Glucocorticoid receptor recruits to enhancers and drives activation by motif-directed binding von McDowell, Ian C, Barrera, Alejandro, D'Ippolito, Anthony M, Vockley, Christopher M, Hong, Linda K, Leichter, Sarah M, Bartelt, Luke C, Majoros, William H, Song, Lingyun, Safi, Alexias, Koçak, D Dewran, Gersbach, Charles A, Hartemink, Alexander J, Crawford, Gregory E, Engelhardt, Barbara E, Reddy, Timothy E

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Direct GR Binding Sites Potentiate Clusters of TF Binding across the Human Genome von Vockley, Christopher M., D’Ippolito, Anthony M., McDowell, Ian C., Majoros, William H., Safi, Alexias, Song, Lingyun, Crawford, Gregory E., Reddy, Timothy E.

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Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers von Hilton, Isaac B, D'Ippolito, Anthony M, Vockley, Christopher M, Thakore, Pratiksha I, Crawford, Gregory E, Reddy, Timothy E, Gersbach, Charles A

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Highly specific epigenome editing by CRISPR-Cas9 repressors for silencing of distal regulatory elements von Thakore, Pratiksha I, D'Ippolito, Anthony M, Song, Lingyun, Safi, Alexias, Shivakumar, Nishkala K, Kabadi, Ami M, Reddy, Timothy E, Crawford, Gregory E, Gersbach, Charles A

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Pre-established Chromatin Interactions Mediate the Genomic Response to Glucocorticoids von D'Ippolito, Anthony M., McDowell, Ian C., Barrera, Alejandro, Hong, Linda K., Leichter, Sarah M., Bartelt, Luke C., Vockley, Christopher M., Majoros, William H., Safi, Alexias, Song, Lingyun, Gersbach, Charles A., Crawford, Gregory E., Reddy, Timothy E.

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From Prescription to Transcription: Genome Sequence as Drug Target von Guo, Cong, D’Ippolito, Anthony M., Reddy, Timothy E.

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Targeted Epigenetic Remodeling of Endogenous Loci by CRISPR/Cas9-Based Transcriptional Activators Directly Converts Fibroblasts to Neuronal Cells von Black, Joshua B., Adler, Andrew F., Wang, Hong-Gang, D’Ippolito, Anthony M., Hutchinson, Hunter A., Reddy, Timothy E., Pitt, Geoffrey S., Leong, Kam W., Gersbach, Charles A.

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Human genome-wide measurement of drug-responsive regulatory activity von Johnson, Graham D., Barrera, Alejandro, McDowell, Ian C., D’Ippolito, Anthony M., Majoros, William H., Vockley, Christopher M., Wang, Xingyan, Allen, Andrew S., Reddy, Timothy E.

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Genomic signatures of high-altitude adaptation and chromosomal polymorphism in geladas von Chiou, Kenneth L., Janiak, Mareike C., Schneider-Crease, India A., Sen, Sharmi, Ayele, Ferehiwot, Chuma, Idrissa S., Knauf, Sascha, Lemma, Alemayehu, Signore, Anthony V., D’Ippolito, Anthony M., Abebe, Belayneh, Haile, Abebaw Azanaw, Kebede, Fanuel, Fashing, Peter J., Nguyen, Nga, McCann, Colleen, Houck, Marlys L., Wall, Jeffrey D., Burrell, Andrew S., Bergey, Christina M., Rogers, Jeffrey, Phillips-Conroy, Jane E., Jolly, Clifford J., Melin, Amanda D., Storz, Jay F., Lu, Amy, Beehner, Jacinta C., Bergman, Thore J., Snyder-Mackler, Noah

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Protamines from liverwort are produced by post-translational cleavage and C-terminal di-aminopropanelation of several male germ-specific H1 histones von D’Ippolito, Robert Anthony, Minamino, Naoki, Rivera-Casas, Ciro, Cheema, Manjinder S., Bai, Dina L., Kasinsky, Harold E., Shabanowitz, Jeffrey, Eirin-Lopez, Jose M., Ueda, Takashi, Hunt, Donald F., Ausió, Juan

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Erythroid lineage chromatin accessibility maps facilitate identification and validation of NFIX as a fetal hemoglobin repressor von Chaand, Mudit, Fiore, Chris, Johnston, Brian, D’Ippolito, Anthony, Moon, Diane H., Carulli, John P., Shearstone, Jeffrey R.

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SY5609, a Potent and Selective CDK7 Inhibitor, Potentiates BTK Inhibitor Activity in Mantle Cell Lymphoma Preclinical Models von Johannessen, Liv, Henry, Susan, Sawant, Priyanka, D'Ippolito, Anthony, Ke, Nan, Lefkowitz, Ariel, Eaton, Matthew, Dworakowski, Wojciech, Rosario, Maria, Hodgson, Graeme

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Activity of SY-5609, an oral, noncovalent, potent, and selective CDK7 inhibitor, in preclinical models of colorectal cancer von Johannessen, Liv, Ke, Nan, Sawant, Priyanka, Dworakowski, Wojciech, D'Ippolito, Anthony, Hu, Shanhu, Rajagopal, Nisha, Eaton, Matthew, Hodgson, Graeme

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Abstract C091: Preclinical evaluation of PK, PD, and antitumor activity of the oral, non-covalent, potent and highly selective CDK7 inhibitor, SY-5609, provides rationale for clini... von Johannessen, Liv H, Hu, Shanhu, Ke, Nan, D'Ippolito, Anthony, Rajagopal, Nisha, Marineau, Jason, Savinainen, Anneli, Zamboni, William, Hodgson, Graeme

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Epidemiology of Pediatric Holiday-Related Injuries Presenting to US Emergency Departments von D'IPPOLITO, Anthony, COLLINS, Christy L, COMSTOCK, R. Dawn

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Glycogen synthase kinase-3 (Gsk-3) plays a fundamental role in maintaining DNA methylation at imprinted loci in mouse embryonic stem cells von Meredith, Gavin D, D'Ippolito, Anthony, Dudas, Miroslav, Zeidner, Leigh C, Hostetter, Logan, Faulds, Kelsie, Arnold, Thomas H, Popkie, Anthony P, Doble, Bradley W, Marnellos, George, Adams, Christopher, Wang, Yulei, Phiel, Christopher J

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The evolution of ribosomal DNA: divergent paralogues and phylogenetic implications von Buckler, E.S. IV, Ippolito, A, Holtsford, T.P

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485. Targeted Epigenome Editing by CRISPR/Cas9-Based Repressors for Silencing of Distal Regulatory Elements von Thakore, Pratiksha I., D'Ippolito, Anthony, Song, Lingyun, Safi, Alexias, Shivakumar, Nishkala K., Kabadi, Ami M., Bledsoe, Peggy, Reddy, Timothy E., Crawford, Gregory E., Gersbach, Charles A.

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Gene Expression Profiling in Mouse Embryonic Stem Cells Reveals Glycogen Synthase Kinase-3-Dependent Targets of Phosphatidylinositol 3-Kinase and Wnt/β-Catenin Signaling Pathways von Bartman, Colleen M, Egelston, Jennifer, Kattula, Sravya, Zeidner, Leigh C, D'Ippolito, Anthony, Doble, Bradley W, Phiel, Christopher J

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O3‐05‐06: Epigenetic regulation of tau gene expression von Meredith, Gavin, D'Ippolito, Anthony, Marnellos, George, Phiel, Christopher

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