Overcoming resistance to checkpoint blockade therapy by targeting PI3Kγ in myeloid cells von De Henau, Olivier, Rausch, Matthew, Winkler, David, Campesato, Luis Felipe, Liu, Cailian, Cymerman, Daniel Hirschhorn, Budhu, Sadna, Ghosh, Arnab, Pink, Melissa, Tchaicha, Jeremy, Douglas, Mark, Tibbitts, Thomas, Sharma, Sujata, Proctor, Jennifer, Kosmider, Nicole, White, Kerry, Stern, Howard, Soglia, John, Adams, Julian, Palombella, Vito J., McGovern, Karen, Kutok, Jeffery L., Wolchok, Jedd D., Merghoub, Taha

Volltext

Targeting tumor-necrosis factor receptor pathways for tumor immunotherapy von Schaer, David A, Hirschhorn-Cymerman, Daniel, Wolchok, Jedd D

Volltext

Cyclophosphamide enhances immunity by modulating the balance of dendritic cell subsets in lymphoid organs von Nakahara, Takeshi, Uchi, Hiroshi, Lesokhin, Alexander M., Avogadri, Francesca, Rizzuto, Gabrielle A., Hirschhorn-Cymerman, Daniel, Panageas, Katherine S., Merghoub, Taha, Wolchok, Jedd D., Houghton, Alan N.

Volltext

Alphavirus replicon particles expressing TRP-2 provide potent therapeutic effect on melanoma through activation of humoral and cellular immunity von Avogadri, Francesca, Merghoub, Taha, Maughan, Maureen F, Hirschhorn-Cymerman, Daniel, Morris, John, Ritter, Erika, Olmsted, Robert, Houghton, Alan N, Wolchok, Jedd D

Volltext

Glucocorticoid-Induced TNF Receptor Family Related Gene Activation Overcomes Tolerance/Ignorance to Melanoma Differentiation Antigens and Enhances Antitumor Immunity von Ramirez-Montagut, Teresa, Chow, Andrew, Hirschhorn-Cymerman, Daniel, Terwey, Theis H, Kochman, Adam A, Lu, Sydney, Miles, Randy C, Sakaguchi, Shimon, Houghton, Alan N, van den Brink, Marcel R. M

Volltext

Overcoming resistance to checkpoint blockade therapy by targeting PI3K in myeloid cells von De Henau, Olivier, Rausch, Matthew, Winkler, David, Campesato, Luis Felipe, Liu, Cailian, Cymerman, Daniel Hirschhorn, Budhu, Sadna, Ghosh, Arnab, Pink, Melissa, Tchaicha, Jeremy, Douglas, Mark, Tibbitts, Thomas, Sharma, Sujata, Proctor, Jennifer, Kosmider, Nicole, White, Kerry, Stern, Howard, Soglia, John, Adams, Julian, Palombella, Vito J, McGovern, Karen, Kutok, Jeffery L, Wolchok, Jedd D, Merghoub, Taha

Volltext

549 Characterizing double positive T cells in the tumor microenvironment: a tale of promiscuous cell fates von Schad, Sara, Chow, Andrew, Pan, Heng, Mangarin, Levi, Zappasodi, Roberta, Gigoux, Mathieu, Redmond, David, Hirschhorn-Cymerman, Daniel, Budhu, Sadna, Zhong, Hong, Yang, Xia, Elemento, Olivier, Wolchok, Jedd, Merghoub, Taha

Volltext

Adjuvanticity of Plasmid DNA Encoding Cytokines Fused to Immunoglobulin Fc Domains von FERRONE, Cristina R, PERALES, Miguel-Angel, WOLCHOK, Jedd D, GOLDBERG, Stacie M, SOMBERG, C. Joy, HIRSCHHORN-CYMERMAN, Daniel, GREGOR, Polly D, TURK, Mary Jo, RAMIREZ-MONTAGUT, Teresa, GOLD, Jason S, HOUGHTON, Alan N

Volltext

Agonist Antibodies to TNFR Molecules That Costimulate T and NK Cells von MELERO, Ignacio, HIRSCHHORN-CYMERMAN, Daniel, MORALES-KASTRESANA, Aizea, SANMAMED, Miguel F, WOLCHOK, Jedd D

Volltext

Monocytic CCR2+ Myeloid-Derived Suppressor Cells Promote Immune Escape by Limiting Activated CD8 T-cell Infiltration into the Tumor Microenvironment von LESOKHIN, Alexander M, HOHL, Tobias M, MERGHOUB, Taha, WOLCHOK, Jedd D, KITANO, Shigehisa, CORTEZ, Czrina, HIRSCHHORN-CYMERMAN, Daniel, AVOGADRI, Francesca, RIZZUTO, Gabrielle A, LAZARUS, John J, PAME, Eric G, HOUGHTON, Alan N

Volltext

Phosphatidylserine targeting antibody enhances anti-tumor activity of adoptive cell therapies in a mouse melanoma model von Schad, Sara, Hirschhorn-Cymerman, Daniel, Budhu, Sadna, Zhong, Hong, Yang, Xia, Merghoub, Taha, Wolchok, Jedd D

Volltext

Induction of tumoricidal function in CD4+ T cells is associated with concomitant memory and terminally differentiated phenotype von Hirschhorn-Cymerman, Daniel, Budhu, Sadna, Kitano, Shigehisa, Liu, Cailian, Zhao, Feng, Zhong, Hong, Lesokhin, Alexander M, Avogadri-Connors, Francesca, Yuan, Jianda, Li, Yanyun, Houghton, Alan N, Merghoub, Taha, Wolchok, Jedd D

Volltext

Immuno-PET imaging of activation markers on antigen-specific CD4 T cells in a mouse model of melanoma von Krebs, Simone, Carter, Lukas, Hirschhorn-Cymerman, Daniel, Wolchok, Jedd, Merghoub, Taha, Schoder, Heiko, Larson, Steven

Volltext

Cutting Edge: OX40 Agonists Can Drive Regulatory T Cell Expansion if the Cytokine Milieu Is Right von Ruby, Carl E, Yates, Melissa A, Hirschhorn-Cymerman, Daniel, Chlebeck, Peter, Wolchok, Jedd D, Houghton, Alan N, Offner, Halina, Weinberg, Andrew D

Volltext

Abstract 3568: Phosphatidylserine targeting antibody enhances antitumor activity of CAR T cells in mouse melanoma von Schad, Sara, Hirschhorn-Cymerman, Daniel, Budhu, Sadna, Zhong, Hong, Yang, Xia, Shan, Joseph, King, Steven, Merghoub, Taha, Wolchok, Jedd

Volltext

OX40 engagement and chemotherapy combination provides potent antitumor immunity with concomitant regulatory T cell apoptosis von Hirschhorn-Cymerman, Daniel, Rizzuto, Gabrielle A, Merghoub, Taha, Cohen, Adam D, Avogadri, Francesca, Lesokhin, Alexander M, Weinberg, Andrew D, Wolchok, Jedd D, Houghton, Alan N

Volltext

Enhancement of tumor-reactive cytotoxic CD4+ T cell responses after ipilimumab treatment in four advanced melanoma patients von Kitano, Shigehisa, Tsuji, Takemasa, Liu, Caillian, Hirschhorn-Cymerman, Daniel, Kyi, Chrisann, Mu, Zhenyu, Allison, James P, Gnjatic, Sacha, Yuan, Jianda D, Wolchok, Jedd D

Volltext

Abstract 1651: Targeting phosphatidylserine in combination with adoptive T cell transfer eliminates advanced tumors without off-target toxicities in a melanoma preclinical model von Hirschhorn-Cymerman, Daniel, Schad, Sara Sara, Budhu, Sadna, Hong, Zhong, Yang, Xia, Jeff, Hutchins T., Freimark, Bruce D., Gray, Michael J., Wolchok, Jedd, Merghoub, Taha

Volltext

Modulation of TFH-like cells and anti-tumor activity of immune checkpoint blockade von Zappasodi, Roberta, Budhu, Sadna, Hellmann, Matthew D., Postow, Michael A., Senbabaoglu, Yasin, Manne, Sasikanth, Gasmi, Billel, Liu, Cailian, Zhong, Hong, Li, Yanyun, Huang, Alexander C., Hirschhorn-Cymerman, Daniel, Panageas, Katherine S., Wherry, E. John, Merghoub, Taha, Wolchok, Jedd D.

Volltext

The New Era of Cancer Immunotherapy: Manipulating T-Cell Activity to Overcome Malignancy von Khalil, Danny N, Budhu, Sadna, Gasmi, Billel, Zappasodi, Roberta, Hirschhorn-Cymerman, Daniel, Plitt, Tamar, De Henau, Olivier, Zamarin, Dmitriy, Holmgaard, Rikke B, Murphy, Judith T, Wolchok, Jedd D, Merghoub, Taha

Volltext