von Pizzolato, Giulia, Moparthi, Lavanya, Pagella, Pierfrancesco, Cantù, Claudio, D’Arcy, Pádraig, Koch, Stefan

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Deubiquitinating Enzymes in Coronaviruses and Possible Therapeutic Opportunities for COVID-19 von Clemente, Valentino, D'Arcy, Padraig, Bazzaro, Martina

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Loss of the proteasomal deubiquitinase USP14 induces growth defects and a senescence phenotype in colorectal cancer cells von Gubat, Johannes, Sjöstrand, Linda, Selvaraju, Karthik, Telli, Kübra, D’Arcy, Pádraig

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Transient interdomain interactions in free USP14 shape its conformational ensemble von Salomonsson, Johannes, Wallner, Björn, Sjöstrand, Linda, D'Arcy, Pádraig, Sunnerhagen, Maria, Ahlner, Alexandra

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Repurposing of auranofin: Thioredoxin reductase remains a primary target of the drug von Zhang, Xiaonan, Selvaraju, Karthik, Saei, Amir Ata, D'Arcy, Padraig, Zubarev, Roman A., Arnér, Elias SJ, Linder, Stig

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The proteasome deubiquitinase inhibitor VLX1570 shows selectivity for ubiquitin-specific protease-14 and induces apoptosis of multiple myeloma cells von Wang, Xin, Mazurkiewicz, Magdalena, Hillert, Ellin-Kristina, Olofsson, Maria Hägg, Pierrou, Stefan, Hillertz, Per, Gullbo, Joachim, Selvaraju, Karthik, Paulus, Aneel, Akhtar, Sharoon, Bossler, Felicitas, Khan, Asher Chanan, Linder, Stig, D’Arcy, Padraig

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Caffeic acid phenethyl ester targets ubiquitin-specific protease 8 and synergizes with cisplatin in endometrioid ovarian carcinoma cells von Colombo, Diego, Gatti, Laura, Sjöstrand, Linda, Carenini, Nives, Costantino, Matteo, Corna, Elisabetta, Arrighetti, Noemi, Zuccolo, Marco, De Cesare, Michelandrea, Linder, Stig, D'Arcy, Pádraig, Perego, Paola

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Synthesis and Evaluation of Derivatives of the Proteasome Deubiquitinase Inhibitor b-AP15 von Wang, Xin, D'Arcy, Pádraig, Caulfield, Thomas R., Paulus, Aneel, Chitta, Kasyapa, Mohanty, Chitralekha, Gullbo, Joachim, Chanan-Khan, Asher, Linder, Stig

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Inhibition of proteasome deubiquitinase activity: a strategy to overcome resistance to conventional proteasome inhibitors? von Selvaraju, Karthik, Mazurkiewicz, Magdalena, Wang, Xin, Gullbo, Joachim, Linder, Stig, D’Arcy, Pádraig

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Analysis of determinants for in vitro resistance to the small molecule deubiquitinase inhibitor b-AP15 von Mofers, Arjan, Perego, Paola, Selvaraju, Karthik, Gatti, Laura, Gullbo, Joachim, Linder, Stig, D'Arcy, Padraig

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Dissecting multi drug resistance in head and neck cancer cells using multicellular tumor spheroids von Azharuddin, Mohammad, Roberg, Karin, Dhara, Ashis Kumar, Jain, Mayur Vilas, Darcy, Padraig, Hinkula, Jorma, Slater, Nigel K. H., Patra, Hirak K.

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Synthesis and bio-properties of 4-piperidone containing compounds as curcumin mimics von Girgis, Adel S, D'Arcy, Padraig, Aboshouk, Dalia R, Bekheit, Mohamed S

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Iron chelators target both proliferating and quiescent cancer cells von Fryknäs, Mårten, Zhang, Xiaonan, Bremberg, Ulf, Senkowski, Wojciech, Olofsson, Maria Hägg, Brandt, Peter, Persson, Ingmar, D’Arcy, Padraig, Gullbo, Joachim, Nygren, Peter, Schughart, Leoni Kunz, Linder, Stig, Larsson, Rolf

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Cytotoxic unsaturated electrophilic compounds commonly target the ubiquitin proteasome system von Selvaraju, Karthik, Mofers, Arjan, Pellegrini, Paola, Salomonsson, Johannes, Ahlner, Alexandra, Morad, Vivian, Hillert, Ellin-Kristina, Espinosa, Belen, Arnér, Elias S. J., Jensen, Lasse, Malmström, Jonas, Turkina, Maria V., D’Arcy, Padraig, Walters, Michael A., Sunnerhagen, Maria, Linder, Stig

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