AZD2014, an Inhibitor of mTORC1 and mTORC2, Is Highly Effective in ER+ Breast Cancer When Administered Using Intermittent or Continuous Schedules von Guichard, Sylvie M, Curwen, Jon, Bihani, Teeru, D'Cruz, Celina M, Yates, James W T, Grondine, Michael, Howard, Zoe, Davies, Barry R, Bigley, Graham, Klinowska, Teresa, Pike, Kurt G, Pass, Martin, Chresta, Christine M, Polanska, Urszula M, McEwen, Robert, Delpuech, Oona, Green, Stephen, Cosulich, Sabina C

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The MET Inhibitor AZD6094 (Savolitinib, HMPL-504) Induces Regression in Papillary Renal Cell Carcinoma Patient-Derived Xenograft Models von Schuller, Alwin G, Barry, Evan R, Jones, Rhys D O, Henry, Ryan E, Frigault, Melanie M, Beran, Garry, Linsenmayer, David, Hattersley, Maureen, Smith, Aaron, Wilson, Joanne, Cairo, Stefano, Déas, Olivier, Nicolle, Delphine, Adam, Ammar, Zinda, Michael, Reimer, Corinne, Fawell, Stephen E, Clark, Edwin A, D'Cruz, Celina M

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c-Myc Transforms Human Mammary Epithelial Cells through Repression of the Wnt Inhibitors DKK1 and SFRP1 von Cowling, Victoria H., D'Cruz, Celina M., Chodosh, Lewis A., Cole, Michael D.

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c-MYC induces mammary tumorigenesis by means of a preferred pathway involving spontaneous Kras2 mutations von Chodosh, Lewis A, D'Cruz, Celina M, Gunther, Edward J, Boxer, Robert B, Hartman, Jennifer L, Sintasath, Louis, Moody, Susan E, Cox, James D, Ha, Seung I, Belka, George K, Golant, Alexander, Cardiff, Robert D

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Generation of stable PDX derived cell lines using conditional reprogramming von Borodovsky, Alexandra, McQuiston, Travis J, Stetson, Daniel, Ahmed, Ambar, Whitston, David, Zhang, Jingwen, Grondine, Michael, Lawson, Deborah, Challberg, Sharon S, Zinda, Michael, Pollok, Brian A, Dougherty, Brian A, D'Cruz, Celina M

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Developmental stage determines the effects of MYC in the mammary epithelium von Blakely, Collin M, Sintasath, Louis, D'Cruz, Celina M, Hahn, Kristina T, Dugan, Katherine D, Belka, George K, Chodosh, Lewis A

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Resistance to everolimus driven by epigenetic regulation of MYC in ER+ breast cancers von Bihani, Teeru, Ezell, Scott A, Ladd, Brendon, Grosskurth, Shaun E, Mazzola, Anne Marie, Pietras, Mark, Reimer, Corinne, Zinda, Michael, Fawell, Stephen, D'Cruz, Celina M

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Acquired savolitinib resistance in non-small cell lung cancer arises via multiple mechanisms that converge on MET-independent mTOR and MYC activation von Henry, Ryan E, Barry, Evan R, Castriotta, Lillian, Ladd, Brendon, Markovets, Aleksandra, Beran, Garry, Ren, Yongxin, Zhou, Feng, Adam, Ammar, Zinda, Michael, Reimer, Corinne, Qing, Weiguo, Su, Weiguo, Clark, Edwin, D'Cruz, Celina M, Schuller, Alwin G

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Effective combination therapies in preclinical endocrine resistant breast cancer models harboring ER mutations von Ladd, Brendon, Mazzola, Anne Marie, Bihani, Teeru, Lai, Zhongwu, Bradford, James, Collins, Michael, Barry, Evan, Goeppert, Anne U, Weir, Hazel M, Hearne, Kelly, Renshaw, Jonathan G, Mohseni, Morvarid, Hurt, Elaine, Jalla, Sanjoo, Bao, Haifeng, Hollingsworth, Robert, Reimer, Corinne, Zinda, Michael, Fawell, Stephen, D'Cruz, Celina M

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Hormone-induced protection against mammary tumorigenesis is conserved in multiple rat strains and identifies a core gene expression signature induced by pregnancy von BLAKELY, Collin M, STODDARD, Alexander J, BELKA, George K, DUGAN, Katherine D, NOTARFRANCESCO, Kathleen L, MOODY, Susan E, D'CRUZ, Celina M, CHODOSH, Lewis A

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Tumors with AKT1E17K Mutations Are Rational Targets for Single Agent or Combination Therapy with AKT Inhibitors von Davies, Barry R, Guan, Nin, Logie, Armelle, Crafter, Claire, Hanson, Lyndsey, Jacobs, Vivien, James, Neil, Dudley, Philippa, Jacques, Kelly, Ladd, Brendon, D'Cruz, Celina M, Zinda, Michael, Lindemann, Justin, Kodaira, Makoto, Tamura, Kenji, Jenkins, Emma L

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Persistent Parity-Induced Changes in Growth Factors, TGF-β3, and Differentiation in the Rodent Mammary Gland von D’Cruz, Celina M, Moody, Susan E, Master, Stephen R, Hartman, Jennifer L, Keiper, Elizabeth A, Imielinski, Marcin B, Cox, James D, Wang, James Y, Ha, Seung I, Keister, Blaine A, Chodosh, Lewis A

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Rapid protein production using CHO stable transfection pools von Ye, Jianxin, Alvin, Krista, Latif, Haythem, Hsu, Amy, Parikh, Vanessa, Whitmer, Travis, Tellers, Melanie, de la Cruz Edmonds, M. Celina, Ly, Jeffrey, Salmon, Peter, Markusen, Julia F.

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Functional Microarray Analysis of Mammary Organogenesis Reveals a Developmental Role in Adaptive Thermogenesis von Master, Stephen R, Hartman, Jennifer L, D’Cruz, Celina M, Moody, Susan E, Keiper, Elizabeth A, Ha, Seung I, Cox, James D, Belka, George K, Chodosh, Lewis A

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Fusion of PAX7 to FKHR by the variant t(1;13)(p36;q14) translocation in alveolar rhabdomyosarcoma von DAVIS, R. J, D'CRUZ, C. M, LOVELL, M. A, BIEGEL, J. A, BARR, F. G

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Functional microarray analysis of mammary organogenesis reveals a developmental role in adaptive thermogenesis von Master, Stephen R, Hartman, Jennifer L, D'Cruz, Celina M, Moody, Susan E, Keiper, Elizabeth A, Ha, Seung I, Cox, James D, Belka, George K, Chodosh, Lewis A

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Trastuzumab deruxtecan (T-DXd) combinations in patients with HER2-positive advanced or metastatic breast cancer: A phase 1b/2, open-label, multicenter, dose-finding and dose-expans... von Andre, Fabrice, Hamilton, Erika P., Loi, Sherene, Schmid, Peter, Anders, Carey K., Yu, Tinghui, Boston, Sarice, D'Cruz, Celina M., Herbolsheimer, Pia, Jhaveri, Komal L.

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Capivasertib (C) and fulvestrant (F) for patients (pts) with aromatase inhibitor (AI)-resistant HR+/HER2– advanced breast cancer (ABC): Characterization and management of common ad... von Rugo, Hope S., Oliveira, Mafalda, Howell, Sacha Jon, Dalenc, Florence, Cortes, Javier, Gomez, Henry Leonidas, Hu, Xichun, Iwata, Hiroji, Jhaveri, Komal L., Loibl, Sibylle, Morales Murillo, Serafin, Okera, Meena, Park, Yeon Hee, Sohn, Joohyuk, Zhukova, Lyudmila, Logan, Jill, Twomey, Ken, Khatun, Mahmuda, D'Cruz, Celina M., Turner, Nicholas C.

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Development of transfection and high-producer screening protocols for the CHOK1SV cell system von de la Cruz Edmonds, M Celina, Tellers, Melanie, Chan, Christine, Salmon, Peter, Robinson, David K, Markusen, Julia

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Production and characterization of a soluble, active form of Tva, the subgroup A avian sarcoma and leukosis virus receptor von Balliet, J.W. (University of Pennsylvania, Philadelphia, PA.), Berson, J, D'Cruz, C.M, Huang, J, Crane, J, Gilbert, J.M, Bates, P

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